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Volumn 4, Issue , 2017, Pages

Flavonoids from Engineered Tomatoes Inhibit Gut Barrier Pro-inflammatory Cytokines and Chemokines, via SAPK/JNK and p38 MAPK Pathways

Author keywords

dendritic cell; diet; epithelial; flavonoid; inflammatory bowel disease

Indexed keywords


EID: 85049518853     PISSN: None     EISSN: 2296861X     Source Type: Journal    
DOI: 10.3389/fnut.2017.00061     Document Type: Article
Times cited : (24)

References (65)
  • 1
    • 84898857713 scopus 로고    scopus 로고
    • Multiple chronic conditions among US adults: a 2012 update
    • 24742395
    • Ward BW, Schiller JS, Goodman RA. Multiple chronic conditions among US adults: a 2012 update. Prev Chronic Dis (2014) 11:130389.10.5888/pcd11.13038924742395
    • (2014) Prev Chronic Dis , vol.11 , pp. 130389
    • Ward, B.W.1    Schiller, J.S.2    Goodman, R.A.3
  • 2
    • 84903830627 scopus 로고    scopus 로고
    • Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European prospective investigation into cancer and nutrition (EPIC)
    • 24920034
    • Bradbury KE, Appleby PN, Key TJ. Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European prospective investigation into cancer and nutrition (EPIC). Am J Clin Nutr (2014) 100:394S–8S.10.3945/ajcn.113.07135724920034
    • (2014) Am J Clin Nutr , vol.100 , pp. 394S-398
    • Bradbury, K.E.1    Appleby, P.N.2    Key, T.J.3
  • 3
    • 84891035918 scopus 로고    scopus 로고
    • Health-promoting components of fruits and vegetables in the diet
    • 23674808
    • Liu RH. Health-promoting components of fruits and vegetables in the diet. Adv Nutr (2013) 4:384S–92S.10.3945/an.112.00351723674808
    • (2013) Adv Nutr , vol.4 , pp. 384S-392
    • Liu, R.H.1
  • 4
    • 79959478455 scopus 로고    scopus 로고
    • Changes in diet and lifestyle and long-term weight gain in women and men
    • 21696306
    • Mozaffarian D, Hao T, Rimm EB, Willett WC, Hu FB. Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med (2011) 364:2392–404.10.1056/NEJMoa101429621696306
    • (2011) N Engl J Med , vol.364 , pp. 2392-2404
    • Mozaffarian, D.1    Hao, T.2    Rimm, E.B.3    Willett, W.C.4    Hu, F.B.5
  • 5
    • 84904967939 scopus 로고    scopus 로고
    • Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies
    • 25073782
    • Wang X, Ouyang Y, Liu J, Zhu M, Zhao G, Bao W, et al. Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. BMJ (2014) 349:g4490.10.1136/bmj.g449025073782
    • (2014) BMJ , vol.349 , pp. g4490
    • Wang, X.1    Ouyang, Y.2    Liu, J.3    Zhu, M.4    Zhao, G.5    Bao, W.6
  • 6
    • 84902657771 scopus 로고    scopus 로고
    • Diet, metabolites, and “western-lifestyle” inflammatory diseases
    • Thorburn AN, Macia L, Mackay CR. Diet, metabolites, and “western-lifestyle” inflammatory diseases. Immunity (2014) 40:833–42.10.1016/j.immuni.2014.05.014
    • (2014) Immunity , vol.40 , pp. 833-842
    • Thorburn, A.N.1    Macia, L.2    Mackay, C.R.3
  • 7
    • 79251523895 scopus 로고    scopus 로고
    • The protective effect of the Mediterranean diet: focus on cancer and cardiovascular risk
    • 21252562
    • Pauwels EKJ. The protective effect of the Mediterranean diet: focus on cancer and cardiovascular risk. Med Princ Pract (2011) 20:103–11.10.1159/00032119721252562
    • (2011) Med Princ Pract , vol.20 , pp. 103-111
    • Pauwels, E.K.J.1
  • 8
    • 84878990778 scopus 로고    scopus 로고
    • Flavonoids and asthma
    • Tanaka T, Takahashi R. Flavonoids and asthma. Nutrients (2013) 5:2128–43.10.3390/nu5062128
    • (2013) Nutrients , vol.5 , pp. 2128-2143
    • Tanaka, T.1    Takahashi, R.2
  • 9
    • 84905860693 scopus 로고    scopus 로고
    • Intestinal antigen-presenting cells in mucosal immune homeostasis: crosstalk between dendritic cells, macrophages and B-cells
