Spread of Carbapenem and Colistin-Resistant Klebsiella pneumoniae ST512 Clinical Isolates in Israel: A Cause for Vigilance

Microbial Drug Resistance

Volumn 25, Issue 1, 2019, Pages 63-71

  Lalaoui, Rym ^a   Bakour, Sofiane ^a,b   Livnat, Kashat ^c   Assous, Marc Victor ^c   Diene, Seydina M ^a   Rolain, Jean Marc ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c SHAARE ZEDEK MEDICAL CENTER   (Israel)

Author keywords

carbapenemases; colistin resistance; Klebsiella pneumoniae; whole genome sequencing

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZTREONAM; BETA LACTAMASE; BETA LACTAMASE KPC; CARBAPENEM; CARBAPENEM DERIVATIVE; CARBAPENEMASE; CEFEPIME; CEFOTAXIME; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; ERTAPENEM; FOSFOMYCIN; IMIPENEM; MALATE DEHYDROGENASE; NITROFURAN; OFLOXACIN; PROTEIN TONB; PSEUDOMONIC ACID; QUINOLONE DERIVATIVE; RIFAMPICIN; RNA POLYMERASE BETA SUBUNIT; SULFANILAMIDE; TAZOBACTAM; TIMENTIN; TRANSPOSASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN;

ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIUM ISOLATE; CARBAPENEM RESISTANCE; COLISTIN RESISTANCE; CONSENSUS SEQUENCE; GAPA GENE; GENE INSERTION SEQUENCE; INFB GENE; ISRAEL; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MISSENSE MUTATION; MRGB GENE; NONHUMAN; PGI GENE; PHOE GENE; PRIORITY JOURNAL; TRANSPOSON; WHOLE GENOME SEQUENCING; ANTIBIOTIC RESISTANCE; DRUG EFFECT; GENETICS; HOSPITAL; HUMAN; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PROCEDURES;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; COLISTIN; DNA TRANSPOSABLE ELEMENTS; DRUG RESISTANCE, BACTERIAL; GENES, BACTERIAL; HOSPITALS; HUMANS; ISRAEL; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MUTATION, MISSENSE;

EID: 85059797468     PISSN: 10766294     EISSN: 19318448     Source Type: Journal    
DOI: 10.1089/mdr.2018.0014     Document Type: Article

References (34)

