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Volumn 5, Issue , 2018, Pages 33-51

The discovery of the antiviral resistance gene Mx: A story of great ideas, great failures, and some success

Author keywords

dynamin like large GTPase; HIV; influenza virus; interferon; Mx; Mx transgenic animals; myxovirus resistance gene

Indexed keywords

COMPLEMENTARY DNA; INTERFERON; MYXOVIRUS RESISTANCE PROTEIN; VIRUS DNA;

EID: 85054242574     PISSN: 2327056X     EISSN: 23270578     Source Type: Journal    
DOI: 10.1146/annurev-virology-092917-043525     Document Type: Article
Times cited : (32)

References (140)
  • 2
    • 0001493994 scopus 로고
    • Inheritance of resistance to influenza virus in mice
    • Lindenmann J. 1964. Inheritance of resistance to influenza virus in mice. Proc. Soc. Exp. Biol. Med. 116:506-9
    • (1964) Proc. Soc. Exp. Biol. Med. , vol.116 , pp. 506-509
    • Lindenmann, J.1
  • 3
    • 0000520727 scopus 로고
    • Virus interference I. The interferon
    • Isaacs A, Lindenmann J. 1957. Virus interference. I. The interferon. Proc. R. Soc. B 147:258-67
    • (1957) Proc. R. Soc. B , vol.147 , pp. 258-267
    • Isaacs, A.1    Lindenmann, J.2
  • 4
    • 84941599402 scopus 로고    scopus 로고
    • A tribute to Jean Lindenmann, co-discoverer of interferon (1924-2015)
    • Haller O. 2015. A tribute to Jean Lindenmann, co-discoverer of interferon (1924-2015). Cytokine 76: 113-15
    • (2015) Cytokine , vol.76 , pp. 113-115
    • Haller, O.1
  • 6
    • 77956794784 scopus 로고
    • Routine experience of the mouse-protection assay of pertussis vaccine
    • Ungar J, Basil B. 1957. Routine experience of the mouse-protection assay of pertussis vaccine. J. Hyg. 55:45-49
    • (1957) J. Hyg. , vol.55 , pp. 45-49
    • Ungar, J.1    Basil, B.2
  • 7
    • 0001368677 scopus 로고
    • Resistance of mice to mouse-adapted influenza A virus
    • Lindenmann J. 1962. Resistance of mice to mouse-adapted influenza A virus. Virology 16:203-4
    • (1962) Virology , vol.16 , pp. 203-204
    • Lindenmann, J.1
  • 8
    • 0039691136 scopus 로고
    • The use of mice in tests of immunity against yellow fever
    • Sawyer WA, Lloyd W. 1931. The use of mice in tests of immunity against yellow fever. J. Exp. Med. 54:533-55
    • (1931) J. Exp. Med. , vol.54 , pp. 533-555
    • Sawyer, W.A.1    Lloyd, W.2
  • 9
    • 0001639977 scopus 로고
    • Inheritance of resistance ofmice to enteric bacterial and neurotropic virus infections
    • Webster LT. 1937. Inheritance of resistance ofmice to enteric bacterial and neurotropic virus infections. J. Exp. Med. 65:261-86
    • (1937) J. Exp. Med. , vol.65 , pp. 261-286
    • Webster, L.T.1
  • 10
    • 0000710387 scopus 로고
    • Nature of inherited resistance to viruses affecting the nervous system
    • Sabin AB. 1952. Nature of inherited resistance to viruses affecting the nervous system. PNAS 38:540-46
    • (1952) PNAS , vol.38 , pp. 540-546
    • Sabin, A.B.1
  • 11
    • 0000044636 scopus 로고
    • Production of interferon by brains of genetically resistant and susceptible mice infected with West Nile virus
    • Vainio T, Gwatkin R, Koprowski H. 1961. Production of interferon by brains of genetically resistant and susceptible mice infected with West Nile virus. Virology 14:385-87
    • (1961) Virology , vol.14 , pp. 385-387
    • Vainio, T.1    Gwatkin, R.2    Koprowski, H.3
  • 12
    • 0001728206 scopus 로고
    • Mouse macrophages as host cells for the mouse hepatitis virus and the genetic basis of their susceptibility
    • Bang FB, Warwick A. 1960. Mouse macrophages as host cells for the mouse hepatitis virus and the genetic basis of their susceptibility. PNAS 46:1065-75
    • (1960) PNAS , vol.46 , pp. 1065-1075
    • Bang, F.B.1    Warwick, A.2
  • 13
    • 0344857637 scopus 로고
    • Further studies on the resistance of mice to myxoviruses
    • Lindenmann J, Klein P. 1966. Further studies on the resistance of mice to myxoviruses. Arch. Gesamte Virusforsch. 19:1-12
    • (1966) Arch. Gesamte Virusforsch. , vol.19 , pp. 1-12
    • Lindenmann, J.1    Klein, P.2
  • 14
    • 0000964244 scopus 로고
    • The resistance of A2G mice to myxoviruses
    • Lindenmann J, Lane CA, Hobson D. 1963. The resistance of A2G mice to myxoviruses. J. Immunol. 90:942-51
    • (1963) J. Immunol. , vol.90 , pp. 942-951
    • Lindenmann, J.1    Lane, C.A.2    Hobson, D.3
  • 15
    • 0013924867 scopus 로고
    • [On the problem of natural antiviral immunity. The hereditary character and mechanism of resistance of mice of the A2G line to influenza virus]
    • (In Russian)
    • Rusanova NA, Solov'ev VD. 1966. [On the problem of natural antiviral immunity. The hereditary character and mechanism of resistance of mice of the A2G line to influenza virus]. Vopr. Virusol. 11:398-402 (In Russian)
    • (1966) Vopr. Virusol. , vol.11 , pp. 398-402
    • Rusanova, N.A.1    Solov'Ev, V.D.2
  • 16
    • 73649160095 scopus 로고
    • Viral oncolysis with host survival
    • Lindenmann J. 1963. Viral oncolysis with host survival. Proc. Soc. Exp. Biol. Med. 113:85-91
    • (1963) Proc. Soc. Exp. Biol. Med. , vol.113 , pp. 85-91
    • Lindenmann, J.1
  • 18
    • 85016517019 scopus 로고    scopus 로고
    • How to develop viruses into anticancer weapons
    • Cattaneo R, Russell SJ. 2017. How to develop viruses into anticancer weapons. PLOS Pathog. 13:e1006190
    • (2017) PLOS Pathog. , vol.13 , pp. e1006190
    • Cattaneo, R.1    Russell, S.J.2
  • 19
    • 0016661169 scopus 로고
    • Effect of immunosuppression on the genetic resistance of A2G mice to neurovirulent influenza virus
    • Fiske RA, Klein PA. 1975. Effect of immunosuppression on the genetic resistance of A2G mice to neurovirulent influenza virus. Infect. Immun. 11:576-87
    • (1975) Infect. Immun. , vol.11 , pp. 576-587
    • Fiske, R.A.1    Klein, P.A.2
  • 20
    • 0015579348 scopus 로고
    • Nonlinkage of neurovirulence exclusively to viral hemagglutinin or neuraminidase in genetic recombinants of A-NWS (H0N1) influenza virus
    • Mayer V, Schulman JL, Kilbourne ED. 1973. Nonlinkage of neurovirulence exclusively to viral hemagglutinin or neuraminidase in genetic recombinants of A-NWS (H0N1) influenza virus. J. Virol. 11:272-78
    • (1973) J. Virol. , vol.11 , pp. 272-278
