메뉴 건너뛰기




Volumn 12, Issue 6, 2018, Pages 1117-1123

SGLT2 inhibitors and the kidney: Effects and mechanisms

Author keywords

Acute kidney injury; Ketones; Key words; Kidney; Nephroprotection; Sodium glucose cotransporter 2

Indexed keywords

GLUCOSE; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR;

EID: 85048858085     PISSN: 18714021     EISSN: 18780334     Source Type: Journal    
DOI: 10.1016/j.dsx.2018.06.003     Document Type: Review
Times cited : (35)

References (82)
  • 2
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • Zinman, B., Wanner, C., Lachin, J.M., Fitchett, D., Bluhmki, E., Hantel, S., et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373 (2015), 2117–2128.
    • (2015) N Engl J Med , vol.373 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3    Fitchett, D.4    Bluhmki, E.5    Hantel, S.6
  • 5
    • 85021254729 scopus 로고    scopus 로고
    • Effects of empagliflozin on the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and established cardiovascular disease: an exploratory analysis from the EMPA-REG OUTCOME randomised, placebo-controlled trial
    • Cherney, D.Z.I., Zinman, B., Inzucchi, S.E., Koitka-Weber, A., Mattheus, M., von Eynatten, M., et al. Effects of empagliflozin on the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and established cardiovascular disease: an exploratory analysis from the EMPA-REG OUTCOME randomised, placebo-controlled trial. Lancet Diabetes Endocrinol 5 (2017), 610–621.
    • (2017) Lancet Diabetes Endocrinol , vol.5 , pp. 610-621
    • Cherney, D.Z.I.1    Zinman, B.2    Inzucchi, S.E.3    Koitka-Weber, A.4    Mattheus, M.5    von Eynatten, M.6
  • 6
    • 85048449544 scopus 로고    scopus 로고
    • Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS program (Canagliflozin cardiovascular assessment study)
    • Mahaffey, K.W., Neal, B., Perkovic, V., de Zeeuw, D., Fulcher, G., Erondu, N., et al. Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS program (Canagliflozin cardiovascular assessment study). Circulation 137 (2018), 323–334.
    • (2018) Circulation , vol.137 , pp. 323-334
    • Mahaffey, K.W.1    Neal, B.2    Perkovic, V.3    de Zeeuw, D.4    Fulcher, G.5    Erondu, N.6
  • 7
    • 85042792101 scopus 로고    scopus 로고
    • Empagliflozin and clinical outcomes in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease
    • Wanner, C., Lachin, J.M., Inzucchi, S.E., Fitchett, D., Mattheus, M., George, J., et al. Empagliflozin and clinical outcomes in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease. Circulation 137 (2018), 119–129.
    • (2018) Circulation , vol.137 , pp. 119-129
    • Wanner, C.1    Lachin, J.M.2    Inzucchi, S.E.3    Fitchett, D.4    Mattheus, M.5    George, J.6
  • 8
    • 85021694438 scopus 로고    scopus 로고
    • Differential effects of dapagliflozin on cardiovascular risk factors at varying degrees of renal function
    • Petrykiv, S., Sjostrom, C.D., Greasley, P.J., Xu, J., Persson, F., Heerspink, H.J.L., Differential effects of dapagliflozin on cardiovascular risk factors at varying degrees of renal function. Clin J Am Soc Nephrol 12 (2017), 751–759.
    • (2017) Clin J Am Soc Nephrol , vol.12 , pp. 751-759
    • Petrykiv, S.1    Sjostrom, C.D.2    Greasley, P.J.3    Xu, J.4    Persson, F.5    Heerspink, H.J.L.6
  • 9
    • 85043534399 scopus 로고    scopus 로고
    • Effects of the sodium-glucose co-transporter 2 inhibitor dapagliflozin in patients with type 2 diabetes and stages 3b-4 chronic kidney disease
    • Epub ahead of print
    • Dekkers, C.C.J., Wheeler, D.C., Sjostrom, C.D., Stefansson, B.V., Cain, V., Heerspink, H.J.L., Effects of the sodium-glucose co-transporter 2 inhibitor dapagliflozin in patients with type 2 diabetes and stages 3b-4 chronic kidney disease. Nephrol Dial Transplant, 2018 Epub ahead of print.
    • (2018) Nephrol Dial Transplant
    • Dekkers, C.C.J.1    Wheeler, D.C.2    Sjostrom, C.D.3    Stefansson, B.V.4    Cain, V.5    Heerspink, H.J.L.6
  • 10
    • 85021849793 scopus 로고    scopus 로고
    • Canagliflozin slows progression of renal function decline independently of glycemic effects
    • Heerspink, H.J., Desai, M., Jardine, M., Balis, D., Meininger, G., Perkovic, V., Canagliflozin slows progression of renal function decline independently of glycemic effects. J Am Soc Nephrol 28 (2017), 368–375.
