Silencing the CSF-1 axis using nanoparticle encapsulated siRNA mitigates viral and autoimmune myocarditis

Frontiers in Immunology

Volumn 9, Issue OCT, 2018, Pages

  Meyer, Ingmar Sören ^a,b   Goetzke, Carl Christoph ^b,c   Kespohl, Meike ^b,c   Sauter, Martina ^d   Heuser, Arnd ^e   Eckstein, Volker ^a   Vornlocher, Hans Peter ^f   Anderson, Daniel G ^g,h,i   Haas, Jan ^a,b   Meder, Benjamin ^a,b   Katus, Hugo Albert ^a,b   Klingel, Karin ^d   Beling, Antje ^b,c   Leuschner, Florian ^a,b  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^f AXOLABS GMBH   (Germany)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Cytokines; Infection immunology; Inflammation and immunmodulation; Innate immunity; Monocytes macrophages; Myocarditis; RNA interference; Virus

Indexed keywords

COLONY STIMULATING FACTOR 1; NANOPARTICLE; SMALL INTERFERING RNA;

ANIMAL; AUTOIMMUNE DISEASE; BAGG ALBINO MOUSE; CARDIAC MUSCLE; COXSACKIE VIRUS INFECTION; DISEASE MODEL; DOWN REGULATION; DRUG EFFECT; ENTEROVIRUS B; GENE SILENCING; GENETICS; HUMAN; INFLAMMATION; MALE; METABOLISM; MONOCYTE; MYOCARDITIS; PATHOLOGY; VIROLOGY;

ANIMALS; AUTOIMMUNE DISEASES; COXSACKIEVIRUS INFECTIONS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENTEROVIRUS B, HUMAN; GENE SILENCING; HUMANS; INFLAMMATION; MACROPHAGE COLONY-STIMULATING FACTOR; MALE; MICE, INBRED BALB C; MONOCYTES; MYOCARDITIS; MYOCARDIUM; NANOPARTICLES; RNA, SMALL INTERFERING;

EID: 85055185196     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2018.02303     Document Type: Article

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