    • Mayer, V.1    Schulman, J.L.2    Kilbourne, E.D.3
  • 21
    • 0016701189 scopus 로고
    • A mouse hepatotropic variant of influenza virus
    • Haller O. 1975. A mouse hepatotropic variant of influenza virus. Arch. Virol. 49:99-116
    • (1975) Arch. Virol. , vol.49 , pp. 99-116
    • Haller, O.1
  • 22
    • 0017260657 scopus 로고
    • Genetically determined resistance to infection by hepatotropic influenza A virus in mice: Effect of immunosuppression
    • Haller O, Arnheiter H, Lindenmann J. 1976. Genetically determined resistance to infection by hepatotropic influenza A virus in mice: effect of immunosuppression. Infect. Immun. 13:844-54
    • (1976) Infect. Immun. , vol.13 , pp. 844-854
    • Haller, O.1    Arnheiter, H.2    Lindenmann, J.3
  • 23
    • 0017168735 scopus 로고
    • Pathology of influenza hepatitis in susceptible and genetically resistant mice
    • Arnheiter H, Haller O, Lindenmann J. 1976. Pathology of influenza hepatitis in susceptible and genetically resistant mice. Exp. Cell Biol. 44:95-107
    • (1976) Exp. Cell Biol. , vol.44 , pp. 95-107
    • Arnheiter, H.1    Haller, O.2    Lindenmann, J.3
  • 24
    • 0016400698 scopus 로고
    • Athymic (nude) mice express gene for myxovirus resistance
    • Haller O, Lindenmann J. 1974. Athymic (nude) mice express gene for myxovirus resistance. Nature 250:679-80
    • (1974) Nature , vol.250 , pp. 679-680
    • Haller, O.1    Lindenmann, J.2
  • 25
    • 0000977850 scopus 로고
    • Macrophages as a cellular expression of inherited natural resistance
    • Goodman GT, KoprowskiH. 1962. Macrophages as a cellular expression of inherited natural resistance. PNAS 48:160-65
    • (1962) PNAS , vol.48 , pp. 160-165
    • Goodman, G.T.1    Koprowski, H.2
  • 26
    • 0017802163 scopus 로고
    • Inborn resistance of mice to myxoviruses: Macrophages express phenotype in vitro
    • Lindenmann J, Deuel E, Fanconi S, Haller O. 1978. Inborn resistance of mice to myxoviruses: macrophages express phenotype in vitro. J. Exp. Med. 147:531-40
    • (1978) J. Exp. Med. , vol.147 , pp. 531-540
    • Lindenmann, J.1    Deuel, E.2    Fanconi, S.3    Haller, O.4
  • 27
    • 0015395632 scopus 로고
    • The origin of alveolar macrophages in mouse radiation chimeras
    • Godleski JJ, Brain JD. 1972. The origin of alveolar macrophages in mouse radiation chimeras. J. Exp. Med. 136:630-43
    • (1972) J. Exp. Med. , vol.136 , pp. 630-643
    • Godleski, J.J.1    Brain, J.D.2
  • 28
    • 84918055848 scopus 로고
    • The origin and immunological significance of Kupffer cells
    • , ed. R van Furth Oxford, UK: Blackwell Sci
    • Howard J. 1978. The origin and immunological significance of Kupffer cells. In Mononuclear Phagocytes, ed. R van Furth, pp. 178-99. Oxford, UK: Blackwell Sci.
    • (1978) Mononuclear Phagocytes , pp. 178-199
    • Howard, J.1
  • 29
    • 0017625480 scopus 로고
    • Role of non-conventional natural killer cells in resistance against syngeneic tumour cells in vivo
    • Haller O, Hansson M, Kiessling R, Wigzell H. 1977. Role of non-conventional natural killer cells in resistance against syngeneic tumour cells in vivo. Nature 270:609-11
    • (1977) Nature , vol.270 , pp. 609-611
    • Haller, O.1    Hansson, M.2    Kiessling, R.3    Wigzell, H.4
  • 30
    • 9044229742 scopus 로고
    • Immune surveillance revisited
    • Baldwin R. 1977. Immune surveillance revisited. Nature 270:557
    • (1977) Nature , vol.270 , pp. 557
    • Baldwin, R.1
  • 31
    • 0018744652 scopus 로고
    • Natural, genetically determined resistance toward influenza virus in hemopoietic mouse chimeras
    • HallerO, Arnheiter H, Lindenmann J. 1979. Natural, genetically determined resistance toward influenza virus in hemopoietic mouse chimeras. Role of mononuclear phagocytes. J. Exp. Med. 150:117-26
    • (1979) Role of Mononuclear Phagocytes. J. Exp. Med. , vol.150 , pp. 117-126
    • Haller, O.1    Arnheiter, H.2    Lindenmann, J.3
  • 32
    • 0018104567 scopus 로고
    • Role of interferon in the pathogenesis of viral diseases of mice as demonstrated by the use of anti-interferon serum. V. Protective role in mouse hepatitis virus type 3 infection of susceptible and resistant strains of mice
    • Virelizier JL, Gresser I. 1978. Role of interferon in the pathogenesis of viral diseases of mice as demonstrated by the use of anti-interferon serum. V. Protective role in mouse hepatitis virus type 3 infection of susceptible and resistant strains of mice. J. Immunol. 120:1616-19
    • (1978) J. Immunol. , vol.120 , pp. 1616-1619
    • Virelizier, J.L.1    Gresser, I.2
  • 33
    • 0017042051 scopus 로고
    • Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease, and influenza viruses
    • Gresser I,Tovey MG,Maury C, BanduMT. 1976. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease, and influenza viruses. J. Exp. Med. 144:1316-23
    • (1976) J. Exp. Med. , vol.144 , pp. 1316-1323
    • Gresser, I.1    Tovey, M.G.2    Maury, C.3    Bandu, M.T.4
  • 34
    • 0018386527 scopus 로고
    • Genetically determined, interferon-dependent resistance to influenza virus in mice
    • Haller O, Arnheiter H, Gresser I, Lindenmann J. 1979. Genetically determined, interferon-dependent resistance to influenza virus in mice. J. Exp. Med. 149:601-12
    • (1979) J. Exp. Med. , vol.149 , pp. 601-612
    • Haller, O.1    Arnheiter, H.2    Gresser, I.3    Lindenmann, J.4
  • 35
    • 0018189717 scopus 로고
    • Purification of mouse interferon by sequential affinity chromatography on poly(U)-and antibody-agarose columns
    • De Maeyer-Guignard J, Tovey MG, Gresser I, DeMaeyer E. 1978. Purification of mouse interferon by sequential affinity chromatography on poly(U)-and antibody-agarose columns. Nature 271:622-25
    • (1978) Nature , vol.271 , pp. 622-625
    • De Maeyer-Guignard, J.1    Tovey, M.G.2    Gresser, I.3    DeMaeyer, E.4
  • 36
    • 0018869587 scopus 로고
    • Host gene influences sensitivity to interferon action selectively for influenza virus
    • Haller O, Arnheiter H, Lindenmann J, Gresser I. 1980. Host gene influences sensitivity to interferon action selectively for influenza virus. Nature 283:660-62
    • (1980) Nature , vol.283 , pp. 660-662
    • Haller, O.1    Arnheiter, H.2    Lindenmann, J.3    Gresser, I.4
  • 37