    • (2017) J Am Soc Nephrol , vol.28 , pp. 368-375
    • Heerspink, H.J.1    Desai, M.2    Jardine, M.3    Balis, D.4    Meininger, G.5    Perkovic, V.6
  • 11
    • 85040947920 scopus 로고    scopus 로고
    • Cardiovascular safety, long-term noncardiovascular safety, and efficacy of sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus: a systemic review and meta-analysis with trial sequential analysis
    • Zhang, X.L., Zhu, Q.Q., Chen, Y.H., Li, X.L., Chen, F., Huang, J.A., et al. Cardiovascular safety, long-term noncardiovascular safety, and efficacy of sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus: a systemic review and meta-analysis with trial sequential analysis. J Am Heart Assoc, 7, 2018.
    • (2018) J Am Heart Assoc , vol.7
    • Zhang, X.L.1    Zhu, Q.Q.2    Chen, Y.H.3    Li, X.L.4    Chen, F.5    Huang, J.A.6
  • 12
    • 85021244090 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 (SGLT2) inhibition on renal function and albuminuria in patients with type 2 diabetes: a systematic review and meta-analysis
    • Xu, L., Li, Y., Lang, J., Xia, P., Zhao, X., Wang, L., et al. Effects of sodium-glucose co-transporter 2 (SGLT2) inhibition on renal function and albuminuria in patients with type 2 diabetes: a systematic review and meta-analysis. PeerJ, 5, 2017, e3405.
    • (2017) PeerJ , vol.5 , pp. e3405
    • Xu, L.1    Li, Y.2    Lang, J.3    Xia, P.4    Zhao, X.5    Wang, L.6
  • 14
    • 85041732630 scopus 로고    scopus 로고
    • Are SGLT2 inhibitors ready for prime time for CKD?
    • Pecoits-Filho, R., Perkovic, V., Are SGLT2 inhibitors ready for prime time for CKD?. Clin J Am Soc Nephrol 13 (2018), 318–320.
    • (2018) Clin J Am Soc Nephrol , vol.13 , pp. 318-320
    • Pecoits-Filho, R.1    Perkovic, V.2
  • 16
    • 85019072998 scopus 로고    scopus 로고
    • Sodium-glucose co-transporters and their inhibition: clinical physiology
    • Ferrannini, E., Sodium-glucose co-transporters and their inhibition: clinical physiology. Cell Metab 26 (2017), 27–38.
    • (2017) Cell Metab , vol.26 , pp. 27-38
    • Ferrannini, E.1
  • 17
    • 79960959816 scopus 로고    scopus 로고
    • Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials
    • Boussageon, R., Bejan-Angoulvant, T., Saadatian-Elahi, M., Lafont, S., Bergeonneau, C., Kassai, B., et al. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ, 343, 2011, d4169.
    • (2011) BMJ , vol.343 , pp. d4169
    • Boussageon, R.1    Bejan-Angoulvant, T.2    Saadatian-Elahi, M.3    Lafont, S.4    Bergeonneau, C.5    Kassai, B.6
  • 18
    • 84882247716 scopus 로고    scopus 로고
    • Sodium-glucose co-transporter 2 inhibitors and the potential for cardiovascular risk reduction in patients with type 2 diabetes mellitus
    • Guthrie, R.M., Sodium-glucose co-transporter 2 inhibitors and the potential for cardiovascular risk reduction in patients with type 2 diabetes mellitus. Postgrad Med 125 (2013), 21–32.
    • (2013) Postgrad Med , vol.125 , pp. 21-32
    • Guthrie, R.M.1
  • 19
    • 84876938443 scopus 로고    scopus 로고
    • The potential of sodium glucose cotransporter 2 (SGLT2) inhibitors to reduce cardiovascular risk in patients with type 2 diabetes (T2DM)
    • Basile, J.N., The potential of sodium glucose cotransporter 2 (SGLT2) inhibitors to reduce cardiovascular risk in patients with type 2 diabetes (T2DM). J Diabetes Compl. 27 (2013), 280–286.
    • (2013) J Diabetes Compl. , vol.27 , pp. 280-286
    • Basile, J.N.1
  • 20
    • 84905238756 scopus 로고    scopus 로고
    • The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR ob/ob type 2 diabetic mice with and without hypertension
    • Gembardt, F., Bartaun, C., Jarzebska, N., Mayoux, E., Todorov, V.T., Hohenstein, B., et al. The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR ob/ob type 2 diabetic mice with and without hypertension. Am J Physiol Renal Physiol 307 (2014), F317–25.
    • (2014) Am J Physiol Renal Physiol , vol.307 , pp. F317-25
    • Gembardt, F.1    Bartaun, C.2    Jarzebska, N.3    Mayoux, E.4    Todorov, V.T.5    Hohenstein, B.6
  • 21
    • 84903528312 scopus 로고    scopus 로고
    • Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice
    • e100777
    • Terami, N., Ogawa, D., Tachibana, H., Hatanaka, T., Wada, J., Nakatsuka, A., et al. Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice. PLoS One, 9, 2014 e100777.
