Human MxB protein, an interferon-α-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope

Journal of Biological Chemistry

Volumn 271, Issue 38, 1996, Pages 23478-23486

  Melén, Krister ^a   Keskinen, Päivi ^a   Ronni, Tapani ^a   Sareneva, Timo ^a   Lounatmaa, Kari ^b   Julkunen, Ilkka ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; PROTEIN MXB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME LOCALIZATION; HETEROCHROMATIN; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN ISOLATION; SIGNAL TRANSDUCTION; VIRUS RESISTANCE;

AMINO ACID SEQUENCE; BIOLOGICAL TRANSPORT; CELL COMPARTMENTATION; CELLS, CULTURED; CYTOKINES; CYTOPLASM; DNA MUTATIONAL ANALYSIS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HETEROCHROMATIN; HUMANS; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MICROSCOPY, IMMUNOELECTRON; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN SORTING SIGNALS; PROTEINS; RECOMBINANT PROTEINS; SEQUENCE DELETION;

ANIMALIA;

EID: 0029813449     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.38.23478     Document Type: Article

References (49)

1. Bourne, H. R., Sanders, D. A., and McCormick, F. (1990) Nature 348, 125-132
2. Bourne, H. R., Sanders, D. A., and McCormick, F. (1991) Nature 349, 117-127
3. Rothman, J. H., Raymond, C. K., Gilbert, T., O'Hara, P. J., and Stevens, T. H. (1990) Cell 61, 1063-1074
4. Wilsbach, K., and Payne, G. S. (1993) EMBO J. 12, 3049-3059
5. Jones, B. A., and Fangman, W. L. (1992) Genes Dev. 6, 380-389
6. Xiangju, G., and Verma, D. P. S. (1996) EMBO J. 15, 696-704
7. van der Bliek, A. M., and Meyerowitz, E. M. (1991) Nature 351, 411-414
8. Obar, R. A., Collins, C. A., Hammarback, J. A., Shpetner, H. S., and Vallee, R. B. (1990) Nature 347, 256-261
9. Vallee, R. B., and Shpetner, H. S. (1993) Nature 365, 107-108
10. Hinshaw, J. E., and Schmid, S. L. (1995) Nature 374, 190-192
11. Takei, K., McPherson, P. S., Schmid, S. L., and DeCamilli, P. (1995) Nature 374, 186-190
12. Kelly, R. B. (1995) Nature 374, 116-117
13. Nakayama, M., Yazaki, K., Kusano, A., Nagata, K., Hanai, N., and Ishihama, A. (1993) J. Biol. Chem. 268, 15033-15038
14. Melén, K., Ronni, T., Broni, B., Krug, R. M., von Bonsdorff, C.-H., and Julkunen, I. (1992) J. Biol. Chem. 267, 25898-25907
15. Arnheiter, H., Frese, M., Kambadur, R., Meier, E., and Haller, O. (1996) Curr. Top. Microbiol. 206, 119-147
16. Nakayama, M., Nagata, K., Kato, A., and Ishihama, A. (1991) J. Biol. Chem. 266, 21404-21408
17. Horisberger, M. A. (1992) J. Virol. 66, 4705-4709
18. Pitossi, F., Blank, A., Schröder, A., Schwarz, A., Hussi, P., Schwemmle, M., Pavlovic, J., and Staeheli, P. (1993) J. Virol. 67, 6726-6732
19. Melén, K., Ronni, T., Lotta, T., and Julkunen, I. (1994) J. Biol. Chem. 269, 2009-2015
20. Richter, M. F., Schwemmle, M., Herrmann, C., Wittinghofer, A., and Staeheli, P. (1995) J. Biol. Chem. 270, 13512-13517
21. Shpetner, H. S., and Vallee, R. B. (1992) Nature 355, 733-735
22. Melén, K., and Julkunen, I. (1994) Virology 205, 269-279
23. Aebi, M., Fäh, J., Hurt, N., Samuel, C. E., Thomis, D., Bazzigher, L., Pavlovic, J., Haller, O., and Staeheli, P. (1989) Mol. Cell. Biol. 9, 5062-5072
24. Ronni, T., Melén, K., Malygin, A., and Julkunen, I. (1993) J. Immunol. 150, 1715-1726
25. Ronni, T., Sareneva, T., Pirhonen, J., and Julkunen, I. (1995)J. Immunol. 154, 2764-2774
26. Summers, M. D., and Smith, G. E. (1986) Tex. Agric. Exp. Stn. Bull. 1555, 1-57
27. Schmaljohn, C. S., Hasty, S. E., Dalrymple, J. M., LeDuc, J. W., Lee, H. W., von Bonsdorff, C.-H., Brummer-Korvenkontio, M., Vaheri, A., Tsai, T. F., Regnery, H. L., Goldgaber, D., and Lee, P. W. (1985) Science 227, 1041-1044
28. Cantell, K., Hirvonen, S., Kauppinen, H.-L., and Myllylä, G. (1981) Methods Enzymol. 78, 29-38
29. Cantell, K., Hirvonen, S., and Kauppinen, H.-L. (1986) Methods Enzymol. 119, 54-63
30. Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., and Erlich, H. A. (1988) Science 239, 487-491
31. Matsuura, Y., Possee, R. D., Overton, H. A., and Bishop, D. H. L. (1987) J. Gen. Virol. 68, 1233-1250
32. Cullen, B. R. (1986) Cell 46, 973-982
33. Gunning, P., Leavitt, J., Muscat, G., Ng, S.-Y., and Kedes, L. (1987) Proc. Natl. Acad. Sci. 84, 4831-4835
34. Laemmli, U. K. (1970) Nature 227, 680-685
35. Harlow, E., and Lane, D. (1988) Antibodies: A Laboratory Manual 1st Ed., pp. 418-419, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
36. Newman, G. R. (1989) in Colloidal Gold: Principles, Methods, and Applications (Hayat, M. A., ed) Vol. 2, Academic Press, San Diego, CA
37. Pavlovic, J., Zürcher, T., Haller, O., and Staeheli, P. (1990) J. Virol. 64, 3370-3375
38. Jans, D. J. (1995) Biochemistry 311, 705-716
39. Warnock, D. E., Terlecky, L. J., and Schmid, S. L. (1995) EMBO J. 14, 1322-1328
40. Horisberger, M. A., McMaster, G. K., Zeller, H., Wathelet, M. G., Dellis, J., and Content, J. (1990) J. Virol. 64, 1171-1181
41. Sen, G. C., and Ransohoff, R. M. (1993) Adv. Virus Res. 42, 57-102
42. Kozak, M. (1987) Nucleic Acids Res. 15, 8125-8148
43. Noteborn, M., Arnheiter, H., Richter-Mann, L., Browning, H., and Weissmann, C. (1987) J. Interferon Res. 7, 657-669
44. Bazzigher, L., Schwarz, A., and Staeheli, P. (1993) Virology 195, 100-112
45. Landschulz, W. H., Johnson, P. F., and McKnight, S. L. (1988) Science 240, 1759-1764
46. Franza, B. R., Jr., Rauscher, F. J., III, Josephs, S. F., and Curran, T. (1988) Science 239, 1150-1153
47. Williamson, M. P. (1994) Biochem. J. 297, 249-260
48. Markby, D. W., Onrust, R., and Bourne, H. R. (1993) Science 262, 1895-1901
49. Schwemmle, M., Richter, M. F., Herrmann, C., Nassar, N., and Staeheli, P. (1995) J. Biol. Chem. 270, 13518-13523