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Volumn 37, Issue 42, 2016, Pages 3192-3200b

Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus

Author keywords

Cardiovascular risk; Diabetes; Empagliflizon; Heart failure; Sodium glucose cotransporter 2 inhibitors

Indexed keywords

BIOLOGICAL MARKER; EMPAGLIFLOZIN; GLUCOSE; SODIUM GLUCOSE COTRANSPORTER 2; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; ANTIDIABETIC AGENT; SODIUM;

EID: 85015765803     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehw110     Document Type: Review
Times cited : (138)

References (71)
  • 1
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998;339:229-234.
    • (1998) N Engl J Med , vol.339 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Rönnemaa, T.3    Pyörälä, K.4    Laakso, M.5
  • 2
    • 84904251303 scopus 로고    scopus 로고
    • Changes in diabetes-related complications in the United States
    • Gregg EW, Williams DE, Geiss L. Changes in diabetes-related complications in the United States. N Engl J Med 2014;371:286-287.
    • (2014) N Engl J Med , vol.371 , pp. 286-287
    • Gregg, E.W.1    Williams, D.E.2    Geiss, L.3
  • 4
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study
    • Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000;321:405-412.
    • (2000) BMJ , vol.321 , pp. 405-412
    • Stratton, I.M.1    Adler, A.I.2    Neil, H.A.3    Matthews, D.R.4    Manley, S.E.5    Cull, C.A.6
  • 5
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352: 837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 7
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • ADVANCE CG, Patel A, MacMahon S, Chalmers J, Neal B, Billot L et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008;358:2560-2572.
    • (2008) N Engl J Med , vol.358 , pp. 2560-2572
    • Advance, C.G.1    Patel, A.2    MacMahon, S.3    Chalmers, J.4    Neal, B.5    Billot, L.6
  • 13
    • 84929289581 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo
    • Bentley-Lewis R, Aguilar D, Riddle MC, Claggett B, Diaz R, Dickstein K et al. Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo. Am Heart J 2015;169:631-8 e7.
    • (2015) Am Heart J , vol.169 , pp. 631-638e7
    • Bentley-Lewis, R.1    Aguilar, D.2    Riddle, M.C.3    Claggett, B.4    Diaz, R.5    Dickstein, K.6
  • 14
    • 84917723836 scopus 로고    scopus 로고
    • Heart failure, saxagliptin, and diabetes mellitus: Observations from the SAVOR-TIMI 53 randomized trial
    • Scirica BM, Braunwald E, Raz I, Cavender MA, Morrow DA, Jarolim P et al. Heart failure, saxagliptin, and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trial. Circulation 2014;130:1579-1588.
    • (2014) Circulation , vol.130 , pp. 1579-1588
    • Scirica, B.M.1    Braunwald, E.2    Raz, I.3    Cavender, M.A.4    Morrow, D.A.5    Jarolim, P.6
  • 17
    • 84902756416 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME)
    • Zinman B, Inzucchi SE, Lachin JM, Wanner C, Ferrari R, Fitchett D et al. Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME). Cardiovasc Diabetol 2014;13:102.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 102
    • Zinman, B.1    Inzucchi, S.E.2    Lachin, J.M.3    Wanner, C.4    Ferrari, R.5    Fitchett, D.6
  • 18
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group
    • Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344:1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 19
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    • Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000;342:145-153.
    • (2000) N Engl J Med , vol.342 , pp. 145-153
    • Yusuf, S.1    Sleight, P.2    Pogue, J.3    Bosch, J.4    Davies, R.5    Dagenais, G.6
  • 20
    • 76249133903 scopus 로고    scopus 로고
    • Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: Therapeutic implications
    • Gerich JE. Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications. Diabet Med 2010;27: 136-142.
    • (2010) Diabet Med , vol.27 , pp. 136-142
    • Gerich, J.E.1
  • 21
    • 64749099761 scopus 로고    scopus 로고
    • Glucose control by the kidney: An emerging target in diabetes
    • Marsenic O. Glucose control by the kidney: an emerging target in diabetes. Am J Kidney Dis 2009;53:875-883.
