Mitochondrial double-stranded RNA triggers antiviral signalling in humans

Nature

Volumn 560, Issue 7717, 2018, Pages 238-242

  Dhir, Ashish ^a   Dhir, Somdutta ^a   Borowski, Lukasz S ^b,c   Jimenez, Laura ^d   Teitell, Michael ^d   Rötig, Agnès ^e   Crow, Yanick J ^e,f,g   Rice, Gillian I ^h   Duffy, Darragh ^i,j   Tamby, Christelle ^e   Nojima, Takayuki ^a   Munnich, Arnold ^e   Schiff, Manuel ^e   de Almeida, Claudia Ribeiro ^a   Rehwinkel, Jan ^k   Dziembowski, Andrzej ^b,c   Szczesny, Roman J ^b,c   Proudfoot, Nicholas J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^c UNIVERSITY OF WARSAW   (Poland)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e IMAGINE INSTITUTE   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

^g UNIVERSITY OF EDINBURGH   (United Kingdom)

^h UNIVERSITY OF MANCHESTER   (United Kingdom)

ⁱ INSTITUT PASTEUR   (France)

^j INSTITUT PASTEUR   (France)

^k UNIVERSITY OF OXFORD   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE; RNA HELICASE; DEAD BOX PROTEIN; DEGRADOSOME; EXORIBONUCLEASE; IFIH1 PROTEIN, HUMAN; INTERFERON; MULTIENZYME COMPLEX; PNPT1 PROTEIN, HUMAN; PROTEIN BAK; PROTEIN BAX; RIBONUCLEASE; SUPV3L1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; BIOACCUMULATION; CELL CULTURE; CONTROLLED STUDY; CYTOPLASM; FEMALE; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENE TARGETING; GENETIC TRANSFECTION; HELA CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; INTERCELLULAR SPACE; LETTER; MALE; MICROARRAY ANALYSIS; MITOCHONDRION; NONHUMAN; PNPT1 GENE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; HUMAN ALPHAHERPESVIRUS 1; IMMUNOLOGY; METABOLISM; MOUSE; MUTATION;

MAMMALIA; PROKARYOTA; VERTEBRATA;

ANIMALS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; DEAD-BOX RNA HELICASES; ENDORIBONUCLEASES; EXORIBONUCLEASES; GENE EXPRESSION REGULATION; HELA CELLS; HERPESVIRUS 1, HUMAN; HUMANS; INTERFERON TYPE I; INTERFERON-INDUCED HELICASE, IFIH1; MICE; MICE, INBRED C57BL; MULTIENZYME COMPLEXES; MUTATION; POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE; RNA HELICASES; RNA, DOUBLE-STRANDED; RNA, MITOCHONDRIAL; SINGLE-CELL ANALYSIS;

EID: 85051246722     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/s41586-018-0363-0     Document Type: Article

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