Novel Potent Decameric Peptide of Spirulina platensis Reduces Blood Pressure Levels Through a PI3K/AKT/eNOS-Dependent Mechanism

Hypertension

Volumn 73, Issue 2, 2019, Pages 449-457

  Carrizzo, Albino ^a,b   Conte, Giulio Maria ^b   Sommella, Eduardo ^b   Damato, Antonio ^a,b   Ambrosio, Mariateresa ^a,b   Sala, Marina ^b,c   Scala, Maria Carmina ^b   Aquino, Rita Patrizia ^b   De Lucia, Massimiliano ^a,b   Madonna, Michele ^a,b   Sansone, Francesca ^b   Ostacolo, Carmine ^b   Capunzo, Mario ^b   Migliarino, Serena ^b   Sciarretta, Sebastiano ^a,b,d   Frati, Giacomo ^a,b,d   Campiglia, Pietro ^b,e   Vecchione, Carmine ^a,b  

^a IRCCS NEUROMED   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e European Biomedical Research Institute of Salerno   (Italy)

Author keywords

blood pressure; endothelium; peptides; spirulina; vasodilation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCHOLINE; ANTIHYPERTENSIVE AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; PEPTIDE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; BACTERIAL PROTEIN; NITRIC OXIDE; NOS3 PROTEIN, MOUSE; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTHROSPIRA PLATENSIS; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL REACTIVITY; DOSE RESPONSE; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENZYME PHOSPHORYLATION; HEMODYNAMICS; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; MESENTERIC ARTERY; MOUSE; NONHUMAN; PEPTIDOMICS; PI3K/AKT SIGNALING; PRIORITY JOURNAL; RESISTANCE BLOOD VESSEL; SINGLE DRUG DOSE; SYSTOLIC BLOOD PRESSURE; VASODILATATION; ANIMAL; BLOOD PRESSURE; CHEMISTRY; DRUG EFFECT; PHYSIOLOGY; SPIRULINA; VASCULAR ENDOTHELIUM;

ANIMALS; BACTERIAL PROTEINS; BLOOD PRESSURE; ENDOTHELIUM, VASCULAR; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PEPTIDES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SPIRULINA; VASODILATION;

EID: 85059796804     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.118.11801     Document Type: Article

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