Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice

Blood

Volumn 129, Issue 12, 2017, Pages 1702-1706

  Deppermann, Carsten ^a   Kraft, Peter ^b   Volz, Julia ^a   Schuhmann, Michael K ^b   Beck, Sarah ^a   Wolf, Karen ^a   Stegner, David ^a   Stoll, Guido ^b   Nieswandt, Bernhard ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CLAUDIN 5; HEMOGLOBIN; OCCLUDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY THROMBOSIS; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CONTROLLED STUDY; DERMATITIS; EXPERIMENTAL INFLAMMATION; HEMOSTASIS; LUNG HEMORRHAGE; MIDDLE CEREBRAL ARTERY OCCLUSION; MORTALITY; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PUNCH BIOPSY; SKIN BLEEDING; SUBARACHNOID HEMORRHAGE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE RELEASE REACTION; ANIMAL; BLEEDING; BLOOD; CEREBRAL ARTERY DISEASE; CEREBRAL HEMORRHAGE; INFLAMMATION; LUNG; PATHOLOGY; PHYSIOLOGY; SECRETION (PROCESS); SECRETORY VESICLE; SKIN; THROMBOCYTE;

ANIMALS; BLOOD PLATELETS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; HEMORRHAGE; HEMOSTASIS; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; LUNG; MICE; SECRETORY VESICLES; SKIN;

EID: 85016244227     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-12-750711     Document Type: Article

References (24)

1. Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med. 2008;359(9):938-949.
2. Jackson SP. Arterial thrombosis-insidious, unpredictable and deadly. Nat Med. 2011;17(11):1423-1436.
3. Blair P, Flaumenhaft R. Platelet a-granules: basic biology and clinical correlates. Blood Rev. 2009;23(4):177-189.
4. Mozaffarian D, Benjamin EJ, Go AS, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2015 update: a report from the American Heart Association [published correction appears in Circulation. 2016]. Circulation. 2015;131(4):e29-e322.
5. Ho-Tin-Noé B, Goerge T, Cifuni S M S, Duerschmied D, Wagner DD. Platelet granule secretion continuously prevents intratumor hemorrhage. Cancer Res. 2008;68(16):6851-6858.
6. Goerge T, Ho-Tin-Noe B, Carbo C, et al. Inflammation induces hemorrhage in thrombocytopenia. Blood. 2008;111(10):4958-4964.
7. Boulaftali Y, Hess PR, Getz TM, et al. Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest. 2013;123(2):908-916.
8. Gros A, Syvannarath V, Lamrani L, et al. Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complexmediated inflammation in mice. Blood. 2015;126(8):1017-1026.
9. Boulaftali Y, Hess PR, Kahn ML, Bergmeier W. Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity. Circ Res. 2014;114(7):1174-1184.
10. Deppermann C, Cherpokova D, Nurden P, et al. Gray platelet syndrome and defective thromboinflammation in Nbeal2-deficient mice. J Clin Invest. 2013;123(8):3331-3342.
11. Deppermann C, Nurden P, Nurden AT, Nieswandt B, Stegner D. The Nbeal2 (-/-) mouse as a model for the gray platelet syndrome. Rare Dis. 2013;1(1):e26561.
12. Stegner D, Deppermann C, Kraft P, et al. Munc13-4-mediated secretion is essential for infarct progression but not intracranial hemostasis in acute stroke. J Thromb Haemost. 2013;11(7):1430-1433.
13. Kleinschnitz C, Pozgajova M, Pham M, Bendszus M, Nieswandt B, Stoll G. Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding. Circulation. 2007;115(17):2323-2330.
14. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 1986;17(3):472-476.
15. Moran PM, Higgins LS, Cordell B, Moser PC. Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein. Proc Natl Acad Sci USA. 1995;92(12):5341-5345.
16. Bergmeier W, Schulte V, Brockhoff G, Bier U, Zirngibl H, Nieswandt B. Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody. Cytometry. 2002;48(2):80-86.
17. Stoll G, Kleinschnitz C, Nieswandt B. Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. Blood. 2008;112(9):3555-3562.
18. Morowski M, Vögtle T, Kraft P, Kleinschnitz C, Stoll G, Nieswandt B. Only severe thrombocytopenia results in bleeding and defective thrombus formation in mice. Blood. 2013;121(24):4938-4947.
19. Adams HP Jr, Effron MB, Torner J, et al; AbESTTII Investigators. Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: Abciximab in Emergency Treatment of Stroke Trial (AbESTT-II). Stroke. 2008;39(1):87-99.
20. Kellert L, Hametner C, Rohde S, et al. Endovascular stroke therapy: tirofiban is associated with risk of fatal intracerebral hemorrhage and poor outcome. Stroke. 2013;44(5):1453-1455.
21. Higgins SJ, Purcell LA, Silver KL, et al. Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria. Sci Transl Med. 2016;8(358):358ra128.
22. Abbott NJ. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol Neurobiol. 2000;20(2):131-147.
23. Nobles M, Revest PA, Couraud PO, Abbott NJ. Characteristics of nucleotide receptors that cause elevation of cytoplasmic calcium in immortalized rat brain endothelial cells (RBE4) and in primary cultures. Br J Pharmacol. 1995;115(7):1245-1252.
24. Schumacher D, Strilic B, Sivaraj KK, Wettschureck N, Offermanns S. Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell. 2013;24(1):130-137.