-
1
-
-
79956327715
-
Using electronic health records to drive discovery in disease genomics
-
Kohane, I.S. (2011) Using electronic health records to drive discovery in disease genomics. Nat. Rev. Genet., 12, 417
-
(2011)
Nat. Rev. Genet
, vol.12
, pp. 417
-
-
Kohane, I.S.1
-
2
-
-
77952822074
-
PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations
-
Denny, J.C., Ritchie, M.D., Basford, M.A., Pulley, J.M., Bastarache, L., Brown-Gentry, K., Wang, D., Masys, D.R., Roden, D.M. and Crawford, D.C. (2010) PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics, 26, 1205-1210
-
(2010)
Bioinformatics
, vol.26
, pp. 1205-1210
-
-
Denny, J.C.1
Ritchie, M.D.2
Basford, M.A.3
Pulley, J.M.4
Bastarache, L.5
Brown-Gentry, K.6
Wang, D.7
Masys, D.R.8
Roden, D.M.9
Crawford, D.C.10
-
3
-
-
85048598103
-
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies
-
Zhou, W., Nielsen, J.B., Fritsche, L.G., Dey, R., Elvestad, M.B., Wolford, B.N., LeFaive, J., VandeHaar, P., Gifford, A., Bastarache, L.A. et al. (2017) Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. bioRxiv, 212357. https://doi.org/10.1101/212357
-
(2017)
BioRxiv
-
-
Zhou, W.1
Nielsen, J.B.2
Fritsche, L.G.3
Dey, R.4
Elvestad, M.B.5
Wolford, B.N.6
LeFaive, J.7
VandeHaar, P.8
Gifford, A.9
Bastarache, L.A.10
-
4
-
-
0032980338
-
An Icelandic saga on a centralized healthcare database and democratic decision making
-
Gulcher, J. and Stefansson, K. (1999) An Icelandic saga on a centralized healthcare database and democratic decision making. Nat. Biotechnol., 17, 620
-
(1999)
Nat. Biotechnol
, vol.17
, pp. 620
-
-
Gulcher, J.1
Stefansson, K.2
-
5
-
-
77953429952
-
Principles of human subjects protections applied in an opt-out, de-identified biobank
-
Pulley, J., Clayton, E., Bernard, G.R., Roden, D.M. and Masys, D.R. (2010) Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin. Transl. Sci., 3, 42-48
-
(2010)
Clin. Transl. Sci
, vol.3
, pp. 42-48
-
-
Pulley, J.1
Clayton, E.2
Bernard, G.R.3
Roden, D.M.4
Masys, D.R.5
-
6
-
-
79251581866
-
The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies
-
McCarty, C.A., Chisholm, R.L., Chute, C.G., Kullo, I.J., Jarvik, G.P., Larson, E.B., Li, R., Masys, D.R., Ritchie, M.D., Roden, D.M. et al. (2011) The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med. Genom., 4, 13
-
(2011)
BMC Med. Genom
, vol.4
, pp. 13
-
-
McCarty, C.A.1
Chisholm, R.L.2
Chute, C.G.3
Kullo, I.J.4
Jarvik, G.P.5
Larson, E.B.6
Li, R.7
Masys, D.R.8
Ritchie, M.D.9
Roden, D.M.10
-
7
-
-
84939426058
-
Genotyping informatics and quality control for 100, 000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
-
Kvale, M.N., Hesselson, S., Hoffmann, T.J., Cao, Y., Chan, D., Connell, S., Croen, L.A., Dispensa, B.P., Eshragh, J., Finn, A. et al. (2015) Genotyping informatics and quality control for 100, 000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics, 200, 1051-1060
-
(2015)
Genetics
, vol.200
, pp. 1051-1060
-
-
Kvale, M.N.1
Hesselson, S.2
Hoffmann, T.J.3
Cao, Y.4
Chan, D.5
Connell, S.6
Croen, L.A.7
Dispensa, B.P.8
Eshragh, J.9
Finn, A.10
-
8
-
-
84938292742
-
The support of human genetic evidence for approved drug indications
-
Floratos, A., Tipney, H., Painter, J.L., Whittaker, J.C., Shen, J., Wang, J., Cardon, L.R., Nelson, M.R., Li, M.J., Sham, P.C. et al. (2015) The support of human genetic evidence for approved drug indications. Nat. Genet., 47, 856
-
(2015)
Nat. Genet
, vol.47
, pp. 856
-
-
Floratos, A.1
Tipney, H.2
Painter, J.L.3
Whittaker, J.C.4
Shen, J.5
Wang, J.6
Cardon, L.R.7
Nelson, M.R.8
