-
1
-
-
68149124472
-
Dietary phenolics: Chemistry, bioavailability and effects on health
-
Crozier, A.; Jaganath, I.B.; Clifford, M.N. Dietary phenolics: Chemistry, bioavailability and effects on health. Nat. Prod. Rep. 2009, 26, 1001–1043. [CrossRef] [PubMed]
-
(2009)
Nat. Prod. Rep.
, vol.26
, pp. 1001-1043
-
-
Crozier, A.1
Jaganath, I.B.2
Clifford, M.N.3
-
2
-
-
84875953344
-
Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases
-
Del Rio, D.; Rodriguez-Mateos, A.; Spencer, J.P.E.; Tognolini, M.; Borges, G.; Crozier, A. Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases. Antioxid. Redox Signal. 2013, 18, 1818–1892. [CrossRef] [PubMed]
-
(2013)
Antioxid. Redox Signal.
, vol.18
, pp. 1818-1892
-
-
Del Rio, D.1
Rodriguez-Mateos, A.2
Spencer, J.P.E.3
Tognolini, M.4
Borges, G.5
Crozier, A.6
-
3
-
-
84867019370
-
Bioavailability of wine-derived phenolic compounds in humans: A review
-
Stockley, C.; Teissedre, P.-L.; Boban, M.; Di Lorenzo, C.; Restani, P. Bioavailability of wine-derived phenolic compounds in humans: A review. Food Funct. 2012, 3, 995–1007. [CrossRef] [PubMed]
-
(2012)
Food Funct
, vol.3
, pp. 995-1007
-
-
Stockley, C.1
Teissedre, P.-L.2
Boban, M.3
Di Lorenzo, C.4
Restani, P.5
-
4
-
-
85027926401
-
Bioavailability of tomato polyphenols is enhanced by processing and fat addition: Evidence from a randomized feeding trial
-
Martínez-Huélamo, M.; Vallverdú-Queralt, A.; Di Lecce, G.; Valderas-Martínez, P.; Tulipani, S.; Jáuregui, O.; Escribano-Ferrer, E.; Estruch, R.; Illan, M.; Lamuela-Raventós, R.M. Bioavailability of tomato polyphenols is enhanced by processing and fat addition: Evidence from a randomized feeding trial. Mol. Nutr. Food Res. 2016, 60, 1578–1589. [CrossRef] [PubMed]
-
(2016)
Mol. Nutr. Food Res.
, vol.60
, pp. 1578-1589
-
-
Martínez-Huélamo, M.1
Vallverdú-Queralt, A.2
Di Lecce, G.3
Valderas-Martínez, P.4
Tulipani, S.5
Jáuregui, O.6
Escribano-Ferrer, E.7
Estruch, R.8
Illan, M.9
Lamuela-Raventós, R.M.10
-
5
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur, J.A.; Pearson, K.J.; Price, N.L.; Jamieson, H.A.; Lerin, C.; Kalra, A.; Prabhu, V.V.; Allard, J.S.; Lopez-Lluch, G.; Lewis, K.; et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444, 337–342. [CrossRef] [PubMed]
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
-
6
-
-
79951794971
-
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
-
Miller, R.A.; Harrison, D.E.; Astle, C.M.; Baur, J.A.; Boyd, A.R.; de Cabo, R.; Fernandez, E.; Flurkey, K.; Javors, M.A.; Nelson, J.F.; et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 2011, 66, 191–201. [CrossRef] [PubMed]
-
(2011)
J. Gerontol. Ser. a Biol. Sci. Med. Sci.
, vol.66
, pp. 191-201
-
-
Miller, R.A.1
Harrison, D.E.2
Astle, C.M.3
Baur, J.A.4
Boyd, A.R.5
de Cabo, R.6
Fernandez, E.7
Flurkey, K.8
Javors, M.A.9
Nelson, J.F.10
-
7
-
-
48349144852
-
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan
-
Pearson, K.J.; Baur, J.A.; Lewis, K.N.; Peshkin, L.; Price, N.L.; Labinskyy, N.; Swindell, W.R.; Kamara, D.; Minor, R.K.; Perez, E.; et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan. Cell Metab. 2008, 8, 157–168. [CrossRef]
-
(2008)
Cell Metab
, vol.8
, pp. 157-168
-
-
Pearson, K.J.1
Baur, J.A.2
Lewis, K.N.3
Peshkin, L.4
Price, N.L.5
Labinskyy, N.6
Swindell, W.R.7
Kamara, D.8
Minor, R.K.9
Perez, E.10
-
8
-
-
48349110303
-
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
-
Barger, J.L.; Kayo, T.; Vann, J.M.; Arias, E.B.; Wang, J.; Hacker, T.A.; Wang, Y.; Raederstorff, D.; Morrow, J.D.; Leeuwenburgh, C.; et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE 2008, 3, e2264. [CrossRef]
-
(2008)
Plos ONE
, vol.3
-
-
Barger, J.L.1
Kayo, T.2
Vann, J.M.3
Arias, E.B.4
Wang, J.5
Hacker, T.A.6
Wang, Y.7
Raederstorff, D.8
Morrow, J.D.9
Leeuwenburgh, C.10
-
9
-
-
33745962138
-
Therapeutic potential of resveratrol: The in vivo evidence
-
Baur, J.A.; Sinclair, D.A. Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. Drug Discov. 2006, 5, 493–506. [CrossRef]
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 493-506
-
-
Baur, J.A.1
Sinclair, D.A.2
-
10
-
-
84875431034
-
High-dose resveratrol supplementation in obese men: An investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition
-
Poulsen, M.M.; Vestergaard, P.F.; Clasen, B.F.; Radko, Y.; Christensen, L.P.; Stødkilde-Jørgensen, H.; Møller, N.; Jessen, N.; Pedersen, S.B.; Jørgensen, J.O.L. High-dose resveratrol supplementation in obese men: An investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. Diabetes 2013, 62, 1186–1195. [CrossRef]
-
(2013)
Diabetes
, vol.62
, pp. 1186-1195
-
-
Poulsen, M.M.1
Vestergaard, P.F.2
Clasen, B.F.3
Radko, Y.4
Christensen, L.P.5
Stødkilde-Jørgensen, H.6
Møller, N.7
Jessen, N.8
Pedersen, S.B.9
Jørgensen, J.O.L.10
-
11
-
-
68449083925
-
Resveratrol protects spatial learning in middle-aged C57BL/6 mice from effects of ethanol
-
Ranney, A.; Petro, M.S. Resveratrol protects spatial learning in middle-aged C57BL/6 mice from effects of ethanol. Behav. Pharmacol. 2009, 20. [CrossRef] [PubMed]
-
(2009)
Behav. Pharmacol.
