Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice

Nature Biotechnology

Volumn 36, Issue 9, 2018, Pages 839-844

  Wang, Dan ^a   Li, Jia ^a   Song, Chun Qing ^a   Tran, Karen ^a   Mou, Haiwei ^a   Wu, Pei Hsuan ^a   Tai, Phillip W L ^a   Mendonca, Craig A ^a   Ren, Lingzhi ^a   Wang, Blake Y ^a   Su, Qin ^a   Gessler, Dominic J ^a   Zamore, Phillip D ^a   Xue, Wen ^a   Gao, Guangping ^a,b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DNA SEQUENCES; MAMMALS; NUCLEIC ACIDS;

DISEASE PHENOTYPES; DNA-TEMPLATE; GENETIC DISORDERS; GENETIC INFORMATION; MOUSE MODELS; VIRAL VECTORS;

GENES;

ADENO ASSOCIATED VIRUS VECTOR; CAS9 PROTIEN; GENOMIC DNA; GUIDE RNA; PROTEIN; UNCLASSIFIED DRUG;

ALLELE; AMPLICON; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA TEMPLATE; GENE EDITING; HEREDITARY TYROSINEMIA TYPE 1; HETEROZYGOTE; HURLER SYNDROME; IMMUNOHISTOCHEMISTRY; INTRON; LIVER CELL; MOUSE; MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECESSIVE GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; TYROSINEMIA; ANIMAL; DEPENDOPARVOVIRUS; GENE VECTOR; GENETICS;

ALLELES; ANIMALS; CRISPR-ASSOCIATED PROTEIN 9; DEPENDOVIRUS; GENE EDITING; GENES, RECESSIVE; GENETIC VECTORS; HETEROZYGOTE; MICE; MUTATION;

EID: 85053085538     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.4219     Document Type: Article

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