Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 7, 2018, Pages E1550-E1559

  Cloutier, Nathalie ^a   Allaeys, Isabelle ^a   Marcoux, Genevieve ^a   Machlus, Kellie R ^b   Mailhot, Benoit ^a   Zufferey, Anne ^a   Levesque, Tania ^a   Becker, Yann ^a   Tessandier, Nicolas ^a   Melki, Imene ^a   Zhi, Huiying ^c   Poirier, Guy ^a   Rondina, Matthew T ^d   Italiano, Joseph E ^b   Flamand, Louis ^a   McKenzie, Steven E ^e   Cote, Francine ^f   Nieswandt, Bernhard ^g   Khan, Waliul I ^h,i   Flick, Matthew J ^j   Newman, Peter J ^c   Lacroix, Steve ^a   Fortin, Paul R ^a   Boilard, Eric ^a,k   more..

^a LAVAL UNIVERSITY   (Canada)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BLOOD RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

^f IMAGINE INSTITUTE   (France)

^g UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^h MCMASTER UNIVERSITY   (Canada)

ⁱ MCMASTER UNIVERSITY   (Canada)

^j CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^k Canadian National Transplant Research Program   (Canada)

more..

Author keywords

Fc receptor; Immune complexes; Platelets; Serotonin; Thrombocytopenia

Indexed keywords

FC RECEPTOR IIA; FIBRINOGEN; PADGEM PROTEIN; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PHOSPHATIDYLSERINE; SEROTONIN; THROMBOCYTE FACTOR 4; FC RECEPTOR; FIBRINOGEN RECEPTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CONTROLLED STUDY; DEGRANULATION; EXTRACELLULAR TRAP; FEMALE; GENE EXPRESSION; HUMAN; INFLAMMATION; MALE; MOUSE; MUTANT; NONHUMAN; NUCLEOSOME; PATHOGENESIS; PLATELET COUNT; PLATELET MICROPARTICLE; PLATELET REACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SEROTONIN BLOOD LEVEL; SEROTONIN RELEASE; SHOCK; SIGNAL TRANSDUCTION; SYSTEMIC DISEASE; THROMBOCYTE ACTIVATION; THROMBOCYTOPENIA; VASODILATATION; ANAPHYLAXIS; ANIMAL; BLOOD; C57BL MOUSE; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; SEPTIC SHOCK; THROMBOCYTE; YOUNG ADULT;

ADULT; ANAPHYLAXIS; ANIMALS; ANTIGEN-ANTIBODY COMPLEX; BLOOD PLATELETS; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLATELET ACTIVATION; PLATELET COUNT; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; RECEPTORS, IGG; SEROTONIN; SHOCK, SEPTIC; YOUNG ADULT;

EID: 85042032644     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1720553115     Document Type: Article

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