, vol.20
-
-
Ranney, A.1
Petro, M.S.2
-
12
-
-
33845580481
-
Dietary polyphenols: Good, bad, or indifferent for your health?
-
Halliwell, B. Dietary polyphenols: Good, bad, or indifferent for your health? Cardiovasc. Res. 2007, 73, 341–347. [CrossRef] [PubMed]
-
(2007)
Cardiovasc. Res.
, vol.73
, pp. 341-347
-
-
Halliwell, B.1
-
13
-
-
33845399894
-
Resveratrol Improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 a
-
Lagouge, M.; Argmann, C.; Gerhart-hines, Z.; Meziane, H.; Lerin, C.; Daussin, F.; Messadeq, N.; Milne, J.; Lambert, P.; Elliott, P.; et al. Resveratrol Improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 a. Cell 2006, 127, 1109–1122. [CrossRef] [PubMed]
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
-
14
-
-
33749349202
-
Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor–deficient mice
-
Zang, M.; Xu, S.; Maitland-Toolan, K.A.; Zuccollo, A.; Hou, X.; Jiang, B.; Wierzbicki, M.; Verbeuren, T.J.; Cohen, R.A. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor–deficient mice. Diabetes 2006, 55, 2180. [CrossRef] [PubMed]
-
(2006)
Diabetes
, vol.55
, pp. 2180
-
-
Zang, M.1
Xu, S.2
Maitland-Toolan, K.A.3
Zuccollo, A.4
Hou, X.5
Jiang, B.6
Wierzbicki, M.7
Verbeuren, T.J.8
Cohen, R.A.9
-
15
-
-
36248975293
-
SIRT1 transgenic mice show phenotypes resembling calorie restriction
-
Bordone, L.; Cohen, D.; Robinson, A.; Motta, M.C.; Van Veen, E.; Czopik, A.; Steele, A.D.; Crowe, H.; Marmor, S.; Luo, J.; et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007, 6, 759–767. [CrossRef] [PubMed]
-
(2007)
Aging Cell
, vol.6
, pp. 759-767
-
-
Bordone, L.1
Cohen, D.2
Robinson, A.3
Motta, M.C.4
van Veen, E.5
Czopik, A.6
Steele, A.D.7
Crowe, H.8
Marmor, S.9
Luo, J.10
-
16
-
-
4444267291
-
Crystal structure of quinone reductase 2 in complex with resveratrol
-
Buryanovskyy, L.; Fu, Y.; Boyd, M.; Ma, Y.; Hsieh, T.; Wu, J.M.; Zhang, Z. Crystal structure of quinone reductase 2 in complex with resveratrol. Biochemistry 2004, 43, 11417–11426. [CrossRef]
-
(2004)
Biochemistry
, vol.43
, pp. 11417-11426
-
-
Buryanovskyy, L.1
Fu, Y.2
Boyd, M.3
Ma, Y.4
Hsieh, T.5
Wu, J.M.6
Zhang, Z.7
-
17
-
-
0035811176
-
Ultrasensitive assay for three polyphenols (Catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection
-
Soleas, G.J.; Yan, J.; Goldberg, D.M. Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection. J. Chromatogr. B Biomed. Sci. Appl. 2001, 757, 161–172. [CrossRef]
-
(2001)
J. Chromatogr. B Biomed. Sci. Appl.
, vol.757
, pp. 161-172
-
-
Soleas, G.J.1
Yan, J.2
Goldberg, D.M.3
-
18
-
-
1242336775
-
Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice
-
Meng, X.; Maliakal, P.; Lu, H.; Lee, M.-J.; Yang, C.S. Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J. Agric. Food Chem. 2004, 52, 935–942. [CrossRef]
-
(2004)
J. Agric. Food Chem.
, vol.52
, pp. 935-942
-
-
Meng, X.1
Maliakal, P.2
Lu, H.3
Lee, M.-J.4
Yang, C.S.5
-
19
-
-
33745471738
-
Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption
-
Zamora-Ros, R.; Urpí-Sardà, M.; Lamuela-Raventós, R.M.; Estruch, R.; Vázquez-Agell, M.; Serrano-Martínez, M.; Jaeger, W.; Andres-Lacueva, C. Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption. Clin. Chem. 2006, 52, 1373–1380. [CrossRef]
-
(2006)
Clin. Chem.
