Platelet-Dense Granules Worsen Pre-Infection Thrombocytopenia during Gram-Negative Pneumonia-Derived Sepsis

Journal of Innate Immunity

Volumn 11, Issue 2, 2019, Pages 168-180

  Claushuis, Theodora A M ^a   De Vos, Alex F ^a   Roelofs, Joris J T H ^b   De Boer, Onno J ^b   Van 'T Veer, Cornelis ^a   Van Der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Animal models; Bacterial infection; Host defense; Platelets; Sepsis

Indexed keywords

CLOPIDOGREL; HPS3 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; CELL GRANULE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; GRAM NEGATIVE SEPSIS; HOST PATHOGEN INTERACTION; HOST RESISTANCE; IMMUNE RESPONSE; INFECTIOUS PNEUMONIA; KLEBSIELLA PNEUMONIAE INFECTION; LUNG HEMORRHAGE; MOUSE; NONHUMAN; OCULAR ALBINISM; PLATELET COUNT; PLATELET DENSE GRANULE; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE FUNCTION; THROMBOCYTOPENIA; ANIMAL; BACTERIAL PNEUMONIA; C57BL MOUSE; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; KLEBSIELLA INFECTION; KLEBSIELLA PNEUMONIAE; METABOLISM; MUTANT MOUSE STRAIN; MUTATION; PHYSIOLOGY; SECRETORY VESICLE; SEPSIS;

ANIMALS; BLOOD PLATELETS; DISEASE MODELS, ANIMAL; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUTATION; PNEUMONIA, BACTERIAL; SECRETORY VESICLES; SEPSIS; THROMBOCYTOPENIA;

EID: 85058821026     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000494147     Document Type: Article

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