    • 25110405
    • Mann ER, Li X. Intestinal antigen-presenting cells in mucosal immune homeostasis: crosstalk between dendritic cells, macrophages and B-cells. World J Gastroenterol (2014) 20:9653–64.10.3748/wjg.v20.i29.965325110405
    • (2014) World J Gastroenterol , vol.20 , pp. 9653-9664
    • Mann, E.R.1    Li, X.2
  • 11
    • 83755219473 scopus 로고    scopus 로고
    • Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review
    • 22001864
    • Molodecky NA, Soon IS, Rabi DM, Ghali WA, Ferris M, Chernoff G, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology (2012) 142:46–54.e42.10.1053/j.gastro.2011.10.00122001864
    • (2012) Gastroenterology , vol.142 , pp. 46-54.e42
    • Molodecky, N.A.1    Soon, I.S.2    Rabi, D.M.3    Ghali, W.A.4    Ferris, M.5    Chernoff, G.6
  • 13
    • 40149093576 scopus 로고    scopus 로고
    • Review article: evolving concepts in treatment and disease modification in ulcerative colitis
    • 18307645
    • Hanauer SB. Review article: evolving concepts in treatment and disease modification in ulcerative colitis. Aliment Pharmacol Ther (2008) 27:15–21.10.1111/j.1365-2036.2008.03606.x18307645
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 15-21
    • Hanauer, S.B.1
  • 14
    • 84931055131 scopus 로고    scopus 로고
    • A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases
    • 25986932
    • Martin DA, Bolling BW. A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases. Food Funct (2015) 6:1773–86.10.1039/C5FO00202H25986932
    • (2015) Food Funct , vol.6 , pp. 1773-1786
    • Martin, D.A.1    Bolling, B.W.2
  • 15
    • 84968690711 scopus 로고    scopus 로고
    • Bilberry-derived anthocyanins modulate cytokine expression in the intestine of patients with ulcerative colitis
    • 27152519
    • Roth S, Spalinger MR, Gottier C, Biedermann L, Zeitz J, Lang S, et al. Bilberry-derived anthocyanins modulate cytokine expression in the intestine of patients with ulcerative colitis. PLoS One (2016) 11:e0154817.10.1371/journal.pone.015481727152519
    • (2016) PLoS One , vol.11 , pp. e0154817
    • Roth, S.1    Spalinger, M.R.2    Gottier, C.3    Biedermann, L.4    Zeitz, J.5    Lang, S.6
  • 16
    • 84900814151 scopus 로고    scopus 로고
    • Pleiotropic beneficial effects of epigallocatechin gallate, quercetin and delphinidin on cardiovascular diseases associated with endothelial dysfunction
    • 24617305
    • Dayoub O, Andriantsitohaina R, Clere N. Pleiotropic beneficial effects of epigallocatechin gallate, quercetin and delphinidin on cardiovascular diseases associated with endothelial dysfunction. Cardiovasc Hematol Agents Med Chem (2013) 11:249–64.10.2174/187152571266614030923304824617305
    • (2013) Cardiovasc Hematol Agents Med Chem , vol.11 , pp. 249-264
    • Dayoub, O.1    Andriantsitohaina, R.2    Clere, N.3
  • 18
    • 29544451767 scopus 로고    scopus 로고
    • Characterization of colonic dendritic cells in normal and colitic mice
    • 16419163
    • Cruickshank SM, English NR, Felsburg PJ, Carding SR. Characterization of colonic dendritic cells in normal and colitic mice. World J Gastroenterol (2005) 11:6338–47.10.3748/wjg.v11.i40.633816419163
    • (2005) World J Gastroenterol , vol.11 , pp. 6338-6347
    • Cruickshank, S.M.1    English, N.R.2    Felsburg, P.J.3    Carding, S.R.4
  • 19
    • 85010377857 scopus 로고    scopus 로고
    • Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease
    • 28126697
    • Kmieć Z, Cyman M, Ślebioda TJ. Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease. Adv Med Sci (2017) 62:1–16.10.1016/j.advms.2016.09.00128126697
    • (2017) Adv Med Sci , vol.62 , pp. 1-16
    • Kmieć, Z.1    Cyman, M.2    Ślebioda, T.J.3
  • 20
    • 84888121508 scopus 로고    scopus 로고
    • Mucosal healing and deep remission: what does it mean?
