Development of the olfactory system

The Neurobiology of Olfaction

Volumn , Issue , 2009, Pages 131-155

  Treloar, Helen B ^a   Miller, Alexandra M ^a   Ray, Arundhati ^a   Greer, Charles A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85057931824     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (175)

1. Altman, J. (1969) Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J Comp Neurol. 137:433-58.
2. Anderson, S.A., Qiu, M., Bulfone, A., Eisenstat, D.D., Meneses, J., Pedersen, R., and Rubenstein, J.L. (1997) Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons. Neuron. 19:27-37.
3. Bailey, M.S., Puche, A.C., and Shipley, M.T. (1999) Development of the olfactory bulb: Evidence for glia-neuron interactions in glomerular formation. J Comp Neurol. 415:423-48.
4. Balmer, C.W. and LaMantia, A.S. (2004) Loss of Gli3 and Shh function disrupts olfactory axon trajectories. J Comp Neurol. 472:292-307.
5. Balmer, C.W. and LaMantia, A.S. (2005) Noses and neurons: Induction, morphogenesis, and neuronal differentiation in the peripheral olfactory pathway. Dev Dyn. 234:464-81.
6. Barnea, G., O’Donnell, S., Mancia, F., Sun, X., Nemes, A., Mendelsohn, M., and Axel, R. (2004) Odorant receptors on axon termini in the brain. Science. 304:1468.
7. Bayer SA. (1983) 3H-thymidine-radiographic studies of neurogenesis in the rat olfactory bulb. Exp Brain Res. 50:329-40.
8. Beites, C.L., Kawauchi, S., Crocker, C.E., and Calof, A.L. (2005) Identification and molecular regulation of neural stem cells in the olfactory epithelium. Exp Cell Res. 306:309-16.
9. Bell, S.M., Schreiner, C.M., Waclaw, R.R., Campbell, K., Potter, S.S., and Scott, W.J. (2003) Sp8 is crucial for limb outgrowth and neuropore closure. Proc Natl Acad Sci USA. 100:12195-200.
10. Bhasin, N., Maynard, T.M., Gallagher, P.A., and LaMantia, A.S. (2003) Mesenchymal/epithelial regulation of retinoic acid signaling in the olfactory placode. Dev Biol. 261:82-98.
11. Bhattacharyya, S. and Bronner-Fraser, M., (2008) Competence, specification and commitment to an olfactory placode fate. Development 135:4165-77.
12. Bishop, K.M., Garel, S., Nakagawa, Y., Rubenstein, J.L., and O’Leary, D.D., (2003) Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding. J Comp Neurol. 457:345-60.
13. Bishop, K.M., Goudreau, G., and O’Leary, D.D., (2000) Regulation of area identity in the mammalian neocortex by Emx2 and Pax6. Science. 288:344-49.
14. Blanchart, A., De C., rlos, J.A., and Lopez-Mascaraque, L., (2006) Time frame of mitral cell development in the mice olfactory bulb. J Comp Neurol. 496:529-43.
15. Briata, P., Di Blas, E., Gulisano, M., Mallamaci, A., Iannone, R., Boncinelli, E., and Corte, G. (1996) EMX1 homeoprotein is expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons. Mech Dev. 57:169-80.
16. Brunet, L.J., Gold, G.H., and Ngai, J. (1996) General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron. 17:681-93.
17. Buck, L. and Axel, R. (1991) A novel multigene family may encode odorant receptors: A molecular basis for odor recognition. Cell. 65:175-87.
18. Bulfone, A., Smiga, S.M., Shimamura, K., Peterson, A., Puelles, L., and Rubenstein, J.L. (1995) T-brain-1: A homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex. Neuron. 15:63-78.
19. Bulfone, A., Wang, F., Hevner, R., Anderson, S., Cutforth, T., Chen, S., Meneses, J., Pedersen, R., Axel, R., and Rubenstein, J.L. (1998) An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron. 21:1273-82.
20. Caggiano, M., Kauer, J.S., and Hunter, D.D. (1994) Globose basal cells are neuronal progenitors in the olfactory epithelium: A lineage analysis using a replication-incompetent retrovirus. Neuron. 13:339-52.
21. Camby, I., Le Mercier, M., Lefranc, F., and Kiss, R. (2006) Galectin-1: A small protein with major functions. Glycobiology. 16:137R-57R.
22. Carson, C., Murdoch, B., and Roskams, A.J. (2006) Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium. Dev Dyn. 235:1678-88.