    • (2009) Am J Kidney Dis , vol.53 , pp. 875-883
    • Marsenic, O.1
  • 22
    • 78651349221 scopus 로고    scopus 로고
    • Biology of human sodium glucose transporters
    • Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiol Rev 2011;91:733-794.
    • (2011) Physiol Rev , vol.91 , pp. 733-794
    • Wright, E.M.1    Loo, D.D.2    Hirayama, B.A.3
  • 23
    • 33644688031 scopus 로고    scopus 로고
    • Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
    • Rahmoune H, Thompson PW, Ward JM, Smith CD, Hong G, Brown J. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes 2005;54:3427-3434.
    • (2005) Diabetes , vol.54 , pp. 3427-3434
    • Rahmoune, H.1    Thompson, P.W.2    Ward, J.M.3    Smith, C.D.4    Hong, G.5    Brown, J.6
  • 24
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
    • Bailey CJ, Gross JL, Pieters A, Bastien A, List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet 2010;375:2223-2233.
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3    Bastien, A.4    List, J.F.5
  • 25
    • 77954242599 scopus 로고    scopus 로고
    • SGLT2 inhibition - A novel strategy for diabetes treatment
    • Chao EC, Henry RR. SGLT2 inhibition - a novel strategy for diabetes treatment. Nat Rev Drug Discov 2010;9:551-559.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 551-559
    • Chao, E.C.1    Henry, R.R.2
  • 26
    • 84916880876 scopus 로고    scopus 로고
    • Dapagliflozin for the treatment of type 2 diabetes: A review of the literature
    • Saeed MA, Narendran P. Dapagliflozin for the treatment of type 2 diabetes: a review of the literature. Drug Des Devel Ther 2014;8:2493-2505.
    • (2014) Drug des Devel Ther , vol.8 , pp. 2493-2505
    • Saeed, M.A.1    Narendran, P.2
  • 27
    • 80052362968 scopus 로고    scopus 로고
    • Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
    • Abdul-Ghani MA, Norton L, Defronzo RA. Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes. Endocr Rev 2011;32: 515-531.
    • (2011) Endocr Rev , vol.32 , pp. 515-531
    • Abdul-Ghani, M.A.1    Norton, L.2    Defronzo, R.A.3
  • 28
    • 84931007816 scopus 로고    scopus 로고
    • The role of sodium-glucose co-transporter 2 inhibitors in the treatment of type 2 diabetes
    • Whalen K, Miller S, Onge ES. The role of sodium-glucose co-transporter 2 inhibitors in the treatment of type 2 diabetes. Clin Ther 2015;37:1150-1166.
    • (2015) Clin Ther , vol.37 , pp. 1150-1166
    • Whalen, K.1    Miller, S.2    Onge, E.S.3
  • 29
    • 84908066747 scopus 로고    scopus 로고
    • Update on developments with SGLT2 inhibitors in the management of type 2 diabetes
    • Nauck MA. Update on developments with SGLT2 inhibitors in the management of type 2 diabetes. Drug Des Devel Ther 2014;8:1335-1380.
    • (2014) Drug des Devel Ther , vol.8 , pp. 1335-1380
    • Nauck, M.A.1
  • 30
    • 84891865819 scopus 로고    scopus 로고
    • Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes
    • DeFronzo RA, Hompesch M, Kasichayanula S, Liu X, Hong Y, Pfister M et al. Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes. Diabetes Care 2013;36:3169-3176.
    • (2013) Diabetes Care , vol.36 , pp. 3169-3176
    • DeFronzo, R.A.1    Hompesch, M.2    Kasichayanula, S.3    Liu, X.4    Hong, Y.5    Pfister, M.6
  • 31
    • 84914154997 scopus 로고    scopus 로고
    • Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus
    • Sha S, Polidori D, Heise T, Natarajan J, Farrell K, Wang SS et al. Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus. Diabetes Obes Metab 2014;16:1087-1095.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 1087-1095
    • Sha, S.1    Polidori, D.2    Heise, T.3    Natarajan, J.4    Farrell, K.5    Wang, S.S.6
  • 32
    • 84941243068 scopus 로고    scopus 로고
    • Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes
    • Ferrannini E, DeFronzo RA. Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes. Eur Heart J 2015;36:2288-2296.