    • 24282345
    • Rogler G, Vavricka S, Schoepfer A, Lakatos PL. Mucosal healing and deep remission: what does it mean? World J Gastroenterol (2013) 19:7552.10.3748/wjg.v19.i43.755224282345
    • (2013) World J Gastroenterol , vol.19 , pp. 7552
    • Rogler, G.1    Vavricka, S.2    Schoepfer, A.3    Lakatos, P.L.4
  • 21
    • 67650474246 scopus 로고    scopus 로고
    • STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    • 19564350
    • Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med (2009) 206:1465–72.10.1084/jem.2008268319564350
    • (2009) J Exp Med , vol.206 , pp. 1465-1472
    • Pickert, G.1    Neufert, C.2    Leppkes, M.3    Zheng, Y.4    Wittkopf, N.5    Warntjen, M.6
  • 22
    • 40049097099 scopus 로고    scopus 로고
    • Epithelial restitution and wound healing in inflammatory bowel disease
    • 18200658
    • Sturm A, Dignass AU. Epithelial restitution and wound healing in inflammatory bowel disease. World J Gastroenterol (2008) 14:348–53.10.3748/wjg.14.34818200658
    • (2008) World J Gastroenterol , vol.14 , pp. 348-353
    • Sturm, A.1    Dignass, A.U.2
  • 23
    • 84945293865 scopus 로고    scopus 로고
    • Multi-level engineering facilitates the production of phenylpropanoid compounds in tomato
    • 26497596
    • Zhang Y, Butelli E, Alseekh S, Tohge T, Rallapalli G, Luo J, et al. Multi-level engineering facilitates the production of phenylpropanoid compounds in tomato. Nat Commun (2015) 6:8635.10.1038/ncomms963526497596
    • (2015) Nat Commun , vol.6 , pp. 8635
    • Zhang, Y.1    Butelli, E.2    Alseekh, S.3    Tohge, T.4    Rallapalli, G.5    Luo, J.6
  • 24
    • 0032504122 scopus 로고    scopus 로고
    • Mechanisms of intestinal epithelial cell injury and colitis in interleukin 2 (IL2)-deficient mice
    • 9682004
    • Baumgart DC, Olivier W-A, Reya T, Peritt D, Rombeau JL, Carding SR. Mechanisms of intestinal epithelial cell injury and colitis in interleukin 2 (IL2)-deficient mice. Cell Immunol (1998) 187:52–66.10.1006/cimm.1998.13079682004
    • (1998) Cell Immunol , vol.187 , pp. 52-66
    • Baumgart, D.C.1    Olivier, W.-A.2    Reya, T.3    Peritt, D.4    Rombeau, J.L.5    Carding, S.R.6
  • 25
    • 0037220898 scopus 로고    scopus 로고
    • Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn’s disease
    • Banks C, Bateman A, Payne R, Johnson P, Sheron N. Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn’s disease. J Pathol (2003) 199:28–35.10.1002/path.1245
    • (2003) J Pathol , vol.199 , pp. 28-35
    • Banks, C.1    Bateman, A.2    Payne, R.3    Johnson, P.4    Sheron, N.5
  • 27
    • 66149137296 scopus 로고    scopus 로고
    • Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis
    • 18942757
    • Alex P, Zachos NC, Nguyen T, Gonzales L, Chen T-E, Conklin LS, et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis (2009) 15:341–52.10.1002/ibd.2075318942757
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 341-352
    • Alex, P.1    Zachos, N.C.2    Nguyen, T.3    Gonzales, L.4    Chen, T.-E.5    Conklin, L.S.6
  • 28
    • 34247346920 scopus 로고    scopus 로고
    • Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis
    • 17088072
