A novel in vivo receptor occupancy methodology for the glucocorticoid receptor: Toward an improved understanding of lung pharmacokinetic/pharmacodynamic relationships

Journal of Pharmacology and Experimental Therapeutics

Volumn 353, Issue 2, 2015, Pages 279-287

  Boger, Elin ^a,b   Ewing, Pär ^a   Eriksson, Ulf G ^a   Fihn, Britt Marie ^a   Chappell, Michael ^b   Evans, Neil ^b   Fridén, Markus ^a,c  

^a ASTRAZENECA R AND D   (Sweden)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FLUTICASONE PROPIONATE; GLUCOCORTICOID RECEPTOR; N (2 AMINO 2 OXO ETHYL) 3 [5 [2 (2,2 DIFLUOROPROPANOYLAMINO) 1 (2,3 DIHYDRO 1,4 BENZODIOXIN 6 YL)PROPOXY]INDAZO 1 YL] N METHYL BENZAMIDE; TRACER; UNCLASSIFIED DRUG; ANDROSTANE DERIVATIVE; FLUTICASONE; INDOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG TISSUE LEVEL; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RECEPTOR OCCUPANCY; TANDEM MASS SPECTROMETRY; ANIMAL; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; GENETIC PROCEDURES; INHALATIONAL DRUG ADMINISTRATION; LUNG; METABOLISM; SPLEEN; WISTAR RAT;

ADMINISTRATION, INHALATION; ANDROSTADIENES; ANIMALS; DRUG DISCOVERY; INDOLES; LUNG; MALE; MOLECULAR PROBE TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID; SPLEEN;

EID: 84929942141     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.221226     Document Type: Article

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