Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models

Neuron

Volumn 101, Issue 4, 2019, Pages 648-661.e4

  Antoine, Michelle W ^a   Langberg, Tomer ^a   Schnepel, Philipp ^a   Feldman, Daniel E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

autism; cerebral cortex; circuit excitability; E I ratio; excitation; Fragile X; homeostasis; inhibition; somatosensory cortex

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTISM; CONDUCTANCE; CONTROLLED STUDY; CORTICAL EXCITABILITY; DEPOLARIZATION; EVOKED RESPONSE; EXCITATION; IN VITRO STUDY; IN VIVO STUDY; INHIBITION (PSYCHOLOGY); MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOMATOSENSORY CORTEX; SPIKE WAVE; SYNAPSE; VIBRISSA; ANIMAL; C57BL MOUSE; CHROMOSOME 16; EXCITATORY POSTSYNAPTIC POTENTIAL; GENETICS; HUMAN; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; SOMATOSENSORY EVOKED POTENTIAL;

CNTNAP2 PROTEIN, MOUSE; FMR1 PROTEIN, MOUSE; FRAGILE X MENTAL RETARDATION PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; TSC2 PROTEIN, MOUSE; TUBERIN;

ANIMALS; AUTISTIC DISORDER; CHROMOSOMES, HUMAN, PAIR 16; EVOKED POTENTIALS, SOMATOSENSORY; EXCITATORY POSTSYNAPTIC POTENTIALS; FRAGILE X MENTAL RETARDATION PROTEIN; HUMANS; INHIBITORY POSTSYNAPTIC POTENTIALS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; SOMATOSENSORY CORTEX; TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN;

EID: 85060099503     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2018.12.026     Document Type: Article

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