    • (2014) PLoS One , vol.9
    • Terami, N.1    Ogawa, D.2    Tachibana, H.3    Hatanaka, T.4    Wada, J.5    Nakatsuka, A.6
  • 22
    • 84872400230 scopus 로고    scopus 로고
    • Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus
    • Vallon, V., Rose, M., Gerasimova, M., Satriano, J., Platt, K.A., Koepsell, H., et al. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol 304 (2013), F156–67.
    • (2013) Am J Physiol Renal Physiol , vol.304 , pp. F156-67
    • Vallon, V.1    Rose, M.2    Gerasimova, M.3    Satriano, J.4    Platt, K.A.5    Koepsell, H.6
  • 23
    • 84892588641 scopus 로고    scopus 로고
    • SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice
    • Vallon, V., Gerasimova, M., Rose, M.A., Masuda, T., Satriano, J., Mayoux, E., et al. SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice. Am J Physiol Renal Physiol 306 (2014), F194–204.
    • (2014) Am J Physiol Renal Physiol , vol.306 , pp. F194-204
    • Vallon, V.1    Gerasimova, M.2    Rose, M.A.3    Masuda, T.4    Satriano, J.5    Mayoux, E.6
  • 24
    • 84880024193 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2-mediated oxidative stress augments advanced glycation end products-induced tubular cell apoptosis
    • Maeda, S., Matsui, T., Takeuchi, M., Yamagishi, S., Sodium-glucose cotransporter 2-mediated oxidative stress augments advanced glycation end products-induced tubular cell apoptosis. Diabetes Metab Res Rev 29 (2013), 406–412.
    • (2013) Diabetes Metab Res Rev , vol.29 , pp. 406-412
    • Maeda, S.1    Matsui, T.2    Takeuchi, M.3    Yamagishi, S.4
  • 25
    • 84873497173 scopus 로고    scopus 로고
    • Effects of SGLT2 inhibition in human kidney proximal tubular cells–renoprotection in diabetic nephropathy?
    • e54442
    • Panchapakesan, U., Pegg, K., Gross, S., Komala, M.G., Mudaliar, H., Forbes, J., et al. Effects of SGLT2 inhibition in human kidney proximal tubular cells–renoprotection in diabetic nephropathy?. PLoS One, 8, 2013 e54442.
    • (2013) PLoS One , vol.8
    • Panchapakesan, U.1    Pegg, K.2    Gross, S.3    Komala, M.G.4    Mudaliar, H.5    Forbes, J.6
  • 27
    • 84996486377 scopus 로고    scopus 로고
    • Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition
    • Vallon, V., Thomson, S.C., Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition. Diabetologia 60 (2017), 215–225.
    • (2017) Diabetologia , vol.60 , pp. 215-225
    • Vallon, V.1    Thomson, S.C.2
  • 28
    • 85020107839 scopus 로고    scopus 로고
    • EMPA-REG OUTCOME: the nephrologist's point of view
    • Wanner, C., EMPA-REG OUTCOME: the nephrologist's point of view. Am J Med 130 (2017), S63–S72.
    • (2017) Am J Med , vol.130 , pp. S63-S72
    • Wanner, C.1
  • 29
    • 84893214045 scopus 로고    scopus 로고
    • Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus
    • Cherney, D.Z., Perkins, B.A., Soleymanlou, N., Maione, M., Lai, V., Lee, A., et al. Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation 129 (2014), 587–597.
    • (2014) Circulation , vol.129 , pp. 587-597
    • Cherney, D.Z.1    Perkins, B.A.2    Soleymanlou, N.3    Maione, M.4    Lai, V.5    Lee, A.6
  • 30
    • 84933523949 scopus 로고    scopus 로고
    • Characterisation of glomerular haemodynamic responses to SGLT2 inhibition in patients with type 1 diabetes and renal hyperfiltration
    • Skrtic, M., Yang, G.K., Perkins, B.A., Soleymanlou, N., Lytvyn, Y., von Eynatten, M., et al. Characterisation of glomerular haemodynamic responses to SGLT2 inhibition in patients with type 1 diabetes and renal hyperfiltration. Diabetologia 57 (2014), 2599–2602.
    • (2014) Diabetologia , vol.57 , pp. 2599-2602
    • Skrtic, M.1    Yang, G.K.2    Perkins, B.A.3    Soleymanlou, N.4    Lytvyn, Y.5    von Eynatten, M.6
  • 31
    • 84938947090 scopus 로고    scopus 로고
    • Reducing albuminuria as surrogate endpoint C. Drug-induced reduction in Albuminuria is associated with subsequent renoprotection: a meta-analysis
    • Heerspink, H.J., Kropelin, T.F., Hoekman, J., de Zeeuw, D., Reducing albuminuria as surrogate endpoint C. Drug-induced reduction in Albuminuria is associated with subsequent renoprotection: a meta-analysis. J Am Soc Nephrol 26 (2015), 2055–2064.