Li, M.J.9
Sham, P.C.10
-
9
-
-
85039768359
-
Genome-wide genetic data on 500 000 UK Biobank participants
-
Bycroft, C., Freeman, C., Petkova, D., Band, G., Elliott, L.T., Sharp, K., Motyer, A., Vukcevic, D., Delaneau, O., O'Connell, J. et al. (2017) Genome-wide genetic data on 500 000 UK Biobank participants. bioRxiv, 166298. https://doi.org/10. 1101/166298
-
(2017)
bioRxiv
-
-
Bycroft, C.1
Freeman, C.2
Petkova, D.3
Band, G.4
Elliott, L.T.5
Sharp, K.6
Motyer, A.7
Vukcevic, D.8
Delaneau, O.9
O'Connell, J.10
-
10
-
-
85048598489
-
Regeneron announces major collaboration to exome sequence UK Biobank genetic data more quickly
-
date last accessed March 14, 2018
-
UK Biobank. (2018). Regeneron announces major collaboration to exome sequence UK Biobank genetic data more quickly. Retrieved from http://www.ukbiobank.ac.uk/2018/01/regeneron-announces-major-collaboration-to-exome-se quence-uk-biobank-genetic-data-more-quickly/; date last accessed March 14, 2018
-
(2018)
-
-
-
12
-
-
85048604025
-
Genetic analysis of lipids in >300 000 participants in the Million Veteran Program; #186
-
October 20 2017 Orlando, FL
-
Klarin, S.D., Cho, S., Duvall, G., Peloso, K.M., Chang, J., Huang, J., Lynch, Y.L., Ho, D., Liu, D., Saleheen, S., et al. (2017) Genetic analysis of lipids in >300 000 participants in the Million Veteran Program; #1869. Presented at the 67th Annual meeting of American Society of Human Genetics. October 20, 2017, Orlando, FL
-
(2017)
Presented at the 67th Annual meeting of American Society of Human Genetics
-
-
Klarin, S.D.1
Cho, S.2
Duvall, G.3
Peloso, K.M.4
Chang, J.5
Huang, J.6
Lynch, Y.L.7
Ho, D.8
Liu, D.9
Saleheen, S.10
-
13
-
-
84957436835
-
Million Veteran Program: a mega-biobank to study genetic influences on health and disease
-
Gaziano, J.M., Concato, J., Brophy, M., Fiore, L., Pyarajan, S., Breeling, J., Whitbourne, S., Deen, J., Shannon, C., Humphries, D. et al. (2016) Million Veteran Program: a mega-biobank to study genetic influences on health and disease. J. Clin. Epidemiol., 70, 214-223
-
(2016)
J. Clin. Epidemiol
, vol.70
, pp. 214-223
-
-
Gaziano, J.M.1
Concato, J.2
Brophy, M.3
Fiore, L.4
Pyarajan, S.5
Breeling, J.6
Whitbourne, S.7
Deen, J.8
Shannon, C.9
Humphries, D.10
-
14
-
-
84899144478
-
Identifying large sets of unrelated individuals and unrelated markers
-
Abraham, K.J. and Diaz, C. (2014) Identifying large sets of unrelated individuals and unrelated markers. Source Code Biol. Med., 9, 6
-
(2014)
Source Code Biol. Med
, vol.9
, pp. 6
-
-
Abraham, K.J.1
Diaz, C.2
-
15
-
-
84884802607
-
Cohort profile: the HUNT Study, Norway
-
Krokstad, S., Langhammer, A., Hveem, K., Holmen, T.L., Midthjell, K., Stene, T.R., Bratberg, G., Heggland, J. and Holmen, J. (2013) Cohort profile: the HUNT Study, Norway. Int. J. Epidemiol., 42, 968-977
-
(2013)
Int. J. Epidemiol
, vol.42
, pp. 968-977
-
-
Krokstad, S.1
Langhammer, A.2
Hveem, K.3
Holmen, T.L.4
Midthjell, K.5
Stene, T.R.6
Bratberg, G.7
Heggland, J.8
Holmen, J.9
-
16
-
-
84924060689
-
Efficient Bayesian mixed-model analysis increases association power in large cohorts
-
Loh, P.-R., Tucker, G., Bulik-Sullivan, B.K., Vilhjálmsson, B.J., Finucane, H.K., Salem, R.M., Chasman, D.I., Ridker, P.M., Neale, B.M., Berger, B. et al. (2015) Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat. Genet., 47, 284-290
-
(2015)
Nat. Genet
, vol.47
, pp. 284-290
-
-
Loh, P.-R.1
Tucker, G.2
Bulik-Sullivan, B.K.3
Vilhjálmsson, B.J.4
Finucane, H.K.5
Salem, R.M.6
Chasman, D.I.7
Ridker, P.M.8
Neale, B.M.9
Berger, B.10
-
17
-
-
85020254440
