Effect of a free radical scavenger, edaravone, on free radical reactions: Related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model

Acta Neurochirurgica, Supplementum

Volumn 110, Issue , 2011, Pages 17-22

  Munakata, Akira ^a   Ohkuma, Hiroki ^a   Shimamura, Norihito ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

Free radical scavenger; Free radicals; SAH; Vasospasm

Indexed keywords

FREE RADICAL; NORPHENAZONE; OXYHEMOGLOBIN; RHO KINASE; SCAVENGER;

ANIMAL TISSUE; BASILAR ARTERY; BLOOD VESSEL DIAMETER; BLOOD VESSEL WALL; BRAIN VASOSPASM; CONFERENCE PAPER; CONTROLLED STUDY; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; SUBARACHNOID HEMORRHAGE; WESTERN BLOTTING;

EID: 85052610101     PISSN: 00651419     EISSN: 00016268     Source Type: Book Series    
DOI: 10.1007/978-3-7091-0356-2_4     Document Type: Conference Paper

References (52)

1. Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T, et al. Phosphorylation and activation of myosin by Rho associated kinase (Rho-kinase). J Biol Chem. 1996;271:20246-9
2. Arai T, Takeyama N, Tanaka T. Glutathione monoethyl ester and inhibition of the oxyhemoglobin-induced increase in cytosolic calcium in cultured smooth muscle cells. J Neurosurg. 1999;90:527-32
3. Asano T, Sasaki T, Koide T, Takakura K, Sano K. Experimental evaluation of the beneficial effect of an antioxidant on cerebral vasospasm. Neurol Res. 1984;6:49-53
4. Baker KF, Zervas NT, Pile-Spellman J, Vacanti FX, Miller D. Angiographic evidence of basilar artery constriction in the rabbit: A new model of vasospasm. Surg Neurol. 1987;27:107-12
5. Barber AA, Bernheim F. Lipid peroxidation: Its measurement, occurrence, and significance in animal tissues. Adv Geront Res. 1976;2:355-403
6. Betuing S, Daviaud D, Pages C, Bonnard E, Valet P, Lafontan M, et al. Gbg-independent coupling of a2-adrenergic receptor to p21rhoA in preadipocytes. J Biol Chem. 1998;273:28700-7
7. Carrell RW, Winterbourn CC, Rachmilewitz EA. Activated oxgen and haemolysis. J Lipid Res. 1977;18:635-44
8. Chrissobolis S, Sobey CG. Recent evidence for an involvement of rho-kinase in cerebral vascular disease. Stroke 2006;37:2174-80
9. Echlin F. Experimental vasospasm, acute and chronic, due to blood in the subarachnoid space. J Neurosurg. 1971;35:646-56
10. Gutteridge JMC. Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides. FEBS Lett. 1986;201:291-5
11. Handa Y, Kaneko M, Takeuchi H, Tsuchida A, Kobayashi H, Kubota T. Effect of an antioxidant, ebselen, on development of chronic cerebral vasospasm after subarachnoid hemorrhage in primates. Surg Neurol. 2000;53:323-9
12. Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, et al. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Ga13. Science 1998;280:2112-4
13. HigashiM, Shimokawa H, Hattori T, Hiroki J, Mukai Y,Morikawa K, et al. Long-Term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: Effect on endothelial NAD(P)H oxidase system. Circ Res. 2003;93:767-75
14. Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, et al. The small GTP-Binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J. 1996;15:1885-93
15. Kassell NF, Sasaki T, Colohan AR, Nazar G. Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke 1985;16: 562-72
16. Katoh H, Aoki J, Yamaguchi Y, Kitano Y, Ichikawa A, Negishi M. Constitutively active Ga12, Ga13 and Gaq induce Rho-dependent neurite retraction through different signaling pathways. J Biol Chem. 1998;273:28700-7
17. Kellogg EW, III, Fridovich I. Liposome oxidation and erythrocyte lysis by enzymatically generated superoxide and hydrogen peroxide. J Biol Chem. 1977;252:6721-8
18. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, et al. Regulation of myosin phosphatase by Rho and Rhoassociated kinase (Rho-kinase). Science 1996;12:245-8
19. Kozasa T, Jiang X, Hart MJ, Stermweis PM, Singer WD, Gilman AG, et al. p115 RhoGEF, a GTPase activating protein for Ga12 and Ga13. Science 1998;280:2109-11
20. Laher I, Zhang JH. Protein kinase C and cerebral vasospasm. J Cereb Blood Flow Metab. 2001;21:887-906
21. Leung T, Manser E, Tan L, Lim L. A novel serine threonine kinase binding the Ras-related RhoA GTPase which translocate the kinase to peripheral membranes. J Biol Chem. 1995;270:29051-4
22. Macdonald RL, Weir BK. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke 1991;22:971-82
23. Macdonald RL, Weir BK. Cerebral vasospasm and free radicals. Free Radic Biol Med. 1994;16:633-43
24. Macdonald RL, Weir BK, Young JD, Grace MG. Cytoskeletal and extracellular matrix proteins in cerebral arteries following subarachnoid hemorrhage in monkeys. J Neurosurg. 1992;76:81-90
25. Matsui T, Asano T. Effects of new 21-Aminosteroid tirilazad mesylate (U74006F) on chronic cerebral vasospasm in a twohemorrhage'' model of beagle dogs. Neurosurgery. 1994;34: 1035-9
