A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy

Materials Science and Engineering C

Volumn 97, Issue , 2019, Pages 833-841

  Amjadi, Sajed ^a   Hamishehkar, Hamed ^c   Ghorbani, Marjan ^b  

^a URMIA UNIVERSITY   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Betanin; Cancer therapy; Doxorubicin; Drug delivery; Stimuli sensitive polymers

Indexed keywords

CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; DISEASES; DRUG DELIVERY; DRUG INTERACTIONS; NANOPARTICLES; ONCOLOGY; PARTICLE SIZE; POLYETHYLENE GLYCOLS; TISSUE;

BETANIN; CANCER THERAPY; DOXORUBICIN; GELATIN NANOPARTICLES; METHOXYPOLYETHYLENE GLYCOL; STIMULI-SENSITIVE POLYMERS; THERAPEUTIC EFFECTS; THERAPEUTIC EFFICACY;

TARGETED DRUG DELIVERY;

ANTINEOPLASTIC AGENT; BETACYANIN; BETANIN; DOXORUBICIN; DRUG CARRIER; GELATIN; MACROGOL; NANOPARTICLE;

APOPTOSIS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; FLUORESCENCE MICROSCOPY; HUMAN; MCF-7 CELL LINE; PARTICLE SIZE; PH;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BETACYANINS; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; DRUG SYNERGISM; GELATIN; HUMANS; HYDROGEN-ION CONCENTRATION; MCF-7 CELLS; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS;

EID: 85059532461     PISSN: 09284931     EISSN: 18730191     Source Type: Journal    
DOI: 10.1016/j.msec.2018.12.104     Document Type: Article

References (55)