    • (2015) J Am Soc Nephrol , vol.26 , pp. 2055-2064
    • Heerspink, H.J.1    Kropelin, T.F.2    Hoekman, J.3    de Zeeuw, D.4
  • 32
    • 84976292796 scopus 로고    scopus 로고
    • Mechanisms of blood pressure reduction with sodium-glucose co-transporter 2 (SGLT2) inhibitors
    • Filippatos, T.D., Tsimihodimos, V., Elisaf, M.S., Mechanisms of blood pressure reduction with sodium-glucose co-transporter 2 (SGLT2) inhibitors. Expert Opin Pharmacother 17 (2016), 1581–1583.
    • (2016) Expert Opin Pharmacother , vol.17 , pp. 1581-1583
    • Filippatos, T.D.1    Tsimihodimos, V.2    Elisaf, M.S.3
  • 33
    • 84945455839 scopus 로고    scopus 로고
    • Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes
    • Chilton, R., Tikkanen, I., Cannon, C.P., Crowe, S., Woerle, H.J., Broedl, U.C., et al. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes Obes Metab 17 (2015), 1180–1193.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 1180-1193
    • Chilton, R.1    Tikkanen, I.2    Cannon, C.P.3    Crowe, S.4    Woerle, H.J.5    Broedl, U.C.6
  • 34
    • 84892959743 scopus 로고    scopus 로고
    • The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
    • Cherney, D.Z., Perkins, B.A., Soleymanlou, N., Har, R., Fagan, N., Johansen, O.E., et al. The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus. Cardiovasc Diabetol, 13, 2014, 28.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 28
    • Cherney, D.Z.1    Perkins, B.A.2    Soleymanlou, N.3    Har, R.4    Fagan, N.5    Johansen, O.E.6
  • 35
  • 36
    • 84975853831 scopus 로고    scopus 로고
    • CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis
    • Ferrannini, E., Mark, M., Mayoux, E., CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis. Diabetes Care 39 (2016), 1108–1114.
    • (2016) Diabetes Care , vol.39 , pp. 1108-1114
    • Ferrannini, E.1    Mark, M.2    Mayoux, E.3
  • 37
    • 85015866863 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 inhibitors on metabolism: unanswered questions and controversies
    • Tsimihodimos, V., Filippatos, T.D., Elisaf, M.S., Effects of sodium-glucose co-transporter 2 inhibitors on metabolism: unanswered questions and controversies. Expert Opin Drug Metab Toxicol 13 (2017), 399–408.
    • (2017) Expert Opin Drug Metab Toxicol , vol.13 , pp. 399-408
    • Tsimihodimos, V.1    Filippatos, T.D.2    Elisaf, M.S.3
  • 38
    • 84921437510 scopus 로고    scopus 로고
    • Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the look AHEAD randomised clinical trial
    • Look, A.R.G., Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol 2 (2014), 801–809.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 801-809
    • Look, A.R.G.1
  • 39
    • 85042173880 scopus 로고    scopus 로고
    • Do Sodium-glucose co-transporter-2 inhibitors prevent heart failure with a preserved ejection fraction by counterbalancing the effects of leptin? A novel hypothesis
    • Packer, M., Do Sodium-glucose co-transporter-2 inhibitors prevent heart failure with a preserved ejection fraction by counterbalancing the effects of leptin? A novel hypothesis. Diabetes Obes Metab 20:6 (2018), 1361–1366.
    • (2018) Diabetes Obes Metab , vol.20 , Issue.6 , pp. 1361-1366
    • Packer, M.1
  • 40
    • 85044500198 scopus 로고    scopus 로고
    • Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes
    • Epub ahead of print
    • Timothy Garvey, W., Van Gaal, L., Leiter, L.A., Vijapurkar, U., List, J., Cuddihy, R., et al. Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes. Metabolism, 2018 Epub ahead of print.
    • (2018) Metabolism
    • Timothy Garvey, W.1    Van Gaal, L.2    Leiter, L.A.3    Vijapurkar, U.4    List, J.5    Cuddihy, R.6
  • 43
    • 84984622380 scopus 로고    scopus 로고
    • Glucagon actions on the kidney revisited: possible role in potassium homeostasis
    • Bankir, L., Bouby, N., Blondeau, B., Crambert, G., Glucagon actions on the kidney revisited: possible role in potassium homeostasis. Am J Physiol Renal Physiol 311 (2016), F469–86.
    • (2016) Am J Physiol Renal Physiol , vol.311 , pp. F469-86
    • Bankir, L.1    Bouby, N.2    Blondeau, B.3    Crambert, G.4
  • 44
    • 84936085884 scopus 로고    scopus 로고
    • Protein- and diabetes-induced glomerular hyperfiltration: role of glucagon, vasopressin, and urea
    • Bankir, L., Roussel, R., Bouby, N., Protein- and diabetes-induced glomerular hyperfiltration: role of glucagon, vasopressin, and urea. Am J Physiol Renal Physiol 309 (2015), F2–23.
