Loss of NAMPT in aging retinal pigment epithelium reduces NAD+ availability and promotes cellular senescence

Aging

Volumn 10, Issue 6, 2018, Pages 1306-1323

  Jadeja, Ravirajsinh N ^a   Powell, Folami L ^a   Jones, Malita A ^a   Fuller, Jasmine ^a   Joseph, Ethan ^a   Thounaojam, Menaka C ^a   Bartoli, Manuela ^a   Martin, Pamela M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Age related macular degeneration (AMD); Aging; NAD+; NAMPT; Retinal pigment epithelium (RPE); Senescence; SIRT1

Indexed keywords

ACRYLAMIDE DERIVATIVE; CYTOKINE; N-(4-(1-BENZOYLPIPERIDIN-4-YL)BUTYL)-3-(PYRIDIN-3-YL)ACRYLAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE NUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, HUMAN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, MOUSE; PIPERIDINE DERIVATIVE;

AGING; ANIMAL; CELL CULTURE; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; MALE; METABOLISM; MOUSE; PHYSIOLOGY; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACRYLAMIDES; AGING; ANIMALS; CELLS, CULTURED; CYTOKINES; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; NAD; NICOTINAMIDE MONONUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PIPERIDINES; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 85049507324     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.101469     Document Type: Article

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