23. Cau, E., Casarosa, S., and Guillemot, F. (2002) Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage. Development. 129:1871-80.
24. Cau, E., Gradwohl, G., Fode, C., and Guillemot, F. (1997) Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. Development. 124:1611-21.
25. Chesler, A., Zou, D.-J., Le Pichon, C., Peterlin, Z., Matthews, G., Pei, X., Miller M., and Firestein S. (2007) A G protein/cAMP signal cascade is required for axonal convergence into olfactory glomeruli. PNAS. 104:1039-44.
26. Chess, A., Simon, I., Cedar, H., and Axel, R. (1994) Allelic inactivation regulates olfactory receptor gene expression. Cell. 78:823-34.
27. Chung, W.C., Moyle, S.S., and Tsai, P.S. (2008) Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons. Endocrinology. 149:4997-5003.
28. Conzelmann, S., Levai, O., Breer, H., and Strotmann, J. (2002) Extraepithelial cells expressing distinct olfactory receptors are associated with axons of sensory cells with the same receptor type. Cell Tissue Res. 307:293-301.
29. Conzelmann, S., Malun, D., Breer, H., and Strotmann, J. (2001) Brain targeting and glomerulus formation of two olfactory neuron populations expressing related receptor types. Eur J Neurosci. 14:1623-32.
30. Cornesse, Y., Pieler, T., and Hollemann, T. (2005) Olfactory and lens placode formation is controlled by the hedgehog-interacting protein (Xhip) in Xenopus. Dev Biol. 277:296-315.
31. Crossley, P.H. and Martin, G.R. (1995) The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development. 121:439-451.
32. Crossley, P.H., Martinez, S., Ohkubo, Y., and Rubenstein, J.L. (2001) Coordinate expression of Fgf8, Otx2, Bmp4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles. Neuroscience. 108:183-206.
33. Cutforth, T., Moring, L., Mendelsohn, M., Nemes, A., Shah, N.M., Kim, M.M., Frisen, J., and Axel, R. (2003) Axonal ephrin-As and odorant receptors: Coordinate determination of the olfactory sensory map. Cell. 114:311-22.
34. De Carlos, J.A., Lopez-Mascaraque, L., and Valverde, F. (1995) The telencephalic vesicles are innervated by olfactory placode-derived cells: A possible mechanism to induce neocortical development. Neuroscience. 68:1167-78.
35. Donner, A.L., Episkopou, V., and Maas, R.L. (2006) Sox2 and Pou2f1 interact to control lens and olfactory placode development. Dev Biol. Nov 6; [Epub ahead of print].
36. Faedo, A., Ficara, F., Ghiani, M., Aiuti, A., Rubenstein, J.L., and Bulfone, A. (2002) Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis. Mech Dev. 116:157-60.
37. Feinstein, P., Bozza, T., Rodriguez, I., Vassalli, A., and Mombaerts, P. (2004) Axon guidance of mouse olfactory sensory neurons by odorant receptors and the beta2 adrenergic receptor. Cell. 117:833-46.
38. Feinstein, P. and Mombaerts, P. (2004) A contextual model for axonal sorting into glomeruli in the mouse olfactory system. Cell. 117:817-31.
39. Fiore, R. and Puschel, A.W. (2003) The function of semaphorins during nervous system development. Front Biosci. 8:s484-99.
40. Fukuchi-Shimogori, T. and Grove, E.A. (2001) Neocortex patterning by the secreted signaling molecule FGF8. Science. 294:1071-74.
41. Furuta, Y., Piston, D.W., and Hogan, B.L. (1997) Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development. 124:2203-12.
42. Garel, S., Huffman, K.J., and Rubenstein, J.L.R. (2003) Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants. Development. 130:1903-14.
43. Gong, Q. and Shipley, M.T. (1995) Evidence that pioneer olfactory axons regulate telencephalon cell cycle kinetics to induce the formation of the olfactory bulb. Neuron. 14:91-101.
44. Gong, Q. and Shipley, M.T. (1996) Expression of extracellular matrix molecules and cell surface molecules in the olfactory nerve pathway during early development. J Comp Neurol. 366:1-14.
45. Goodman, C.S. and Shatz, C.J. (1993) Developmental mechanisms that generate precise patterns of neuronal connectivity. Cell. 72 Suppl:77-98.
46. Guillemot, F., Lo, L.C., Johnson, J.E., Auerbach, A., Anderson, D.J., and Joyner, A.L. (1993) Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell. 75:463-76.