26. Matsui T, Amano M, Yamamoto T, Chihara K, Nakafuku M, Ito M, et al. Rho-Associated kinase, a novel serine/threonine kinase, as a putative target for the small GTP binding protein Rho. EMBO J. 1996;15:2208-16
27. Matsui T, Kaizu H, Itoh S, Asano T. The role of active smoothmuscle contraction in the occurrence of chronic vasospasm in the canine two-hemorrhage model. J Neurosurg. 1994;80:276-82
28. Matsui T, Sugawa M, Johshita H, Takuwa Y, Asano T. Activation of the protein kinase C-mediated contractile system in canine basilar artery undergoing chronic vasospasm. Stroke 1991;22:1183-7
29. Matsui T, Takuwa Y, Johshita H, Yamashita K, Asano T. Possible role of protein kinase C-dependent smooth muscle contraction in the pathogenesis of chronic cerebral vasospasm. J Cereb Blood Flow Metab. 1991;11:143-9
30. Matthew JM, Gustavo P, Federico GL, Quoc-Anh T, Pablo FR, Rafael JT, et al. Systemic administration of simvastatin after the onset of experimental subarachnoid hemorrhage attenuates cerebral vasospasm. Neurosurgery 2006;58:945-51
31. Megyesi JF, Vollrath B, Cook DA, Findlay JM. In vivo animal models of cerebral vasospasm: A review. Neurosurgery 2000;46: 448-60
32. Misra HP, Fridovich I. The generation of superoxide radical during the autoxidation of hemoglobin. J Biol Chem. 1972;247:6960-2
33. Nakajima T, Sasakuri Y, Yamashita M, Yamashita S. Morphological study on lipid peroxides in the atheromatous plaque in human. Kasankashishitu Kenkyu. 1991;5:13-7
34. Sako M, Nishihara J, Ohta S, Wang J, Sakaki S. Role of protein kinase C in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 1993;13:247-54
35. Sasaki S, Kuwabara H, Ohta S. Biological defence mechanism in the pathogenesis of prolonged cerebral vasospasm in the patients with ruptured intracranial aneurysms. Stroke 1986;17:196-202
36. Sasaki S, Ohta S, Nakamura H. Free radical reaction and biological defence mechanism in the pathogenesis of prolonged vasospasm in experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 1988;8:1-8
37. Sato M, Tani E, Fujikawa H, Kaibuchi K. Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res. 2000;87:195-200
38. Scherer EQ, Herzog M, Wangemann P. Endothelin-1-induced vasospasms of spiral modiolar artery are mediated by rho-kinaseinduced Ca(2) sensitization of contractile apparatus and reversed by calcitonin gene-related Peptide. Stroke 2000;33:2965-71
39. Seasholtz TM, Majumdar M, Brown JH. Rho as a mediation of G protein-coupled receptor signaling. Mol Pharmacol. 1999;55: 949-56
40. Steele JA, Stockbridge N, Maljkovic G. Free radicals mediate actions of oxyhemoglobin on cerebrovascular smooth muscle cells. Circ Res. 1991;68:416-23
41. Takuwa Y, Matsui T, Abe Y, Nagafuji T, Yamashita K, Asano T. Alterations in protein kinase C activity and membrane lipid metabolism in cerebral vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 1993;13:409-15
42. The Edaravone Acute Brain Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction: Randomized, placebo-controlled, double-Blind study at multicenters. Cerebrovasc Dis. 2003;15:222-9
43. Toshima Y, Satoh S, Ikegaki I, Asano T. A new model of cerebral microthrombosis in rats and the neuroprotective effect of a Rhokinase inhibitor. Stroke 2000;31:2245-50
44. Tsurutani H, Ohkuma H, Suzuki S. Effects of thrombin inhibitor on thrombin-related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model. Stroke 2003;34:1497-500
45. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, et al. (1997) Calcium sensitization of smooth muscle mediated by a Rho-Associated protein kinase in hypertension. Nature 1997;30: 990-994
46. Vollmer DG, Hongo K, Ogawa H. A study of the effectiveness of the iron-chelating agent deferoxamine as vasospasm prophylaxis in a rabbit model of subarachnoid hemorrhage. Neurosurgery 1991; 28:27-32
47. Vollrath B, Cook D, Megyesi J, Findlay JM, Ohkuma H. Novel mechanism by which hemoglobin induces constriction of cerebral arteries. Eur J Pharmacol. 1998;361:311-9
48. Wickman G, Lan C, Vollrath B. Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: Relevance to subarachnoid hemorrhage and vasospasm. Circ Res. 2003;92: 809-16
49. Winterbourn CC, McGrath BM, Carrell RW. Reactions involving superoxide and normal and unstable haemoglobins. Biochem J. 1976;155:493-502
50. Zhang JH. Role of protein kinase C in cerebral vasospasm: Past and future. Neurol Res. 2000;22:369-78
51. Zhang N, Komine-Kobayashi M, Tanaka R, Liu M, Mizuno Y, Urabe T. Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Stroke 2005;36:2220-5
52. Zuccarello M, Marsch JT, Schmitt G, Woodward J, Anderson DK. Effect of the 21-Aminosteroid U-74006F on cerebral vasospasm following subarachnoid hemorrhage. J Neurosurg. 1989;71: 98-104