    • (2015) Am J Physiol Renal Physiol , vol.309 , pp. F2-23
    • Bankir, L.1    Roussel, R.2    Bouby, N.3
  • 45
    • 85033774082 scopus 로고    scopus 로고
    • Diuretic treatment in heart failure
    • Ellison, D.H., Felker, G.M., Diuretic treatment in heart failure. N Engl J Med 377 (2017), 1964–1975.
    • (2017) N Engl J Med , vol.377 , pp. 1964-1975
    • Ellison, D.H.1    Felker, G.M.2
  • 46
    • 85032620814 scopus 로고    scopus 로고
    • Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action
    • Packer, M., Anker, S.D., Butler, J., Filippatos, G., Zannad, F., Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action. JAMA Cardiol 2 (2017), 1025–1029.
    • (2017) JAMA Cardiol , vol.2 , pp. 1025-1029
    • Packer, M.1    Anker, S.D.2    Butler, J.3    Filippatos, G.4    Zannad, F.5
  • 47
    • 85019367291 scopus 로고    scopus 로고
    • Increased hematocrit during sodium-glucose cotransporter 2 inhibitor therapy indicates recovery of tubulointerstitial function in diabetic kidneys
    • Sano, M., Takei, M., Shiraishi, Y., Suzuki, Y., Increased hematocrit during sodium-glucose cotransporter 2 inhibitor therapy indicates recovery of tubulointerstitial function in diabetic kidneys. J Clin Med Res 8 (2016), 844–847.
    • (2016) J Clin Med Res , vol.8 , pp. 844-847
    • Sano, M.1    Takei, M.2    Shiraishi, Y.3    Suzuki, Y.4
  • 49
    • 0028216159 scopus 로고
    • Increased renal metabolism in diabetes. Mechanism and functional implications
    • Korner, A., Eklof, A.C., Celsi, G., Aperia, A., Increased renal metabolism in diabetes. Mechanism and functional implications. Diabetes 43 (1994), 629–633.
    • (1994) Diabetes , vol.43 , pp. 629-633
    • Korner, A.1    Eklof, A.C.2    Celsi, G.3    Aperia, A.4
  • 50
    • 51849094304 scopus 로고    scopus 로고
    • Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics
    • Fine, L.G., Norman, J.T., Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics. Kidney Int 74 (2008), 867–872.
    • (2008) Kidney Int , vol.74 , pp. 867-872
    • Fine, L.G.1    Norman, J.T.2
  • 51
    • 85044426288 scopus 로고    scopus 로고
    • SGLT2 inhibition in a kidney with reduced nephron number: modeling and analysis of solute transport and metabolism
    • Layton, A.T., Vallon, V., SGLT2 inhibition in a kidney with reduced nephron number: modeling and analysis of solute transport and metabolism. Am J Physiol Renal Physiol, 2018.
    • (2018) Am J Physiol Renal Physiol
    • Layton, A.T.1    Vallon, V.2
  • 52
    • 85044431418 scopus 로고    scopus 로고
    • Cardiovascular benefits of SGLT2 inhibition in diabetes and chronic kidney diseases
    • e13050
    • Layton, A.T., Vallon, V., Cardiovascular benefits of SGLT2 inhibition in diabetes and chronic kidney diseases. Acta Physiol (Oxf), 222, 2018 e13050.
    • (2018) Acta Physiol (Oxf) , vol.222
    • Layton, A.T.1    Vallon, V.2
  • 53
    • 33746655373 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in the kidney
    • Haase, V.H., Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol 291 (2006), F271–81.
    • (2006) Am J Physiol Renal Physiol , vol.291 , pp. F271-81
    • Haase, V.H.1
  • 54
    • 84978743298 scopus 로고    scopus 로고
    • Dapagliflozin, SGLT2 inhibitor, attenuates renal ischemia-reperfusion injury
    • e0158810
    • Chang, Y.K., Choi, H., Jeong, J.Y., Na, K.R., Lee, K.W., Lim, B.J., et al. Dapagliflozin, SGLT2 inhibitor, attenuates renal ischemia-reperfusion injury. PLoS One, 11, 2016 e0158810.
    • (2016) PLoS One , vol.11
    • Chang, Y.K.1    Choi, H.2    Jeong, J.Y.3    Na, K.R.4    Lee, K.W.5    Lim, B.J.6
  • 55
    • 84898854471 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis
    • e9
    • Baker, W.L., Smyth, L.R., Riche, D.M., Bourret, E.M., Chamberlin, K.W., White, W.B., Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis. J Am Soc Hypertens 8 (2014), 262–275 e9.
