Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases

FEBS Journal

Volumn 286, Issue 1, 2019, Pages 169-183

  Salimraj, Ramya ^a   Hinchliffe, Philip ^a   Kosmopoulou, Magda ^a   Tyrrell, Jonathan M ^b   Brem, Jürgen ^c   van Berkel, Sander S ^c   Verma, Anil ^d   Owens, Raymond J ^d   McDonough, Michael A ^c   Walsh, Timothy R ^b   Schofield, Christopher J ^c   Spencer, James ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d RUTHERFORD APPLETON LABORATORY   (United Kingdom)

Author keywords

antibiotic resistance; carbapenem; metallo lactamase; VIM; X ray crystallography

Indexed keywords

BACTERIAL ENZYME; MEROPENEM; METALLO BETA LACTAMASE; UNCLASSIFIED DRUG; VIM 1 ENZYME; BACTERIAL PROTEIN; BETA LACTAMASE; PROTEIN BINDING; VIM-1 METALLO-BETA-LACTAMASE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; BINDING SITE; CHEMISTRY; ENTEROBACTERIACEAE; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; BETA-LACTAMASES; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENTEROBACTERIACEAE; MEROPENEM; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 85059697756     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.14695     Document Type: Article

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