, vol.52
, pp. 1373-1380
-
-
Zamora-Ros, R.1
Urpí-Sardà, M.2
Lamuela-Raventós, R.M.3
Estruch, R.4
Vázquez-Agell, M.5
Serrano-Martínez, M.6
Jaeger, W.7
Andres-Lacueva, C.8
-
20
-
-
84937019534
-
Properties of resveratrol: In vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans
-
Gambini, J.; Inglés, M.; Olaso, G.; Lopez-Grueso, R.; Bonet-Costa, V.; Gimeno-Mallench, L.; Mas-Bargues, C.; Abdelaziz, K.M.; Gomez-Cabrera, M.C.; Vina, J.; Borras, C. Properties of resveratrol: In vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans. Oxid. Med. Cell. Longev. 2015, 2015, 1–13. [CrossRef]
-
(2015)
Oxid. Med. Cell. Longev.
, vol.2015
, pp. 1-13
-
-
Gambini, J.1
Inglés, M.2
Olaso, G.3
Lopez-Grueso, R.4
Bonet-Costa, V.5
Gimeno-Mallench, L.6
Mas-Bargues, C.7
Abdelaziz, K.M.8
Gomez-Cabrera, M.C.9
Vina, J.10
Borras, C.11
-
21
-
-
9444296057
-
High absorption but very low bioavailability of oral resveratrol in humans
-
Walle, T.; Hsieh, F.; DeLegge, M.H.; Oatis, J.E.J.; Walle, U.K. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab. Dispos. 2004, 32, 1377–1382. [CrossRef] [PubMed]
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 1377-1382
-
-
Walle, T.1
Hsieh, F.2
Delegge, M.H.3
Oatis, J.E.J.4
Walle, U.K.5
-
22
-
-
78549288940
-
Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: Safety, pharmacokinetics, and effect on the insulin-like growth factor axis
-
Brown, V.A.; Patel, K.R.; Viskaduraki, M.; Crowell, J.A.; Perloff, M.; Booth, T.D.; Vasilinin, G.; Sen, A.; Schinas, A.M.; Piccirilli, G.; et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: Safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. 2010, 70, 9003–9011. [CrossRef] [PubMed]
-
(2010)
Cancer Res
, vol.70
, pp. 9003-9011
-
-
Brown, V.A.1
Patel, K.R.2
Viskaduraki, M.3
Crowell, J.A.4
Perloff, M.5
Booth, T.D.6
Vasilinin, G.7
Sen, A.8
Schinas, A.M.9
Piccirilli, G.10
-
23
-
-
84903218648
-
Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: A randomised, double-blind, placebo-controlled, cross-over investigation
-
Wightman, E.L.; Reay, J.L.; Haskell, C.F.; Williamson, G.; Dew, T.P.; Kennedy, D.O. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: A randomised, double-blind, placebo-controlled, cross-over investigation. Br. J. Nutr. 2014, 112, 203–213. [CrossRef] [PubMed]
-
(2014)
Br. J. Nutr.
, vol.112
, pp. 203-213
-
-
Wightman, E.L.1
Reay, J.L.2
Haskell, C.F.3
Williamson, G.4
Dew, T.P.5
Kennedy, D.O.6
-
24
-
-
84944790420
-
A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
-
Turner, R.S.; Thomas, R.G.; Craft, S.; van Dyck, C.H.; Mintzer, J.; Reynolds, B.A.; Brewer, J.B.; Rissman, R.A.; Raman, R.; Aisen, P.S. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology 2015, 85, 1383–1391. [CrossRef] [PubMed]
-
(2015)
Neurology
, vol.85
, pp. 1383-1391
-
-
Turner, R.S.1
Thomas, R.G.2
Craft, S.3
van Dyck, C.H.4
Mintzer, J.5
Reynolds, B.A.6
Brewer, J.B.7
Rissman, R.A.8
Raman, R.9
Aisen, P.S.10
-
25
-
-
84929839801
-
An open-label trial in Friedreich ataxia suggests clinical benefit with high-dose resveratrol, without effect on frataxin levels
-
Yiu, E.M.; Tai, G.; Peverill, R.E.; Lee, K.J.; Croft, K.D.; Mori, T.A.; Scheiber-Mojdehkar, B.; Sturm, B.; Praschberger, M.; Vogel, A.P.; et al. An open-label trial in Friedreich ataxia suggests clinical benefit with high-dose resveratrol, without effect on frataxin levels. J. Neurol. 2015, 262, 1344–1353. [CrossRef] [PubMed]
-
(2015)
J. Neurol.
, vol.262
, pp. 1344-1353
-
-
Yiu, E.M.1
Tai, G.2
Peverill, R.E.3
Lee, K.J.4
Croft, K.D.5
Mori, T.A.6
Scheiber-Mojdehkar, B.7
Sturm, B.8
Praschberger, M.9
Vogel, A.P.10
-
26
-
-
84950170835
-
Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure
-
Wong, R.H.X.; Howe, P.R.C.; Buckley, J.D.; Coates, A.M.; Kunz, I.; Berry, N.M. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr. Metab. Cardiovasc. Dis. 2011, 21, 851–856. [CrossRef] [PubMed]
-
(2011)
Nutr. Metab. Cardiovasc. Dis.