    • (2014) J Am Soc Hypertens , vol.8 , pp. 262-275
    • Baker, W.L.1    Smyth, L.R.2    Riche, D.M.3    Bourret, E.M.4    Chamberlin, K.W.5    White, W.B.6
  • 56
    • 84868231976 scopus 로고    scopus 로고
    • Renoprotection by continuous erythropoietin receptor activator in puromycin aminonucleoside-induced nephrotic syndrome
    • Aizawa, K., Takeda, S., Tashiro, Y., Yorozu, K., Hirata, M., Kanada, H., et al. Renoprotection by continuous erythropoietin receptor activator in puromycin aminonucleoside-induced nephrotic syndrome. Am J Nephrol 36 (2012), 419–426.
    • (2012) Am J Nephrol , vol.36 , pp. 419-426
    • Aizawa, K.1    Takeda, S.2    Tashiro, Y.3    Yorozu, K.4    Hirata, M.5    Kanada, H.6
  • 57
    • 84946555058 scopus 로고    scopus 로고
    • Epoetin beta pegol prevents endothelial dysfunction as evaluated by flow-mediated dilation in chronic kidney disease rats
    • Serizawa, K., Yogo, K., Tashiro, Y., Aizawa, K., Kawasaki, R., Hirata, M., et al. Epoetin beta pegol prevents endothelial dysfunction as evaluated by flow-mediated dilation in chronic kidney disease rats. Eur J Pharmacol 767 (2015), 10–16.
    • (2015) Eur J Pharmacol , vol.767 , pp. 10-16
    • Serizawa, K.1    Yogo, K.2    Tashiro, Y.3    Aizawa, K.4    Kawasaki, R.5    Hirata, M.6
  • 58
    • 84961233580 scopus 로고    scopus 로고
    • Pleiotropic and renoprotective effects of erythropoietin beta on experimental diabetic nephropathy model
    • Eren, Z., Gunal, M.Y., Ari, E., Coban, J., Cakalagaoglu, F., Caglayan, B., et al. Pleiotropic and renoprotective effects of erythropoietin beta on experimental diabetic nephropathy model. Nephron 132 (2016), 292–300.
    • (2016) Nephron , vol.132 , pp. 292-300
    • Eren, Z.1    Gunal, M.Y.2    Ari, E.3    Coban, J.4    Cakalagaoglu, F.5    Caglayan, B.6
  • 59
    • 84959234523 scopus 로고    scopus 로고
    • Erythropoiesis-stimulating agent slows the progression of chronic kidney disease: a possibility of a direct action of erythropoietin
    • Tsuruya, K., Yoshida, H., Suehiro, T., Fujisaki, K., Masutani, K., Kitazono, T., Erythropoiesis-stimulating agent slows the progression of chronic kidney disease: a possibility of a direct action of erythropoietin. Ren Fail 38 (2016), 390–396.
    • (2016) Ren Fail , vol.38 , pp. 390-396
    • Tsuruya, K.1    Yoshida, H.2    Suehiro, T.3    Fujisaki, K.4    Masutani, K.5    Kitazono, T.6
  • 61
    • 84968772300 scopus 로고    scopus 로고
    • Angiotensin-(1-7): a novel peptide to treat hypertension and nephropathy in diabetes?
    • Padda, R.S., Shi, Y., Lo, C.S., Zhang, S.L., Chan, J.S., Angiotensin-(1-7): a novel peptide to treat hypertension and nephropathy in diabetes?. J Diabetes Metab, 6, 2015.
    • (2015) J Diabetes Metab , vol.6
    • Padda, R.S.1    Shi, Y.2    Lo, C.S.3    Zhang, S.L.4    Chan, J.S.5
  • 62
    • 85028961931 scopus 로고    scopus 로고
    • The anti-inflammatory potential of ACE2/Angiotensin-(1-7)/Mas receptor axis: evidence from basic and clinical research
    • Rodrigues Prestes, T.R., Rocha, N.P., Miranda, A.S., Teixeira, A.L., Simoes, E.S.A.C., The anti-inflammatory potential of ACE2/Angiotensin-(1-7)/Mas receptor axis: evidence from basic and clinical research. Curr Drug Targets 18 (2017), 1301–1313.
    • (2017) Curr Drug Targets , vol.18 , pp. 1301-1313
    • Rodrigues Prestes, T.R.1    Rocha, N.P.2    Miranda, A.S.3    Teixeira, A.L.4    Simoes, E.S.A.C.5
  • 63
    • 84928929919 scopus 로고    scopus 로고
    • Angiotensin-(1-7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice
    • Shi, Y., Lo, C.S., Padda, R., Abdo, S., Chenier, I., Filep, J.G., et al. Angiotensin-(1-7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice. Clin Sci (Lond) 128 (2015), 649–663.