    • 82955187705 scopus 로고    scopus 로고
    • Interferon-stimulated genes and their antiviral effector functions
    • Schoggins JW, Rice CM. 2011. Interferon-stimulated genes and their antiviral effector functions. Curr. Opin. Virol. 1:519-25
    • (2011) Curr. Opin. Virol. , vol.1 , pp. 519-525
    • Schoggins, J.W.1    Rice, C.M.2
  • 38
    • 0018903368 scopus 로고
    • Primary monolayer culture of adult mouse hepatocytes-A model for the study of hepatotropic viruses
    • Arnheiter H. 1980. Primary monolayer culture of adult mouse hepatocytes-A model for the study of hepatotropic viruses. Arch. Virol. 63:11-22
    • (1980) Arch. Virol. , vol.63 , pp. 11-22
    • Arnheiter, H.1
  • 39
    • 0019979235 scopus 로고
    • Adult mouse hepatocytes in primary monolayer culture express genetic resistance to mouse hepatitis virus type 3
    • Arnheiter H, Baechi T, Haller O. 1982. Adult mouse hepatocytes in primary monolayer culture express genetic resistance to mouse hepatitis virus type 3. J. Immunol. 129:1275-81
    • (1982) J. Immunol. , vol.129 , pp. 1275-1281
    • Arnheiter, H.1    Baechi, T.2    Haller, O.3
  • 40
    • 0018837632 scopus 로고
    • Host gene influence on interferon action in adult mouse hepatocytes: Specificity for influenza virus
    • Arnheiter H, Haller O, Lindenmann J. 1980. Host gene influence on interferon action in adult mouse hepatocytes: specificity for influenza virus. Virology 103:11-20
    • (1980) Virology , vol.103 , pp. 11-20
    • Arnheiter, H.1    Haller, O.2    Lindenmann, J.3
  • 41
    • 0020619717 scopus 로고
    • Expression of interferon dependent resistance to influenza virus in mouse embryo cells
    • Arnheiter H, Staeheli P. 1983. Expression of interferon dependent resistance to influenza virus in mouse embryo cells. Arch. Virol. 76:127-37
    • (1983) Arch. Virol. , vol.76 , pp. 127-137
    • Arnheiter, H.1    Staeheli, P.2
  • 42
    • 0019478770 scopus 로고
    • Virus-specific interferon action Protection of newborn Mx carriers against lethal infection with influenza virus
    • Haller O, Arnheiter H, Gresser I, Lindenmann J. 1981. Virus-specific interferon action. Protection of newborn Mx carriers against lethal infection with influenza virus. J. Exp. Med. 154:199-203
    • (1981) J. Exp. Med. , vol.154 , pp. 199-203
    • Haller, O.1    Arnheiter, H.2    Gresser, I.3    Lindenmann, J.4
  • 43
    • 0019751240 scopus 로고
    • Inborn resistance of mice to orthomyxoviruses
    • Haller O. 1981. Inborn resistance of mice to orthomyxoviruses. Curr. Top. Microbiol. Immunol. 92:25-52
    • (1981) Curr. Top. Microbiol. Immunol. , vol.92 , pp. 25-52
    • Haller, O.1
  • 44
    • 0020617402 scopus 로고
    • Mx gene control of interferon action: Different kinetics of the antiviral state against influenza virus and vesicular stomatitis virus
    • Arnheiter H, Haller O. 1983. Mx gene control of interferon action: different kinetics of the antiviral state against influenza virus and vesicular stomatitis virus. J. Virol. 47:626-30
    • (1983) J. Virol. , vol.47 , pp. 626-630
    • Arnheiter, H.1    Haller, O.2
  • 45
    • 0020002134 scopus 로고
    • Biochemistry of interferons and their actions
    • Lengyel P. 1982. Biochemistry of interferons and their actions. Annu. Rev. Biochem. 51:251-82
    • (1982) Annu. Rev. Biochem. , vol.51 , pp. 251-282
    • Lengyel, P.1
  • 46
    • 0021330402 scopus 로고
    • Mx-dependent resistance to influenza viruses is induced by mouse interferons αand βbut not γ
    • Staeheli P, Horisberger MA, Haller O. 1984. Mx-dependent resistance to influenza viruses is induced by mouse interferons αand βbut not γ. Virology 132:456-61
    • (1984) Virology , vol.132 , pp. 456-461
    • Staeheli, P.1    Horisberger, M.A.2    Haller, O.3
  • 47
    • 0026089169 scopus 로고
    • Interferon-regulated Mx genes are not responsive to interleukin-1, tumor necrosis factor, and other cytokines
    • Simon A, Fah J, Haller O, Staeheli P. 1991. Interferon-regulated Mx genes are not responsive to interleukin-1, tumor necrosis factor, and other cytokines. J. Virol. 65:968-71
    • (1991) J. Virol. , vol.65 , pp. 968-971
    • Simon, A.1    Fah, J.2    Haller, O.3    Staeheli, P.4
  • 48
    • 34447268941 scopus 로고    scopus 로고
    • Induction of MxA gene expression by influenza A virus requires type i or type III interferon signaling
    • Holzinger D, Jorns C, Stertz S, Boisson-Dupuis S, Thimme R, et al. 2007. Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling. J. Virol. 81:7776-85
    • (2007) J. Virol. , vol.81 , pp. 7776-7785
    • Holzinger, D.1    Jorns, C.2    Stertz, S.3    Boisson-Dupuis, S.4    Thimme, R.5
  • 49
    • 77951983557 scopus 로고    scopus 로고
    • Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections
    • MordsteinM,NeugebauerE,DittV, JessenB,RiegerT, et al. 2010. Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections. J. Virol. 84:5670-77
    • (2010) J. Virol. , vol.84 , pp. 5670-5677
    • Mordstein, M.1    Neugebauer, E.2    Ditt, V.3    Jessen, B.4    Rieger, T.5
  • 50
    • 0019161771 scopus 로고
    • Interferon-dependent genetic resistance to influenza virus in mice: Virus replication in macrophages is inhibited at an early step
    • Horisberger MA, Haller O, Arnheiter H. 1980. Interferon-dependent genetic resistance to influenza virus in mice: Virus replication in macrophages is inhibited at an early step. J. Gen. Virol. 50:205-10
    • (1980) J. Gen. Virol. , vol.50 , pp. 205-210
    • Horisberger, M.A.1    Haller, O.2    Arnheiter, H.3
  • 51
    • 0019394947 scopus 로고
    • A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription
    • Plotch SJ, Bouloy M, Ulmanen I, Krug RM. 1981. A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription. Cell 23:847-58
    • (1981) Cell , vol.23 , pp. 847-858
    • Plotch, S.J.1    Bouloy, M.2    Ulmanen, I.3    Krug, R.M.4
  • 52
    • 0022374451 scopus 로고
    • Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product
    • Krug RM, Shaw M, Broni B, Shapiro G, Haller O. 1985. Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product. J. Virol. 56:201-6
    • (1985) J. Virol. , vol.56 , pp. 201-206
    • Krug, R.M.1    Shaw, M.2    Broni, B.3    Shapiro, G.4    Haller, O.5
  • 53
    • 0025260545 scopus 로고
