Short-term amino acid infusion improves protein balance in critically ill patients

Critical Care

Volumn 19, Issue 1, 2015, Pages

  Liebau, Felix ^a   Sundström, Martin ^a   van Loon, Luc JC ^b   Wernerman, Jan ^a   Rooyackers, Olav ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GLUTAMINE; PHENYLALANINE; STABLE ISOTOPE; TYROSINE; PROTEIN;

ADULT; AGED; AMINOHYDROXYLATION; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DIET SUPPLEMENTATION; ENTERIC FEEDING; FEMALE; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; ISOTOPE LABELING; MALE; NUTRITIONAL ASSESSMENT; NUTRITIONAL SUPPORT; PARENTERAL NUTRITION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTAKE; PROTEIN METABOLISM; PROTEIN SYNTHESIS; BLOOD; METABOLISM; MIDDLE AGED; PARENTERAL DRUG ADMINISTRATION; PILOT STUDY;

AMINO ACIDS; CRITICAL ILLNESS; ENTERAL NUTRITION; FEMALE; HUMANS; INFUSIONS, PARENTERAL; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PHENYLALANINE; PILOT PROJECTS; PROTEINS;

EID: 84928014858     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-015-0844-6     Document Type: Article

References (22)

1. Hoffer LJ, Bistrian BR. Appropriate protein provision in critical illness: a systematic and narrative review. Am J Clin Nutr. 2012;96:591-600.
2. McClave SA, Martindale RG, Vanek VW, McCarthy M, Roberts P, Taylor B, et al. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr. 2009;33:277-316.
3. Singer P, Berger MM, Van den Berghe G, Biolo G, Calder P, Forbes A, et al. ESPEN Guidelines on Parenteral Nutrition: intensive care. Clin Nutr. 2009;28:387-400.
4. Young VR. Nutritional balance studies: indicators of human requirements or of adaptive mechanisms? J Nutr. 1986;116:700-3.
5. Berg A, Rooyackers O, Bellander BM, Wernerman J. Whole body protein kinetics during hypocaloric and normocaloric feeding in critically ill patients. Crit Care. 2013;17:R158.
6. Dvir D, Cohen J, Singer P. Computerized energy balance and complications in critically ill patients: an observational study. Clin Nutr. 2006;25:37-44.
7. van Loon LJ, Boirie Y, Gijsen AP, Fauquant J, de Roos AL, Kies AK, et al. The production of intrinsically labeled milk protein provides a functional tool for human nutrition research. J Dairy Sci. 2009;92:4812-22.
8. Boirie Y, Gachon P, Corny S, Fauquant J, Maubois JL, Beaufrère B. Acute postprandial changes in leucine metabolism as assessed with an intrinsically labeled milk protein. Am J Physiol. 1996;271:E1083-91.
9. Rooyackers O, Kouchek-Zadeh R, Tjäder I, Norberg Å, Klaude M, Wernerman J. Whole body protein turnover in critically ill patients with multiple organ failure. Clin Nutr. 2015;34:95-100.
10. 3]-3-methylhistidine: a new method. Metabolism. 2004;53:1076-80.
11. Liebau F, Jensen MD, Nair KS, Rooyackers O. Upper-body obese women are resistant to postprandial stimulation of protein synthesis. Clin Nutr. 2014;33:802-7.
12. Tessari P, Barazzoni R, Zanetti M. Differences in estimates of forearm protein synthesis between leucine and phenylalanine tracers following unbalanced amino acid infusion. Metabolism. 1999;48:1564-9.
13. Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011;365:506-17.
14. Tessari P, Barazzoni R, Zanetti M, Kiwanuka E, Tiengo A. The role of substrates in the regulation of protein metabolism. Baillieres Clin Endocrinol Metab. 1996;10:511-32.
15. 13C]leucine exchange. Eur J Clin Invest. 1990;20:41-50. A published erratum appears in Eur J Clin Invest. 1990;20:479.
16. Chevalier S, Goulet ED, Burgos SA, Wykes LJ, Morais JA. Protein anabolic responses to a fed steady state in healthy aging. J Gerontol A Biol Sci Med Sci. 2011;66:681-8.
17. Boirie Y, Gachon P, Beaufrère B. Splanchnic and whole-body leucine kinetics in young and elderly men. Am J Clin Nutr. 1997;65:489-95.
18. Kalhan SC, Edmison JM. Effect of intravenous amino acids on protein kinetics in preterm infants. Curr Opin Clin Nutr Metab Care. 2007;10:69-74.
19. Verbruggen SC, Coss-Bu J, Wu M, Schierbeek H, Joosten KF, Dhar A, et al. Current recommended parenteral protein intakes do not support protein synthesis in critically ill septic, insulin-resistant adolescents with tight glucose control. Crit Care Med. 2011;39:2518-25.
20. Essén P, McNurlan MA, Gamrin L, Hunter K, Calder G, Garlick PJ, et al. Tissue protein synthesis rates in critically ill patients. Crit Care Med. 1998;26:92-100.
21. Klaude M, Mori M, Tjäder I, Gustafsson T, Wernerman J, Rooyackers O. Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis. Clin Sci (Lond). 2012;122:133-42.
22. Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, et al. Acute skeletal muscle wasting in critical illness. JAMA. 2013;310:1591-600.