47. Gunhaga, L., Marklund, M., Sjodal, M., Hsieh, J.C., Jessell, T.M., and Edlund, T. (2003) Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat Neurosci. 6:701-7.
48. Hébert, J.M., Lin, M., Partanen, J., Rossant, J., and McConnell, S.K. (2003) FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. Development. 130:1101-11.
49. Hébert, J.M., Mishina, Y., and McConnell, S.K. (2002) BMP signaling is required locally to pattern the dorsal telencephalic midline. Neuron. 35:1029-41.
50. Henion, T.R., Raitcheva, D., Grosholz, R., Biellmann, F., Skarnes, W.C., Hennet, T., and Schwarting, G.A. (2005) b1,3-N-acetylglucosaminyltransferase 1 glycosylation is required for axon pathfinding by olfactory sensory neurons. J Neurosci. 25:1894-1903.
51. Hinds, J.W., (1968a) Autoradiographic study of histogenesis in the mouse olfactory bulb. I. Time of origin of neurons and neuroglia. J Comp Neurol. 134:287-304.
52. Hinds, J.W., (1968b) Autoradiographic study of histogenesis in the mouse olfactory bulb. II. Cell proliferation and migration. J Comp Neurol. 134:305-22.
53. Hinds, J.W. and Hinds, P.L. (1976) Synapse formation in the mouse olfactory bulb. I. Quantitative studies. J Comp Neurol. 169:15-40.
54. Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y., and Hibi, M. (2006) Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously. Development. 133:1433-43.
55. Holt, C.E. and Dickson, B.J. (2005) Sugar codes for axons? Neuron. 46:169-72.
56. Huard, J.M., Youngentob, S.L., Goldstein, B.J., Luskin, M.B., and Schwob, J.E. (1998) Adult olfactory epithelium contains multipotent progenitors that give rise to neurons and non-neural cells. J Comp Neurol. 400:469-586.
57. Hwang, H.M. and Cohen, R.S. (1985) Freeze-fracture analysis of synaptogenesis in glomeruli of mouse olfactory bulb. J Neurocytol. 14:997-1018.
58. Ikeda, K., Ookawara, S., Sato, S., Ando, Z., Kageyama, R., and Kawakami, K. (2007) Six1 is essential for early neurogenesis in the development of olfactory epithelium. Dev Biol. 311:53-68.
59. Imai, T. and Sakano, H. (2008) Odorant receptor-mediated signaling in the mouse. Curr Opin Neurobiol. 18:251-60.
60. Imai, T., Suzuki, M., and Sakano, H. (2006) Odorant receptor-derived cAMP signals direct axonal targeting. Science. 314:657-61.
61. Inaki, K., Nishimura, S., Nakashiba, T., Itohara, S., and Yoshihara, Y. (2004) Laminar organization of the developing lateral olfactory tract revealed by differential expression of cell recognition molecules. J Comp Neurol. 479:243-56.
62. Itoh, N. and Ornitz, D.M. (2004) Evolution of the Fgf and Fgfr gene families. Trends Genet. 20:563-69.
63. Iwema, C.L., Fang, H., Kurtz, D.B., Youngentob, S.L., and Schwob, J.E. (2004) Odorant receptor expression patterns are restored in lesion-recovered rat olfactory epithelium. J Neurosci. 24:356-69.
64. Jimenez, D., Garcia, C., de Castro, F., Chedotal, A., Sotelo, C., de Carlos, J.A., Valverde, F., and Lopez-Mascaraque, L., (2000) Evidence for intrinsic development of olfactory structures in Pax-6 mutant mice. J Comp Neurol. 428:511-26.
65. Katz, L.C. and Shatz, C.J. (1996) Synaptic activity and the construction of cortical circuits. Science. 274:1133-38.
66. Kawauchi, S., Beites, C.L., Crocker, C.E., Wu, H.H., Bonnin, A., Murray, R., and Calof, A.L. (2004) Molecular signals regulating proliferation of stem and progenitor cells in mouse olfactory epithelium. Dev Neurosci. 26:166-80.
67. Kawauchi, S., Shou, J., Santos, R., Hébert, J.M., McConnell, S.K., Mason, I., and Calof, A.L. (2005) Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development. 132:5211-23. Epub Nov 2.
