Impact of drug administration route on drug delivery and distribution into the lung: An imaging mass spectrometry approach

European Journal of Mass Spectrometry

Volumn 19, Issue 6, 2013, Pages 475-482

  Zecchi, Riccardo ^a   Trevisani, Marcello ^b   Pittelli, Maria ^b   Pedretti, Pamela ^b   Manni, Maria Elena ^b   Pieraccini, Giuseppe ^a   Pioselli, Barbara ^b   Amadei, Francesco ^b   Moneti, Gloriano ^a   Catinellac, Silvia ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b CHIESI FARMACEUTICI S P A   (Italy)

Author keywords

COPD; Intratracheal administration; MALDI IMS; Nebulized aerosol; Tiotropium

Indexed keywords

AEROSOLS; BIOLOGICAL ORGANS; DESORPTION; DIAGNOSIS; DRUG PRODUCTS; MAMMALS; PULMONARY DISEASES; SECONDARY ION MASS SPECTROMETRY; TARGETED DRUG DELIVERY;

CHRONIC OBSTRUCTIVE PULMONARY DISEASE; COPD; INTRATRACHEAL; INTRATRACHEAL INSTILLATION; MALDI-IMS; MATRIX ASSISTED LASER DESORPTION/IONIZATION; TECHNOLOGICAL IMPROVEMENTS; TIOTROPIUM;

CONTROLLED DRUG DELIVERY;

AEROSOL; CHOLINERGIC RECEPTOR BLOCKING AGENT; SCOPOLAMINE DERIVATIVE; TIOTROPIUM BROMIDE;

AEROSOL; ANIMAL; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG DEVELOPMENT; GUINEA PIG; INHALATIONAL DRUG ADMINISTRATION; LUNG; MALE; MASS SPECTROMETRY; METABOLISM; NEBULIZER; PROCEDURES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; TISSUE DISTRIBUTION; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; METHODOLOGY;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; CHOLINERGIC ANTAGONISTS; DRUG ADMINISTRATION ROUTES; DRUG DELIVERY SYSTEMS; DRUG DISCOVERY; GUINEA PIGS; LUNG; MALE; NEBULIZERS AND VAPORIZERS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SCOPOLAMINE DERIVATIVES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TISSUE DISTRIBUTION;

EID: 84893086135     PISSN: None     EISSN: 17516838     Source Type: Journal    
DOI: 10.1255/ejms.1254     Document Type: Article

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