    • Melgar S, Drmotova M, Rehnström E, Jansson L, Michaëlsson E. Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis. Cytokine (2006) 35:275–83.10.1016/j.cyto.2006.09.00717088072
    • (2006) Cytokine , vol.35 , pp. 275-283
    • Melgar, S.1    Drmotova, M.2    Rehnström, E.3    Jansson, L.4    Michaëlsson, E.5
  • 29
    • 22644431611 scopus 로고    scopus 로고
    • Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model
    • 16009684
    • Pender SL-F, Chance V, Whiting CV, Buckley M, Edwards M, Pettipher R, et al. Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model. Gut (2005) 54:1114–20.10.1136/gut.2004.05277916009684
    • (2005) Gut , vol.54 , pp. 1114-1120
    • Pender, S.L.-F.1    Chance, V.2    Whiting, C.V.3    Buckley, M.4    Edwards, M.5    Pettipher, R.6
  • 31
    • 33645956193 scopus 로고    scopus 로고
    • Evaluation of intranuclear BrdU detection procedures for use in multicolor flow cytometry
    • 16538653
    • Rothaeusler K, Baumgarth N. Evaluation of intranuclear BrdU detection procedures for use in multicolor flow cytometry. Cytometry A (2006) 69A:249–59.10.1002/cyto.a.2025216538653
    • (2006) Cytometry A , vol.69A , pp. 249-259
    • Rothaeusler, K.1    Baumgarth, N.2
  • 32
    • 55749105106 scopus 로고    scopus 로고
    • Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors
    • 18953354
    • Butelli E, Titta L, Giorgio M, Mock H-P, Matros A, Peterek S, et al. Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nat Biotechnol (2008) 26:1301–8.10.1038/nbt.150618953354
    • (2008) Nat Biotechnol , vol.26 , pp. 1301-1308
    • Butelli, E.1    Titta, L.2    Giorgio, M.3    Mock, H.-P.4    Matros, A.5    Peterek, S.6
  • 33
    • 9444228220 scopus 로고    scopus 로고
    • Inhibition of p38 MAP kinase- and RICK/NF- B-signaling suppresses inflammatory bowel disease
    • Hollenbach E. Inhibition of p38 MAP kinase- and RICK/NF- B-signaling suppresses inflammatory bowel disease. FASEB J (2004) 18:1550–2.10.1096/fj.04-1642fje
    • (2004) FASEB J , vol.18 , pp. 1550-1552
    • Hollenbach, E.1
  • 34
    • 33644961069 scopus 로고    scopus 로고
    • Pro-inflammatory signaling by Jun-N-terminal kinase in inflammatory bowel disease
    • 16465391
    • Mitsuyama K, Suzuki A, Tomiyasu N, Tsuruta O, Kitazaki S, Takeda T, et al. Pro-inflammatory signaling by Jun-N-terminal kinase in inflammatory bowel disease. Int J Mol Med (2006) 17:449–55.10.3892/ijmm.17.3.44916465391
    • (2006) Int J Mol Med , vol.17 , pp. 449-455
    • Mitsuyama, K.1    Suzuki, A.2    Tomiyasu, N.3    Tsuruta, O.4    Kitazaki, S.5    Takeda, T.6
  • 35
    • 0035910753 scopus 로고    scopus 로고
    • CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
    • 11181699
    • Suzuki A, Hanada T, Mitsuyama K, Yoshida T, Kamizono S, Hoshino T, et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 193:471–81.10.1084/jem.193.4.47111181699
    • (2001) J Exp Med , vol.193 , pp. 471-481
    • Suzuki, A.1    Hanada, T.2    Mitsuyama, K.3    Yoshida, T.4    Kamizono, S.5    Hoshino, T.6
  • 36
    • 79959837093 scopus 로고    scopus 로고
    • How can research on plants contribute to promoting human health?