68. Kitamura, K., Yanazawa, M., Sugiyama, N., Miura, H., Iizuka-Kogo, A., Kusaka, M., Omichi, K., Suzuki, R., Kato-Fukui, Y., Kamiirisa, K., Matsuo, M., Kamijo, S., Kasahara, M., Yoshioka, H., Ogata, T., Fukuda, T., Kondo, I., Kato, M., Dobyns, W.B., Yokoyama, M., and Morohashi, K. (2002) Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. Nat Genet. 32:359-69.
69. Kiyama, H., Sato, M., Emson, P.C., and Tohyama, M. (1991) Transient expression of neurotensin mRNA in the mitral cells of rat olfactory bulb during development. Neurosci Lett. 128:85-89.
70. Klenoff, J. and Greer, C. (1998) Postnatal development of olfactory receptor cell axonal arbors. J Comp Neurol. 390:256-67.
71. LaMantia, A.S., Bhasin, N., Rhodes, K., and Heemskerk, J. (2000) Mesenchymal/epithelial induction mediates olfactory pathway formation. Neuron. 28:411-25.
72. Laub, F., Lei, L., Sumiyoshi, H., Kajimura, D., Dragomir, C., Smaldone, S., Puche, A.C., Petros, T.J., Mason, C., Parada, L.F., and Ramirez, F. (2005) Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Mol Cell Biol. 25:5699-5711.
73. Levi, G., Puche, A.C., Mantero, S., Barbieri, O., Trombino, S., Paleari, L., Egeo, A., and Merlo, G.R. (2003) The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse. Mol Cell Neurosci. 22:530-43.
74. Lewcock, J.W. and Reed, R.R. (2004) A feedback mechanism regulates monoallelic odorant receptor expression. Proc Natl Acad Sci USA. 101:1069-74.
75. Lin, D.M., Wang, F., Lowe, G., Gold, G.H., Axel, R., Ngai, J., and Brunet, L. (2000) Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. Neuron. 26:69-80.
76. Lipscomb, B.W., Treloar, H.B., and Greer, C.A. (2002) Novel microglomerular structures in the olfactory bulb of mice. J Neurosci. 22(3):766-74.
77. Liu, J.K., Ghattas, I., Liu, S., Chen, S., and Rubenstein, J.L. (1997) Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation. Dev Dyn. 210:498-512.
78. Long, J.E., Garel, S., Depew, M.J., Tobet, S., and Rubenstein, J.L. (2003) DLX5 regulates development of peripheral and central components of the olfactory system. J Neurosci. 23:568-78.
79. Lopez-Mascaraque, L., De Carlos, J.A., and Valverde, F. (1996) Early onset of the rat olfactory bulb projections. Neuroscience. 70:255-66.
80. Lopez-Mascaraque, L., and de Castro, F. (2002) The olfactory bulb as an independent developmental domain. Cell Death Differ. 9:1279-86.
81. Mahanthappa, N.K., Cooper, D.N., Barondes, S.H., and Schwarting, G.A. (1994) Rat olfactory neurons can utilize the endogenous lectin, L-14, in a novel adhesion mechanism. Development. 120:1373-84.
82. Mallamaci, A., Muzio, L., Chan, C.H., Parnavelas, J., and Boncinelli, E. (2000) Area identity shifts in the early cerebral cortex of Emx2S/S mutant mice. Nat Neurosci. 3:679-86.
83. Mallamaci, A. and Stoykova, A. (2006) Gene networks controlling early cerebral cortex arealization. Eur J Neurosci. 23:847-56.
84. Malnic, B., Hirono, J., Sato, T., and Buck, L.B. (1999) Combinatorial receptor codes for odors. Cell. 96:713-23.
85. Malun, D. and Brunjes, P.C. (1996) Development of olfactory glomeruli: Temporal and spatial interactions between olfactory receptor axons and mitral cells in opossum and rats. J Comp Neurol. 368:1-16.
86. Marin-Padilla, M. and Amieva, M.R. (1989) Early neurogenesis of the mouse olfactory nerve: Golgi and electron microscopic studies. J Comp Neurol. 288:339-52.
87. Maruoka, Y., Ohbayashi, N., Hoshikawa, M., Itoh, N., Hogan, B.M., and Furuta, Y. (1998) Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. Mech Dev. 74:175-77.
88. Matsutani, S. and Yamamoto, N. (2000) Differentiation of mitral cell dendrites in the developing main olfactory bulbs of normal and naris-occluded rats. J Comp Neurol. 418:402-10.
89. McWhirter, J.R., Goulding, M., Weiner, J., Chun, J., and Murre, C. (1997) A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development. 124:3221-32.