-
A fast and accurate algorithm to test for binary phenotypes and its application to PheWAS
-
Dey, R., Schmidt, E.M., Abecasis, G.R. and Lee, S. (2017) A fast and accurate algorithm to test for binary phenotypes and its application to PheWAS. Am. J. Hum. Genet., 101, 37-49
-
(2017)
Am. J. Hum. Genet
, vol.101
, pp. 37-49
-
-
Dey, R.1
Schmidt, E.M.2
Abecasis, G.R.3
Lee, S.4
-
18
-
-
84880059657
-
The electronic medical records and genomics (eMERGE) network: past, present, and future
-
Gottesman, O., Kuivaniemi, H., Tromp, G., Faucett, W.A., Li, R., Manolio, T.A., Sanderson, S.C., Kannry, J., Zinberg, R., Basford, M.A. et al. (2013) The electronic medical records and genomics (eMERGE) network: past, present, and future. Genet. Med., 15, 761
-
(2013)
Genet. Med
, vol.15
, pp. 761
-
-
Gottesman, O.1
Kuivaniemi, H.2
Tromp, G.3
Faucett, W.A.4
Li, R.5
Manolio, T.A.6
Sanderson, S.C.7
Kannry, J.8
Zinberg, R.9
Basford, M.A.10
-
19
-
-
85022176529
-
Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record
-
Wei, W.-Q., Bastarache, L.A., Carroll, R.J., Marlo, J.E., Osterman, T.J., Gamazon, E.R., Cox, N.J., Roden, D.M. and Denny, J.C. (2017) Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record. PLoS ONE, 12, e0175508
-
(2017)
PLoS ONE
, vol.12
-
-
Wei, W.-Q.1
Bastarache, L.A.2
Carroll, R.J.3
Marlo, J.E.4
Osterman, T.J.5
Gamazon, E.R.6
Cox, N.J.7
Roden, D.M.8
Denny, J.C.9
-
20
-
-
84890107642
-
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data
-
Denny, J.C., Bastarache, L., Ritchie, M.D., Carroll, R.J., Zink, R., Mosley, J.D., Field, J.R., Pulley, J.M., Ramirez, A.H., Bowton, E. et al. (2013) Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat. Biotechnol., 31, 1102
-
(2013)
Nat. Biotechnol
, vol.31
, pp. 1102
-
-
Denny, J.C.1
Bastarache, L.2
Ritchie, M.D.3
Carroll, R.J.4
Zink, R.5
Mosley, J.D.6
Field, J.R.7
Pulley, J.M.8
Ramirez, A.H.9
Bowton, E.10
-
21
-
-
84991527531
-
Methodological challenges and analytic opportunities for modeling and interpreting Big Healthcare Data
-
Dinov, I.D. (2016) Methodological challenges and analytic opportunities for modeling and interpreting Big Healthcare Data. Gigascience, 5, 12
-
(2016)
Gigascience
, vol.5
, pp. 12
-
-
Dinov, I.D.1
-
22
-
-
85028633613
-
Improving power of association tests using multiple sets of imputed genotypes from distributed reference panels
-
Zhou, W., Fritsche, L.G., Das, S., Zhang, H., Nielsen, J.B., Holmen, O.L., Chen, J., Lin, M., Elvestad, M.B., Hveem, K. et al. (2017) Improving power of association tests using multiple sets of imputed genotypes from distributed reference panels. Genet. Epidemiol., 41, 744-755
-
(2017)
Genet. Epidemiol
, vol.41
, pp. 744-755
-
-
Zhou, W.1
Fritsche, L.G.2
Das, S.3
Zhang, H.4
Nielsen, J.B.5
Holmen, O.L.6
Chen, J.7
Lin, M.8
Elvestad, M.B.9
Hveem, K.10
-
23
-
-
84941702459
-
Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel
-
Huang, J., Howie, B., McCarthy, S., Memari, Y., Walter, K., Min, J.L., Danecek, P., Malerba, G., Trabetti, E., Zheng, H.-F. et al. (2015) Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Nat. Commun., 6, 8111
-
(2015)
Nat. Commun
, vol.6
, pp. 8111
-
-
Huang, J.1
Howie, B.2
McCarthy, S.3
Memari, Y.4
Walter, K.5
Min, J.L.6
Danecek, P.7
Malerba, G.8
Trabetti, E.9
Zheng, H.-F.10
-
24
-
-
84929132687
-
Large-scale whole-genome sequencing of the Icelandic population
-
Gudbjartsson, D.F., Helgason, H., Gudjonsson, S.A., Zink, F., Oddson, A., Gylfason, A., Besenbacher, S., Magnusson, G., Halldorsson, B.V., Hjartarson, E. et al. (2015) Large-scale whole-genome sequencing of the Icelandic population. Nat. Genet., 47, 435-444