1. Lerner, A., E. Solter, E. Rachi, A. Adler, H. Rechnitzer, D. Miron, L. Krupnick, S. Sela, E. Aga, Y. Ziv, A. Peretz, K. Labay, G. Rahav, Y. Geffen, K. Hussein, O. Eluk, Y. Carmeli, and M.J. Schwaber. 2016. Detection and characterization of carbapenemase-producing Enterobacteriaceae in wounded Syrian patients admitted to hospitals in northern Israel. Eur J Clin Microbiol Infect Dis. 35:149-154.
2. Yigit, H., A.M. Queenan, G.J. Anderson, A. Domenech-Sanchez, J.W. Biddle, C.D. Steward, S. Alberti, K. Bush, and F.C. Tenover. 2001. Novel carbapenem-hydrolyzing b-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother. 45: 1151-1161.
3. Nordmann, P., and L. Poirel. 2014. The difficult-To-control spread of carbapenemase producers among Enterobacteriaceae worldwide. Clin Microbiol Infect. 20:821-830.
4. Leavitt, A., I. Chmelnitsky, I. Ofek, Y. Carmeli, and S. Navon-Venezia. 2010. Plasmid pKpQIL encoding KPC-3 and TEM-1 confers carbapenem resistance in an extremely drug-resistant epidemic Klebsiella pneumoniae strain. J Antimicrob Chemother. 65:243-248.
5. Pitout, J.D.D., P. Nordmann, and L. Poirel. 2015. Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance. Antimicrob Agents Chemother. 59:5873-5884.
6. Leavitt, A., S. Navon-Venezia, I. Chmelnitsky, M.J. Schwaber, and Y. Carmeli. 2007. Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. Antimicrob Agents Chemother. 51:3026-3029.
7. Adler, A., O. Hussein, D. Ben-David, S. Masarwa, S. Navon-Venezia, M.J. Schwaber, and Y. Carmeli. 2015. Persistence of Klebsiella pneumoniae ST258 as the predominant clone of carbapenemase-producing Enterobacteriaceae in post-Acute-care hospitals in Israel, 2008-2013. J Antimicrob Chemother. 70:89-92.
8. Biswas, S., J.M. Brunel, J.C. Dubus, M. Reynaud-Gaubert, and J.M. Rolain. 2012. Colistin: An update on the antibiotic of the 21st century. Anti Infect Ther. 10:917-934.
9. Olaitan, A.O., S. Morand, and J.M. Rolain. 2014. Mechanisms of polymyxin resistance: Acquired and intrinsic resistance in bacteria. Front Microbiol. 5:643.
10. Olaitan, A.O., S.M. Diene, M. Kempf, M. Berrazeg, S. Bakour, S.K. Gupta, B. Thongmalayvong, K. Akkhavong, S. Somphavong, P. Paboriboune, K. Chaisiri, C. Komalamisra, O.O. Adelowo, O.E. Fagade, O.A. Banjo, A.J. Oke, A. Adler, M.V. Assous, S. Morand, D. Raoult, and J.M. Rolain. 2014. Worldwide emergence of colistin resistance in Klebsiella pneumoniae from healthy humans and patients in Lao PDR, Thailand, Israel, Nigeria and France owing to inactivation of the PhoP/PhoQ regulator mgrB: An epidemiological and molecular study. Int J Antimicrob Agents. 44:500-507.
11. Bakour, S., A.O. Olaitan, H. Ammari, A. Touati, S. Saoudi, K. Saoudi, and J.M. Rolain. 2015. Emergence of colistinand carbapenem-resistant Acinetobacter baumannii ST2 clinical isolate in Algeria: first case report. Microb Drug Resist. 21:279-285.
12. Baron, S., L. Hadjadj, J.M. Rolain, and A.O. Olaitan. 2016. Molecular mechanisms of polymyxin resistance: knowns and unknowns. Int J Antimicrob Agents. 48:583-591.
13. Liu, Y.Y., Y. Wang, T.R. Walsh, L.X. Yi, R. Zhang, J. Spencer, Y. Doi, G. Tian, B. Dong, X. Huang, L.F. Yu, D. Gu, H. Ren, X. Chen, L. Lv, D. He, H. Zhou, Z. Liang, J.H. Liu, and J. Shen. 2016. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study. Lancet Infect Dis. 16:161-168.
14. Seng, P., M. Drancourt, F. Gouriet, B. La Scola, P.E. Fournier, J.M. Rolain, and D. Raoult. 2009. Ongoing revolution in bacteriology: routine identification of bacteria by matrix-Assisted laser desorption ionization time-of-flight mass spectrometry. Clin Infect Dis. 49:543-551.
15. Bakour, S., V. Garcia, L. Loucif, J.M. Brunel, A. Gharout-Sait, A. Touati, and J.M. 2015. Rapid identification of carbapenemase-producing Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii using a modified Carba NP test. New Microbes New Infect. 7:89-93.
16. Lee, K. C.K. Kim, D. Yong, S.H. Jeong, J.H. Yum, Y.H. Seo, J.D. Docquier, and Y. Chong. 2010. Improved performance of the modified Hodge test with MacConkey agar for screening carbapenemases producing Gram-negative bacilli. J Microbiol Methods. 83:149-152.