90. Merlo, G.R., Mantero, S., Zaghetto, A.A., Peretto, P., Paina, S., and Gozzo, M. (2007) The role of Dlx homeo-genes in early development of the olfactory pathway. J Mol Histol. 38:347-58.
91. Meyers, E.N., Lewandoski, M., and Martin, G.R. (1998) An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet. 18:136-41.
92. Miyamichi, K., Serizawa, S., Kimura, H.M., and Sakano, H. (2005) Continuous and overlapping expression domains of odorant receptor genes in the olfactory epithelium determine the dorsal/ventral positioning of glomeruli in the olfactory bulb. J Neurosci. 25:3586-92.
93. Mombaerts, P., (2006) Axonal wiring in the mouse olfactory system. Annu Rev Cell Dev Biol. 22:713-37.
94. Mombaerts, P., Wang, F., Dulac, C., Chao, S.K., Nemes, A., Mendelsohn, M., Edmondson, J., and Axel, R. (1996) Visualizing an olfactory sensory map. Cell. 87:675-86.
95. Nedelec, S., Foucher, I., Brunet, I., Bouillot, C., Prochiantz, A., and Trembleau, A. (2004) Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons. Proc Natl Acad Sci USA. 101:10815-20.
96. Neuman, T., Keen, A., Zuber, M.X., Kristjansson, G.I., Gruss, P., and Nornes, H.O. (1993) Neuronal expression of regulatory helix-loop-helix factor Id2 gene in mouse. Dev Biol. 160:186-95.
97. Nicolay, D.J., Doucette, J.R., and Nazarali, A.J. (2006) Transcriptional regulation of neurogenesis in the olfactory epithelium. Cell Mol Neurobiol. 26:803-21.
98. Panganiban, G. and Rubenstein, J.L. (2002) Developmental functions of the Distal-less/Dlx homeobox genes. Development. 129:4371-86.
99. Pedersen, P., Stewart, W., Greer, C., and Shepherd, G. (1983) Evidence for olfactory function in utero. Science. 221:478-80.
100. Pellier, V., Astic, L., Oestreicher, A.B., and Saucier, D. (1994) B-50/GAP-43 expression by the olfactory receptor cells and the neurons migrating from the olfactory placode in embryonic rats. Dev Brain Res. 80:63-72.
101. Plendl, J. and Sinowatz, F. (1998) Glycobiology of the olfactory system. Acta Anat (Basel). 161:234-53.
102. Poirier, K., Van Esch, H., Friocourt, G., Saillour, Y., Bahi, N., Backer, S., Souil, E., Castelnau-Ptakhine, L., Beldjord, C., Francis, F., Bienvenu, T., and Chelly, J. (2004) Neuroanatomical distribution of ARX in brain and its localisation in GABAergic neurons. Mol Brain Res. 122:35-46.
103. Puche, A.C. and Key, B. (1996) N-acetyl-lactosamine in the rat olfactory system: Expression and potential role in neurite growth. J Comp Neurol. 364:267-78.
104. Puche, A.C., Poirier, F., Hair, M., Bartlett, P.F., and Key, B. (1996) Role of galectin-1 in the developing mouse olfactory system. Dev Biol. 179:274-87.
105. Qiu, M., Bulfone, A., Martinez, S., Meneses, J.J., Shimamura, K., Pedersen, R.A., and Rubenstein, J.L. (1995) Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain. Genes Dev. 9:2523-38.
106. Rakic, P., (1988) Specification of cerebral cortical areas. Science. 241:170-76.
107. Ramon-Cueto, A. and Avila, J. (1998) Olfactory ensheathing glia: Properties and function. Brain Res Bull. 46:175-87.
108. Rash, B.G. and Grove, E.A. (2006) Area and layer patterning in the developing cerebral cortex. Curr Opin Neurobiol. 16:25-34.
109. Rawson, N.E. and LaMantia, A.S. (2006) Once and again: Retinoic acid signaling in the developing and regenerating olfactory pathway. J Neurobiol. 66:653-76.
110. Ressler, K.J., Sullivan, S.L., and Buck, L.B. (1993) A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell. 73:597-609.
111. Ressler, K.J., Sullivan, S.L., and Buck, L.B. (1995) Information coding in the olfactory system: Evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell. 79:1245-55.
112. Rodriguez-Gil, D. and Greer, C. (2008) Wnt/Frizzled family members mediate olfactory sensory neuron axon extension. J Comp Neurol. 511:301-17.
113. Rosselli-Austin, L. and Altman, J. (1979) The postnatal development of the main olfactory bulb of the rat. J Dev Physiol. 1:295-313.