-
(2015)
Nat. Genet
, vol.47
, pp. 435-444
-
-
Gudbjartsson, D.F.1
Helgason, H.2
Gudjonsson, S.A.3
Zink, F.4
Oddson, A.5
Gylfason, A.6
Besenbacher, S.7
Magnusson, G.8
Halldorsson, B.V.9
Hjartarson, E.10
-
26
-
-
84983479616
-
A reference panel of 64, 976 haplotypes for genotype imputation
-
McCarthy, S., Das, S., Kretzschmar, W., Delaneau, O., Wood, A.R., Teumer, A., Kang, H.M., Fuchsberger, C., Danecek, P., et al. (2016) A reference panel of 64, 976 haplotypes for genotype imputation. Nat. Genet., 48, 1279
-
(2016)
Nat. Genet
, vol.48
, pp. 1279
-
-
McCarthy, S.1
Das, S.2
Kretzschmar, W.3
Delaneau, O.4
Wood, A.R.5
Teumer, A.6
Kang, H.M.7
Fuchsberger, C.8
Danecek, P.9
-
27
-
-
84984598118
-
Next-generation genotype imputation service and methods
-
Das, S., Forer, L., Schönherr, S., Sidore, C., Locke, A.E., Kwong, A., Vrieze, S.I., Chew, E.Y., Levy, S., McGue, M. et al. (2016) Next-generation genotype imputation service and methods. Nat. Genet., 48, 1284-1287
-
(2016)
Nat. Genet
, vol.48
, pp. 1284-1287
-
-
Das, S.1
Forer, L.2
Schönherr, S.3
Sidore, C.4
Locke, A.E.5
Kwong, A.6
Vrieze, S.I.7
Chew, E.Y.8
Levy, S.9
McGue, M.10
-
28
-
-
79959524146
-
A haplotype map of the human genome
-
International HapMap Consortium (2005) A haplotype map of the human genome. Nature, 437, 1299-1320
-
(2005)
Nature
, vol.437
, pp. 1299-1320
-
-
-
29
-
-
0029741063
-
The future of genetic studies of complex human diseases
-
Risch, N. and Merikangas, K. (1996) The future of genetic studies of complex human diseases. Science, 273, 1516-1517
-
(1996)
Science
, vol.273
, pp. 1516-1517
-
-
Risch, N.1
Merikangas, K.2
-
30
-
-
39649108872
-
Genome-wide significance for dense SNP and resequencing data
-
Hoggart, C.J., Clark, T.G., De Iorio, M., Whittaker, J.C. and Balding, D.J. (2008) Genome-wide significance for dense SNP and resequencing data. Genet. Epidemiol., 32, 179-185
-
(2008)
Genet. Epidemiol
, vol.32
, pp. 179-185
-
-
Hoggart, C.J.1
Clark, T.G.2
De Iorio, M.3
Whittaker, J.C.4
Balding, D.J.5
-
31
-
-
85028693072
-
Association analyses based on false discovery rate implicate new loci for coronary artery disease
-
Nelson, C.P., Goel, A., Butterworth, A.S., Kanoni, S., Webb, T.R., Marouli, E., Zeng, L., Ntalla, I., Lai, F.Y., Hopewell, J.C. et al. (2017) Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nat. Genet., 49, 1385-1391
-
(2017)
Nat. Genet
, vol.49
, pp. 1385-1391
-
-
Nelson, C.P.1
Goel, A.2
Butterworth, A.S.3
Kanoni, S.4
Webb, T.R.5
Marouli, E.6
Zeng, L.7
Ntalla, I.8
Lai, F.Y.9
Hopewell, J.C.10
-
32
-
-
85018389876
-
Phenome-wide heritability analysis of the UK Biobank
-
Ge, T., Chen, C.-Y., Neale, B.M., Sabuncu, M.R. and Smoller, J.W. (2017) Phenome-wide heritability analysis of the UK Biobank. PLoS Genet., 13, e1006711
-
(2017)
PLoS Genet
, vol.13
-
-
Ge, T.1
Chen, C.-Y.2
Neale, B.M.3
Sabuncu, M.R.4
Smoller, J.W.5
-
33
-
-
85000692305
-
An atlas of genetic correlations across human diseases and traits
-
Bulik-Sullivan, B., Finucane, H.K., Anttila, V., Gusev, A., Day, F.R., Loh, P.-R., Duncan, L., Perry, J.R.B., Patterson, N., Robinson, E.B. et al. (2015) An atlas of genetic correlations across human diseases and traits. Nat. Genet., 47, 1236-1241
-
(2015)
Nat. Genet
, vol.47
, pp. 1236-1241
-
-
Bulik-Sullivan, B.1
Finucane, H.K.2
Anttila, V.3
Gusev, A.4
Day, F.R.5
Loh, P.-R.6
Duncan, L.7
Perry, J.R.B.8
Patterson, N.9
Robinson, E.B.10
-
34
-
-
85041590577
-
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases
