Effect of systemic high dose vitamin C therapy on forearm blood flow reactivity during endotoxemia in healthy human subjects

Vascular Pharmacology

Volumn 61, Issue 1, 2014, Pages 25-29

  Aschauer, S ^a   Gouya, G ^a   Klickovic, U ^a   Storka, A ^a   Weisshaar, S ^a   Vollbracht, C ^b   Krick, B ^b   Weiss, G ^b   Wolzt, M ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Medizinischwissenschaftliche Abteilung   (Germany)

Author keywords

Endothelial dysfunction; Endotoxemia; Forearm blood flow; Inflammation; Vitamin C

Indexed keywords

ACETYLCHOLINE; ASCORBIC ACID; ESCHERICHIA COLI ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLYCERYL TRINITRATE; NITRIC OXIDE; PLACEBO; UNCLASSIFIED DRUG; VITAMIN C INJEKTOPAS; BACTERIUM LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE;

ADULT; ANTIOXIDANT ACTIVITY; ARM BLOOD VESSEL; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG MEGADOSE; ENDOTOXEMIA; FLU LIKE SYNDROME; FOREARM BLOOD FLOW; HUMAN; LOW DRUG DOSE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM; VASODILATATION; VITAMIN BLOOD LEVEL; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; HUMAN EXPERIMENT; INFLAMMATION; LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA; SYSTEMIC THERAPY; VASCULAR RESISTANCE; BLOOD FLOW; DRUG EFFECTS; FOREARM; PATHOPHYSIOLOGY; VASCULARIZATION;

ADULT; ASCORBIC ACID; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTOXEMIA; FOREARM; HEALTHY VOLUNTEERS; HUMANS; LIPOPOLYSACCHARIDES; MALE; REGIONAL BLOOD FLOW;

EID: 84898031901     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2014.01.007     Document Type: Article

References (35)