    • 21586682
    • Martin C, Butelli E, Petroni K, Tonelli C. How can research on plants contribute to promoting human health? Plant Cell (2011) 23:1685–99.10.1105/tpc.111.08327921586682
    • (2011) Plant Cell , vol.23 , pp. 1685-1699
    • Martin, C.1    Butelli, E.2    Petroni, K.3    Tonelli, C.4
  • 37
    • 0030870251 scopus 로고    scopus 로고
    • Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells
    • 9322516
    • Yang SK, Eckmann L, Panja A, Kagnoff MF. Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells. Gastroenterology (1997) 113:1214–23.10.1053/gast.1997.v113.pm93225169322516
    • (1997) Gastroenterology , vol.113 , pp. 1214-1223
    • Yang, S.K.1    Eckmann, L.2    Panja, A.3    Kagnoff, M.F.4
  • 38
    • 38149055699 scopus 로고    scopus 로고
    • Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers
    • 18021752
    • Kobayashi S, Tanabe S, Sugiyama M, Konishi Y. Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers. Biochim Biophys Acta (2008) 1778:33–41.10.1016/j.bbamem.2007.08.02018021752
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 33-41
    • Kobayashi, S.1    Tanabe, S.2    Sugiyama, M.3    Konishi, Y.4
  • 39
    • 47849094565 scopus 로고    scopus 로고
    • Absorption of black currant anthocyanins by monolayers of human intestinal epithelial Caco-2 cells mounted in ussing type chambers
    • 18540609
    • Steinert RE, Ditscheid B, Netzel M, Jahreis G. Absorption of black currant anthocyanins by monolayers of human intestinal epithelial Caco-2 cells mounted in ussing type chambers. J Agric Food Chem (2008) 56:4995–5001.10.1021/jf703670h18540609
    • (2008) J Agric Food Chem , vol.56 , pp. 4995-5001
    • Steinert, R.E.1    Ditscheid, B.2    Netzel, M.3    Jahreis, G.4
  • 40
    • 42549162065 scopus 로고    scopus 로고
    • Estimation of daily human intake of food flavonoids
    • 17852474
    • Mullie P, Clarys P, Deriemaeker P, Hebbelinck M. Estimation of daily human intake of food flavonoids. Int J Food Sci Nutr (2008) 59:291–8.10.1080/0968763070153929317852474
    • (2008) Int J Food Sci Nutr , vol.59 , pp. 291-298
    • Mullie, P.1    Clarys, P.2    Deriemaeker, P.3    Hebbelinck, M.4
  • 42
    • 0033863355 scopus 로고    scopus 로고
    • Dietary intake and bioavailability of polyphenols
    • 10917926
    • Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr (2000) 130:2073S–85S.10917926
    • (2000) J Nutr , vol.130 , pp. 2073S-2085
    • Scalbert, A.1    Williamson, G.2
  • 43
    • 24044511500 scopus 로고    scopus 로고
    • Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease
    • 16132362
    • Kim H, Kong H, Choi B, Yang Y, Kim Y, Lim MJ, et al. Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease. Pharm Res (2005) 22:1499–509.10.1007/s11095-005-6250-z16132362
    • (2005) Pharm Res , vol.22 , pp. 1499-1509
    • Kim, H.1    Kong, H.2    Choi, B.3    Yang, Y.4    Kim, Y.5    Lim, M.J.6
  • 45
    • 84939478859 scopus 로고    scopus 로고
    • Regulatory immune cells in regulation of intestinal inflammatory response to microbiota
    • Sun M, He C, Cong Y, Liu Z. Regulatory immune cells in regulation of intestinal inflammatory response to microbiota. Mucosal Immunol (2015) 8:969.10.1038/mi.2015.49
    • (2015) Mucosal Immunol , vol.8 , pp. 969
    • Sun, M.1    He, C.2    Cong, Y.3    Liu, Z.4
  • 46
    • 84975733133 scopus 로고    scopus 로고
    • TNF-α modulation by natural bioactive molecules in mouse RAW 264.7 macrophage cells
    • 26457790
    • Nayak BN, Kaur G, Buttar HS. TNF-α modulation by natural bioactive molecules in mouse RAW 264.7 macrophage cells. J Complement Integr Med (2016) 13:1–7.10.1515/jcim-2015-002426457790
    • (2016) J Complement Integr Med , vol.13 , pp. 1-7
    • Nayak, B.N.1    Kaur, G.2    Buttar, H.S.3
  • 47
    • 84900525909 scopus 로고    scopus 로고
    • Quercetin suppresses MIP-1α-induced adipose inflammation by downregulating its receptors CCR1/CCR5 and inhibiting inflammatory signaling