-
Kanai, M., Akiyama, M., Takahashi, A., Matoba, N., Momozawa, Y., Ikeda, M., Iwata, N., Ikegawa, S., Hirata, M., Matsuda, K. et al. (2018) Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. Nat. Genet. doi:10.1038/s41588-018-0047-6
-
(2018)
Nat. Genet
-
-
Kanai, M.1
Akiyama, M.2
Takahashi, A.3
Matoba, N.4
Momozawa, Y.5
Ikeda, M.6
Iwata, N.7
Ikegawa, S.8
Hirata, M.9
Matsuda, K.10
-
35
-
-
85007330927
-
PCSK9 genetic variants and risk of type 2 diabetes: a Mendelian randomisation study
-
Schmidt, A.F., Swerdlow, D.I., Holmes, M.V., Patel, R.S., Fairhurst-Hunter, Z., Lyall, D.M., Hartwig, F.P., Horta, B.L., Hyppönen, E., Power, C. et al. (2017) PCSK9 genetic variants and risk of type 2 diabetes: a Mendelian randomisation study. Lancet Diabetes Endocrinol., 5, 97-105
-
(2017)
Lancet Diabetes Endocrinol
, vol.5
, pp. 97-105
-
-
Schmidt, A.F.1
Swerdlow, D.I.2
Holmes, M.V.3
Patel, R.S.4
Fairhurst-Hunter, Z.5
Lyall, D.M.6
Hartwig, F.P.7
Horta, B.L.8
Hyppönen, E.9
Power, C.10
-
36
-
-
85035099523
-
Using human 'experiments of nature' to predict drug safety issues: an example with PCSK9 inhibitors
-
Jerome, R.N., Pulley, J.M., Roden, D.M., Shirey-Rice, J.K., Bastarache, L.A., Bernard, G.R., Ekstrom, L.B., Lancaster, W.J. and Denny, J.C. (2017) Using human 'experiments of nature' to predict drug safety issues: an example with PCSK9 inhibitors. Drug Saf., 41, 303-311
-
(2017)
Drug Saf
, vol.41
, pp. 303-311
-
-
Jerome, R.N.1
Pulley, J.M.2
Roden, D.M.3
Shirey-Rice, J.K.4
Bastarache, L.A.5
Bernard, G.R.6
Ekstrom, L.B.7
Lancaster, W.J.8
Denny, J.C.9
-
37
-
-
85048633432
-
Phenomewide association study of life course health events: Analyzing 50 yaers of hospitalization, prescription drug use and death data; #37
-
October 21 2017, Orlando, FL
-
Ripatti, S., Havulinna, A., Kiiskinen, T., Helkkula, P., Hautakangas, H., Häppölä, P., Ruotsalainen, S., Koskela, J., Kurki, M., Surakka, I. et al. (2017) Phenomewide association study of life course health events: Analyzing 50 yaers of hospitalization, prescription drug use and death data; #372. Presented at the 67th Annual meeting of American Society of Human Genetics. October 21, 2017, Orlando, FL
-
(2017)
Presented at the 67th Annual meeting of American Society of Human Genetics
-
-
Ripatti, S.1
Havulinna, A.2
Kiiskinen, T.3
Helkkula, P.4
Hautakangas, H.5
Häppölä, P.6
Ruotsalainen, S.7
Koskela, J.8
Kurki, M.9
Surakka, I.10
-
38
-
-
84962866425
-
Variants near CHRNA3/5 and APOE have age-and sex-related effects on human lifespan
-
Joshi, P.K., Fischer, K., Schraut, K.E., Campbell, H., Esko, T. and Wilson, J.F. (2016) Variants near CHRNA3/5 and APOE have age-and sex-related effects on human lifespan. Nat. Commun., 7, 11174
-
(2016)
Nat. Commun
, vol.7
-
-
Joshi, P.K.1
Fischer, K.2
Schraut, K.E.3
Campbell, H.4
Esko, T.5
Wilson, J.F.6
-
39
-
-
85009815269
-
Case-control association mapping by proxy using family history of disease
-
Liu, J.Z., Erlich, Y. and Pickrell, J.K. (2017) Case-control association mapping by proxy using family history of disease. Nat. Genet., 49, 325-331
-
(2017)
Nat. Genet
, vol.49
, pp. 325-331
-
-
Liu, J.Z.1
Erlich, Y.2
Pickrell, J.K.3
-
40
-
-
85048626865
-
GWAS on family history of Alzheimer's disease
-
Marioni, R., Harris, S.E., McRae, A.F., Zhang, Q., Hagenaars, S.P., Hill, W.D., Davies, G., Ritchie, C.W., Gale, C., Starr, J.M. et al. (2018) GWAS on family history of Alzheimer's disease. bioRxiv, 246223. https://doi.org/10.1101/246223
-
(2018)
bioRxiv
-
-
Marioni, R.1
Harris, S.E.2
McRae, A.F.3
Zhang, Q.4
