Sympathetic transmitters control thermogenic efficacy of brown adipocytes by modulating mitochondrial complex V

Signal Transduction and Targeted Therapy

Volumn 2, Issue , 2017, Pages

  Xie, Tao Rong ^a   Liu, Chun Feng ^a,b   Kang, Jian Sheng ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b Shanghai Entry Exit Inspection and Quarantine Bureau   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85056634800     PISSN: 20959907     EISSN: 20593635     Source Type: Journal    
DOI: 10.1038/sigtrans.2017.60     Document Type: Article

References (34)

1. Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature 2000; 404: 652–660.
2. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84: 277–359.
3. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360: 1509–1517.
4. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JMAFL, Kemerink GJ, Bouvy ND et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009; 360: 1500–1508.
5. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009; 360: 1518–1525.
6. Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med 2013; 19: 1252–1263.
7. Betz MJ, Enerbäck S. Human brown adipose tissue: what we have learned so far. Diabetes 2015; 64: 2352–2360.
8. Nakamura K, Morrison SF. A thermosensory pathway that controls body temperature. Nat Neurosci 2008; 11: 62–71.
9. Fedorenko A, Lishko PV, Kirichok Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell 2012; 151: 400–413.
10. Xie T-R, Liu C-F, Kang J-S. Dye-based mito-thermometry and its application in thermogenesis of brown adipocytes. Biophys Rep 2017; doi: 10.1007/s41048-017-0039-6.
11. Arch JRS. Challenges in β3-adrenoceptor agonist drug development. Ther Adv Endocrinol Metab 2011; 2: 59–64.
12. Carey AL, Formosa MF, Every BV, Bertovic D, Eikelis N, Lambert GW et al. Ephe-drine activates brown adipose tissue in lean but not obese humans. Diabetologia 2012; 56: 147–155.
13. Lucero MT, Pappone PA. Voltage-gated potassium channels in brown fat cells. J Gen Physiol 1989; 93: 451–472.
14. Fain JN, Reed N, Saperstein R. The isolation and metabolism of brown fat cells. J Biol Chem 1967; 242: 1887–1894.
15. Burchfield JG, Lopez JA, Hughes WE. Using total internal reflection fluorescence microscopy (TIRFM) to visualise insulin action. In: Badoer E (ed). Visualization Techniques. Humana Press: Australia, 2012, pp 97–109.
16. Georgakoudi I, Quinn KP. Optical imaging using endogenous contrast to assess metabolic state. Annu Rev Biomed Eng 2012; 14: 351–367.
17. Sakanoue J, Ichikawa K, Nomura Y, Tamura M. Rhodamine 800 as a probe of energization of cells and tissues in the near-infrared region: a study with isolated rat liver mitochondria and hepatocytes. J Biochem 1997; 121: 29–37.
18. Wikstrom JD, Mahdaviani K, Liesa M, Sereda SB, Si Y, Las G et al. Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure. EMBO J 2014; 33: 418–436.
19. Lafontan M, Berlan M. Fat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res 1993; 34: 1057–1091.
20. Cinti S, Cancello R, Zingaretti MC, Ceresi E, Matteis RD, Giordano A et al. CL316,243 and cold stress induce heterogeneous expression of UCP1 mRNA and protein in rodent brown adipocytes. J Histochem Cytochem 2002; 50: 21–31.
21. Schuster S, Ouhabi R, Rigoulet M, Mazat J-P. Modelling the interrelation between the transmembrane potential and pH difference across membranes with electrogenic proton transport upon build-up of the proton-motive force. Bioe-lectrochem Bioenerg 1998; 45: 181–192.
22. Imamura H, Huynh Nhat KP, Togawa H, Saito K, Iino R, Kato-Yamada Y et al. Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators. Proc Natl Acad Sci USA 2009; 106: 15651–15656.
23. Nicholls D, Fergusion S. Bioenergetics, 3rd edn. Academic Press: London, 2002. http://store.elsevier.com/Bioenergetics/David-Nicholls/isbn-9780080527932/(accessed 26 Oct 2016).
24. Orava J, Nuutila P, Lidell ME, Oikonen V, Noponen T, Viljanen T et al. Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab 2011; 14: 272–279.
25. Vallerand AL, Perusse F, Bukowiecki LJ. Stimulatory effects of cold exposure and cold acclimation on glucose uptake in rat peripheral tissues. Am J Physiol Regul Integr Comp Physiol 1990; 259: R1043–R1049.
26. Burnstock G. Historical review: ATP as a neurotransmitter. Trends Pharmacol Sci 2006; 27: 166–176.
27. Palmer AE, Tsien RY. Measuring calcium signaling using genetically targetable fluorescent indicators. Nat Protoc 2006; 1: 1057–1065.
28. Omatsu-Kanbe M, Isono T, Matsuura H. Multiple P2 receptors contribute to a transient increase in intracellular Ca2+ concentration in ATP-stimulated rat brown adipocytes. Exp Physiol 2002; 87: 643–652.
29. Tarasov AI, Griffiths EJ, Rutter GA. Regulation of ATP production by mitochondrial Ca2+. Cell Calcium 2012; 52: 28–35.
30. Cypess AM, Chen Y-C, Sze C, Wang K, English J, Chan O et al. Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc Natl Acad Sci USA 2012; 109: 10001–10005.
31. Dittrich M, Hayashi S, Schulten K. On the mechanism of ATP hydrolysis in F1-ATPase. Biophys J 2003; 85: 2253–2266.
32. Rafael J, Pampel I, Wang X. Effect of pH and MgCl2 on the binding of purine nucleotides to the uncoupling protein in membrane particles from brown fat mitochondria. Eur J Biochem 1994; 223: 971–980.
33. Guyton A, Hall J. Textbook of Medical Physiology, 11th edn. Elsevier Saunders: Philadelphia, 2006.http://www.us.elsevierhealth.com/physiology/textbook-of-medical-physiology-hardcover/9780721602400/(accessed 22 Feb 2016).
34. Than A, Xu S, Li R, Leow M-S, Sun L, Chen P. Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis. Signal Transduct Target Ther 2017; 2: 17022.