    • (2015) Clin Sci (Lond) , vol.128 , pp. 649-663
    • Shi, Y.1    Lo, C.S.2    Padda, R.3    Abdo, S.4    Chenier, I.5    Filep, J.G.6
  • 64
    • 85044521391 scopus 로고    scopus 로고
    • A new class of drugs for heart failure: SGLT2 inhibitors reduce sympathetic overactivity
    • Sano, M., A new class of drugs for heart failure: SGLT2 inhibitors reduce sympathetic overactivity. J Cardiol 71 (2018), 471–476.
    • (2018) J Cardiol , vol.71 , pp. 471-476
    • Sano, M.1
  • 65
    • 85020677458 scopus 로고    scopus 로고
    • Role of the sympathetic nervous system in regulation of the sodium glucose cotransporter 2
    • Matthews, V.B., Elliot, R.H., Rudnicka, C., Hricova, J., Herat, L., Schlaich, M.P., Role of the sympathetic nervous system in regulation of the sodium glucose cotransporter 2. J Hypertens 35 (2017), 2059–2068.
    • (2017) J Hypertens , vol.35 , pp. 2059-2068
    • Matthews, V.B.1    Elliot, R.H.2    Rudnicka, C.3    Hricova, J.4    Herat, L.5    Schlaich, M.P.6
  • 66
    • 85052302177 scopus 로고    scopus 로고
    • Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model
    • ajprenal003142017
    • Mishima, E., Fukuda, S., Kanemitsu, Y., Saigusa, D., Mukawa, C., Asaji, K., et al. Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model. Am J Physiol Renal Physiol, 2017 ajprenal003142017.
    • (2017) Am J Physiol Renal Physiol
    • Mishima, E.1    Fukuda, S.2    Kanemitsu, Y.3    Saigusa, D.4    Mukawa, C.5    Asaji, K.6
  • 67
    • 85016626296 scopus 로고    scopus 로고
    • SGLT2 protein expression is increased in human diabetic nephropathy: SGLT2 protein inhibition decreases renal lipid accumulation, inflammation, and the development of nephropathy in diabetic mice
    • Wang, X.X., Levi, J., Luo, Y., Myakala, K., Herman-Edelstein, M., Qiu, L., et al. SGLT2 protein expression is increased in human diabetic nephropathy: SGLT2 protein inhibition decreases renal lipid accumulation, inflammation, and the development of nephropathy in diabetic mice. J Biol Chem 292 (2017), 5335–5348.
    • (2017) J Biol Chem , vol.292 , pp. 5335-5348
    • Wang, X.X.1    Levi, J.2    Luo, Y.3    Myakala, K.4    Herman-Edelstein, M.5    Qiu, L.6
  • 69
    • 85034996868 scopus 로고    scopus 로고
    • Acute renal failure with sodium-glucose-cotransporter-2 inhibitors: analysis of the FDA adverse event report system database
    • Perlman, A., Heyman, S.N., Matok, I., Stokar, J., Muszkat, M., Szalat, A., Acute renal failure with sodium-glucose-cotransporter-2 inhibitors: analysis of the FDA adverse event report system database. Nutr Metab Cardiovasc Dis 27 (2017), 1108–1113.
    • (2017) Nutr Metab Cardiovasc Dis , vol.27 , pp. 1108-1113
    • Perlman, A.1    Heyman, S.N.2    Matok, I.3    Stokar, J.4    Muszkat, M.5    Szalat, A.6
  • 70
    • 85017337183 scopus 로고    scopus 로고
    • Sodium-glucose co-transporter-2 inhibitors and risk of adverse renal outcomes among patients with type 2 diabetes: a network and cumulative meta-analysis of randomized controlled trials
    • Tang, H., Li, D., Zhang, J., Li, Y., Wang, T., Zhai, S., et al. Sodium-glucose co-transporter-2 inhibitors and risk of adverse renal outcomes among patients with type 2 diabetes: a network and cumulative meta-analysis of randomized controlled trials. Diabetes Obes Metab 19 (2017), 1106–1115.
    • (2017) Diabetes Obes Metab , vol.19 , pp. 1106-1115
    • Tang, H.1    Li, D.2    Zhang, J.3    Li, Y.4    Wang, T.5    Zhai, S.6
  • 71
    • 85033219798 scopus 로고    scopus 로고
    • Acute kidney injury in patients on sglt2 inhibitors: a propensity-matched analysis
    • Nadkarni, G.N., Ferrandino, R., Chang, A., Surapaneni, A., Chauhan, K., Poojary, P., et al. Acute kidney injury in patients on sglt2 inhibitors: a propensity-matched analysis. Diabetes Care 40 (2017), 1479–1485.
    • (2017) Diabetes Care , vol.40 , pp. 1479-1485
    • Nadkarni, G.N.1    Ferrandino, R.2    Chang, A.3    Surapaneni, A.4    Chauhan, K.5    Poojary, P.6
  • 72
    • 85015765803 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus
    • Marx, N., McGuire, D.K., Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus. Eur Heart J, 2016, 10.1093/eurheartj/ehw110.