Hagenaars, S.P.5
Hill, W.D.6
Davies, G.7
Ritchie, C.W.8
Gale, C.9
Starr, J.M.10
-
41
-
-
84994229145
-
Genome-wide association for major depression through age at onset stratification: major depressive disorder working group of the Psychiatric Genomics Consortium
-
Power, R.A., Tansey, K.E., Buttenschøn, H.N., Cohen-Woods, S., Bigdeli, T., Hall, L.S., Kutalik, Z., Lee, S.H., Ripke, S., Steinberg, S. et al. (2017) Genome-wide association for major depression through age at onset stratification: major depressive disorder working group of the Psychiatric Genomics Consortium. Biol. Psychiatry, 81, 325-335
-
(2017)
Biol. Psychiatry
, vol.81
, pp. 325-335
-
-
Power, R.A.1
Tansey, K.E.2
Buttenschøn, H.N.3
Cohen-Woods, S.4
Bigdeli, T.5
Hall, L.S.6
Kutalik, Z.7
Lee, S.H.8
Ripke, S.9
Steinberg, S.10
-
42
-
-
85007138010
-
Genetic identification of familial hypercholesterolemia within a single U.S health care system
-
Abul-Husn, N.S., Manickam, K., Jones, L.K., Wright, E.A., Hartzel, D.N., Gonzaga-Jauregui, C., O'Dushlaine, C., Leader, J.B., Lester Kirchner, H., Lindbuchler, D.A.M. et al. (2016) Genetic identification of familial hypercholesterolemia within a single U.S. health care system. Science, 354, aaf7000
-
(2016)
Science
, vol.354
-
-
Abul-Husn, N.S.1
Manickam, K.2
Jones, L.K.3
Wright, E.A.4
Hartzel, D.N.5
Gonzaga-Jauregui, C.6
O'Dushlaine, C.7
Leader, J.B.8
Lester Kirchner, H.9
Lindbuchler, D.A.M.10
-
43
-
-
84961948174
-
Inactivating variants in ANGPTL4 and risk of coronary artery disease
-
Dewey, F.E., Gusarova, V., O'Dushlaine, C., Gottesman, O., Trejos, J., Hunt, C., Van Hout, C.V., Habegger, L., Buckler, D., Lai, K.-M.V. et al. (2016) Inactivating variants in ANGPTL4 and risk of coronary artery disease. N. Engl. J.Med., 374, 1123-1133
-
(2016)
N. Engl. J.Med
, vol.374
, pp. 1123-1133
-
-
Dewey, F.E.1
Gusarova, V.2
O'Dushlaine, C.3
Gottesman, O.4
Trejos, J.5
Hunt, C.6
Van Hout, C.V.7
Habegger, L.8
Buckler, D.9
Lai, K.-M.V.10
-
44
-
-
85015922086
-
Association of rare and common variation in the lipoprotein lipase gene with coronary artery disease
-
Khera, A.V., Won, H.-H., Peloso, G.M., O'Dushlaine, C., Liu, D., Stitziel, N.O., Natarajan, P., Nomura, A., Emdin, C.A., Gupta, N. et al. (2017) Association of rare and common variation in the lipoprotein lipase gene with coronary artery disease. JAMA, 317, 937-946
-
(2017)
JAMA
, vol.317
, pp. 937-946
-
-
Khera, A.V.1
Won, H.-H.2
Peloso, G.M.3
O'Dushlaine, C.4
Liu, D.5
Stitziel, N.O.6
Natarajan, P.7
Nomura, A.8
Emdin, C.A.9
Gupta, N.10
-
45
-
-
85047752186
-
The identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease
-
van der Harst, P. and Verweij, N. (2018) The identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease. Circ. Res., 122, 433-443
-
(2018)
Circ. Res
, vol.122
, pp. 433-443
-
-
van der Harst, P.1
Verweij, N.2
-
46
-
-
85048611402
-
Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation
-
Nielsen, J.B., Thorolfsdottir, R.B., Fritsche, L.G., Zhou, W., Skov, M.W., Graham, S.E., Herron, T.J., McCarthy, S., Schmidt, E.M., Sveinbjornsson, G. et al. (2018) Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation. bioRxiv, 242149. https://doi.org/10.1101/242149
-
(2018)
bioRxiv
-
-
Nielsen, J.B.1
Thorolfsdottir, R.B.2
Fritsche, L.G.3
Zhou, W.4
Skov, M.W.5
Graham, S.E.6
Herron, T.J.7
McCarthy, S.8
Schmidt, E.M.9
Sveinbjornsson, G.10
-
47
-
-
85027077950
-
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney
-
