Platelet and endothelial cell P-selectin are required for host defense against Klebsiella pneumoniae-induced pneumosepsis

Journal of Thrombosis and Haemostasis

Volumn 13, Issue 6, 2015, Pages 1128-1138

  de Stoppelaar, S F ^a   van't Veer, C ^a   Roelofs, J J T H ^a   Claushuis, T A M ^a   de Boer, O J ^a   Tanck, M W T ^b   Hoogendijk, A J ^a   van der Poll, T ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Endothelium; P selectin; Platelets; Pneumonia; Sepsis

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COMPLEMENT COMPONENT C5A; D DIMER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; PADGEM PROTEIN; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CYTOKINE;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERIAL LOAD; BACTERIAL SURVIVAL; BLOOD CLOTTING; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSE; ENDOTHELIUM CELL; HOST RESISTANCE; KLEBSIELLA PNEUMONIAE INFECTION; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE ACTIVATION; LUNG LAVAGE; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PLATELET LYMPHOCYTE RATIO; PNEUMOSEPSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SEPSIS; THROMBOCYTE COUNT; VASCULAR ENDOTHELIUM; WILD TYPE; ANIMAL; BACTERIAL PNEUMONIA; BLOOD; BONE MARROW TRANSPLANTATION; C57BL MOUSE; DISEASE MODEL; GENETICS; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INNATE IMMUNITY; KLEBSIELLA INFECTION; KLEBSIELLA PNEUMONIAE; KNOCKOUT MOUSE; LUNG; METABOLISM; MICROBIOLOGY; NEUTROPHIL CHEMOTAXIS; PATHOGENICITY; PROTECTION; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; TIME FACTOR;

ANIMALS; BACTERIAL LOAD; BLOOD COAGULATION; BLOOD PLATELETS; BONE MARROW TRANSPLANTATION; CHEMOTAXIS, LEUKOCYTE; CYTOKINES; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HOST-PATHOGEN INTERACTIONS; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LUNG; MICE, INBRED C57BL; MICE, KNOCKOUT; P-SELECTIN; PLATELET ACTIVATION; PNEUMONIA, BACTERIAL; PROTECTIVE FACTORS; SEPSIS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84930180527     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12893     Document Type: Article

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