114. Rubenstein, J.L., Anderson, S., Shi, L., Miyashita-Lin, E., Bulfone, A., and Hevner, R. (1999) Genetic control of cortical regionalization and connectivity. Cereb Cortex. 9:524-32.
115. Sato, Y., Hirata, T., Ogawa, M., and Fujisawa, H. (1998) Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tract. J Neurosci. 18:7800-10.
116. Schlosser G. (2006) Induction and specification of cranial placodes. Dev Biol. 294:303-51.
117. Schoenfeld, T.A., Clancy, A.N., Forbes, W.B., and Macrides, F. (1994) The spatial organization of the peripheral olfactory system of the hamster. Part I: Receptor neuron projections to the main olfactory bulb. Brain Res Bull. 34:183-210.
118. Schwanzel-Fukuda, M. and Pfaff, D.W. (1989) Origin of luteinizing hormone-releasing hormone neurons. Nature. 338:161-64.
119. Schwarting, G.A., Raitcheva, D., Crandall, J.E., Burkhardt, C., and Puschel, A.W. (2004) Semaphorin 3A-me-diated axon guidance regulates convergence and targeting of P2 odorant receptor axons. Eur J Neurosci. 19:1800-10.
120. Scolnick, J.A., Cui, K., Duggan, C.D., Xuan, S., Yuan, X.B., Efstratiadis, A., and Ngai, J. (2008) Role of IGF signaling in olfactory sensory map formation and axon guidance. Neuron. 57:847-57.
121. Serizawa, S., Ishii, T., Nakatani, H., Tsuboi, A., Nagawa, F., Asano, M., Sudo, K., Sakagami, J., Sakano, H., Ijiri, T., Matsuda, Y., Suzuki, M., Yamamori, T., Iwakura, Y., and Sakano, H. (2000) Mutually exclusive expression of odorant receptor transgenes. Nat Neurosci. 3:687-93.
122. Serizawa, S., Miyamichi, K., Nakatani, H., Suzuki, M., Saito, M., Yoshihara, Y., and Sakano, H. (2003) Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Science. 302:2088-94.
123. Serizawa, S., Miyamichi, K., Takeuchi, H., Yamagishi, Y., Suzuki, M., and Sakano, H. (2006) A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting. Cell. 127:1057-69.
124. Shay, E., Greer, C., and Treloar, H. (2008) Dynamic expression patterns of ECM molecules in the developing mouse olfactory pathway. Dev Dyn. 237:1837-50.
125. Shimamura, K. and Rubenstein, J.L. (1997) Inductive interactions direct early regionalization of the mouse forebrain. Development. 124:2709-18.
126. Shykind, B.M., Rohani, S.C., O’Donnell, S., Nemes, A., Mendelsohn, M., Sun, Y., Axel, R., and Barnea, G. (2004) Gene switching and the stability of odorant receptor gene choice. Cell. 117:801-15.
127. Smart, I.H., (1971) Location and orientation of mitotic figures in the developing mouse olfactory epithelium. J Anat. 109:243-51.
128. St John, J.A., Clarris, H.J., and Key, B. (2002) Multiple axon guidance cues establish the olfactory topographic map: How do these cues interact? Int J Dev Biol. 46:639-47.
129. St John, J.A., Claxton, C., Robinson, M.W., Yamamoto, F., Domino, S.E., and Key, B. (2006) Genetic manipulation of blood group carbohydrates alters development and pathfinding of primary sensory axons of the olfactory systems. Dev Biol. 298:470-84.
130. St John, J.A. and Key, B. (2001) EphB2 and two of its ligands have dynamic protein expression patterns in the developing olfactory system. Dev Brain Res. 126:43-56.
131. St John, J.A., Pasquale, E.B., and Key, B. (2002) EphA receptors and ephrin-A ligands exhibit highly regulated spatial and temporal expression patterns in the developing olfactory system. Dev Brain Res. 138:1-14.
132. St John, J.A., Tisay, K.T., Caras, I.W., and Key, B. (2000) Expression of EphA5 during development of the olfactory nerve pathway in rat. J Comp Neurol. 416:540-50.
133. Strotmann, J., Conzelmann, S., Beck, A., Feinstein, P., Breer, H., and Mombaerts, P. (2000) Local permutations in the glomerular array of the mouse olfactory bulb. J Neurosci. 20:6927-38.
