Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: Anticatabolic impact of ketone bodies

American Journal of Clinical Nutrition

Volumn 108, Issue 4, 2018, Pages 857-867

  Thomsen, Henrik H ^a,b   Rittig, Nikolaj ^b   Johannsen, Mogens ^b   Møller, Andreas B ^b   Jørgensen, Jens Otto ^b   Jessen, Niels ^b   Møller, Niels ^b  

^a VIBORG HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

amino acid tracer; cachexia; endotoxin model; ketone bodies; phenylalanine

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACIPIMOX; HYDROCORTISONE; INITIATION FACTOR 2ALPHA; INTERLEUKIN 10; INTERLEUKIN 6; INTRALIPID; INTRALIPID KOMB; KETONE BODY; LC3I PROTEIN; LC3II PROTEIN; LIPOPOLYSACCHARIDE; MAMMALIAN TARGET OF RAPAMYCIN; MUSCLE PROTEIN; MUSCLE RING FINGER 1 PROTEIN; NEUTRAL INSULIN; NITROGEN 15; PEPTIDES AND PROTEINS; PHENYLALANINE; PLACEBO; PROTEIN KINASE B; S6 KINASE; SEQUESTOSOME 1; SERINE; SERINE THREONINE PROTEIN KINASE ULK1; SODIUM CHLORIDE; TRANSCRIPTION FACTOR FKHRL1; TUMOR NECROSIS FACTOR; TYROSINE; UNCLASSIFIED DRUG; UREA; UREA C 13; ANTILIPEMIC AGENT; BIOLOGICAL MARKER; FATTY ACID; PYRAZINE DERIVATIVE;

ADULT; ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFICACY; DRUG POTENCY; FOREARM; HUMAN; HYPERINSULINEMIC-EUGLYCEMIC CLAMP TECHNIQUE; INSULIN SENSITIVITY; INTRACELLULAR SIGNALING; ISOTOPE LABELING; KINETICS; LIPOLYSIS; LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION; MALE; MUSCLE BIOPSY; NORMAL HUMAN; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; WESTERN BLOTTING; DRUG EFFECT; GLUCOSE CLAMP TECHNIQUE; INFLAMMATION; INSULIN RESISTANCE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; YOUNG ADULT;

3-HYDROXYBUTYRIC ACID; ADULT; BIOMARKERS; BLOTTING, WESTERN; FATTY ACIDS, NONESTERIFIED; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPOLIPIDEMIC AGENTS; INFLAMMATION; INSULIN RESISTANCE; KETONE BODIES; KINETICS; LIPOPOLYSACCHARIDES; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEOLYSIS; PYRAZINES; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 85055080903     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.1093/ajcn/nqy170     Document Type: Article

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