    • Parental influenza virion nucleocapsids are efficiently transported into the nuclei ofmurine cells expressing the nuclear interferoninduced Mx protein
    • Broni B, Julkunen I, Condra JH, Davies ME, Berry MJ, Krug RM. 1990. Parental influenza virion nucleocapsids are efficiently transported into the nuclei ofmurine cells expressing the nuclear interferoninduced Mx protein. J. Virol. 64:6335-40
    • (1990) J. Virol. , vol.64 , pp. 6335-6340
    • Broni, B.1    Julkunen, I.2    Condra, J.H.3    Davies, M.E.4    Berry, M.J.5    Krug, R.M.6
  • 54
    • 0026524496 scopus 로고
    • Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle
    • Pavlovic J, Haller O, Staeheli P. 1992. Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle. J. Virol. 66:2564-69
    • (1992) J. Virol. , vol.66 , pp. 2564-2569
    • Pavlovic, J.1    Haller, O.2    Staeheli, P.3
  • 55
    • 0027372154 scopus 로고
    • Function of the mouse Mx1 protein is inhibited by overexpression of the PB2 protein of influenza virus
    • Stranden AM, Staeheli P, Pavlovic J. 1993. Function of the mouse Mx1 protein is inhibited by overexpression of the PB2 protein of influenza virus. Virology 197:642-51
    • (1993) Virology , vol.197 , pp. 642-651
    • Stranden, A.M.1    Staeheli, P.2    Pavlovic, J.3
  • 57
    • 0026729086 scopus 로고
    • Overexpression of the influenza virus polymerase can titrate out inhibition by the murine Mx1 protein
    • Huang T, Pavlovic J, Staeheli P, Krystal M. 1992. Overexpression of the influenza virus polymerase can titrate out inhibition by the murine Mx1 protein. J. Virol. 66:4154-60
    • (1992) J. Virol. , vol.66 , pp. 4154-4160
    • Huang, T.1    Pavlovic, J.2    Staeheli, P.3    Krystal, M.4
  • 58
    • 0015968975 scopus 로고
    • A protein synthesizing system from interferon-treated cells that discriminates between cellular and viral messenger RNAs
    • Samuel CE, Joklik WK. 1974. A protein synthesizing system from interferon-treated cells that discriminates between cellular and viral messenger RNAs. Virology 58:476-91
    • (1974) Virology , vol.58 , pp. 476-491
    • Samuel, C.E.1    Joklik, W.K.2
  • 59
    • 0017948303 scopus 로고
    • Inhibition of cell-free protein synthesis by pppA2p5A2p5 A: A novel oligonucleotide synthesized by interferon-treated L cell extracts
    • Clemens MJ,Williams BR. 1978. Inhibition of cell-free protein synthesis by pppA2p5A2p5 A: a novel oligonucleotide synthesized by interferon-treated L cell extracts. Cell 13:565-72
    • (1978) Cell , vol.13 , pp. 565-572
    • Clemens, M.J.1    Williams, B.R.2
  • 60
    • 0018363340 scopus 로고
    • The (2-5) oligoadenylate (ppA2-5A2-5A) synthetase and protein kinase(s) from interferon-treated cells
    • Hovanessian AG, Kerr IM. 1979. The (2-5) oligoadenylate (ppA2-5A2-5A) synthetase and protein kinase(s) from interferon-treated cells. Eur. J. Biochem. 93:515-26
    • (1979) Eur. J. Biochem. , vol.93 , pp. 515-526
    • Hovanessian, A.G.1    Kerr, I.M.2
  • 61
    • 0018352913 scopus 로고
    • Interferon-induced enzymatic activities and their role in the antiviral state
    • Baglioni C. 1979. Interferon-induced enzymatic activities and their role in the antiviral state. Cell 17:255-64
    • (1979) Cell , vol.17 , pp. 255-264
    • Baglioni, C.1
  • 62
    • 0017696571 scopus 로고
    • High resolution two-dimensional electrophoresis of basic as well as acidic proteins
    • O'Farrell PZ, Goodman HM, O'Farrell PH. 1977. High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell 12:1133-41
    • (1977) Cell , vol.12 , pp. 1133-1141
    • O'Farrell, P.Z.1    Goodman, H.M.2    O'Farrell, P.H.3
  • 63
    • 0019140033 scopus 로고
    • The large P proteins of influenza A viruses are composed of one acidic and two basic polypeptides
    • Horisberger MA. 1980. The large P proteins of influenza A viruses are composed of one acidic and two basic polypeptides. Virology 107:302-5
    • (1980) Virology , vol.107 , pp. 302-305
    • Horisberger, M.A.1
  • 64
    • 0020607951 scopus 로고
    • Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus
    • HorisbergerMA, Staeheli P, Haller O. 1983. Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus. PNAS 80:1910-14
    • (1983) PNAS , vol.80 , pp. 1910-1914
    • Horisberger, M.A.1    Staeheli, P.2    Haller, O.3
  • 65
    • 0021943947 scopus 로고
    • Polyclonal and monoclonal antibodies to the interferon-inducible protein Mx of influenza virus-resistant mice
    • Staeheli P, Dreiding P, Haller O, Lindenmann J. 1985. Polyclonal and monoclonal antibodies to the interferon-inducible protein Mx of influenza virus-resistant mice. J. Biol. Chem. 260:1821-25
    • (1985) J. Biol. Chem. , vol.260 , pp. 1821-1825
    • Staeheli, P.1    Dreiding, P.2    Haller, O.3    Lindenmann, J.4
  • 66
    • 0022002772 scopus 로고
    • Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses
    • Dreiding P, Staeheli P, Haller O. 1985. Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses. Virology 140:192-96
    • (1985) Virology , vol.140 , pp. 192-196
    • Dreiding, P.1    Staeheli, P.2    Haller, O.3
  • 67
    • 4043064324 scopus 로고    scopus 로고
    • Mx1 GTPase accumulates in distinct nuclear domains and inhibits influenza A virus in cells that lack promyelocytic leukaemia protein nuclear bodies
    • Engelhardt OG, Sirma H, Pandolfi PP, Haller O. 2004. Mx1 GTPase accumulates in distinct nuclear domains and inhibits influenza A virus in cells that lack promyelocytic leukaemia protein nuclear bodies. J. Gen. Virol. 85:2315-26
    • (2004) J. Gen. Virol. , vol.85 , pp. 2315-2326
    • Engelhardt, O.G.1    Sirma, H.2    Pandolfi, P.P.3    Haller, O.4
  • 68
    • 0035842439 scopus 로고    scopus 로고
    • Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies
    • Engelhardt OG, Ullrich E, Kochs G, Haller O. 2001. Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies. Exp. Cell Res. 271:286-95
    • (2001) Exp. Cell Res. , vol.271 , pp. 286-295
    • Engelhardt, O.G.1    Ullrich, E.2    Kochs, G.3    Haller, O.4
  • 69
    • 0024007966 scopus 로고
    • Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins
    • Arnheiter H, Haller O. 1988. Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins. EMBO J. 7:1315-20
    • (1988) EMBO J. , vol.7 , pp. 1315-1320