, vol.21
, pp. 851-856
-
-
Wong, R.H.X.1
Howe, P.R.C.2
Buckley, J.D.3
Coates, A.M.4
Kunz, I.5
Berry, N.M.6
-
27
-
-
84978764735
-
Acute resveratrol consumption improves neurovascular coupling capacity in adults with type 2 diabetes mellitus
-
Wong, R.H.X.; Raederstorff, D.; Howe, P.R.C. Acute resveratrol consumption improves neurovascular coupling capacity in adults with type 2 diabetes mellitus. Nutrients 2016, 8, 425. [CrossRef]
-
(2016)
Nutrients
, vol.8
, pp. 425
-
-
Wong, R.H.X.1
Raederstorff, D.2
Howe, P.R.C.3
-
28
-
-
84858709095
-
Administration of resveratrol: What formulation solutions to bioavailability limitations?
-
Amri, A.; Chaumeil, J.C.; Sfar, S.; Charrueau, C. Administration of resveratrol: What formulation solutions to bioavailability limitations? J. Control. Release 2012, 158, 182–193. [CrossRef]
-
(2012)
J. Control. Release
, vol.158
, pp. 182-193
-
-
Amri, A.1
Chaumeil, J.C.2
Sfar, S.3
Charrueau, C.4
-
29
-
-
84877729850
-
Optimization of trans-Resveratrol bioavailability for human therapy
-
Amiot, M.J.; Romier, B.; Dao, T.A.; Fanciullino, R.; Ciccolini, J.; Burcelin, R.; Pechere, L.; Emond, C.; Savouret, J.; Seree, E. Optimization of trans-Resveratrol bioavailability for human therapy. Biochimie 2013, 95, 1233–1238. [CrossRef]
-
(2013)
Biochimie
, vol.95
, pp. 1233-1238
-
-
Amiot, M.J.1
Romier, B.2
Dao, T.A.3
Fanciullino, R.4
Ciccolini, J.5
Burcelin, R.6
Pechere, L.7
Emond, C.8
Savouret, J.9
Seree, E.10
-
30
-
-
84901917125
-
Resveratrol metabolic fingerprinting after acute and chronic intakes of a functional beverage in humans
-
Rotches-Ribalta, M.; Urpi-Sarda, M.; Martí, M.M.; Reglero, G.; Andres-Lacueva, C. Resveratrol metabolic fingerprinting after acute and chronic intakes of a functional beverage in humans. Electrophoresis 2014, 35, 1637–1643. [CrossRef]
-
(2014)
Electrophoresis
, vol.35
, pp. 1637-1643
-
-
Rotches-Ribalta, M.1
Urpi-Sarda, M.2
Martí, M.M.3
Reglero, G.4
Andres-Lacueva, C.5
-
31
-
-
84866740513
-
Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets
-
Rotches-Ribalta, M.; Andres-Lacueva, C.; Estruch, R.; Escribano, E.; Urpi-Sarda, M. Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets. Pharmacol. Res. 2012, 66, 375–382. [CrossRef] [PubMed]
-
(2012)
Pharmacol. Res.
, vol.66
, pp. 375-382
-
-
Rotches-Ribalta, M.1
Andres-Lacueva, C.2
Estruch, R.3
Escribano, E.4
Urpi-Sarda, M.5
-
32
-
-
0024596954
-
The effect of particle size distribution on dissolution rate and oral absorption
-
Hintz, R.; Johnson, K. The effect of particle size distribution on dissolution rate and oral absorption. Int. J. Pharm. 1989, 51, 9–17. [CrossRef]
-
(1989)
Int. J. Pharm.
, vol.51
, pp. 9-17
-
-
Hintz, R.1
Johnson, K.2
-
33
-
-
80052572943
-
Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases—Safety, pharmacokinetics, and pharmacodynamics
-
Howells, L.M.; Berry, D.P.; Elliott, P.J.; Jacobson, E.W.; Hoffmann, E.; Hegarty, B.; Brown, K.; Steward, W.P.; Gescher, A.J. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases—Safety, pharmacokinetics, and pharmacodynamics. Cancer Prev. Res. 2011, 4, 1419–1425. [CrossRef] [PubMed]
-
(2011)
Cancer Prev. Res.
, vol.4
, pp. 1419-1425
-
-
Howells, L.M.1
Berry, D.P.2
Elliott, P.J.3
Jacobson, E.W.4
Hoffmann, E.5
Hegarty, B.6
Brown, K.7
Steward, W.P.8
Gescher, A.J.9
-
34
-
-
77953353711
-
Steady-State Pharmacokinetics and Tolerability of Trans-Resveratrol 2000 mg Twice Daily with Food, Quercetin and Alcohol (Ethanol) in Healthy Human Subjects
-
La Porte, C.; Voduc, N.; Zhang, G.; Seguin, I.; Tardiff, D.; Singhal, N.; Cameron, D.W. Steady-State Pharmacokinetics and Tolerability of Trans-Resveratrol 2000 mg Twice Daily with Food, Quercetin and Alcohol (Ethanol) in Healthy Human Subjects. Clin. Pharmacokinet. 2010, 49, 449–454. [CrossRef] [PubMed]
-
(2010)
Clin. Pharmacokinet.