1. Landmesser U. Endothelial function: a critical determinant in atherosclerosis?. Circulation 2004, 109(21_Suppl_1):II-27-II-33.
2. Förstermann U., Münzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006, 113(13):1708-1714.
3. Natali A., Ferrannini E. Endothelial dysfunction in type 2 diabetes. Diabetologia 2012, 55(6):1559-1563.
4. Szabo C., Goldstein B. Endothelial dysfunction as predictor of mortality in sepsis. Crit Care Med 2011, 39(4):878-879.
5. Förstermann U. Nitric oxide and oxidative stress in vascular disease. Pflugers Arch - Eur J Physiol 2010, 459(6):923-939.
6. Siekmeier R., Grammer T., März W. Roles of oxidants, nitric oxide, and asymmetric dimethylarginine in endothelial function. J Cardiovasc Pharmacol Ther 2008, 13(4):279-297.
7. Pleiner J., Mittermayer F., Schaller G., Marsik C., MacAllister R.J., Wolzt M. Inflammation-induced vasoconstrictor hyporeactivity is caused by oxidative stress. J Am Coll Cardiol 2003, 42(9):1656-1662.
8. Long C.L., Maull K.I., Krishnan R.S., Laws H.L., Geiger J.W., Borghesi L., et al. Ascorbic acid dynamics in the seriously ill and injured. J Surg Res 2003, 109(2):144-148.
9. Schorah C.J., Downing C., Piripitsi A., Gallivan L., Al-Hazaa A.H., Sanderson M.J., et al. Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients. Am J Clin Nutr 1996, 63(5):760-765.
10. Crandon J.H., Landau B., Mikal S., Balmanno J., Jefferson M., Mahoney N. Ascorbic acid economy in surgical patients as indicated by blood ascorbic acid levels. N Engl J Med 1958, 258(3):105-113.
11. Pleiner J., Mittermayer F., Schaller G., MacAllister R.J., Wolzt M. High doses of vitamin C reverse Escherichia coli endotoxin-induced hyporeactivity to acetylcholine in the human forearm. Circulation 2002, 106(12):1460-1464.
12. Simera I., Moher D., Hoey J., Schulz K.F., Altman D.G. A catalogue of reporting guidelines for health research. Eur J Clin Invest 2010, 40(1):35-53.
13. Hokanson D.E., Sumner D.S., Strandness D.E. An electrically calibrated plethysmograph for direct measurement of limb blood flow. IEEE Trans Biomed Eng 1975, 22(1):25-29.
14. Pleiner J., Heere-Ress E., Langenberger H., Sieder A.E., Bayerle-Eder M., Mittermayer F., et al. Adrenoceptor hyporeactivity is responsible for Escherichia coli endotoxin-induced acute vascular dysfunction in humans. Arterioscler Thromb Vasc Biol 2002, 22(1):95-100.
15. Suffredini A.F., Fromm R.E., Parker M.M., Brenner M., Kovacs J.A., Wesley R.A., et al. The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 1989, 321(5):280-287.
16. Pernerstorfer T., Hollenstein U., Hansen J., Knechtelsdorfer M., Stohlawetz P., Graninger W., et al. Heparin blunts endotoxin-induced coagulation activation. Circulation 1999, 100(25):2485-2490.
17. Carr A., Frei B. Does vitamin C act as a pro-oxidant under physiological conditions?. FASEB J 1999, 13(9):1007-1024.
18. Mühlhöfer A., Mrosek S., Schlegel B., Trommer W., Rozario F., Böhles H., et al. High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers. Eur J Clin Nutr 2004, 58(8):1151-1158.
19. Garhofer G., Zawinka C., Resch H., Menke M., Schmetterer L., Dorner G.T. Effect of intravenous administration of sodium-lactate on retinal blood flow in healthy subjects. Invest Ophthalmol Vis Sci 2003, 44(9):3972-3976.
20. Nadi E., Tavakoli F., Zeraati F., Goodarzi M.T., Hashemi S.H. Effect of vitamin C administration on leukocyte vitamin C level and severity of bronchial asthma. Acta Med Iran 2012, 50(4):233-238.
21. Kvietys P.R., Granger D.N. Role of reactive oxygen and nitrogen species in the vascular responses to inflammation. Free Radic Biol Med 2012, (52):556-592.
22. Higashi Y., Noma K., Yoshizumi M., Kihara Y. Endothelial function and oxidative stress in cardiovascular diseases. Circ J 2009, 73(3):411-418.
23. Heitzer T., Schlinzig T., Krohn K., Meinertz T., Münzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001, 104(22):2673-2678.
24. Wilson J.X. Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium. Biofactors 2009, 35(1):5-13.
25. Wilson J.X. Evaluation of vitamin C for adjuvant sepsis therapy. Antioxid Redox Signal 2013, 19(17):2129-2140.
26. Han M., Pendem S., Teh S.L., Sukumaran D.K., Wu F., Wilson J.X. Ascorbate protects endothelial barrier function during septic insult: role of protein phosphatase type 2A. Free Radic Biol Med 2010, 48(1):128-135.
27. Fisher B.J., Seropian I.M., Kraskauskas D., Thakkar J.N., Voelkel N.F., Fowler A.A., et al. Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury. Crit Care Med 2011, 39(6):1454-1460.
28. Pleiner J., Schaller G., Mittermayer F., Marsik C., MacAllister R.J., Kapiotis S., et al. Intra-arterial vitamin C prevents endothelial dysfunction caused by ischemia-reperfusion. Atherosclerosis 2008, 197(1):383-391.
29. Biesalski H.K., McGregor G.P. Antioxidant therapy in critical care - is the microcirculation the primary target?. Crit Care Med 2007, 35:S577-S583. [Suppl.].
30. Jackson T.S., Xu A., Vita J.A., Keaney J.F. Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res 1998, 83(9):916-922.
31. Lehr H.A., Germann G., McGregor G.P., Migeod F., Roesen P., Tanaka H., et al. Consensus meeting on "Relevance of parenteral vitamin C in acute endothelial dependent pathophysiological conditions (EDPC)". Eur J Med Res 2006, 516-526.
32. Padayatty S.J., Sun A.Y., Chen Q., Espey M.G., Drisko J., Levine M. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One 2010, 5(7):e11414.
33. Stephenson C.M., Levin R.D., Spector T., Lis C.G. Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer. Cancer Chemother Pharmacol 2013, 72(1):139-146.
34. Fowler A.A., Syed A.A., Knowlson S., Sculthorpe R., Farthing D., Dewilde C., Farthing C.A., Larus T.L., Martin E., Brophy D.F., Gupta S., Fisher B.J., Natarajan R. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med 2014, 12:32.
35. Duvall W.L. Endothelial dysfunction and antioxidants. Mt Sinai J Med 2005, 72(2):71-80.