    • Arnheiter, H.1    Haller, O.2
  • 70
    • 0021876864 scopus 로고
    • Interferon-induced human protein with homology to proteinMx of influenza virus-resistant mice
    • Staeheli P, HallerO. 1985. Interferon-induced human protein with homology to proteinMx of influenza virus-resistant mice. Mol. Cell. Biol. 5:2150-53
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 2150-2153
    • Staeheli, P.1    Haller, O.2
  • 72
    • 0022540467 scopus 로고
    • Mx protein: Constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus
    • Staeheli P, Haller O, BollW, Lindenmann J,Weissmann C. 1986. Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell 44:147-58
    • (1986) Cell , vol.44 , pp. 147-158
    • Staeheli, P.1    Haller, O.2    Boll, W.3    Lindenmann, J.4    Weissmann, C.5
  • 73
    • 0025376380 scopus 로고
    • A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting
    • Rothman JH, Raymond CK, Gilbert T, O'Hara PJ, Stevens TH. 1990. A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting. Cell 61:1063-74
    • (1990) Cell , vol.61 , pp. 1063-1074
    • Rothman, J.H.1    Raymond, C.K.2    Gilbert, T.3    O'Hara, P.J.4    Stevens, T.H.5
  • 74
    • 0025006964 scopus 로고
    • Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTPbinding proteins
    • Obar RA, Collins CA, Hammarback JA, Shpetner HS, Vallee RB. 1990. Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTPbinding proteins. Nature 347:256-61
    • (1990) Nature , vol.347 , pp. 256-261
    • Obar, R.A.1    Collins, C.A.2    Hammarback, J.A.3    Shpetner, H.S.4    Vallee, R.B.5
  • 75
    • 84925410974 scopus 로고    scopus 로고
    • Mx GTPases: Dynamin-like antiviral machines of innate immunity
    • Haller O, Staeheli P, Schwemmle M, Kochs G. 2015. Mx GTPases: dynamin-like antiviral machines of innate immunity. Trends Microbiol. 23:154-63
    • (2015) Trends Microbiol. , vol.23 , pp. 154-163
    • Haller, O.1    Staeheli, P.2    Schwemmle, M.3    Kochs, G.4
  • 76
    • 84867659115 scopus 로고    scopus 로고
    • Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA
    • Mitchell PS, Patzina C, Emerman M, Haller O, Malik HS, Kochs G. 2012. Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA. Cell Host Microbe 12:598-604
    • (2012) Cell Host Microbe , vol.12 , pp. 598-604
    • Mitchell, P.S.1    Patzina, C.2    Emerman, M.3    Haller, O.4    Malik, H.S.5    Kochs, G.6
  • 77
    • 84882883270 scopus 로고    scopus 로고
    • An evolutionary perspective on the broad antiviral specificity of MxA
    • Mitchell PS, Emerman M, Malik HS. 2013. An evolutionary perspective on the broad antiviral specificity of MxA. Curr. Opin. Microbiol. 16:493-99
    • (2013) Curr. Opin. Microbiol. , vol.16 , pp. 493-499
    • Mitchell, P.S.1    Emerman, M.2    Malik, H.S.3
  • 78
    • 0023791475 scopus 로고
    • Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation
    • Staeheli P, Grob R, Meier E, Sutcliffe JG, Haller O. 1988. Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation. Mol. Cell. Biol. 8:4518-23
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 4518-4523
    • Staeheli, P.1    Grob, R.2    Meier, E.3    Sutcliffe, J.G.4    Haller, O.5
  • 79
    • 0023470520 scopus 로고
    • Influenza virus resistance of wild mice:Wild-type and mutant Mx alleles occur at comparable frequencies
    • Haller O, Acklin M, Staeheli P. 1987. Influenza virus resistance of wild mice:Wild-type and mutant Mx alleles occur at comparable frequencies. J. Interferon Res. 7:647-56
    • (1987) J. Interferon Res. , vol.7 , pp. 647-656
    • Haller, O.1    Acklin, M.2    Staeheli, P.3
  • 81
    • 0037213794 scopus 로고    scopus 로고
    • Wild mice: An ever-increasing contribution to a popular mammalian model
    • Guenet JL, Bonhomme F. 2003. Wild mice: an ever-increasing contribution to a popular mammalian model. Trends Genet. 19:24-31
    • (2003) Trends Genet. , vol.19 , pp. 24-31
    • Guenet, J.L.1    Bonhomme, F.2
  • 82
    • 84964286037 scopus 로고    scopus 로고
    • Antiviral responses of inbred mice
    • Iwasaki A. 2016. Antiviral responses of inbred mice. Nat. Rev. Immunol. 16:339
    • (2016) Nat. Rev. Immunol. , vol.16 , pp. 339
    • Iwasaki, A.1
  • 83
    • 84964798222 scopus 로고    scopus 로고
    • Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
    • Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, et al. 2016. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science 352:463-66
    • (2016) Science , vol.352 , pp. 463-466
    • Pillai, P.S.1    Molony, R.D.2    Martinod, K.3    Dong, H.4    Pang, I.K.5
  • 84
    • 0028944742 scopus 로고
    • Tick-borne Thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1
    • Haller O, Frese M, Rost D, Nuttall PA, Kochs G. 1995. Tick-borne Thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1. J. Virol. 69:2596-601
    • (1995) J. Virol. , vol.69 , pp. 2596-2601
    • Haller, O.1    Frese, M.2    Rost, D.3    Nuttall, P.A.4    Kochs, G.5
  • 85
    • 0023774752 scopus 로고
    • Identification of a second interferon-regulated murine Mx gene
    • Staeheli P, Sutcliffe JG. 1988. Identification of a second interferon-regulated murine Mx gene. Mol. Cell. Biol. 8:4524-28
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 4524-4528
    • Staeheli, P.1    Sutcliffe, J.G.2
  • 86
    • 0022542286 scopus 로고
    • Interferon-regulated influenza virus resistance gene Mx is localized on mouse chromosome 16
    • Staeheli P, Pravtcheva D, Lundin LG, Acklin M, Ruddle F, et al. 1986. Interferon-regulated influenza virus resistance gene Mx is localized on mouse chromosome 16. J. Virol. 58:967-69
    • (1986) J. Virol. , vol.58 , pp. 967-969
    • Staeheli, P.1    Pravtcheva, D.2    Lundin, L.G.3    Acklin, M.4    Ruddle, F.5
  • 87
    • 0023683261 scopus 로고
    • Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21
    • Reeves RH, O'Hara BF, Pavan WJ, Gearhart JD, Haller O. 1988. Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21. J. Virol. 62:4372-75
    • (1988) J. Virol. , vol.62 , pp. 4372-4375
    • Reeves, R.H.1    O'Hara, B.F.2    Pavan, W.J.3    Gearhart, J.D.4    Haller, O.5
  • 88
    • 0026550735 scopus 로고
    • Mouse Mx2 protein inhibits vesicular stomatitis virus but not influenza virus
