Breakthroughs in the Health Effects of Plant Food Bioactives: A Perspective on Microbiomics, Nutri(epi)genomics, and Metabolomics

Journal of Agricultural and Food Chemistry

Volumn 66, Issue 41, 2018, Pages 10686-10692

  Bayram, Banu ^a   González Sarrías, Antonio ^b   Istas, Geoffrey ^c   Garcia Aloy, Mar ^d,e   Morand, Christine ^f   Tuohy, Kieran ^g   García Villalba, Rocío ^b   Mena, Pedro ^h  

^a UNIVERSITY OF HEALTH SCIENCES   (Turkey)

^b RESEARCH GROUP ON QUALITY   (Spain)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF BARCELONA   (Spain)

^e Unidad de Gestión Clínica de Laboratorios Clínicos   (Spain)

^f INRA and University of Auvergne   (France)

^g RESEARCH AND INNOVATION CENTRE   (Italy)

^h UNIVERSITY OF PARMA   (Italy)

Author keywords

gut microbiota; interindividual variability; metabolome; personalized nutrition; phytochemicals

Indexed keywords

METABOLITES;

BIOACTIVE COMPOUNDS; GUT MICROBIOTA; HOLISTIC APPROACH; INDIVIDUAL LEVELS; INTERINDIVIDUAL VARIABILITY; METABOLOMES; PHYTOCHEMICALS; SECONDARY METABOLITES;

NUTRITION;

PLANT EXTRACT;

ANIMAL; CHEMISTRY; GENETICS; GENOMICS; HUMAN; INTESTINE FLORA; METABOLISM; METABOLOMICS; NUTRITIONAL VALUE; PLANT;

ANIMALS; GASTROINTESTINAL MICROBIOME; GENOMICS; HUMANS; METABOLOMICS; NUTRITIVE VALUE; PLANT EXTRACTS; PLANTS;

EID: 85054819161     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.8b03385     Document Type: Article

References (30)