134. Strotmann, J., Levai, O., Fleischer, J., Schwarzenbacher, K., and Breer, H. (2004) Olfactory receptor proteins in axonal processes of chemosensory neurons. J Neurosci. 24:7754-61.
135. Strotmann, J., Wanner, I., Helfrich, T., Beck, A., Meinken, C., Kubick, S., and Breer, H. (1994) Olfactory neurones expressing distinct odorant receptor subtypes are spatially segregated in the nasal neuroepithelium. Cell Tissue Res. 276:429-38.
136. Sugisaki, N., Hirata, T., Naruse, I., Kawakami, A., Kitsukawa, T., and Fujisawa, H. (1996) Positional cues that are strictly localized in the telencephalon induce preferential growth of mitral cell axons. J Neurobiol. 29:127-37.
137. Sullivan, S.L., Bohm, S., Ressler, K.J., Horowitz, L.F., and Buck, L.B. (1995) Target-independent pattern specification in the olfactory epithelium. Neuron. 15:779-89.
138. Sur, M. and Rubenstein, J.L. (2005) Patterning and plasticity of the cerebral cortex. Science. 310:805-10.
139. Taniguchi, M., Nagao, H., Takahashi, Y.K., Yamaguchi, M., Mitsui, S., Yagi, T., Mori, K., and Shimizu, T. (2003) Distorted odor maps in the olfactory bulb of semaphorin 3A-deficient mice. J Neurosci. 23:1390-97.
140. Terkelsen, O.B., Bock, E., and Mollgard, K. (1989) NCAM and Thy-1 in special sense organs of the developing mouse. Anat Embryol (Berl). 179:31131-38.
141. Tessier-Lavigne T and Goodman, C.S. (1996) The molecular biology of axon guidance. Science. 274:1123-33.
142. Theiler, K., (1972) The House Mouse. Development and Normal Stages from Fertilization to 4 Weeks of Age. Berlin-Heidelberg-New York: Springer.
143. Tran, H., Chen, H., Walz, A., Posthumus, J.C., and Gong, Q. (2008) Influence of olfactory epithelium on mitral/tufted cell dendritic outgrowth. Plos ONE. 3:e3816.
144. Treichel, D., Schock, F., Jackle, H., Gruss, P., and Mansouri, A. (2003) mBtd is required to maintain signaling during murine limb development. Genes Dev. 17:2630-35.
145. Treloar, H., Tomasiewicz, H., Magnuson, T., and Key, B. (1997) The central pathway of primary olfactory axons is abnormal in mice lacking the N-CAM-180 isoform. J Neurobiol. 32:643-58.
146. Treloar, H.B., Gabeau, D., Yoshihara, Y., Mori, K., and Greer, C.A. (2003) Inverse expression of olfactory cell adhesion molecule in a subset of olfactory axons and a subset of mitral/tufted cells in the developing rat main olfactory bulb. J Comp Neurol. 458:389-403.
147. Treloar, H.B., Nurcombe, V., and Key, B. (1996) Expression of extracellular matrix molecules in the embryonic rat olfactory pathway. J Neurobiol. 31:41-55.
148. Treloar, H.B., Purcell, A.L., and Greer, C.A. (1999) Glomerular formation in the developing rat olfactory bulb. J Comp Neurol. 413:289-304.
149. Tucker, E.S., Polleux, F., and LaMantia, A.S. (2006) Position and time specify the migration of a pioneering population of olfactory bulb interneurons. Dev Biol. 297:387-401.
150. Valverde, F., Heredia, M., and Santacana, M. (1993) Characterization of neuronal cell varieties migrating from the olfactory epithelium during prenatal development in the rat. Immunocytochemical study using antibodies against olfactory marker protein (OMP) and luteinizing hormone-releasing hormone (LH-RH). Dev Brain Res. 71:209-20.
151. Valverde, F., Santacana, M., and Heredia, M. (1992) Formation of an olfactory glomerulus: Morphological aspects of development and organization. Neuroscience. 49:255-75.
152. Vassar, R., Chao, S.K., Sitcheran, R., Nunez, J.M., Vosshall, L.B., and Axel, R. (1994) Topographic organization of sensory projections to the olfactory bulb. Cell. 79:981-91.
153. Vassar, R., Ngai, J., and Axel, R. (1993) Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell. 74:309-18.
154. Waclaw, R.R., Allen, Z.J.,2nd, Bell, S.M., Erdelyi, F., Szabo, G., Potter, S.S., and Campbell, K. (2006) The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons. Neuron. 49:503-16.