, vol.49
, pp. 449-454
-
-
la Porte, C.1
Voduc, N.2
Zhang, G.3
Seguin, I.4
Tardiff, D.5
Singhal, N.6
Cameron, D.W.7
-
35
-
-
56749153720
-
Effect of food on the pharmacokinetic profile of trans-resveratrol
-
Vaz-da-Silva, M.; Loureiro, A.I.; Falcao, A.; Nunes, T.; Rocha, J.-F.; Fernandes-Lopes, C.; Soares, E.; Wright, L.; Almeida, L.; Soares-da-Silva, P. Effect of food on the pharmacokinetic profile of trans-resveratrol. Int. J. Clin. Pharmacol. Ther. 2008, 46, 564–570. [CrossRef] [PubMed]
-
(2008)
Int. J. Clin. Pharmacol. Ther.
, vol.46
, pp. 564-570
-
-
Vaz-Da-Silva, M.1
Loureiro, A.I.2
Falcao, A.3
Nunes, T.4
Rocha, J.-F.5
Fernandes-Lopes, C.6
Soares, E.7
Wright, L.8
Almeida, L.9
Soares-Da-Silva, P.10
-
36
-
-
84896373168
-
Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: Proof of concept
-
Blanchard, O.L.; Friesenhahn, G.; Javors, M.A.; Smoliga, J.M. Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: Proof of concept. PLoS ONE 2014, 9, e90131. [CrossRef] [PubMed]
-
(2014)
Plos ONE
, vol.9
-
-
Blanchard, O.L.1
Friesenhahn, G.2
Javors, M.A.3
Smoliga, J.M.4
-
37
-
-
85006742065
-
Impact of proteins on the uptake, distribution, and excretion of phenolics in the human body
-
Draijer, R.; Van Dorsten, F.A.; Zebregs, Y.E.; Hollebrands, B.; Peters, S.; Duchateau, G.S.; Grün, C.H. Impact of proteins on the uptake, distribution, and excretion of phenolics in the human body. Nutrients 2016, 8, 814. [CrossRef]
-
(2016)
Nutrients
, vol.8
, pp. 814
-
-
Draijer, R.1
van Dorsten, F.A.2
Zebregs, Y.E.3
Hollebrands, B.4
Peters, S.5
Duchateau, G.S.6
Grün, C.H.7
-
38
-
-
84868143162
-
Gut and microbial resveratrol metabolite profiling after moderate long-term consumption of red wine versus dealcoholized red wine in humans by an optimized ultra-high-pressure liquid chromatography tandem mass spectrometry method
-
Rotches-Ribalta, M.; Urpi-Sarda, M.; Llorach, R.; Boto-Ordoñez, M.; Jauregui, O.; Chiva-Blanch, G.; Perez-Garcia, L.; Jaeger, W.; Guillen, M.; Corella, D.; et al. Gut and microbial resveratrol metabolite profiling after moderate long-term consumption of red wine versus dealcoholized red wine in humans by an optimized ultra-high-pressure liquid chromatography tandem mass spectrometry method. J. Chromatogr. A 2012, 1265, 105–113. [CrossRef]
-
(2012)
J. Chromatogr. A
, vol.1265
, pp. 105-113
-
-
Rotches-Ribalta, M.1
Urpi-Sarda, M.2
Llorach, R.3
Boto-Ordoñez, M.4
Jauregui, O.5
Chiva-Blanch, G.6
Perez-Garcia, L.7
Jaeger, W.8
Guillen, M.9
Corella, D.10
-
39
-
-
67649999248
-
Soares-da-Silva, P. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers
-
Almeida, L.; Vaz-da-Silva, M.; Falcão, A.; Soares, E.; Costa, R.; Loureiro, A.I.; Fernandes-Lopes, C.; Rocha, J.; Nunes, T.; Wright, L.; Soares-da-Silva, P. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol. Nutr. Food Res. 2009, 53, 7–15. [CrossRef]
-
(2009)
Mol. Nutr. Food Res.
, vol.53
, pp. 7-15
-
-
Almeida, L.1
Vaz-Da-Silva, M.2
Falcão, A.3
Soares, E.4
Costa, R.5
Loureiro, A.I.6
Fernandes-Lopes, C.7
Rocha, J.8
Nunes, T.9
Wright, L.10
-
40
-
-
84873368632
-
In vivo and in vitro metabolism of trans-resveratrol by human gut
-
Bode, L.M.; Bunzel, D.; Huch, M.; Cho, G.; Ruhland, D.; Bunzel, M.; Bub, A.; Franz, C.M.A.P.; Kulling, S.E. In vivo and in vitro metabolism of trans-resveratrol by human gut. Am. J. Clin. Nutr. 2013, 97, 295–309. [CrossRef]
-
(2013)
Am. J. Clin. Nutr.
, vol.97
, pp. 295-309
-
-
Bode, L.M.1
Bunzel, D.2
Huch, M.3
Cho, G.4
Ruhland, D.5
Bunzel, M.6
Bub, A.7
Franz, C.M.A.P.8
Kulling, S.E.9
-
41
-
-
85028661005
-
Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women
-
Most, J.; Penders, J.; Lucchesi, M.; Goossens, G.H.; Blaak, E.E. Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women. Eur. J. Clin. Nutr. 2017, 71, 1040–1045. [CrossRef] [PubMed]
-
(2017)
Eur. J. Clin. Nutr.