    • 24325454
    • Noh H-J, Kim C-S, Kang J-H, Park J-Y, Choe S-Y, Hong S-M, et al. Quercetin suppresses MIP-1α-induced adipose inflammation by downregulating its receptors CCR1/CCR5 and inhibiting inflammatory signaling. J Med Food (2014) 17:550–7.10.1089/jmf.2013.291224325454
    • (2014) J Med Food , vol.17 , pp. 550-557
    • Noh, H.-J.1    Kim, C.-S.2    Kang, J.-H.3    Park, J.-Y.4    Choe, S.-Y.5    Hong, S.-M.6
  • 48
    • 84878634805 scopus 로고    scopus 로고
    • Flavonoid naringenin: a potential immunomodulator for Chlamydia trachomatis inflammation
    • 23766556
    • Yilma AN, Singh SR, Morici L, Dennis VA. Flavonoid naringenin: a potential immunomodulator for Chlamydia trachomatis inflammation. Mediators Inflamm (2013) 2013:102457.10.1155/2013/10245723766556
    • (2013) Mediators Inflamm , vol.2013 , pp. 102457
    • Yilma, A.N.1    Singh, S.R.2    Morici, L.3    Dennis, V.A.4
  • 49
    • 84958527429 scopus 로고    scopus 로고
    • Control of intestinal inflammation by interleukin-10
    • 25004812
    • Kole A, Maloy KJ. Control of intestinal inflammation by interleukin-10. Curr Top Microbiol Immunol (2014) 380:19–38.10.1007/978-3-662-43492-5_225004812
    • (2014) Curr Top Microbiol Immunol , vol.380 , pp. 19-38
    • Kole, A.1    Maloy, K.J.2
  • 50
    • 84883199752 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in innate immunity
    • 23954936
    • Arthur JSC, Ley SC. Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol (2013) 13:679–92.10.1038/nri349523954936
    • (2013) Nat Rev Immunol , vol.13 , pp. 679-692
    • Arthur, J.S.C.1    Ley, S.C.2
  • 51
    • 80053412980 scopus 로고    scopus 로고
    • The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease
    • 21955425
    • Feng YJ, Li YY. The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease. J Dig Dis (2011) 12:327–32.10.1111/j.1751-2980.2011.00525.x21955425
    • (2011) J Dig Dis , vol.12 , pp. 327-332
    • Feng, Y.J.1    Li, Y.Y.2
  • 52
    • 0038442102 scopus 로고    scopus 로고
    • TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism
    • 12702497
    • Yu Y, Zeng H, Lyons S, Carlson A, Merlin D, Neish AS, et al. TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. Am J Physiol (2003) 285:G282–90.10.1152/ajpgi.00503.200212702497
    • (2003) Am J Physiol , vol.285 , pp. G282-G290
    • Yu, Y.1    Zeng, H.2    Lyons, S.3    Carlson, A.4    Merlin, D.5    Neish, A.S.6
  • 53
    • 84906545516 scopus 로고    scopus 로고
    • HIV-1 Nef induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors
    • 24658403
    • Liu X, Shah A, Gangwani MR, Silverstein PS, Fu M, Kumar A. HIV-1 Nef induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors. Sci Rep (2014) 4:4450.10.1038/srep0445024658403
    • (2014) Sci Rep , vol.4 , pp. 4450
    • Liu, X.1    Shah, A.2    Gangwani, M.R.3    Silverstein, P.S.4    Fu, M.5    Kumar, A.6
  • 54
    • 0037394607 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells
    • 12667212
    • Parhar K, Ray A, Steinbrecher U, Nelson C, Salh B. The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells. Immunology (2003) 108:502–12.10.1046/j.1365-2567.2003.01603.x12667212
    • (2003) Immunology , vol.108 , pp. 502-512
    • Parhar, K.1    Ray, A.2    Steinbrecher, U.3    Nelson, C.4    Salh, B.5
  • 55
    • 39849098748 scopus 로고    scopus 로고
    • Role of the JNK signal transduction pathway in inflammatory bowel disease
    • 18186555
    • Roy PK, Rashid F, Bragg J, Ibdah JA. Role of the JNK signal transduction pathway in inflammatory bowel disease. World J Gastroenterol (2008) 14:200–2.10.3748/wjg.14.20018186555
    • (2008) World J Gastroenterol , vol.14 , pp. 200-202
    • Roy, P.K.1    Rashid, F.2    Bragg, J.3    Ibdah, J.A.4
  • 56
    • 33749525325 scopus 로고    scopus 로고
    • Differential pattern of inflammatory molecule regulation in intestinal epithelial cells stimulated with IL-1
    • 17015748
