Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis

Arthritis Research and Therapy

Volumn 18, Issue 1, 2016, Pages

  Garcia, Samuel ^a,b   Hartkamp, Linda M ^a,b   Malvar Fernandez, B ^a,b   van Es, Inge E ^a   Lin, Haishan ^c   Wong, Justin ^c   Long, Li ^c   Zanghi, James A ^c   Rankin, Andrew L ^c   Masteller, Emma L ^c   Wong, Brian R ^c   Radstake, Timothy R D J ^b   Tak, Paul P ^a,d,e   Reedquist, Kris A ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c FIVE PRIME THERAPEUTICS INC   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CD14 ANTIGEN; CD163 ANTIGEN; CD206 ANTIGEN; CD64 ANTIGEN; COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR RECEPTOR; COLONY STIMULATING FACTOR RECEPTOR BLOCKING AGENT; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; ETANERCEPT; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GELATINASE A; GELATINASE B; GRANULOCYTE CHEMOTACTIC PROTEIN 2; INTERLEUKIN 1BETA; INTERLEUKIN 34; INTERLEUKIN 6; INTERLEUKIN 8; LYMPHOCYTE ANTIGEN; MATRIX METALLOPROTEINASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; MUAB5; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; BENZ[A]ANTHRACENE DERIVATIVE; DIBENZOANTHRACENE-5,6-DIHYDRODIOL; INTERLEUKIN DERIVATIVE; INTERLEUKIN-34, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CSF 1 GENE; CYTOKINE PRODUCTION; DIGITAL IMAGING; DRUG MECHANISM; FLUORESCENCE ACTIVATED CELL SORTING; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IL 34 GENE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PSORIATIC ARTHRITIS; RHEUMATOID ARTHRITIS; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; EXPERIMENTAL ARTHRITIS; FEMALE; FLOW CYTOMETRY; IMAGE PROCESSING; IMMUNOLOGY; MACROPHAGE; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SCID MOUSE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BENZ(A)ANTHRACENES; FEMALE; FLOW CYTOMETRY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERLEUKINS; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MALE; MICE; MICE, SCID; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR;

EID: 84977483969     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-016-0973-6     Document Type: Article

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