, vol.71
, pp. 1040-1045
-
-
Most, J.1
Penders, J.2
Lucchesi, M.3
Goossens, G.H.4
Blaak, E.E.5
-
42
-
-
84918791665
-
Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease
-
Chachay, V.S.; Macdonald, G.A.; Martin, J.H.; Whitehead, J.P.; O’Moore–Sullivan, T.M.; Lee, P.; Franklin, M.; Klein, K.; Taylor, P.J.; Ferguson, M.; et al. Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease. Clin. Gastroenterol. Hepatol. 2014, 12, 2092–2103. e6. [CrossRef] [PubMed]
-
(2014)
Clin. Gastroenterol. Hepatol
, vol.12
, pp. 2092-2103
-
-
Chachay, V.S.1
Macdonald, G.A.2
Martin, J.H.3
Whitehead, J.P.4
O’Moore-Sullivan, T.M.5
Lee, P.6
Franklin, M.7
Klein, K.8
Taylor, P.J.9
Ferguson, M.10
-
43
-
-
34250901592
-
Phase i dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
-
Boocock, D.J.; Faust, G.E.S.; Patel, K.R.; Schinas, A.M.; Brown, V.A.; Ducharme, M.P.; Booth, T.D.; Crowell, J.A.; Perloff, M.; Gescher, A.J.; et al. Phase i dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol. Biomark. Prev. 2007, 16, 1246–1253. [CrossRef]
-
(2007)
Cancer Epidemiol. Biomark. Prev.
, vol.16
, pp. 1246-1253
-
-
Boocock, D.J.1
Faust, G.E.S.2
Patel, K.R.3
Schinas, A.M.4
Brown, V.A.5
Ducharme, M.P.6
Booth, T.D.7
Crowell, J.A.8
Perloff, M.9
Gescher, A.J.10
-
44
-
-
84871445402
-
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
-
Yoshino, J.; Conte, C.; Fontana, L.; Mittendorfer, B.; Imai, S.I.; Schechtman, K.B.; Gu, C.; Kunz, I.; Fanelli, F.R.; Patterson, B.W.; et al. Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab. 2012, 16, 658–664. [CrossRef] [PubMed]
-
(2012)
Cell Metab
, vol.16
, pp. 658-664
-
-
Yoshino, J.1
Conte, C.2
Fontana, L.3
Mittendorfer, B.4
Imai, S.I.5
Schechtman, K.B.6
Gu, C.7
Kunz, I.8
Fanelli, F.R.9
Patterson, B.W.10
-
45
-
-
84860131782
-
Pilot study of resveratrol in older adults with impaired glucose tolerance
-
Crandall, J.P.; Oram, V.; Trandafirescu, G.; Reid, M.; Kishore, P.; Hawkins, M.; Cohen, H.W.; Barzilai, N. Pilot study of resveratrol in older adults with impaired glucose tolerance. J. Gerontol. Ser. A 2012, 67, 1307–1312. [CrossRef] [PubMed]
-
(2012)
J. Gerontol. Ser. A
, vol.67
, pp. 1307-1312
-
-
Crandall, J.P.1
Oram, V.2
Trandafirescu, G.3
Reid, M.4
Kishore, P.5
Hawkins, M.6
Cohen, H.W.7
Barzilai, N.8
-
46
-
-
84911887244
-
A novel red grape cells complex: Health effects and bioavailability of natural resveratrol
-
Azachi, M.; Yatuv, R.; Katz, A.; Hagay, Y.; Danon, A. A novel red grape cells complex: Health effects and bioavailability of natural resveratrol. Int. J. Food Sci. Nutr. 2014, 65, 848–855. [CrossRef]
-
(2014)
Int. J. Food Sci. Nutr.
, vol.65
, pp. 848-855
-
-
Azachi, M.1
Yatuv, R.2
Katz, A.3
Hagay, Y.4
Danon, A.5
-
47
-
-
85009286774
-
Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease
-
Moussa, C.; Hebron, M.; Huang, X.; Ahn, J.; Rissman, R.A.; Aisen, P.S.; Turner, R.S. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease. J. Neuroinflamm. 2017, 14, 1. [CrossRef] [PubMed]
-
(2017)
J. Neuroinflamm.
, vol.14
, Issue.1
-
-
Moussa, C.1
Hebron, M.2
Huang, X.3
Ahn, J.4
Rissman, R.A.5
Aisen, P.S.6
Turner, R.S.7
-
48
-
-
77953032816
-
Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: A double-blind, placebo-controlled, crossover
-
Kennedy, D.O.; Wightman, E.L.; Reay, J.L.; Lietz, G.; Okello, E.J.; Wilde, A.; Haskell, C.F. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: A double-blind, placebo-controlled, crossover. Am. J. Clin. Nutr. 2010, 91, 1590–1597. [CrossRef]
-
(2010)
Am. J. Clin. Nutr.
, vol.91
, pp. 1590-1597
-
-
Kennedy, D.O.1
Wightman, E.L.2
Reay, J.L.3
Lietz, G.4
Okello, E.J.5
Wilde, A.6
Haskell, C.F.7
-
49
-
-
77950493668
-
An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: A nutrigenomics approach 1–4
-
Bakker, G.C.M.; Van Erk, M.J.; Pellis, L.; Wopereis, S.; Rubingh, C.M.; Cnubben, N.H.P.; Kooistra, T.; Van Ommen, B.; Hendriks, H.F.J. An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: A nutrigenomics approach 1–4. Am. J. Clin. Nutr. 2010, 91, 1044–1059. [CrossRef] [PubMed]
-
(2010)
Am. J. Clin. Nutr.
