Uncovering the regional localization of inhaled salmeterol retention in the lung

Drug Delivery

Volumn 25, Issue 1, 2018, Pages 838-845

  Bäckström, Erica ^a   Hamm, Gregory ^b   Nilsson, Anna ^c   Fihn, Britt Marie ^a   Strittmatter, Nicole ^b   Andrén, Per ^c   Goodwin, Richard J A ^b   Fridén, Markus ^a,c  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Inhalation; Lung retention; Mass spectrometry imaging; Pharmacokinetics; Pulmonary distribution

Indexed keywords

SALMETEROL; 1,2-DIPALMITOYL-3-PHOSPHATIDYLETHANOLAMINE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; DEUTERIUM; DRUG VEHICLE; MACROGOL; MONOMETHOXYPOLYETHYLENE GLYCOL; PHOSPHATIDYLETHANOLAMINE; POLYSORBATE; SALMETEROL XINAFOATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHUS; BRONCHUS TISSUE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RETENTION; DRUG TISSUE LEVEL; IONIZATION; LUNG ALVEOLUS; LUNG EPITHELIUM; MALE; MASS SPECTROMETRY; NEBULIZATION; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTEMIC THERAPY; ANIMAL; CHEMISTRY; CLUSTER ANALYSIS; COMPARATIVE STUDY; CYTOLOGY; DIAGNOSTIC IMAGING; DRUG EFFECT; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG; METABOLISM; MOLECULAR IMAGING; RESPIRATORY FUNCTION; RESPIRATORY MUCOSA; TISSUE DISTRIBUTION; WISTAR RAT;

ADMINISTRATION, INHALATION; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; BRONCHI; BRONCHODILATOR AGENTS; CLUSTER ANALYSIS; DEUTERIUM; INJECTIONS, INTRAVENOUS; LUNG; MALE; MASS SPECTROMETRY; MOLECULAR IMAGING; PHARMACEUTICAL VEHICLES; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; POLYSORBATES; PULMONARY ALVEOLI; RATS, WISTAR; RESPIRATORY MUCOSA; RESPIRATORY TRACT ABSORPTION; SALMETEROL XINAFOATE; TISSUE DISTRIBUTION;

EID: 85052910292     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717544.2018.1455762     Document Type: Article

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