    • (2016) Eur Heart J
    • Marx, N.1    McGuire, D.K.2
  • 73
    • 85029902950 scopus 로고    scopus 로고
    • Can SGLT2 inhibitors cause acute renal failure? Plausible role for altered glomerular hemodynamics and medullary hypoxia
    • Szalat, A., Perlman, A., Muszkat, M., Khamaisi, M., Abassi, Z., Heyman, S.N., Can SGLT2 inhibitors cause acute renal failure? Plausible role for altered glomerular hemodynamics and medullary hypoxia. Drug Saf 41 (2018), 239–252.
    • (2018) Drug Saf , vol.41 , pp. 239-252
    • Szalat, A.1    Perlman, A.2    Muszkat, M.3    Khamaisi, M.4    Abassi, Z.5    Heyman, S.N.6
  • 74
    • 84995678272 scopus 로고    scopus 로고
    • Acute kidney injury from SGLT2 inhibitors: potential mechanisms
    • Hahn, K., Ejaz, A.A., Kanbay, M., Lanaspa, M.A., Johnson, R.J., Acute kidney injury from SGLT2 inhibitors: potential mechanisms. Nat Rev Nephrol 12 (2016), 711–712.
    • (2016) Nat Rev Nephrol , vol.12 , pp. 711-712
    • Hahn, K.1    Ejaz, A.A.2    Kanbay, M.3    Lanaspa, M.A.4    Johnson, R.J.5
  • 75
    • 84938613439 scopus 로고    scopus 로고
    • Acute SGLT inhibition normalizes O2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats
    • O'Neill, J., Fasching, A., Pihl, L., Patinha, D., Franzen, S., Palm, F., Acute SGLT inhibition normalizes O2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats. Am J Physiol Renal Physiol 309 (2015), F227–34.
    • (2015) Am J Physiol Renal Physiol , vol.309 , pp. F227-34
    • O'Neill, J.1    Fasching, A.2    Pihl, L.3    Patinha, D.4    Franzen, S.5    Palm, F.6
  • 76
    • 85030530784 scopus 로고    scopus 로고
    • Harnessing basic and clinic tools to evaluate SGLT2 inhibitor nephrotoxicity
    • Saly, D.L., Perazella, M.A., Harnessing basic and clinic tools to evaluate SGLT2 inhibitor nephrotoxicity. Am J Physiol Renal Physiol 313 (2017), F951–F954.
    • (2017) Am J Physiol Renal Physiol , vol.313 , pp. F951-F954
    • Saly, D.L.1    Perazella, M.A.2
  • 77
  • 79
    • 0031911795 scopus 로고    scopus 로고
    • Inhibition of myo-inositol transport causes acute renal failure with selective medullary injury in the rat
    • Kitamura, H., Yamauchi, A., Sugiura, T., Matsuoka, Y., Horio, M., Tohyama, M., et al. Inhibition of myo-inositol transport causes acute renal failure with selective medullary injury in the rat. Kidney Int 53 (1998), 146–153.
    • (1998) Kidney Int , vol.53 , pp. 146-153
    • Kitamura, H.1    Yamauchi, A.2    Sugiura, T.3    Matsuoka, Y.4    Horio, M.5    Tohyama, M.6
  • 80
    • 85027511295 scopus 로고    scopus 로고
    • SGLT2 inhibitors-induced electrolyte abnormalities: an analysis of the associated mechanisms
    • Filippatos, T.D., Tsimihodimos, V., Liamis, G., Elisaf, M.S., SGLT2 inhibitors-induced electrolyte abnormalities: an analysis of the associated mechanisms. Diabetes Metab Syndr 12 (2018), 59–63.
    • (2018) Diabetes Metab Syndr , vol.12 , pp. 59-63
    • Filippatos, T.D.1    Tsimihodimos, V.2    Liamis, G.3    Elisaf, M.S.4
  • 81
    • 85042724310 scopus 로고    scopus 로고
    • Dapagliflozin aggravates renal injury via promoting gluconeogenesis in db/db mice
    • Jia, Y., He, J., Wang, L., Su, L., Lei, L., Huang, W., et al. Dapagliflozin aggravates renal injury via promoting gluconeogenesis in db/db mice. Cell Physiol Biochem 45 (2018), 1747–1758.
    • (2018) Cell Physiol Biochem , vol.45 , pp. 1747-1758
    • Jia, Y.1    He, J.2    Wang, L.3    Su, L.4    Lei, L.5    Huang, W.6
  • 82
    • 85042128920 scopus 로고    scopus 로고
    • Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect
    • Secker, P.F., Beneke, S., Schlichenmaier, N., Delp, J., Gutbier, S., Leist, M., et al. Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect. Cell Death Dis, 9, 2018, 226.
    • (2018) Cell Death Dis , vol.9 , pp. 226
    • Secker, P.F.1    Beneke, S.2    Schlichenmaier, N.3    Delp, J.4    Gutbier, S.5    Leist, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.