    • Zurcher T, Pavlovic J, Staeheli P. 1992. Mouse Mx2 protein inhibits vesicular stomatitis virus but not influenza virus. Virology 187:796-800
    • (1992) Virology , vol.187 , pp. 796-800
    • Zurcher, T.1    Pavlovic, J.2    Staeheli, P.3
  • 89
    • 0026766204 scopus 로고
    • Nuclear localization of mouse Mx1 protein is necessary for inhibition of influenza virus
    • Zurcher T, Pavlovic J, Staeheli P. 1992. Nuclear localization of mouse Mx1 protein is necessary for inhibition of influenza virus. J. Virol. 66:5059-66
    • (1992) J. Virol. , vol.66 , pp. 5059-5066
    • Zurcher, T.1    Pavlovic, J.2    Staeheli, P.3
  • 90
    • 0027512117 scopus 로고
    • Switch in antiviral specificity of a GTPase upon translocation from the cytoplasm to the nucleus
    • Johannes L, Arnheiter H, Meier E. 1993. Switch in antiviral specificity of a GTPase upon translocation from the cytoplasm to the nucleus. J. Virol. 67:1653-57
    • (1993) J. Virol. , vol.67 , pp. 1653-1657
    • Johannes, L.1    Arnheiter, H.2    Meier, E.3
  • 91
    • 0024349524 scopus 로고
    • A double-stranded RNA-inducible fish gene homologous to the murine influenza virus resistance gene Mx
    • Staeheli P, Yu YX, Grob R, Haller O. 1989. A double-stranded RNA-inducible fish gene homologous to the murine influenza virus resistance gene Mx. Mol. Cell. Biol. 9:3117-21
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3117-3121
    • Staeheli, P.1    Yu, Y.X.2    Grob, R.3    Haller, O.4
  • 92
    • 0348047396 scopus 로고    scopus 로고
    • In vitro inhibition of fish rhabdoviruses by Japanese flounder, Paralichthys olivaceus Mx
    • Caipang CM, Hirono I, Aoki T. 2003. In vitro inhibition of fish rhabdoviruses by Japanese flounder, Paralichthys olivaceus Mx. Virology 317:373-82
    • (2003) Virology , vol.317 , pp. 373-382
    • Caipang, C.M.1    Hirono, I.2    Aoki, T.3
  • 93
    • 3242721329 scopus 로고    scopus 로고
    • Inhibition of infectious pancreatic necrosis virus replication by Atlantic salmon Mx1 protein
    • Larsen R, Rokenes TP, Robertsen B. 2004. Inhibition of infectious pancreatic necrosis virus replication by Atlantic salmon Mx1 protein. J. Virol. 78:7938-44
    • (2004) J. Virol. , vol.78 , pp. 7938-7944
    • Larsen, R.1    Rokenes, T.P.2    Robertsen, B.3
  • 94
    • 22844439565 scopus 로고    scopus 로고
    • The interferon system of teleost fish
    • Robertsen B. 2006. The interferon system of teleost fish. Fish Shellfish Immunol. 20:172-91
    • (2006) Fish Shellfish Immunol. , vol.20 , pp. 172-191
    • Robertsen, B.1
  • 95
    • 0036228520 scopus 로고    scopus 로고
    • Functional diversity of Mx proteins: Variations on a theme of host resistance to infection
    • Lee SH, Vidal SM. 2002. Functional diversity of Mx proteins: variations on a theme of host resistance to infection. Genome Res. 12:527-30
    • (2002) Genome Res. , vol.12 , pp. 527-530
    • Lee, S.H.1    Vidal, S.M.2
  • 96
    • 0027296520 scopus 로고
    • No enhanced influenza virus resistance of murine and avian cells expressing cloned duck Mx protein
    • Bazzigher L, Schwarz A, Staeheli P. 1993. No enhanced influenza virus resistance of murine and avian cells expressing cloned duck Mx protein. Virology 195:100-12
    • (1993) Virology , vol.195 , pp. 100-112
    • Bazzigher, L.1    Schwarz, A.2    Staeheli, P.3
  • 97
    • 0028937519 scopus 로고
    • The interferon-induced Mx protein of chickens lacks antiviral activity
    • Bernasconi D, SchultzU, Staeheli P. 1995. The interferon-induced Mx protein of chickens lacks antiviral activity. J. Interferon Cytokine Res. 15:47-53
    • (1995) J. Interferon Cytokine Res. , vol.15 , pp. 47-53
    • Bernasconi, D.1    Schultz, U.2    Staeheli, P.3
  • 99
    • 68149098653 scopus 로고    scopus 로고
    • Protective role of interferon-inducedMxGTPases against influenza viruses
    • HallerO, Staeheli P,Kochs G. 2009. Protective role of interferon-inducedMxGTPases against influenza viruses. Rev. Sci. Tech. 28:219-31
    • (2009) Rev. Sci. Tech. , vol.28 , pp. 219-231
    • Haller, O.1    Staeheli, P.2    Kochs, G.3
  • 100
    • 0026558058 scopus 로고
    • Resistance to influenza virus infection of Mx transgenic mice expressing Mx protein under the control of two constitutive promoters
    • Kolb E, Laine E, Strehler D, Staeheli P. 1992. Resistance to influenza virus infection of Mx transgenic mice expressing Mx protein under the control of two constitutive promoters. J. Virol. 66:1709-16
    • (1992) J. Virol. , vol.66 , pp. 1709-1716
    • Kolb, E.1    Laine, E.2    Strehler, D.3    Staeheli, P.4
  • 101
    • 0026457204 scopus 로고
    • Transgenic pigs carrying cDNA copies encoding the murine Mx1 protein which confers resistance to influenza virus infection
    • Muller M, Brenig B, Winnacker EL, Brem G. 1992. Transgenic pigs carrying cDNA copies encoding the murine Mx1 protein which confers resistance to influenza virus infection. Gene 121:263-70
    • (1992) Gene , vol.121 , pp. 263-270
    • Muller, M.1    Brenig, B.2    Winnacker, E.L.3    Brem, G.4
  • 102
    • 0025369703 scopus 로고
    • Transgenic mice with intracellular immunity to influenza virus
    • Arnheiter H, Skuntz S, Noteborn M, Chang S, Meier E. 1990. Transgenic mice with intracellular immunity to influenza virus. Cell 62:51-61
    • (1990) Cell , vol.62 , pp. 51-61
    • Arnheiter, H.1    Skuntz, S.2    Noteborn, M.3    Chang, S.4    Meier, E.5
  • 104
    • 0024342148 scopus 로고
    • CDNA structures and regulation of two interferon-induced human Mx proteins
    • Aebi M, Fah J, Hurt N, Samuel CE, Thomis D, et al. 1989. cDNA structures and regulation of two interferon-induced human Mx proteins. Mol. Cell. Biol. 9:5062-72
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 5062-5072
    • Aebi, M.1    Fah, J.2    Hurt, N.3    Samuel, C.E.4    Thomis, D.5
  • 105
    • 0025331030 scopus 로고
    • Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein
    • Pavlovic J, Zurcher T, Haller O, Staeheli P. 1990. Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. J. Virol. 64:3370-75
    • (1990) J. Virol. , vol.64 , pp. 3370-3375
    • Pavlovic, J.1    Zurcher, T.2    Haller, O.3    Staeheli, P.4
  • 106
    • 0032775260 scopus 로고    scopus 로고