    • (2015) Eur Heart J , vol.36 , pp. 2288-2296
    • Ferrannini, E.1    DeFronzo, R.A.2
  • 33
    • 84864283226 scopus 로고    scopus 로고
    • SGLT2 inhibition in diabetes mellitus: Rationale and clinical prospects
    • Ferrannini E, Solini A. SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects. Nat Rev Endocrinol 2012;8:495-502.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 495-502
    • Ferrannini, E.1    Solini, A.2
  • 34
    • 84869745717 scopus 로고    scopus 로고
    • Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes
    • pii: e001007
    • Clar C, Gill JA, Court R, Waugh N. Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes. BMJ Open 2012;2:pii: e001007.
    • (2012) BMJ Open , vol.2
    • Clar, C.1    Gill, J.A.2    Court, R.3    Waugh, N.4
  • 35
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
    • Ferrannini E, Muscelli E, Frascerra S, Baldi S, Mari A, Heise T et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest 2014;124:499-508.
    • (2014) J Clin Invest , vol.124 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3    Baldi, S.4    Mari, A.5    Heise, T.6
  • 37
    • 84937763347 scopus 로고    scopus 로고
    • Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
    • Bonner C, Kerr-Conte J, Gmyr V, Queniat G, Moerman E, Thevenet J et al. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat Med 2015;21:512-517.
    • (2015) Nat Med , vol.21 , pp. 512-517
    • Bonner, C.1    Kerr-Conte, J.2    Gmyr, V.3    Queniat, G.4    Moerman, E.5    Thevenet, J.6
  • 38
    • 84923448295 scopus 로고    scopus 로고
    • SGLT-2 inhibitors and cardiovascular risk: Proposed pathways and review of ongoing outcome trials
    • Inzucchi SE, Zinman B, Wanner C, Ferrari R, Fitchett D, Hantel S et al. SGLT-2 inhibitors and cardiovascular risk: proposed pathways and review of ongoing outcome trials. Diab Vasc Dis Res 2015;12:90-100.
    • (2015) Diab Vasc Dis Res , vol.12 , pp. 90-100
    • Inzucchi, S.E.1    Zinman, B.2    Wanner, C.3    Ferrari, R.4    Fitchett, D.5    Hantel, S.6
  • 40
    • 84882251091 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: A systematic review and meta-analysis
    • Vasilakou D, Karagiannis T, Athanasiadou E, Mainou M, Liakos A, Bekiari E et al. Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis. Ann Intern Med 2013;159:262-274.
    • (2013) Ann Intern Med , vol.159 , pp. 262-274
    • Vasilakou, D.1    Karagiannis, T.2    Athanasiadou, E.3    Mainou, M.4    Liakos, A.5    Bekiari, E.6
  • 42
    • 84908332537 scopus 로고    scopus 로고
    • Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: A 104-week randomised, active-controlled, double-blind, phase 3 trial
    • Ridderstrale M, Andersen KR, Zeller C, Kim G, Woerle HJ, Broedl UC et al. Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trial. Lancet Diabetes Endocrinol 2014;2:691-700.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 691-700
    • Ridderstrale, M.1    Andersen, K.R.2    Zeller, C.3    Kim, G.4    Woerle, H.J.5    Broedl, U.C.6
  • 43
    • 84892479365 scopus 로고    scopus 로고
    • Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin
    • Bolinder J, Ljunggren O, Johansson L, Wilding J, Langkilde AM, Sjostrom CD et al. Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin. Diabetes Obes Metab 2014;16:159-169.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 159-169
    • Bolinder, J.1    Ljunggren, O.2    Johansson, L.3    Wilding, J.4    Langkilde, A.M.5    Sjostrom, C.D.6
  • 44
    • 84884167643 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    • Cefalu WT, Leiter LA, Yoon KH, Arias P, Niskanen L, Xie J et al. Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial. Lancet 2013;382:941-950.