, vol.91
, pp. 1044-1059
-
-
Bakker, G.C.M.1
van Erk, M.J.2
Pellis, L.3
Wopereis, S.4
Rubingh, C.M.5
Cnubben, N.H.P.6
Kooistra, T.7
van Ommen, B.8
Hendriks, H.F.J.9
-
50
-
-
80052910300
-
Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
-
Brasnyó, P.; Molnár, G.A.; Mohás, M.; Markó, L.; Laczy, B.; Cseh, J.; Mikolás, E.; Szijártó, I.A.; Mérei, Á.; Halmai, R.; Mészáros, L.G.; et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br. J. Nutr. 2011, 106, 383–389. [CrossRef] [PubMed]
-
(2011)
Br. J. Nutr.
, vol.106
, pp. 383-389
-
-
Brasnyó, P.1
Molnár, G.A.2
Mohás, M.3
Markó, L.4
Laczy, B.5
Cseh, J.6
Mikolás, E.7
Szijártó, I.A.8
Mérei, Á.9
Halmai, R.10
Mészáros, L.G.11
-
51
-
-
84888200040
-
High-dose resveratrol treatment for 2 weeks inhibits intestinal and hepatic lipoprotein production in overweight/obese men
-
Dash, S.; Xiao, C.; Morgantini, C.; Szeto, L.; Lewis, G.F. High-dose resveratrol treatment for 2 weeks inhibits intestinal and hepatic lipoprotein production in overweight/obese men. Arterioscler. Thromb. Vasc. Biol. 2013, 33, 2895–2901. [CrossRef] [PubMed]
-
(2013)
Arterioscler. Thromb. Vasc. Biol.
, vol.33
, pp. 2895-2901
-
-
Dash, S.1
Xiao, C.2
Morgantini, C.3
Szeto, L.4
Lewis, G.F.5
-
52
-
-
85006086219
-
Resveratrol as add-on therapy in subjects with well-controlled type 2 diabetes: A randomized controlled trial
-
Timmers, S.; de Ligt, M.; Phielix, E.; van de Weijer, T.; Hansen, J.; Moonen-Kornips, E.; Schaart, G.; Kunz, I.; Hesselink, M.K.C.; Schrauwen-Hinderling, V.B.; et al. Resveratrol as add-on therapy in subjects with well-controlled type 2 diabetes: A randomized controlled trial. Diabetes Care 2016, 39, 2211–2217. [CrossRef] [PubMed]
-
(2016)
Diabetes Care
, vol.39
, pp. 2211-2217
-
-
Timmers, S.1
de Ligt, M.2
Phielix, E.3
van de Weijer, T.4
Hansen, J.5
Moonen-Kornips, E.6
Schaart, G.7
Kunz, I.8
Hesselink, M.K.C.9
Schrauwen-Hinderling, V.B.10
-
53
-
-
84884729090
-
Thirty days of resveratrol supplementation does not affect postprandial incretin hormone responses, but suppresses postprandial glucagon in obese subjects
-
Knop, F.K.; Konings, E.; Timmers, S.; Schrauwen, P.; Holst, J.J.; Blaak, E.E. Thirty days of resveratrol supplementation does not affect postprandial incretin hormone responses, but suppresses postprandial glucagon in obese subjects. Diabet. Med. 2013, 30, 1214–1218. [CrossRef] [PubMed]
-
(2013)
Diabet. Med.
, vol.30
, pp. 1214-1218
-
-
Knop, F.K.1
Konings, E.2
Timmers, S.3
Schrauwen, P.4
Holst, J.J.5
Blaak, E.E.6
-
54
-
-
44049086893
-
Understanding pathways of calorie restriction: A way to prevent cancer?
-
Grifantini, K. Understanding pathways of calorie restriction: A way to prevent cancer? J. Natl. Cancer Inst. 2008, 100, 619–621. [CrossRef] [PubMed]
-
(2008)
J. Natl. Cancer Inst.
, vol.100
, pp. 619-621
-
-
Grifantini, K.1
-
55
-
-
8744256642
-
Endothelial dysfunction and coronary artery disease
-
Caramori, P.R.; Zago, A.J. Endothelial dysfunction and coronary artery disease. Arq. Bras. Cardiol. 2000, 75, 163–182. [CrossRef] [PubMed]
-
(2000)
Arq. Bras. Cardiol.
, vol.75
, pp. 163-182
-
-
Caramori, P.R.1
Zago, A.J.2
-
56
-
-
73949108211
-
Structural and functional alterations of subcutaneous small resistance arteries in severe human obesity
-
Grassi, G.; Seravalle, G.; Scopelliti, F.; Dell’Oro, R.; Fattori, L.; Quarti-Trevano, F.; Brambilla, G.; Schiffrin, E.L.; Mancia, G. Structural and functional alterations of subcutaneous small resistance arteries in severe human obesity. Obesity 2010, 18, 92–98. [CrossRef] [PubMed]
-
(2010)
Obesity
, vol.18
, pp. 92-98
-
-
Grassi, G.1
Seravalle, G.2
Scopelliti, F.3
Dell’Oro, R.4
Fattori, L.5
Quarti-Trevano, F.6
Brambilla, G.7
Schiffrin, E.L.8
Mancia, G.9
-
57
-
-
84860276621
-
High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients
-
Zamora-Ros, R.; Urpi-Sarda, M.; Lamuela-Raventós, R.M.; Martínez-González, M.Á.; Salas-Salvadó, J.; Arós, F.; Fitó, M.; Lapetra, J.; Estruch, R.; Andres-Lacueva, C. High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients. Pharmacol. Res. 2012, 65, 615–620. [CrossRef]
-
(2012)
Pharmacol. Res.