    • Human MxA protein protects mice lacking a functional alpha/beta interferon system against la Crosse virus and other lethal viral infections
    • Hefti HP, Frese M, Landis H, Di Paolo C, Aguzzi A, et al. 1999. Human MxA protein protects mice lacking a functional alpha/beta interferon system against La Crosse virus and other lethal viral infections. J. Virol. 73:6984-91
    • (1999) J. Virol. , vol.73 , pp. 6984-6991
    • Hefti, H.P.1    Frese, M.2    Landis, H.3    Di Paolo, C.4    Aguzzi, A.5
  • 107
    • 0035127114 scopus 로고    scopus 로고
    • Expression of human MxA protein in mosquito cells interferes with LaCrosse virus replication
    • Miura TA, Carlson JO, Beaty BJ, Bowen RA, Olson KE. 2001. Expression of human MxA protein in mosquito cells interferes with LaCrosse virus replication. J. Virol. 75:3001-3
    • (2001) J. Virol. , vol.75 , pp. 3001-3003
    • Miura, T.A.1    Carlson, J.O.2    Beaty, B.J.3    Bowen, R.A.4    Olson, K.E.5
  • 108
    • 1342285200 scopus 로고    scopus 로고
    • Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome
    • Turan K,Mibayashi M, Sugiyama K, Saito S,Numajiri A,Nagata K. 2004. Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. Nucleic Acids Res. 32:643-52
    • (2004) Nucleic Acids Res. , vol.32 , pp. 643-652
    • Turan, K.1    Mibayashi, M.2    Sugiyama, K.3    Saito, S.4    Numajiri, A.5    Nagata, K.6
  • 109
    • 79961202011 scopus 로고    scopus 로고
    • The viral nucleoprotein determines Mx sensitivity of influenza A viruses
    • Zimmermann P,Manz B,HallerO, SchwemmleM, Kochs G. 2011. The viral nucleoprotein determines Mx sensitivity of influenza A viruses. J. Virol. 85:8133-40
    • (2011) J. Virol. , vol.85 , pp. 8133-8140
    • Zimmermann, P.1    Manz, B.2    Haller, O.3    Schwemmle, M.4    Kochs, G.5
  • 110
    • 84875985517 scopus 로고    scopus 로고
    • Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein
    • Manz B, Dornfeld D, Gotz V, Zell R, Zimmermann P, et al. 2013. Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein. PLOS Pathog. 9:e1003279
    • (2013) PLOS Pathog. , vol.9 , pp. e1003279
    • Manz, B.1    Dornfeld, D.2    Gotz, V.3    Zell, R.4    Zimmermann, P.5
  • 111
    • 0029813449 scopus 로고    scopus 로고
    • Human MxB protein, an interferon-α-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope
    • Melen K, Keskinen P, Ronni T, Sareneva T, Lounatmaa K, Julkunen I. 1996. Human MxB protein, an interferon-α-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope. J. Biol. Chem. 271:23478-86
    • (1996) J. Biol. Chem. , vol.271 , pp. 23478-23486
    • Melen, K.1    Keskinen, P.2    Ronni, T.3    Sareneva, T.4    Lounatmaa, K.5    Julkunen, I.6
  • 112
    • 2942676463 scopus 로고    scopus 로고
    • Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB
    • King MC, Raposo G, Lemmon MA. 2004. Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB. PNAS 101:8957-62
    • (2004) PNAS , vol.101 , pp. 8957-8962
    • King, M.C.1    Raposo, G.2    Lemmon, M.A.3
  • 113
    • 84886953102 scopus 로고    scopus 로고
    • HumanMX2 is an interferon-induced post-entry inhibitor of HIV-1 infection
    • Goujon C, Moncorge O, Bauby H, DoyleT,Ward CC, et al. 2013. HumanMX2 is an interferon-induced post-entry inhibitor of HIV-1 infection. Nature 502:559-62
    • (2013) Nature , vol.502 , pp. 559-562
    • Goujon, C.1    Moncorge, O.2    Bauby, H.3    Doyle, T.4    Ward, C.C.5
  • 114
    • 84886949134 scopus 로고    scopus 로고
    • MX2 is an interferon-induced inhibitor of HIV-1 infection
    • KaneM, Yadav SS, Bitzegeio J, Kutluay SB, Zang T, et al. 2013. MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature 502:563-66
    • (2013) Nature , vol.502 , pp. 563-566
    • Kane, M.1    Yadav, S.S.2    Bitzegeio, J.3    Kutluay, S.B.4    Zang, T.5
  • 115
    • 84885987626 scopus 로고    scopus 로고
    • The interferon-inducible MxB protein inhibits HIV-1 infection
    • Liu Z, Pan Q, Ding S, Qian J, Xu F, et al. 2013. The interferon-inducible MxB protein inhibits HIV-1 infection. Cell Host Microbe 14:398-410
    • (2013) Cell Host Microbe , vol.14 , pp. 398-410
    • Liu, Z.1    Pan, Q.2    Ding, S.3    Qian, J.4    Xu, F.5
  • 116
    • 84886046324 scopus 로고    scopus 로고
    • Dynamins are forever: MxB inhibits HIV-1
    • Haller O. 2013. Dynamins are forever: MxB inhibits HIV-1. Cell Host Microbe 14:371-73
    • (2013) Cell Host Microbe , vol.14 , pp. 371-373
    • Haller, O.1
  • 117
    • 77953028450 scopus 로고    scopus 로고
    • Structural basis of oligomerization in the stalk region of dynamin-like MxA
    • Gao S, von derMalsburgA, Paeschke S, Behlke J,HallerO, et al. 2010. Structural basis of oligomerization in the stalk region of dynamin-like MxA. Nature 465:502-6
    • (2010) Nature , vol.465 , pp. 502-506
    • Gao, S.1    Von Dermalsburg, A.2    Paeschke, S.3    Behlke, J.4    Haller, O.5
  • 118
    • 80755153638 scopus 로고    scopus 로고
    • Structure of myxovirus resistance protein A reveals intra-and intermolecular domain interactions required for the antiviral function
    • Gao S, von der Malsburg A, Dick A, Faelber K, Schroder GF, et al. 2011. Structure of myxovirus resistance protein A reveals intra-and intermolecular domain interactions required for the antiviral function. Immunity 35:514-25
    • (2011) Immunity , vol.35 , pp. 514-525
    • Gao, S.1    Von Der Malsburg, A.2    Dick, A.3    Faelber, K.4    Schroder, G.F.5
  • 119
    • 77956268333 scopus 로고    scopus 로고
    • Dynamin-likeMxA GTPase: Structural insights into oligomerization and implications for antiviral activity
    • HallerO,Gao S, von der MalsburgA,DaumkeO,Kochs G. 2010. Dynamin-likeMxA GTPase: structural insights into oligomerization and implications for antiviral activity. J. Biol. Chem. 285:28419-24
    • (2010) J. Biol. Chem. , vol.285 , pp. 28419-28424
    • Haller, O.1    Gao, S.2    Von Der Malsburg, A.3    Daumke, O.4    Kochs, G.5
  • 120
    • 79952054310 scopus 로고    scopus 로고
    • Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module
    • Daumke O, Gao S, von derMalsburg A, Haller O, Kochs G. 2010. Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module. Small GTPases 1:62-64
    • (2010) Small GTPases , vol.1 , pp. 62-64
    • Daumke, O.1    Gao, S.2    Von Dermalsburg, A.3    Haller, O.4    Kochs, G.5
  • 121