1. Teo, J.Y., Chin, W., Ke, X., Gao, S., Liu, S., Cheng, W., et al. pH and redox dual-responsive biodegradable polymeric micelles with high drug loading for effective anticancer drug delivery. Nanomedicine Nanotechnology, Biol. Med. 13 (2017), 431–442.
2. Kumar, S., Meena, V.K., Hazari, P.P., Sharma, R.K., PEG coated and doxorubicin loaded multimodal Gadolinium oxide nanoparticles for simultaneous drug delivery and imaging applications. Int. J. Pharm. 527 (2017), 142–150.
3. Kohay, H., Sarisozen, C., Sawant, R., Jhaveri, A., Torchilin, V.P., Mishael, Y.G., PEG-PE/clay composite carriers for doxorubicin: effect of composite structure on release, cell interaction and cytotoxicity. Acta Biomater. 55 (2017), 443–454.
4. Rai, G., Mishra, S., Suman, S., Shukla, Y., Resveratrol improves the anticancer effects of doxorubicin in vitro and in vivo models: a mechanistic insight. Phytomedicine 23 (2016), 233–242.
5. Alavi-Tabari, S.A.R., Khalilzadeh, M.A., Karimi-Maleh, H., Zareyee, D., An amplified platform nanostructure sensor for the analysis of epirubicin in the presence of topotecan as two important chemotherapy drugs for breast cancer therapy. New J. Chem. 42 (2018), 3828–3832.
6. Hajipour, H., Hamishehkar, H., Nazari Soltan Ahmad, S., Barghi, S., Maroufi, N.F., Taheri, R.A., Improved anticancer effects of epigallocatechin gallate using RGD-containing nanostructured lipid carriers. Artif. Cells Nanomedicine Biotechnol., 2018, 1–10.
7. Yang, Z., Sun, N., Cheng, R., Zhao, C., Liu, Z., Li, X., et al. pH multistage responsive micellar system with charge-switch and PEG layer detachment for co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells. Biomaterials 147 (2017), 53–67.
8. Lin, J., Cai, Q., Tang, Y., Xu, Y., Wang, Q., Li, T., et al. PEGylated lipid bilayer coated mesoporous silica nanoparticles for co-delivery of paclitaxel and curcumin: design, characterization and its cytotoxic effect. Int. J. Pharm. 536 (2018), 272–282.
9. Suh, M.S., Shen, J., Kuhn, L.T., Burgess, D.J., Layer-by-layer nanoparticle platform for cancer active targeting. Int. J. Pharm. 517 (2017), 58–66.
10. Fan, Y., Yuan, S., Huo, M.M., Sen Chaudhuri, A., Zhao, M., Wu, Z., et al. Spatial controlled multistage nanocarriers through hybridization of dendrimers and gelatin nanoparticles for deep penetration and therapy into tumor tissue. Nanomed. Nanotechnol. Biol. Med. 13 (2017), 1399–1410.
11. Zeng, S.-Q., Chen, Y.-Z., Chen, Y., Liu, H., Lipid–polymer hybrid nanoparticles for synergistic drug delivery to overcome cancer drug resistance. New J. Chem. 41 (2017), 1518–1525.
12. Shaaruddin, S., Ghazali, H.M., Hamed Mirhosseini, S., Muhammad, K., Stability of betanin in pitaya powder and confection as affected by resistant maltodextrin. LWT Food Sci. Technol. 84 (2017), 129–134.
13. Han, J., Tan, C., Wang, Y., Yang, S., Tan, D., Betanin reduces the accumulation and cross-links of collagen in high-fructose-fed rat heart through inhibiting non-enzymatic glycation. Chem. Biol. Interact. 227 (2015), 37–44.
14. Farabegoli, F., Scarpa, E.S., Frati, A., Serafini, G., Papi, A., Spisni, E., et al. Betalains increase vitexin-2-O-xyloside cytotoxicity in CaCo-2 cancer cells. Food Chem. 218 (2017), 356–364.
15. Kapadia, G.J., Rao, G.S., Ramachandran, C., Iida, A., Suzuki, N., Tokuda, H., Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. J. Complement. Integr. Med. 10 (2013), 113–122.
16. Das, S., Filippone, S.M., Williams, D.S., Das, A., Kukreja, R.C., Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells. Mol. Cell. Biochem. 421 (2016), 89–101.
17. Khan, M.I., Plant betalains: safety, antioxidant activity, clinical efficacy, and bioavailability. Compr. Rev. Food Sci. Food Saf. 15 (2016), 316–330.
18. Amjadi, S., Ghorbani, M., Hamishehkar, H., Roufegarinejad, L., Improvement in the stability of betanin by liposomal nanocarriers: its application in gummy candy as a food model. Food Chem. 256 (2018), 156–162.