Wain, L.V., Vaez, A., Jansen, R., Joehanes, R., van der Most, P.J., Erzurumluoglu, A.M., O'Reilly, P.F., Cabrera, C.P., Warren, H.R., Rose, L.M. et al. (2017) Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney. Hypertension, 70, e4-e19
-
(2017)
Hypertension
, vol.70
-
-
Wain, L.V.1
Vaez, A.2
Jansen, R.3
Joehanes, R.4
van der Most, P.J.5
Erzurumluoglu, A.M.6
O'Reilly, P.F.7
Cabrera, C.P.8
Warren, H.R.9
Rose, L.M.10
-
48
-
-
85018974417
-
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function
-
Wild, P.S., Felix, J.F., Schillert, A., Teumer, A., Chen, M.-H., Leening, M.J.G., Völker, U., Großmann, V., Brody, J.A., Irvin, M.R. et al. (2017) Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J. Clin. Invest., 127, 1798-1812
-
(2017)
J. Clin. Invest
, vol.127
, pp. 1798-1812
-
-
Wild, P.S.1
Felix, J.F.2
Schillert, A.3
Teumer, A.4
Chen, M.-H.5
Leening, M.J.G.6
Völker, U.7
Großmann, V.8
Brody, J.A.9
Irvin, M.R.10
-
49
-
-
85039153797
-
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
-
Turcot, V., Lu, Y., Highland, H.M., Schurmann, C., Justice, A.E., Fine, R.S., Bradfield, J.P., Esko, T., Giri, A., Graff, M. et al. (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat. Genet., 50, 26-41
-
(2018)
Nat. Genet
, vol.50
, pp. 26-41
-
-
Turcot, V.1
Lu, Y.2
Highland, H.M.3
Schurmann, C.4
Justice, A.E.5
Fine, R.S.6
Bradfield, J.P.7
Esko, T.8
Giri, A.9
Graff, M.10
-
50
-
-
85035766416
-
Exome-wide association study of plasma lipids in >300, 000 individuals
-
Liu, D.J., Peloso, G.M., Yu, H., Butterworth, A.S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A.C. et al. (2017) Exome-wide association study of plasma lipids in >300, 000 individuals. Nat. Genet., 49, 1758-1766
-
(2017)
Nat. Genet
, vol.49
, pp. 1758-1766
-
-
Liu, D.J.1
Peloso, G.M.2
Yu, H.3
Butterworth, A.S.4
Wang, X.5
Mahajan, A.6
Saleheen, D.7
Emdin, C.8
Alam, D.9
Alves, A.C.10
-
51
-
-
85015504398
-
Risk of coronary artery disease in patients with ankylosing spondylitis: a systematic review and meta-analysis
-
Ungprasert, P., Srivali, N. and Kittanamongkolchai, W. (2015) Risk of coronary artery disease in patients with ankylosing spondylitis: a systematic review and meta-analysis. Ann. Transl. Med., 3, 51
-
(2015)
Ann. Transl. Med
, vol.3
, pp. 51
-
-
Ungprasert, P.1
Srivali, N.2
Kittanamongkolchai, W.3
-
52
-
-
85064168626
-
UK Biobank: opportunities for cardiovascular research
-
Littlejohns, T.J., Sudlow, C., Allen, N.E. and Collins, R. (2017) UK Biobank: opportunities for cardiovascular research. Eur. Heart J. https://doi.org/10.1093/eurheartj/ehx254
-
(2017)
Eur. Heart J
-
-
Littlejohns, T.J.1
Sudlow, C.2
Allen, N.E.3
Collins, R.4
-
53
-
-
0035097027
-
The genealogic approach to human genetics of disease
-
Gulcher, J., Kong, A. and Stefansson, K. (2001) The genealogic approach to human genetics of disease. Cancer J., 7, 61-68
-
(2001)
Cancer J
, vol.7
, pp. 61-68
-
-
Gulcher, J.1
Kong, A.2
Stefansson, K.3
-
54
-
-
85040991713
-
The nature of nurture: effects of parental genotypes
-
Kong, A., Thorleifsson, G., Frigge, M.L., Vilhjalmsson, B.J., Young, A.I., Thorgeirsson, T.E., Benonisdottir, S., Oddsson, A., Halldorsson, B.V., Masson, G. et al. (2018) The nature of nurture: effects of parental genotypes. Science, 359, 424-428
-
(2018)
Science
, vol.359
, pp. 424-428
-
-
Kong, A.1
Thorleifsson, G.2
Frigge, M.L.3
Vilhjalmsson, B.J.4
Young, A.I.5
Thorgeirsson, T.E.6
Benonisdottir, S.7
Oddsson, A.8
Halldorsson, B.V.9
Masson, G.10
-
55
-
-
85016438418
-
Overview of the BioBank Japan Project: study design and profile
-