    • 80053352142 scopus 로고    scopus 로고
    • Crystal structure of nucleotide-free dynamin
    • Faelber K, Posor Y, Gao S, Held M, Roske Y, et al. 2011. Crystal structure of nucleotide-free dynamin. Nature 477:556-60
    • (2011) Nature , vol.477 , pp. 556-560
    • Faelber, K.1    Posor, Y.2    Gao, S.3    Held, M.4    Roske, Y.5
  • 122
    • 80053376521 scopus 로고    scopus 로고
    • The crystal structure of dynamin
    • Ford MG, Jenni S, Nunnari J. 2011. The crystal structure of dynamin. Nature 477:561-66
    • (2011) Nature , vol.477 , pp. 561-566
    • Ford, M.G.1    Jenni, S.2    Nunnari, J.3
  • 123
    • 84988884419 scopus 로고    scopus 로고
    • Membrane fission by dynamin: What we know and what we need to know
    • Antonny B, Burd C, De Camilli P, Chen E, Daumke O, et al. 2016. Membrane fission by dynamin: what we know and what we need to know. EMBO J. 35:2270-84
    • (2016) EMBO J. , vol.35 , pp. 2270-2284
    • Antonny, B.1    Burd, C.2    De Camilli, P.3    Chen, E.4    Daumke, O.5
  • 124
    • 84953211349 scopus 로고    scopus 로고
    • Evolutionary analyses suggest a function ofMxB immunity proteins beyond lentivirus restriction
    • Mitchell PS, Young JM, Emerman M, Malik HS. 2015. Evolutionary analyses suggest a function ofMxB immunity proteins beyond lentivirus restriction. PLOS Pathog. 11:e1005304
    • (2015) PLOS Pathog. , vol.11 , pp. e1005304
    • Mitchell, P.S.1    Young, J.M.2    Emerman, M.3    Malik, H.S.4
  • 125
    • 84890476408 scopus 로고    scopus 로고
    • Mx proteins: Antiviral gatekeepers that restrain the uninvited
    • Verhelst J, Hulpiau P, Saelens X. 2013. Mx proteins: antiviral gatekeepers that restrain the uninvited. Microbiol. Mol. Biol. Rev. 77:551-66
    • (2013) Microbiol. Mol. Biol. Rev. , vol.77 , pp. 551-566
    • Verhelst, J.1    Hulpiau, P.2    Saelens, X.3
  • 127
    • 84858235640 scopus 로고    scopus 로고
    • The role of host genetics in susceptibility to influenza: A systematic review
    • Horby P, Nguyen NY, Dunstan SJ, Baillie JK. 2012. The role of host genetics in susceptibility to influenza: a systematic review. PLOS ONE 7:e33180
    • (2012) PLOS ONE , vol.7 , pp. e33180
    • Horby, P.1    Nguyen, N.Y.2    Dunstan, S.J.3    Baillie, J.K.4
  • 128
    • 0029029528 scopus 로고
    • Enhanced virus resistance of transgenic mice expressing the human MxA protein
    • Pavlovic J, Arzet HA, Hefti HP, Frese M, Rost D, et al. 1995. Enhanced virus resistance of transgenic mice expressing the human MxA protein. J. Virol. 69:4506-10
    • (1995) J. Virol. , vol.69 , pp. 4506-4510
    • Pavlovic, J.1    Arzet, H.A.2    Hefti, H.P.3    Frese, M.4    Rost, D.5
  • 129
    • 85021854371 scopus 로고    scopus 로고
    • In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein
    • Deeg CM, Hassan E, Mutz P, Rheinemann L, Gotz V, et al. 2017. In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein. J. Exp. Med. 214:1239-48
    • (2017) J. Exp. Med. , vol.214 , pp. 1239-1248
    • Deeg, C.M.1    Hassan, E.2    Mutz, P.3    Rheinemann, L.4    Gotz, V.5
  • 130
  • 131
    • 0023696621 scopus 로고
    • Organization of the murine Mx gene and characterization of its interferon-and virus-inducible promoter
    • Hug H, Costas M, Staeheli P, Aebi M, Weissmann C. 1988. Organization of the murine Mx gene and characterization of its interferon-and virus-inducible promoter. Mol. Cell. Biol. 8:3065-79
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 3065-3079
    • Hug, H.1    Costas, M.2    Staeheli, P.3    Aebi, M.4    Weissmann, C.5
  • 133
    • 84978531772 scopus 로고    scopus 로고
    • Potential pitfalls of theMx1-Cre system: Implications for experimental modeling of normal and malignant hematopoiesis
    • Velasco-HernandezT, Sawen P, Bryder D, Cammenga J. 2016. Potential pitfalls of theMx1-Cre system: implications for experimental modeling of normal and malignant hematopoiesis. Stem Cell Rep. 7:11-18
    • (2016) Stem Cell Rep. , vol.7 , pp. 11-18
    • Velasco-Hernandez, T.1    Sawen, P.2    Bryder, D.3    Cammenga, J.4
  • 134
    • 0025267921 scopus 로고
    • The interferon-induced Mx-homologous protein in people with symptomatic HIV-1 infection
    • von Wussow P, Jakschies D, Block B, Tschechne B, Schedel I, et al. 1990. The interferon-induced Mx-homologous protein in people with symptomatic HIV-1 infection. AIDS 4:119-24
    • (1990) AIDS , vol.4 , pp. 119-124
    • Von Wussow, P.1    Jakschies, D.2    Block, B.3    Tschechne, B.4    Schedel, I.5
  • 136
    • 0028896631 scopus 로고
    • Expression of MxA protein in inflammatory dermatoses
    • Fah J, Pavlovic J, Burg G. 1995. Expression of MxA protein in inflammatory dermatoses. J. Histochem. Cytochem. 43:47-52
    • (1995) J. Histochem. Cytochem. , vol.43 , pp. 47-52
    • Fah, J.1    Pavlovic, J.2    Burg, G.3
  • 137
    • 0028274170 scopus 로고
    • MxA gene expression after live virus vaccination: A sensitive marker for endogenous type i interferon
    • Roers A,HochkeppelHK, HorisbergerMA, Hovanessian A, Haller O. 1994. MxA gene expression after live virus vaccination: a sensitive marker for endogenous type I interferon. J. Infect. Dis. 169:807-13
    • (1994) J. Infect. Dis. , vol.169 , pp. 807-813
    • Roers, A.1    Hochkeppel, H.K.2    Horisberger, M.A.3    Hovanessian, A.4    Haller, O.5
  • 138
    • 28944453446 scopus 로고    scopus 로고
    • Rapid and simple detection of IFN-neutralizing antibodies in chronic hepatitis C non-responsive to IFN-α
    • Jorns C, Holzinger D, Thimme R, Spangenberg HC, Weidmann M, et al. 2006. Rapid and simple detection of IFN-neutralizing antibodies in chronic hepatitis C non-responsive to IFN-α. J. Med. Virol. 78:74-82
    • (2006) J. Med. Virol. , vol.78 , pp. 74-82
    • Jorns, C.1    Holzinger, D.2    Thimme, R.3    Spangenberg, H.C.4    Weidmann, M.5
  • 139
    • 85047259099 scopus 로고    scopus 로고
    • MxBis an interferon-induced restriction factor of human herpesviruses
    • CrameriM,Bauer M, CaduffN,Walker R, Steiner F, et al. 2018.MxBis an interferon-induced restriction factor of human herpesviruses. Nat. Commun. 9:1980
    • (2018) Nat. Commun. , vol.9 , pp. 1980
    • Crameri, M.1    Bauer, M.2    Caduff, N.3    Walker, R.4    Steiner, F.5


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