19. Lee, E.J., Lim, K.H., Hardly water-soluble drug-loaded gelatin nanoparticles sustaining a slow release: preparation by novel single-step O/W/O emulsion accompanying solvent diffusion. Bioprocess Biosyst. Eng. 40 (2017), 1701–1712.
20. Bini, R.A., Silva, M.F., Varanda, L.C., da Silva, M.A., Dreiss, C.A., Soft nanocomposites of gelatin and poly(3-hydroxybutyrate) nanoparticles for dual drug release. Colloids Surf. B: Biointerfaces 157 (2017), 191–198.
21. Shilpi, D., Kushwah, V., Agrawal, A.K., Jain, S., Improved stability and enhanced oral bioavailability of atorvastatin loaded stearic acid modified gelatin nanoparticles. Pharm. Res. 34 (2017), 1505–1516.
22. Mahor, A., Prajapati, S.K., Verma, A., Gupta, R., Singh, T.R.R., Kesharwani, P., Development, in-vitro and in-vivo characterization of gelatin nanoparticles for delivery of an anti-inflammatory drug. J. Drug Delivery Sci. Technol. 36 (2016), 55–61.
23. Ghorbani, M., Hamishehkar, H., Decoration of gold nanoparticles with thiolated pH-responsive polymeric (PEG-b-p(2-dimethylamio ethyl methacrylate-co-itaconic acid) shell: a novel platform for targeting of anticancer agent. Mater. Sci. Eng. C 81 (2017), 561–570.
24. Grossen, P., Witzigmann, D., Sieber, S., Huwyler, J., PEG-PCL-based nanomedicines: a biodegradable drug delivery system and its application. J. Control. Release 260 (2017), 46–60.
25. Danafar, H., Sharafi, A., Kheiri Manjili, H., Andalib, S., Sulforaphane delivery using mPEG–PCL co-polymer nanoparticles to breast cancer cells. Pharm. Dev. Technol. 22 (2017), 642–651.
26. Yang, X.Z., Du, X.J., Liu, Y., Zhu, Y.H., Liu, Y.Z., Li, Y.P., et al. Rational design of polyion complex nanoparticles to overcome cisplatin resistance in cancer therapy. Adv. Mater. 26 (2014), 931–936.
27. Khalil, I.A., Harashima, H., An efficient PEGylated gene delivery system with improved targeting: synergism between octaarginine and a fusogenic peptide. Int. J. Pharm. 538 (2018), 179–187.
28. Fan, F., Yu, Y., Zhong, F., Gao, M., Sun, T., Liu, J., et al. Design of tumor acidity-responsive sheddable nanoparticles for fluorescence/magnetic resonance imaging-guided photodynamic therapy. Theranostics 7 (2017), 1290–1302.
29. Ghorbani, M., Hamishehkar, H., Redox and pH-responsive gold nanoparticles as a new platform for simultaneous triple anti-cancer drugs targeting. Int. J. Pharm. 520 (2017), 126–138.
30. Lili, Y., Ruihua, M., Li, L., Fei, L., Lin, Y., Li, S., Intracellular doxorubicin delivery of a core cross-linked, redox-responsive polymeric micelles. Int. J. Pharm. 498 (2016), 195–204.
31. Wang, L., Zhang, J., Song, M., Tian, B., Li, K., Liang, Y., et al. A shell-crosslinked polymeric micelle system for pH/redox dual stimuli-triggered DOX on-demand release and enhanced antitumor activity. Colloids Surf. B: Biointerfaces 152 (2017), 1–11.
32. Bhattacharya, D., Behera, B., Sahu, S.K., Ananthakrishnan, R., Maiti, T.K., Pramanik, P., Design of dual stimuli responsive polymer modified magnetic nanoparticles for targeted anti-cancer drug delivery and enhanced MR imaging. New J. Chem. 40 (2016), 545–557.
33. Verma, G., Shetake, N.G., Barick, K.C., Pandey, B.N., Hassan, P.A., Priyadarsini, K.I., Covalent immobilization of doxorubicin in glycine functionalized hydroxyapatite nanoparticles for pH-responsive release. New J. Chem. 42 (2018), 6283–6292.
34. Xu, X., Li, L., Zhou, Z., Sun, W., Huang, Y., Dual-pH responsive micelle platform for co-delivery of axitinib and doxorubicin. Int. J. Pharm. 507 (2016), 50–60.
35. Mahor, A., Prajapati, S.K., Verma, A., Gupta, R., Iyer, A.K., Kesharwani, P., Moxifloxacin loaded gelatin nanoparticles for ocular delivery: formulation and in-vitro, in-vivo evaluation. J. Colloid Interface Sci. 483 (2016), 132–138.
36. Liu, C., Li, Y., Gao, B., Li, Y., Duan, Q., Kakuchi, T., Comb-shaped, temperature-tunable and water-soluble porphyrin-based thermoresponsive copolymer for enhanced photodynamic therapy. Mater. Sci. Eng. C 82 (2018), 155–162.
37. Mura, S., Nicolas, J., Couvreur, P., Stimuli-responsive nanocarriers for drug delivery. Nat. Mater. 12 (2013), 991–1003.