Nagai, A., Hirata, M., Kamatani, Y., Muto, K., Matsuda, K., Kiyohara, Y., Ninomiya, T., Tamakoshi, A., Yamagata, Z., Mushiroda, T. et al. (2017) Overview of the BioBank Japan Project: study design and profile. J. Epidemiol., 27, S9-S8
-
(2017)
J. Epidemiol
, vol.27
, pp. S8-S9
-
-
Nagai, A.1
Hirata, M.2
Kamatani, Y.3
Muto, K.4
Matsuda, K.5
Kiyohara, Y.6
Ninomiya, T.7
Tamakoshi, A.8
Yamagata, Z.9
Mushiroda, T.10
-
56
-
-
83455213326
-
China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up
-
Chen, Z., Chen, J., Collins, R., Guo, Y., Peto, R., Wu, F. and Li, L. (2011) China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up. Int. J. Epidemiol., 40, 1652-1666
-
(2011)
Int. J. Epidemiol
, vol.40
, pp. 1652-1666
-
-
Chen, Z.1
Chen, J.2
Collins, R.3
Guo, Y.4
Peto, R.5
Wu, F.6
Li, L.7
-
57
-
-
85020565329
-
A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults
-
Millwood, I.Y., Bennett, D.A., Walters, R.G., Clarke, R., Waterworth, D., Johnson, T., Chen, Y., Yang, L., Guo, Y., Bian, Z. et al. (2016) A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults. Int. J. Epidemiol., 45, 1588-1599
-
(2016)
Int. J. Epidemiol
, vol.45
, pp. 1588-1599
-
-
Millwood, I.Y.1
Bennett, D.A.2
Walters, R.G.3
Clarke, R.4
Waterworth, D.5
Johnson, T.6
Chen, Y.7
Yang, L.8
Guo, Y.9
Bian, Z.10
-
58
-
-
85027864262
-
Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study
-
Jorgenson, E., Thai, K.K., Hoffmann, T.J., Sakoda, L.C., Kvale, M.N., Banda, Y., Schaefer, C., Risch, N., Mertens, J., Weisner, C. et al. (2017) Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. Mol. Psychiatry, 22, 1359-1367
-
(2017)
Mol. Psychiatry
, vol.22
, pp. 1359-1367
-
-
Jorgenson, E.1
Thai, K.K.2
Hoffmann, T.J.3
Sakoda, L.C.4
Kvale, M.N.5
Banda, Y.6
Schaefer, C.7
Risch, N.8
Mertens, J.9
Weisner, C.10
-
59
-
-
84935119369
-
Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: a Danish population-based study andmeta-analysis
-
Agerbo, E., Sullivan, P.F., Vilhjálmsson, B.J., Pedersen, C.B., Mors, O., Børglum, A.D., Hougaard, D.M., Hollegaard, M.V., Meier, S., Mattheisen, M. et al. (2015) Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: a Danish population-based study andmeta-analysis. JAMA Psychiatry, 72, 635-641
-
(2015)
JAMA Psychiatry
, vol.72
, pp. 635-641
-
-
Agerbo, E.1
Sullivan, P.F.2
Vilhjálmsson, B.J.3
Pedersen, C.B.4
Mors, O.5
Børglum, A.D.6
Hougaard, D.M.7
Hollegaard, M.V.8
Meier, S.9
Mattheisen, M.10
-
60
-
-
85039767541
-
Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development
-
Nielsen, J.B., Fritsche, L.G., Zhou, W., Teslovich, T.M., Holmen, O.L., Gustafsson, S., Gabrielsen, M.E., Schmidt, E.M., Beaumont, R., Wolford, B.N. et al. (2018) Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development. Am. J. Hum. Genet., 102, 103-115
-
(2018)
Am. J. Hum. Genet
, vol.102
, pp. 103-115
-
-
Nielsen, J.B.1
Fritsche, L.G.2
Zhou, W.3
Teslovich, T.M.4
Holmen, O.L.5
Gustafsson, S.6
Gabrielsen, M.E.7
Schmidt, E.M.8
Beaumont, R.9
Wolford, B.N.10
-
61
-
-
85007028930
-
Distribution and clinical impact of functional variants in 50, 726 whole-exome sequences from the DiscovEHR study
-
Dewey, F.E., Murray, M.F., Overton, J.D., Habegger, L., Leader, J.B., Fetterolf, S.N., O'Dushlaine, C., Hout, C.V.V., Staples, J., Gonzaga-Jauregui, C. et al. (2016) Distribution and clinical impact of functional variants in 50, 726 whole-exome sequences from the DiscovEHR study. Science, 354, aaf6814
-
(2016)
Science
, vol.354
-
-
Dewey, F.E.1
Murray, M.F.2
Overton, J.D.3
Habegger, L.4
Leader, J.B.5
Fetterolf, S.N.6
O'Dushlaine, C.7
Hout, C.V.V.8
Staples, J.9
Gonzaga-Jauregui, C.10
|