A thermosensory pathway that controls body temperature

Nature Neuroscience

Volumn 11, Issue 1, 2008, Pages 62-71

  Nakamura, Kazuhiro ^a   Morrison, Shaun F ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE; ELECTROPHYSIOLOGY; IN VIVO STUDY; MALE; NONHUMAN; PARABRACHIAL NUCLEUS; PREOPTIC AREA; PRIORITY JOURNAL; RAT; SENSORY NERVE; SENSORY NERVE CELL; SOMATOSENSORY CORTEX; THALAMOCORTICAL TRACT; THERMOREGULATION;

ACTION POTENTIALS; AFFERENT PATHWAYS; ANALYSIS OF VARIANCE; ANIMALS; BODY TEMPERATURE; BODY TEMPERATURE REGULATION; BRACHIAL PLEXUS; BRAIN; BRAIN MAPPING; CHOLERA TOXIN; ELECTROENCEPHALOGRAPHY; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; HEALTH SERVICES RESEARCH; MALE; MEMBRANE POTENTIALS; NEURONS, AFFERENT; PHOSPHOPYRUVATE HYDRATASE; PREOPTIC AREA; RATS; RATS, SPRAGUE-DAWLEY;

EID: 37549014480     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn2027     Document Type: Article

References (50)

1. Hammel, H.T. Regulation of internal body temperature. Annu. Rev. Physiol. 30, 641-710 (1968).
2. Hensel, H. Thermoreception and temperature regulation. Monogr. Physiol. Soc. 38, 1-321 (1981).
3. Boulant, J.A. & Gonzalez, R.R. The effect of skin temperature on the hypothalamic control of heat loss and heat production. Brain Res. 120, 367-372 (1977).
4. Nagashima, K., Nakai, S., Tanaka, M. & Kanosue, K. Neuronal circuitries involved in thermoregulation. Auton. Neurosci. 85, 18-25 (2000).
5. Nakamura, K. & Morrison, S.F. Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R127-R136 (2007).
6. Romanovsky, A.A. Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R37-R46 (2007).
7. Huckaba, C.E., Downey, J.A. & Darling, R.C. A feedback-feedforward mechanism describing the interaction of central and peripheral signals in human thermoregulation. Int. J. Biometeorol. 15, 141-145 (1971).
8. Savage, M.V. & Brengelmann, G.L. Control of skin blood flow in the neutral zone of human body temperature regulation. J. Appl. Physiol. 80, 1249-1257 (1996).
9. Craig, A.D., Bushnell, M.C., Zhang, E-T. & Blomqvist, A. A thalamic nucleus specific for pain and temperature sensation. Nature 372, 770-773 (1994).
10. Craig, A.D. How do you feel? Interoception: the sense of the physiological condition of the body. Nat. Rev. Neurosci. 3, 655-666 (2002).
11. Sagar, S.M., Sharp, F.R. & Curran, T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science 240, 1328-1331 (1988).
12. Saper, C.B. & Loewy, A.D. Efferent connections of the parabrachial nucleus in the rat. Brain Res. 197, 291-317 (1980).
13. Fulwiler, C.E. & Saper, C.B. Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat. Brain Res. Rev. 7, 229-259 (1984).
14. Krukoff, T.L., Harris, K.H. & Jhamandas, J.H. Efferent projections from the parabrachial nucleus demonstrated with the anterograde tracer Phaseolus vulgaris leucoagglutinin. Brain Res. Bull. 30, 163-172 (1993).
15. Bester, H., Besson, J-M. & Bernard, J-F. Organization of efferent projections from the parabrachial area to the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat. J. Comp. Neurol. 383, 245-281 (1997).
16. Lumpkin, E.A. & Caterina, M.J. Mechanisms of sensory transduction in the skin. Nature 445, 858-865 (2007).
17. Cechetto, D.F., Standaert, D.G. & Saper, C.B. Spinal and trigeminal dorsal horn projections to the parabrachial nucleus in the rat. J. Comp. Neurol. 240, 153-160 (1985).
18. Bernard, J.-F., Dallel, R., Raboisson, P., Villanueva, L. & Le Bars, D. Organization of the efferent projections from the spinal cervical enlargement to the parabrachial area and periaqueductal gray: a PHA-L study in the rat. J. Comp. Neurol. 353, 480-505 (1995).
19. Feil, K. & Herbert, H. Topographic organization of spinal and trigeminal somatosensory pathways to the rat parabrachial and Kölliker-Fuse nuclei. J. Comp. Neurol. 353, 506-528 (1995).
20. Bester, H., Menendez, L., Besson, J.M. & Bernard, J.F. Spino(trigemino)parabrachio-hypothalamic pathway: electrophysiological evidence for an involvement in pain processes. J. Neurophysiol. 73, 568-585 (1995).
21. A receptor pharmacology. Pharmacol. Ther. 69, 173-198 (1996).
22. Nakamura, K. et al. The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area. J. Neurosci. 22, 4600-4610 (2002).
23. Madden, C.J. & Morrison, S.F. Excitatory amino acid receptor activation in the raphe pallidus area mediates prostaglandin-evoked thermogenesis. Neuroscience 122, 5-15 (2003).
24. 2 into the preoptic area in anesthetized rats. Neurosci. Lett. 340, 1-4 (2003).