38. Zhao, P., Liu, M.-C., Lin, H.-C., Sun, X.-Y., Li, Y.-Y., Yan, S.-Q., Synthesis and drug delivery applications for mesoporous silica nanoparticles. J. Med. Biotechnol. 1 (2017), 1–5.
39. Zhang, Y., Chen, J., Zhang, G., Lu, J., Yan, H., Liu, K., Sustained release of ibuprofen from polymeric micelles with a high loading capacity of ibuprofen in media simulating gastrointestinal tract fluids. React. Funct. Polym. 72 (2012), 359–364.
40. Dixit, N., Vaibhav, K., Pandey, R.S., Jain, U.K., Katare, O.P., Katyal, A., et al. Improved cisplatin delivery in cervical cancer cells by utilizing folate-grafted non-aggregated gelatin nanoparticles. Biomed. Pharmacother. 69 (2015), 1–10.
41. Zhang, L., Wang, L., Yao, H., Xu, F., Chen, Y., Biodegradable and biocompatible monodispersed hollow mesoporous organosilica with large pores for delivering biomacromolecules. J. Mater. Chem. B. 5 (2017), 8013–8025.
42. Shargh, V.H., Hondermarck, H., Liang, M., Gelatin-albumin hybrid nanoparticles as matrix metalloproteinases-degradable delivery systems for breast cancer therapy. Nanomedicine 12 (2017), 977–989.
43. Xu, J.-H., Gao, F.-P., Liu, X.-F., Zeng, Q., Guo, S.-S., Tang, Z.-Y., et al. Supramolecular gelatin nanoparticles as matrix metalloproteinase responsive cancer cell imaging probes. Chem. Commun., 49, 2013, 4462.
44. Chen, K., Xu, J., Luft, J.C., Tian, S., Raval, J.S., Desimone, J.M., Design of asymmetric particles containing a charged interior and a neutral surface charge: comparative study on in vivo circulation of polyelectrolyte microgels. J. Am. Chem. Soc. 136 (2014), 9947–9952.
45. Ghorbani, M., Hamishehkar, H., Arsalani, N., Entezami, A.A., A novel dual-responsive core-crosslinked magnetic-gold nanogel for triggered drug release. Mater. Sci. Eng. C 68 (2016), 436–444.
46. Ghorbani, M., Hamishehkar, H., Arsalani, N., Entezami, A.A., Surface decoration of magnetic nanoparticles with folate-conjugated poly(N-isopropylacrylamide-co-itaconic acid): a facial synthesis of dual-responsive nanocarrier for targeted delivery of doxorubicin. Int. J. Polym. Mater. Polym. Biomater. 65 (2016), 683–694.
47. Nezhad-Mokhtari, P., Arsalani, N., Ghorbani, M., Hamishehkar, H., Development of biocompatible fluorescent gelatin nanocarriers for cell imaging and anticancer drug targeting. J. Mater. Sci., 53, 2018.
48. Mura, S., Nicolas, J., Couvreur, P., Stimuli-responsive nanocarriers for drug delivery. Nat. Mater. 12 (2013), 991–1003.
49. Guo, Y., He, W., Yang, S., Zhao, D., Li, Z., Luan, Y., Co-delivery of docetaxel and verapamil by reduction-sensitive PEG-PLGA-SS-DTX conjugate micelles to reverse the multi-drug resistance of breast cancer. Colloids Surf. B: Biointerfaces 151 (2017), 119–127.
50. Samanta, S., Pradhan, L., Bahadur, D., Mesoporous lipid-silica nanohybrids for folate-targeted drug-resistant ovarian cancer. New J. Chem., 8324, 2018.
51. Bonferoni, M.C., Rossi, S., Sandri, G., Ferrari, F., Nanoparticle formulations to enhance tumor targeting of poorly soluble polyphenols with potential anticancer properties. Semin. Cancer Biol. 46 (2017), 205–214.
52. Karthikeyan, S., Hoti, S.L., Prasad, N.R., Resveratrol loaded gelatin nanoparticles synergistically inhibits cell cycle progression and constitutive NF-kappaB activation, and induces apoptosis in non-small cell lung cancer cells. Biomed. Pharmacother. 70 (2015), 274–282.
53. Ghorbani, M., Hamishehkar, H., Hajipour, H., Arsalani, N., Entezami, A.A., Ternary-responsive magnetic nanocarriers for targeted delivery of thiol-containing anticancer drugs. New J. Chem. 40 (2016), 3561–3570.
54. Nowacki, L., Vigneron, P., Rotellini, L., Cazzola, H., Merlier, F., Prost, E., et al. Betanin-enriched red beetroot (Beta vulgaris {L}.) extract induces apoptosis and autophagic cell death in {MCF}-7 cells. Phytother. Res. 1973 (2015), 1964–1973.
55. Zielińska-Przyjemska, M., Olejnik, A., Dobrowolska-Zachwieja, A., Łuczak, M., Baer-Dubowska, W., DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin. Postepy Hig. Med. Dosw. 70 (2016), 265–271.