17. Jeong, S.H., I.K. Bae, K.O. Park, Y.J. An, S.G. Sohn, S.J. Jang, K.H. Sung, K.S. Yang, K. Lee, D. Young, and S.H. Lee. 2006. Outbreaks of imipenem-resistant Acinetobacter baumannii producing carbapenemases in Korea. J Microbiol. 44:423-431.
18. Gupta, S.K., B.R. Padmanabhan, S.M. Diene, R. Lopez-Rojas, M. Kempf, L. Landraud, and J.M. Rolain. 2014. ARG-ANNOT, a new bioinformatic tool to discover antibiotic resistance genes in bacterial genomes. Antimicrob Agents Chemother. 58:212-220.
19. Chabou, S., T. Leangapichart, L. Okdah, S. Le Page, L. Hadjadj, and J.M. Rolain. 2016. Real-Time quantitative PCR assay with Taqman probe for rapid detection of MCR-1 plasmid-mediated colistin resistance. New Microbes New Infect. 13:71-74.
20. Wu, W., Y. Feng, A. Carattoli, and Z. Zonga. 2015. Characterization of an Enterobacter cloacae strain producing both KPC and NDM carbapenemases by whole-genome sequencing. Antimicrob Agents Chemother. 59:6625-6628.
21. Cuzon, G., T. Naas, and P. Nordmann. 2010. KPC carbapenemases: what is at stake in clinical microbiology? [In French]. Pathol Biol (Paris). 58:39-45.
22. Bakour, S., F. Sahli, A. Touati, and J.M. Rolain. 2014. Emergence of KPC-producing Klebsiella pneumoniae ST512 isolated from cerebrospinal fluid of a child in Algeria. New Microbes New Infect. 3:34-36.
23. Yong, D., M.A. Toleman, C.G. Giske, H.S. Cho, K. Sundman, K. Lee, and T.R. Walsh. 2009. Characterization of a new metallo-b-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother. 53:5046-5054.
24. Lachish, T., M. Elimelech, N. Arieli, A. Adler, J.M. Rolain, and M.V. Assous. 2012. Emergence of New Delhi metallob-lactamase in Jerusalem, Israel. Int J Antimicrob Agents. 40:566-567.
25. Olaitan, A.O., S.M. Diene, S.K. Gupta, A. Adler, M.V. Assous, and J.M. Rolain. 2014. Genome analysis of NDM-1 producing Morganella morganii clinical isolate. Expert Rev Anti Infect Ther. 12:1297-1305.
26. Olaitan, A.O., S.M. Diene, M.V. Assous, and J.M. Rolain. 2016. Genomic plasticity of multidrug-resistant NDM-1 positive clinical isolate of Providencia rettgeri. Genome Biol Evol. 8:723-728.
27. Chen, L., B. Mathema, K.D. Chavda, F.R. DeLeo, R.A. Bonomo, and B.N. Kreiswirth. 2014. Carbapenemaseproducing Klebsiella pneumoniae: molecular and genetic decoding. Trends Microbiol. 22:686-696.
28. Bakour, S., S.A. Sankar, J. Rathored, P. Biagini, D. Raoult, and P.E. Fournier. 2016. Identification of virulence factors and antibiotic resistance markers using bacterial genomics. Future Microbiol. 11:455-466.
29. Mathers, A.J., N. Stoesser, W. Chai, J. Carroll, K. Barry, A. Cherunvanky, R. Sebra, A. Kasarskis, T.E. Peto, A.S.Walker, C.D. Sifri, D.W. Crook, and A.E. Sheppard. 2016. Chromosomal integration of the Klebsiella pneumoniae carbapenemase gene, blaKPC, in Klebsiella species is elusive but not rare. Antimicrob Agents Chemother. 61:e01823-16.
30. Rodrigues, C., E. Machado, H. Ramos, L. Peixe, and A. Novais. 2014. Expansion of ESBL-producing Klebsiella pneumoniae in hospitalized patients: A successful story of international clones (ST15, ST147, ST336) and epidemic plasmids (IncR, IncFIIK). Int J Med Microbiol. 304:1100-1108.
31. Pereira, P.S., M. Borghi, C.F. de Araú jo, C.A. Aires, J.C. Oliveira, M.D. Asensi, and A.P. Carvalho-Assefa. 2015. Clonal dissemination of OXA-370-producing Klebsiella pneumoniae in Rio de Janeiro, Brazil. Antimicrob Agents Chemother. 59:4453-4456.
32. Zhu, J., L. Sun, B. Ding, Y. Yang, X. Xu, W. Liu, D. Zhu, F. Yang, H. Zhang, and F. Hu. 2016. Outbreak of NDM-1-producing Klebsiella pneumoniae ST76 and ST37 isolates in neonates. Eur J Clin Microbiol Infect Dis. 35:611-618.
33. Keith, S.K., C.G. Ana, and D. Grégory. 2017. Old antibiotics for multidrug-resistant pathogens: from in vitro activity to clinical outcomes. Int J Med Microbiol. 49:542-548.
34. Dubourg, G., L. Okdah, S. Le Page, J.M. Rolain, D. Raoult. 2015. In vitro activity of ?old antibiotics? against highly resistant Gram-negative bacteria. Int J Antimicrob Agents. 46:718-720.