Acute SGLT inhibition normalizes O2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats

American Journal of Physiology - Renal Physiology

Volumn 309, Issue 3, 2015, Pages F227-F234

  O’Neill, Julie ^a   Fasching, Angelica ^b   Pihl, Liselotte ^a   Patinha, Daniela ^a   Franzén, Stephanie ^a   Palm, Fredrik ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Diabetes; Oxgen consumption; Renal hypoxia; Sodium transport; Sodium glucose linked transport

Indexed keywords

OXYGEN; PHLORIZIN; SODIUM; SODIUM GLUCOSE COTRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; GLUCOSE TRANSPORT; HOMEOSTASIS; HYPOXIA; KIDNEY BLOOD FLOW; KIDNEY CORTEX; KIDNEY MEDULLA; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; MALE; NEPHRON; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PROTEINURIA; RAT; SODIUM GLUCOSE LINKED TRANSPORT; SODIUM TRANSPORT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ULTRAFILTRATION; ANESTHESIA; ANIMAL; ANOXIA; ANTAGONISTS AND INHIBITORS; DIABETIC NEPHROPATHY; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; OXYGEN CONSUMPTION; SPRAGUE DAWLEY RAT; URODYNAMICS;

ANESTHESIA; ANIMALS; ANOXIA; ARTERIAL PRESSURE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; KIDNEY CORTEX; KIDNEY MEDULLA; MALE; OXYGEN CONSUMPTION; PHLORHIZIN; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; SODIUM-GLUCOSE TRANSPORT PROTEINS; URODYNAMICS;

EID: 84938613439     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00689.2014     Document Type: Article

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