155. Walz, A., Mombaerts, P., Greer, C.A., and Treloar, H.B. (2006) Disrupted compartmental organization of axons and dendrites within olfactory glomeruli of mice deficient in the olfactory cell adhesion molecule, O.CAM. Mol Cell Neurosci. 32:1-14.
156. Walz, A., Omura, M., and Mombaerts, P. (2006) Development and topography of the lateral olfactory tract in the mouse: Imaging by genetically encoded and injected fluorescent markers. J Neurobiol. 66:835-46.
157. Wang, F., Nemes, A., Mendelsohn, M., and Axel, R. (1998) Odorant receptors govern the formation of a precise topographic map. Cell. 93:47-60.
158. Whitesides, J.G. and LaMantia, A.S. (1996) Differential adhesion and the initial assembly of the mammalian olfactory nerve. J Comp Neurol. 373:240-54.
159. Whitman, M. and Greer, C., (2007a) Adult-generated neurons exhibit diverse developmental fates. Dev Neurobiol. 67:1079-93.
160. Whitman, M. and Greer, C., (2007b) Synaptic integration of adult-generated olfactory bulb granule cells: Basal axodendritic centrifugal input precedes apical dendrodendritic local circuits. J Neurosci. 27:9951-61.
161. Wilkinson, D.G., (2001) Multiple roles of EPH receptors and ephrins in neural development. Nat Rev Neurosci. 2:155-64.
162. Wilson, D.A., Kadohisa, M., and Fletcher, M.L. (2006) Cortical contributions to olfaction: Plasticity and perception. Semin Cell Dev Biol. 17:462-70.
163. Wray, S., Grant, P., and Gainer, H., (1989a) Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode. Proc Natl Acad Sci USA. 86:8132-36.
164. Wray, S., Nieburgs, A., and Elkabes, S., (1989b) Spatiotemporal cell expression of luteinizing hormone-releasing hormone in the prenatal mouse: Evidence for an embryonic origin in the olfactory placode. Dev Brain Res. 46:309-18.
165. Yazdani, U. and Terman, J.R. (2006) The semaphorins. Genome Biol. 7:211 doi:10.1186/gb-2006-7-3-211.
166. Yoshida, M., Suda, Y., Matsuo, I., Miyamoto, N., Takeda, N., Kuratani, S., and Aizawa, S. (1997) Emx1 and Emx2 functions in development of dorsal telencephalon. Development. 124:101-11.
167. Yoshihara, S., Omichi, K., Yanazawa, M., Kitamura, K., and Yoshihara, Y. (2005) Arx homeobox gene is essential for development of mouse olfactory system. Development. 132:751-62.
168. Yoshihara, Y., Kawasaki, M., Tamada, A., Fujita, H., Hayashi, H., Kagamiyama, H., and Mori, K. (1997) OCAM: A new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons. J Neurosci. 17:5830-42.
169. Yu CR, Power, J., Barnea, G., O’Donnell, S., Brown, H.E., Osborne, J., Axel, R., and Gogos, J.A. (2004) Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map. Neuron. 42:553-66.
170. Zhang, J.H., Cerretti, D.P., Yu, T., Flanagan, J.G., and Zhou, R. (1996) Detection of ligands in regions anatomically connected to neurons expressing the Eph receptor Bsk: Potential roles in neuron-target interaction. J Neurosci. 16:7182-92.
171. Zhang, J.H., Pimenta, A.F., Levitt, P., and Zhou, R. (1997) Dynamic expression suggests multiple roles of the eph family receptor brain-specific kinase (Bsk) during mouse neurogenesis. Mol Brain Res. 47:202-14.
172. Zheng, C., Feinstein, P., Bozza, T., Rodriguez, I., and Mombaerts, P. (2000) Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit. Neuron. 26:81-91.
173. Zhou, C., Tsai, S.Y., and Tsai, M.J. (2001) COUP-TFI: An intrinsic factor for early regionalization of the neocortex. Genes Dev. 15:2054-59.
174. Zou, D.-J., Chesler, A., Le, P., Chon, C., Kuznetsov, A., Pei, X., Hwang, E., and Firstein, S. (2007) Absence of adenylyl cyclase 3 perturbs peripheral olfactory projections in mice. J Neurosci. 27:6675-83.
175. Zou, D.-J., Feinstein, P., Rivers, A.L., Mathews, G.A., Kim, A., Greer, C.A., Mombaerts, P., and Firestein, S. (2004) Postnatal refinement of peripheral olfactory projections. Science. 304:1976-79.