    • (2013) Lancet , vol.382 , pp. 941-950
    • Cefalu, W.T.1    Leiter, L.A.2    Yoon, K.H.3    Arias, P.4    Niskanen, L.5    Xie, J.6
  • 45
    • 84945455839 scopus 로고    scopus 로고
    • Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes
    • Chilton R, Tikkanen I, Cannon CP, Crowe S, Woerle HJ, Broedl UC et al. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes Obes Metab 2015;17:1180-1193.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 1180-1193
    • Chilton, R.1    Tikkanen, I.2    Cannon, C.P.3    Crowe, S.4    Woerle, H.J.5    Broedl, U.C.6
  • 46
    • 84892959743 scopus 로고    scopus 로고
    • The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
    • Cherney DZ, Perkins BA, Soleymanlou N, Har R, Fagan N, Johansen OE et al. The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus. Cardiovasc Diabetol 2014;13:28.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 28
    • Cherney, D.Z.1    Perkins, B.A.2    Soleymanlou, N.3    Har, R.4    Fagan, N.5    Johansen, O.E.6
  • 47
    • 84893214045 scopus 로고    scopus 로고
    • Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus
    • Cherney DZ, Perkins BA, Soleymanlou N, Maione M, Lai V, Lee A et al. Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation 2014;129:587-597.
    • (2014) Circulation , vol.129 , pp. 587-597
    • Cherney, D.Z.1    Perkins, B.A.2    Soleymanlou, N.3    Maione, M.4    Lai, V.5    Lee, A.6
  • 48
    • 84890572455 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on cardiovascular risk: A meta-analysis of randomized clinical trials
    • Monami M, Dicembrini I, Nardini C, Fiordelli I, Mannucci E. Effects of glucagon-like peptide-1 receptor agonists on cardiovascular risk: a meta-analysis of randomized clinical trials. Diabetes Obes Metab 2014;16:38-47.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 38-47
    • Monami, M.1    Dicembrini, I.2    Nardini, C.3    Fiordelli, I.4    Mannucci, E.5
  • 49
    • 84899960517 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: A pooled analysis of clinical studies
    • Sinclair A, Bode B, Harris S, Vijapurkar U, Mayer C, Fung A et al. Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. BMC Endocr Disord 2014;14:37.
    • (2014) BMC Endocr Disord , vol.14 , pp. 37
    • Sinclair, A.1    Bode, B.2    Harris, S.3    Vijapurkar, U.4    Mayer, C.5    Fung, A.6
  • 50
    • 84964696031 scopus 로고    scopus 로고
    • Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice
    • Lin B, Koibuchi N, Hasegawa Y, Sueta D, Toyama K, Uekawa K et al. Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice. Cardiovasc Diabetol 2014;13:148.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 148
    • Lin, B.1    Koibuchi, N.2    Hasegawa, Y.3    Sueta, D.4    Toyama, K.5    Uekawa, K.6
  • 51
    • 70449729537 scopus 로고    scopus 로고
    • SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states
    • Banerjee SK, McGaffin KR, Pastor-Soler NM, Ahmad F. SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states. Cardiovasc Res 2009;84:111-118.
    • (2009) Cardiovasc Res , vol.84 , pp. 111-118
    • Banerjee, S.K.1    McGaffin, K.R.2    Pastor-Soler, N.M.3    Ahmad, F.4
  • 52
    • 84892576563 scopus 로고    scopus 로고
    • Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia
    • Rieg T, Masuda T, Gerasimova M, Mayoux E, Platt K, Powell DR et al. Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia. Am J Physiol Renal Physiol 2014;306:F188-F193.