    • Yan SR, Joseph RR, Wang J, Stadnyk AW. Differential pattern of inflammatory molecule regulation in intestinal epithelial cells stimulated with IL-1. J Immunol (2006) 177:5604–11.10.4049/jimmunol.177.8.560417015748
    • (2006) J Immunol , vol.177 , pp. 5604-5611
    • Yan, S.R.1    Joseph, R.R.2    Wang, J.3    Stadnyk, A.W.4
  • 57
    • 33645828828 scopus 로고    scopus 로고
    • The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis
    • 16630028
    • Assi K, Pillai R, Gómez-Muñoz A, Owen D, Salh B. The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. Immunology (2006) 118:112–21.10.1111/j.1365-2567.2006.02349.x16630028
    • (2006) Immunology , vol.118 , pp. 112-121
    • Assi, K.1    Pillai, R.2    Gómez-Muñoz, A.3    Owen, D.4    Salh, B.5
  • 58
    • 70349562760 scopus 로고    scopus 로고
    • Dietary polyphenols can modulate the intestinal inflammatory response
    • 19566597
    • Romier B, Schneider Y-J, Larondelle Y, During A. Dietary polyphenols can modulate the intestinal inflammatory response. Nutr Rev (2009) 67:363–78.10.1111/j.1753-4887.2009.00210.x19566597
    • (2009) Nutr Rev , vol.67 , pp. 363-378
    • Romier, B.1    Schneider, Y.-J.2    Larondelle, Y.3    During, A.4
  • 59
    • 70449379193 scopus 로고    scopus 로고
    • Gnotobiotic IL-10−/−; NF-κBEGFP mice develop rapid and severe colitis following Campylobacter jejuni infection
    • Lippert E, Karrasch T, Sun X, Allard B, Herfarth HH, Threadgill D, et al. Gnotobiotic IL-10−/−; NF-κBEGFP mice develop rapid and severe colitis following Campylobacter jejuni infection. PLoS One (2009) 4:e7413.10.1371/journal.pone.0007413
    • (2009) PLoS One , vol.4 , pp. e7413
    • Lippert, E.1    Karrasch, T.2    Sun, X.3    Allard, B.4    Herfarth, H.H.5    Threadgill, D.6
  • 60
    • 34047173496 scopus 로고    scopus 로고
    • Epithelial NEMO links innate immunity to chronic intestinal inflammation
    • 17361131
    • Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature (2007) 446:557–61.10.1038/nature0569817361131
    • (2007) Nature , vol.446 , pp. 557-561
    • Nenci, A.1    Becker, C.2    Wullaert, A.3    Gareus, R.4    van Loo, G.5    Danese, S.6
  • 62
    • 84928949548 scopus 로고    scopus 로고
    • STAT3-activating cytokines: a therapeutic opportunity for inflammatory bowel disease?
    • 25760898
    • Nguyen PM, Putoczki TL, Ernst M. STAT3-activating cytokines: a therapeutic opportunity for inflammatory bowel disease? J Interferon Cytokine Res (2015) 35:340–50.10.1089/jir.2014.022525760898
    • (2015) J Interferon Cytokine Res , vol.35 , pp. 340-350
    • Nguyen, P.M.1    Putoczki, T.L.2    Ernst, M.3
  • 63
    • 77953143699 scopus 로고    scopus 로고
    • Activation of epithelial STAT3 regulates intestinal homeostasis
    • 20160497
    • Neufert C, Pickert G, Zheng Y, Wittkopf N, Warntjen M, Nikolaev A, et al. Activation of epithelial STAT3 regulates intestinal homeostasis. Cell Cycle (2010) 9:652–5.10.4161/cc.9.4.1061520160497
    • (2010) Cell Cycle , vol.9 , pp. 652-655
    • Neufert, C.1    Pickert, G.2    Zheng, Y.3    Wittkopf, N.4    Warntjen, M.5    Nikolaev, A.6
  • 64
    • 84875489998 scopus 로고    scopus 로고
    • Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation
    • 23395676
    • Farache J, Koren I, Milo I, Gurevich I, Kim KW, Zigmond E, et al. Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation. Immunity (2013) 38:581–95.10.1016/j.immuni.2013.01.00923395676
    • (2013) Immunity , vol.38 , pp. 581-595
    • Farache, J.1    Koren, I.2    Milo, I.3    Gurevich, I.4    Kim, K.W.5    Zigmond, E.6
  • 65
    • 84902595389 scopus 로고    scopus 로고
    • Dendritic cell-epithelial cell crosstalk in the gut
    • 24942686
    • Rescigno M. Dendritic cell-epithelial cell crosstalk in the gut. Immunol Rev (2014) 260:118–28.10.1111/imr.1218124942686
    • (2014) Immunol Rev , vol.260 , pp. 118-128
    • Rescigno, M.1


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