25. Madden, C.J. & Morrison, S.F. Excitatory amino acid receptors in the dorsomedial hypothalamus mediate prostaglandin-evoked thermogenesis in brown adipose tissue. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286, R320-R325 (2004).
26. Nakamura, K. Fever-inducing sympathetic neural pathways. J. Therm. Biol. 29, 339-344 (2004).
27. Nakamura, K., Matsumura, K., Kobayashi, S. & Kaneko, T. Sympathetic premotor neurons mediating thermoregulatory functions. Neurosci. Res. 51, 1-8 (2005).
28. Nakamura, Y. et al. Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus. Eur. J. Neurosci. 22, 3137-3146 (2005).
29. Gauriau, C. & Bernard, J.-F. A comparative reappraisal of projections from the superficial laminae of the dorsal horn in the rat: the forebrain. J. Comp. Neurol. 468, 24-56 (2004).
30. Zhang, X., Davidson, S. & Giesler, G.J., Jr. Thermally identified subgroups of marginal zone neurons project to distinct regions of the ventral posterior lateral nucleus in rats. J. Neurosci. 26, 5215-5223 (2006).
31. Kobayashi, A. & Osaka, T. Involvement of the parabrachial nucleus in thermogenesis induced by environmental cooling in the rat. Pflugers Arch. 446, 760-765 (2003).
32. Hylden, J.L.K., Anton, F. & Nahin, R.L. Spinal lamina I projection neurons in the rat: collateral innervation of parabrachial area and thalamus. Neuroscience 28, 27-37 (1989).
33. Broman, J. & Ottersen, O.P. Cervicothalamic tract terminals are enriched in glutamate-like immunoreactivity: an electron microscopic double-labeling study in the cat. J. Neurosci. 12, 204-221 (1992).
34. Blomqvist, A., Ericson, A.C., Craig, A.D. & Broman, J. Evidence for glutamate as a neurotransmitter in spinothalamic tract terminals in the posterior region of owl monkeys. Exp. Brain Res. 108, 33-44 (1996).
35. Bratincsák, A. & Palkovits, M. Evidence that peripheral rather than intracranial thermal signals induce thermoregulation. Neuroscience 135, 525-532 (2005).
36. Chen, X.-M., Hosono, T., Yoda, T., Fukuda, Y. & Kanosue, K. Efferent projection from the preoptic area for the control of non-shivering thermogenesis in rats. J. Physiol. (Lond.) 512, 883-892 (1998).
37. Nakamura, K. et al. Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus. Neurosci. Lett. 260, 117-120 (1999).
38. Lazarus, M. et al. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat. Neurosci. 10, 1131-1133 (2007).
39. Bester, H., Chapman, V., Besson, J.-M. & Bernard, J.-F. Physiological properties of the lamina I spinoparabrachial neurons in the rat. J. Neurophysiol. 83, 2239-2259 (2000).
40. Craig, A.D. & Dostrovsky, J.O. Differential projections of thermoreceptive and nociceptive lamina I trigeminothalamic and spinothalamic neurons in the cat. J. Neurophysiol. 86, 856-870 (2001).
41. Boulant, J.A. & Hardy, J.D. The effect of spinal and skin temperatures on the firing rate and thermosensitivity of preoptic neurones. J. Physiol. (Lond.) 240, 639-660 (1974).
42. Hellon, R.F., Hensel, H. & Schäfer, K. Thermal receptors in the scrotum of the rat. J. Physiol. (Lond.) 248, 349-357 (1975).
43. Saper, C.B. The central autonomic nervous system: conscious visceral perception and autonomic pattern generation. Annu. Rev. Neurosci. 25, 433-469 (2002).
44. Hori, T., Nakashima, T., Koga, H., Kiyohara, T. & Inoue, T. Convergence of thermal, osmotic and cardiovascular signals on preoptic and anterior hypothalamic neurons in the rat. Brain Res. Bull. 20, 879-885 (1988).
45. Morrison, S.F. Central pathways controlling brown adipose tissue thermogenesis. News Physiol. Sci. 19, 67-74 (2004).
46. Nakamura, K. et al. Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J. Neurosci. 24, 5370-5380 (2004).
47. Nakamura, K. et al. Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system. J. Comp. Neurol. 421, 543-569 (2000).
48. Nakamura, K., Li, Y.-Q., Kaneko, T., Katoh, H. & Negishi, M. Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: a double immunofluorescence study in the rat brain. Neuroscience 103, 763-775 (2001).
49. Morrison, S.F. & Cao, W.-H. Different adrenal sympathetic preganglionic neurons regulate epinephrine and norepinephrine secretion. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279, R1763-R1775 (2000).
50. Pinault, D. A novel single-cell staining procedure performed in vivo under electrophysiological control: morpho-functional features of juxtacellularly labeled thalamic cells and other central neurons with biocytin or Neurobiotin. J. Neurosci. Methods 65, 113-136 (1996).