    • (2014) Am J Physiol Renal Physiol , vol.306 , pp. F188-F193
    • Rieg, T.1    Masuda, T.2    Gerasimova, M.3    Mayoux, E.4    Platt, K.5    Powell, D.R.6
  • 53
    • 0037046203 scopus 로고    scopus 로고
    • Adaptation and maladaptation of the heart in diabetes: Part I: General concepts
    • Taegtmeyer H, McNulty P, Young ME. Adaptation and maladaptation of the heart in diabetes: Part I: general concepts. Circulation 2002;105:1727-1733.
    • (2002) Circulation , vol.105 , pp. 1727-1733
    • Taegtmeyer, H.1    McNulty, P.2    Young, M.E.3
  • 54
    • 84975698839 scopus 로고    scopus 로고
    • Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: Results of the EMPA-REG OUTCOME(R) trial
    • Fitchett D, Zinman B, Wanner C, Lachin JM, Hantel S, Salsali A et al. Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME(R) trial. Eur Heart J 2016;
    • (2016) Eur Heart J
    • Fitchett, D.1    Zinman, B.2    Wanner, C.3    Lachin, J.M.4    Hantel, S.5    Salsali, A.6
  • 56
    • 84908514103 scopus 로고    scopus 로고
    • Sodium glucose cotransport-2 inhibition and intrarenal RAS activity in people with type 1 diabetes
    • Cherney DZ, Perkins BA, Soleymanlou N, Xiao F, Zimpelmann J, Woerle HJ et al. Sodium glucose cotransport-2 inhibition and intrarenal RAS activity in people with type 1 diabetes. Kidney Int 2014;86:1057-1058.
    • (2014) Kidney Int , vol.86 , pp. 1057-1058
    • Cherney, D.Z.1    Perkins, B.A.2    Soleymanlou, N.3    Xiao, F.4    Zimpelmann, J.5    Woerle, H.J.6
  • 57
    • 84898854471 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: A systematic review and meta-analysis
    • Baker WL, Smyth LR, Riche DM, Bourret EM, Chamberlin KW, White WB. Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis. J Am Soc Hypertens 2014;8:262-275 e9.
    • (2014) J Am Soc Hypertens , vol.8 , pp. 262-275e9
    • Baker, W.L.1    Smyth, L.R.2    Riche, D.M.3    Bourret, E.M.4    Chamberlin, K.W.5    White, W.B.6
  • 58
    • 84880850027 scopus 로고    scopus 로고
    • Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
    • Lambers Heerspink HJ, de Zeeuw D, Wie L, Leslie B, List J. Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab 2013;15:853-862.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 853-862
    • Lambers Heerspink, H.J.1    De Zeeuw, D.2    Wie, L.3    Leslie, B.4    List, J.5
  • 59
    • 0016659653 scopus 로고
    • The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man
    • DeFronzo RA, Cooke CR, Andres R, Faloona GR, Davis PJ. The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. J Clin Invest 1975;55:845-855.
    • (1975) J Clin Invest , vol.55 , pp. 845-855
    • DeFronzo, R.A.1    Cooke, C.R.2    Andres, R.3    Faloona, G.R.4    Davis, P.J.5
  • 60
    • 0028089126 scopus 로고
    • Sodium metabolism, hypertension, and diabetes
    • Weder AB. Sodium metabolism, hypertension, and diabetes. Am J Med Sci 1994; 307(Suppl. 1):S53-S59.
    • (1994) Am J Med Sci , vol.307 , pp. S53-S59
    • Weder, A.B.1
  • 61
    • 0026035348 scopus 로고
    • Central role of sodium in hypertension in diabetic subjects
    • Weidmann P, Ferrari P. Central role of sodium in hypertension in diabetic subjects. Diabetes Care 1991;14:220-232.
    • (1991) Diabetes Care , vol.14 , pp. 220-232
    • Weidmann, P.1    Ferrari, P.2
  • 62
    • 84873059580 scopus 로고    scopus 로고
    • Late sodium current inhibition in acquired and inherited ventricular (dys)function and arrhythmias
    • Remme CA, Wilde AA. Late sodium current inhibition in acquired and inherited ventricular (dys)function and arrhythmias. Cardiovasc Drugs Ther 2013;27:91-101.