, vol.65
, pp. 615-620
-
-
Zamora-Ros, R.1
Urpi-Sarda, M.2
Lamuela-Raventós, R.M.3
Martínez-González, M.Á.4
Salas-Salvadó, J.5
Arós, F.6
Fitó, M.7
Lapetra, J.8
Estruch, R.9
Andres-Lacueva, C.10
-
58
-
-
84925428166
-
Resveratrol does not influence metabolic risk markers related to cardiovascular health in overweight and slightly obese subjects: A randomized, placebo-controlled crossover trial
-
Van Der Made, S.M.; Plat, J.; Mensink, R.P. Resveratrol does not influence metabolic risk markers related to cardiovascular health in overweight and slightly obese subjects: A randomized, placebo-controlled crossover trial. PLoS ONE 2015, 10, 1–13. [CrossRef]
-
(2015)
Plos ONE
, vol.10
, pp. 1-13
-
-
van Der Made, S.M.1
Plat, J.2
Mensink, R.P.3
-
59
-
-
85020936885
-
Trans-resveratrol supplementation and endothelial function during the fasting and postprandial phase: A randomized placebo-controlled trial in overweight and slightly obese participants
-
Van der Made, S.M.; Plat, J.; Mensink, R.P. Trans-resveratrol supplementation and endothelial function during the fasting and postprandial phase: A randomized placebo-controlled trial in overweight and slightly obese participants. Nutrients 2017, 9, 596. [CrossRef]
-
(2017)
Nutrients
, vol.9
, pp. 596
-
-
van der Made, S.M.1
Plat, J.2
Mensink, R.P.3
-
60
-
-
80455143206
-
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
-
Timmers, S.; Konings, E.; Bilet, L.; Houtkooper, R.H.; van de Weijer, T.; Goossens, G.H.; Hoeks, J.; van der Krieken, S.; Ryu, D.; Kersten, S.; et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011, 14, 612–622. [CrossRef]
-
(2011)
Cell Metab
, vol.14
, pp. 612-622
-
-
Timmers, S.1
Konings, E.2
Bilet, L.3
Houtkooper, R.H.4
van de Weijer, T.5
Goossens, G.H.6
Hoeks, J.7
van der Krieken, S.8
Ryu, D.9
Kersten, S.10
-
61
-
-
84977111942
-
Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: A randomized controlled trial
-
Most, J.; Timmers, S.; Warnke, I.; Jocken, J.W.; van Boekschoten, M.; de Groot, P.; Bendik, I.; Schrauwen, P.; Goossens, G.H.; Blaak, E.E. Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: A randomized controlled trial. Am. J. Clin. Nutr. 2016, 104, 215–227. [CrossRef] [PubMed]
-
(2016)
Am. J. Clin. Nutr.
, vol.104
, pp. 215-227
-
-
Most, J.1
Timmers, S.2
Warnke, I.3
Jocken, J.W.4
van Boekschoten, M.5
de Groot, P.6
Bendik, I.7
Schrauwen, P.8
Goossens, G.H.9
Blaak, E.E.10
-
62
-
-
84885008835
-
Resveratrol enhances TNF-α production in human monocytes upon bacterial stimulation
-
Gualdoni, G.A.; Kovarik, J.J.; Hofer, J.; Dose, F.; Doberer, D.; Steinberger, P.; Wolzt, M.; Zlabinger, G.J. Resveratrol enhances TNF-α production in human monocytes upon bacterial stimulation. Biochim. Biophys. Acta Gen. Subj. 2014, 1840, 95–105. [CrossRef] [PubMed]
-
(2014)
Biochim. Biophys. Acta Gen. Subj.
, vol.1840
, pp. 95-105
-
-
Gualdoni, G.A.1
Kovarik, J.J.2
Hofer, J.3
Dose, F.4
Doberer, D.5
Steinberger, P.6
Wolzt, M.7
Zlabinger, G.J.8
-
63
-
-
85019589303
-
The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans
-
Espinoza, J.L.; Trung, L.Q.; Inaoka, P.T.; Yamada, K.; An, D.T.; Mizuno, S.; Nakao, S.; Takami, A. The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans. Oxid. Med. Cell. Longev. 2017, 2017, 6781872. [CrossRef] [PubMed]
-
(2017)
Oxid. Med. Cell. Longev.
, vol.2017
-
-
Espinoza, J.L.1
Trung, L.Q.2
Inaoka, P.T.3
Yamada, K.4
An, D.T.5
Mizuno, S.6
Nakao, S.7
Takami, A.8
-
64
-
-
84956887439
-
Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: A prospective, randomized, double-blind study
-
Lin, C.; Sun, X.; Lin, A. Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: A prospective, randomized, double-blind study. Ren. Fail. 2016, 38, 214–221. [CrossRef] [PubMed]
-
(2016)
Ren. Fail.
, vol.38
, pp. 214-221
-
-
Lin, C.1
Sun, X.2
Lin, A.3
|