1. Cicero, A. F. G.; Fogacci, F.; Colletti, A. Food and plant bioactives for reducing cardiometabolic disease risk: An evidence based approach. Food Funct. 2017, 8, 2076-2088, 10.1039/C7FO00178A
2. Manach, C.; Milenkovic, D.; Van de Wiele, T.; Rodriguez-Mateos, A.; de Roos, B.; Garcia-Conesa, M. T.; Landberg, R.; Gibney, E. R.; Heinonen, M.; Tomas-Barberan, F.; Morand, C. Addressing the inter-individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction. Mol. Nutr. Food Res. 2017, 61, 1600557, 10.1002/mnfr.201600557
3. Milenkovic, D.; Morand, C.; Cassidy, A.; Konic-Ristic, A.; Tomás-Barberán, F.; Ordovas, J. M.; Kroon, P.; De Caterina, R.; Rodriguez-Mateos, A. Interindividual Variability in Biomarkers of Cardiometabolic Health after Consumption of Major Plant-Food Bioactive Compounds and the Determinants Involved. Adv. Nutr. 2017, 8, 558-570, 10.3945/an.116.013623
4. Valdés, A.; Cifuentes, A.; León, C. Foodomics evaluation of bioactive compounds in foods. TrAC, Trends Anal. Chem. 2017, 96, 2-13, 10.1016/j.trac.2017.06.004
5. Anhe, F. F.; Varin, T. V.; Le Barz, M.; Desjardins, Y.; Levy, E.; Roy, D.; Marette, A. Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts. Curr. Obes. Rep. 2015, 4, 389-400, 10.1007/s13679-015-0172-9
6. Qin, J.; Li, R.; Raes, J.; Arumugam, M.; Burgdorf, K. S.; Manichanh, C.; Nielsen, T.; Pons, N.; Levenez, F.; Yamada, T.; Mende, D. R.; Li, J.; Xu, J.; Li, S.; Li, D.; Cao, J.; Wang, B.; Liang, H.; Zheng, H.; Xie, Y.; Tap, J.; Lepage, P.; Bertalan, M.; Batto, J. M.; Hansen, T.; Le Paslier, D.; Linneberg, A.; Nielsen, H. B.; Pelletier, E.; Renault, P.; Sicheritz-Ponten, T.; Turner, K.; Zhu, H.; Yu, C.; Jian, M.; Zhou, Y.; Li, Y.; Zhang, X.; Qin, N.; Yang, H.; Wang, J.; Brunak, S.; Doré, J.; Guarner, F.; Kristiansen, K.; Pedersen, O.; Parkhill, J.; Weissenbach, J.; Bork, P.; Ehrlich, S. D.; Antolin, M.; Artiguenave, F.; Blottiere, H.; Borruel, N.; Bruls, T.; Casellas, F.; Chervaux, C.; Cultrone, A.; Delorme, C.; Denariaz, G.; Dervyn, R.; Forte, M.; Friss, C.; Van De Guchte, M.; Guedon, E.; Haimet, F.; Jamet, A.; Juste, C.; Kaci, G.; Kleerebezem, M.; Knol, J.; Kristensen, M.; Layec, S.; Le Roux, K.; Leclerc, M.; Maguin, E.; Melo Minardi, R.; Oozeer, R.; Rescigno, M.; Sanchez, N.; Tims, S.; Torrejon, T.; Varela, E.; De Vos, W.; Winogradsky, Y.; Zoetendal, E. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010, 464, 59-65, 10.1038/nature08821
7. Castello, F.; Costabile, G.; Bresciani, L.; Tassotti, M.; Naviglio, D.; Luongo, D.; Ciciola, P.; Vitale, M.; Vetrani, C.; Galaverna, G.; Brighenti, F.; Giacco, R.; Del Rio, D.; Mena, P. Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humans. Arch. Biochem. Biophys. 2018, 646, 1-9, 10.1016/j.abb.2018.03.021
8. Gonzalez-Sarrias, A.; Garcia-Villalba, R.; Romo-Vaquero, M.; Alasalvar, C.; Orem, A.; Zafrilla, P.; Tomas-Barberan, F. A.; Selma, M. V.; Espin, J. C. Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial. Mol. Nutr. Food Res. 2017, 61, 1600830, 10.1002/mnfr.201600830
9. Mena, P.; Ludwig, I. A.; Tomatis, V. B.; Acharjee, A.; Calani, L.; Rosi, A.; Brighenti, F.; Ray, S.; Griffin, J. L.; Bluck, L. J.; Del Rio, D. Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypes. Eur. J. Nutr. 2018, 10.1007/s00394-018-1683-4
10. Setchell, K. D.; Clerici, C. Equol: history, chemistry, and formation. J. Nutr. 2010, 140, 1355S-1362S, 10.3945/jn.109.119776
11. Bolca, S.; Possemiers, S.; Maervoet, V.; Huybrechts, I.; Heyerick, A.; Vervarcke, S.; Depypere, H.; De Keukeleire, D.; Bracke, M.; De Henauw, S.; Verstraete, W.; Van de Wiele, T. Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: A dietary intervention trial with fifty healthy post-menopausal Caucasian women. Br. J. Nutr. 2007, 98, 950-959, 10.1017/S0007114507749243
12. Trost, K.; Ulaszewska, M. M.; Stanstrup, J.; Albanese, D.; De Filippo, C.; Tuohy, K. M.; Natella, F.; Scaccini, C.; Mattivi, F. Host: Microbiome co-metabolic processing of dietary polyphenols-An acute, single blinded, cross-over study with different doses of apple polyphenols in healthy subjects. Food Res. Int. 2018, 112, 108-128, 10.1016/j.foodres.2018.06.016
13. Ferguson, L. R.; De Caterina, R.; Gorman, U.; Allayee, H.; Kohlmeier, M.; Prasad, C.; Choi, M. S.; Curi, R.; de Luis, D. A.; Gil, A.; Kang, J. X.; Martin, R. L.; Milagro, F. I.; Nicoletti, C. F.; Nonino, C. B.; Ordovas, J. M.; Parslow, V. R.; Portillo, M. P.; Santos, J. L.; Serhan, C. N.; Simopoulos, A. P.; Velazquez-Arellano, A.; Zulet, M. A.; Martinez, J. A. Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1-Fields of Precision Nutrition. J. Nutrigenet. Nutrigenomics 2016, 9, 12-27, 10.1159/000445350