    • (2013) Cardiovasc Drugs Ther , vol.27 , pp. 91-101
    • Remme, C.A.1    Wilde, A.A.2
  • 63
    • 0030940680 scopus 로고    scopus 로고
    • The role of the Na+ channel in the accumulation of intracellular Na+ during myocardial ischemia: Consequences for post-ischemic recovery
    • van Emous JG, Nederhoff MG, Ruigrok TJ, van Echteld CJ. The role of the Na+ channel in the accumulation of intracellular Na+ during myocardial ischemia: consequences for post-ischemic recovery. J Mol Cell Cardiol 1997;29:85-96.
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 85-96
    • Van Emous, J.G.1    Nederhoff, M.G.2    Ruigrok, T.J.3    Van Echteld, C.J.4
  • 64
    • 84903195508 scopus 로고    scopus 로고
    • Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure
    • Liu T, Takimoto E, Dimaano VL, DeMazumder D, Kettlewell S, SmithG et al. Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure. Circ Res 2014;115:44-54.
    • (2014) Circ Res , vol.115 , pp. 44-54
    • Liu, T.1    Takimoto, E.2    Dimaano, V.L.3    DeMazumder, D.4    Kettlewell, S.5    Smith, G.6
  • 65
    • 67349275999 scopus 로고    scopus 로고
    • Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus
    • Komoroski B, Vachharajani N, Feng Y, Li L, Kornhauser D, Pfister M. Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus. Clin Pharmacol Ther 2009;85: 513-519.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 513-519
    • Komoroski, B.1    Vachharajani, N.2    Feng, Y.3    Li, L.4    Kornhauser, D.5    Pfister, M.6
  • 66
    • 84906795005 scopus 로고    scopus 로고
    • Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy
    • Kitada K, Nakano D, Ohsaki H, Hitomi H, Minamino T, Yatabe J et al. Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. J Diabetes Complicat 2014;28: 604-611.
    • (2014) J Diabetes Complicat , vol.28 , pp. 604-611
    • Kitada, K.1    Nakano, D.2    Ohsaki, H.3    Hitomi, H.4    Minamino, T.5    Yatabe, J.6
  • 67
    • 84885476895 scopus 로고    scopus 로고
    • Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice
    • Tahara A, Kurosaki E, Yokono M, Yamajuku D, Kihara R, Hayashizaki Y et al. Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. Eur J Pharmacol 2013;715:246-255.
    • (2013) Eur J Pharmacol , vol.715 , pp. 246-255
    • Tahara, A.1    Kurosaki, E.2    Yokono, M.3    Yamajuku, D.4    Kihara, R.5    Hayashizaki, Y.6
  • 68
    • 0015024929 scopus 로고
    • Haemodynamic effects of glucagon during acute myocardial infarction with left ventricular failure in man
    • Diamond G, Forrester J, Danzig R, ParmleyWW, Swan HJ. Haemodynamic effects of glucagon during acute myocardial infarction with left ventricular failure in man. Br Heart J 1971;33:290-295.
    • (1971) Br Heart J , vol.33 , pp. 290-295
    • Diamond, G.1    Forrester, J.2    Danzig, R.3    Parmley, W.W.4    Swan, H.J.5
  • 70
    • 0032768735 scopus 로고    scopus 로고
    • A review of potential cardiovascular uses of intravenous glucagon administration
    • White CM. A review of potential cardiovascular uses of intravenous glucagon administration. J Clin Pharmacol 1999;39:442-447.
    • (1999) J Clin Pharmacol , vol.39 , pp. 442-447
    • White, C.M.1
  • 71
    • 0015135764 scopus 로고
    • Effect of glucagon on ventricular arrhythmias after coronary artery occlusion and on ventricular automaticity in the dog
    • Madan BR. Effect of glucagon on ventricular arrhythmias after coronary artery occlusion and on ventricular automaticity in the dog. Br J Pharmacol 1971;43: 279-286.
    • (1971) Br J Pharmacol , vol.43 , pp. 279-286
    • Madan, B.R.1


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