14. Pavlidis, C.; Nebel, J. C.; Katsila, T.; Patrinos, G. P. Nutrigenomics 2.0: The Need for Ongoing and Independent Evaluation and Synthesis of Commercial Nutrigenomics Tests' Scientific Knowledge Base for Responsible Innovation. OMICS 2016, 20, 65-68, 10.1089/omi.2015.0170
15. Pena-Romero, A. C.; Navas-Carrillo, D.; Marin, F.; Orenes-Pinero, E. The future of nutrition: Nutrigenomics and nutrigenetics in obesity and cardiovascular diseases. Crit. Rev. Food Sci. Nutr. 2017, 5, 1-12, 10.1080/10408398.2017.1349731
16. Bohn, T.; Desmarchelier, C.; Dragsted, L. O.; Nielsen, C. S.; Stahl, W.; Ruhl, R.; Keijer, J.; Borel, P. Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. Mol. Nutr. Food Res. 2017, 61, 1600685, 10.1002/mnfr.201600685
17. Strandhagen, E.; Zetterberg, H.; Aires, N.; Palmer, M.; Rymo, L.; Blennow, K.; Thelle, D. S. The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee. Lipids Health Dis. 2004, 3, 26, 10.1186/1476-511X-3-26
18. Sanchez-Muniz, F. J.; Maki, K. C.; Schaefer, E. J.; Ordovas, J. M. Serum lipid and antioxidant responses in hypercholesterolemic men and women receiving plant sterol esters vary by apolipoprotein E genotype. J. Nutr. 2009, 139, 13-19, 10.3945/jn.108.090969
19. Llorach, R.; Garcia-Aloy, M.; Tulipani, S.; Vazquez-Fresno, R.; Andres-Lacueva, C. Nutrimetabolomic Strategies To Develop New Biomarkers of Intake and Health Effects. J. Agric. Food Chem. 2012, 60, 8797-8808, 10.1021/jf301142b
20. Rangel-Huerta, O. D.; Gil, A. Nutrimetabolomics: An Update on Analytical Approaches to Investigate the Role of Plant-Based Foods and Their Bioactive Compounds in Non-Communicable Chronic Diseases. Int. J. Mol. Sci. 2016, 17, 2072, 10.3390/ijms17122072
21. Pimentel, G.; Burton, K. J.; Vergères, G.; Dupont, D. The role of foodomics to understand the digestion/bioactivity relationship of food. Curr. Opin. Food Sci. 2018, 22, 67-73, 10.1016/j.cofs.2018.02.002
22. Martinez-Gonzalez, M. A.; Ruiz-Canela, M.; Hruby, A.; Liang, L.; Trichopoulou, A.; Hu, F. B. Intervention Trials with the Mediterranean Diet in Cardiovascular Prevention: Understanding Potential Mechanisms through Metabolomic Profiling. J. Nutr. 2015, 146, 913S-919S, 10.3945/jn.115.219147
23. Suárez, M.; Caimari, A.; del Bas, J. M.; Arola, L. Metabolomics: An emerging tool to evaluate the impact of nutritional and physiological challenges. TrAC, Trends Anal. Chem. 2017, 96, 79-88, 10.1016/j.trac.2017.06.003
24. O'Gorman, A.; Brennan, L. The role of metabolomics in determination of new dietary biomarkers. Proc. Nutr. Soc. 2017, 76, 295-302, 10.1017/S0029665116002974
25. Manach, C.; Brennan, L.; Dragsted, L. O. Using metabolomics to evaluate food intake: Applications in nutritional epidemiology. In Metabolomics as a Tool in Nutrition Research; Sébédio, J. L., Brennan, L., Eds.; Publisher: Woodhead Publishing, 2015; pp 168-196.
26. Garcia-Aloy, M.; Andres-Lacueva, C. Food Intake Biomarkers for Increasing the Efficiency of Dietary Pattern Assessment through the Use of Metabolomics: Unforeseen Research Requirements for Addressing Current Gaps. J. Agric. Food Chem. 2018, 66, 5-7, 10.1021/acs.jafc.7b05586
27. Pujos-Guillot, E.; Hubert, J.; Martin, J.-F.; Lyan, B.; Quintana, M.; Claude, S.; Chabanas, B.; Rothwell, J. A.; Bennetau-Pelissero, C.; Scalbert, A.; Comte, B.; Hercberg, S.; Morand, C.; Galan, P.; Manach, C. Mass Spectrometry-based Metabolomics for the Discovery of Biomarkers of Fruit and Vegetable Intake: Citrus Fruit as a Case Study. J. Proteome Res. 2013, 12, 1645-1659, 10.1021/pr300997c
28. Gibbons, H.; Michielsen, C. J. R.; Rundle, M.; Frost, G.; McNulty, B. A.; Nugent, A. P.; Walton, J.; Flynn, A.; Gibney, M. J.; Brennan, L. Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example. Mol. Nutr. Food Res. 2017, 61, 1700037, 10.1002/mnfr.201700037
29. Brennan, L. Metabolomics: a tool to aid dietary assessment in nutrition. Curr. Opin. Food Sci. 2017, 16, 96-99, 10.1016/j.cofs.2017.09.003
30. Garcia-Aloy, M.; Llorach, R.; Urpi-Sarda, M.; Jáuregui, O.; Corella, D.; Ruiz-Canela, M.; Salas-Salvadó, J.; Fitó, M.; Ros, E.; Estruch, R.; Andres-Lacueva, C. A metabolomics-driven approach to predict cocoa product consumption by designing a multimetabolite biomarker model in free-living subjects from the PREDIMED study. Mol. Nutr. Food Res. 2015, 59, 212-220, 10.1002/mnfr.201400434