Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets from Blood and the Kidney

Hypertension

Volumn 70, Issue 3, 2017, Pages e4-e19

  Wain, Louise V ^a   Vaez, Ahmad ^b,f   Jansen, Rick ^g   Joehanes, Roby ^h,i   Van Der Most, Peter J ^b   Erzurumluoglu, A Mesut ^a   O'Reilly, Paul F ^j   Cabrera, Claudia P ^k   Warren, Helen R ^k   Rose, Lynda M ^l   Verwoert, Germaine C ^b   Hottenga, Jouke Jan ^g   Strawbridge, Rona J ^o,p   Esko, Tonu ^q,s,t   Arking, Dan E ^u   Hwang, Shih Jen ^i,v   Guo, Xiuqing ^z   Kutalik, Zoltan ^ab,ac   Trompet, Stella ^b   Shrine, Nick ^a   Teumer, Alexander ^ae,ag   Ried, Janina S ^ah   Bis, Joshua C ^ai   Smith, Albert V ^ak,al   Amin, Najaf ^m   Nolte, Ilja M ^b   Lyytikäinen, Leo Pekka ^am,an   Mahajan, Anubha ^ao   Wareham, Nicholas J ^aq   Hofer, Edith ^ar,as   Joshi, Peter K ^au   Kristiansson, Kati ^b   Traglia, Michela ^ba   Havulinna, Aki S ^b   Goel, Anuj ^ao,ap   Nalls, Mike A ^w,bb   Sõber, Siim ^r   Vuckovic, Dragana ^bc,bd   Luan, Jian'An ^aq   Del Greco, Fabiola M ^be   Ayers, Kristin L ^b   Marrugat, Jaume ^bh   Ruggiero, Daniela ^bi   Lopez, Lorna M ^av,bj,bk   Niiranen, Teemu ^b   Enroth, Stefan ^bm   Jackson, Anne U ^bn   Nelson, Christopher P ^a,bo   Huffman, Jennifer E ^ay   Zhang, Weihua ^bp,bt   Marten, Jonathan ^ay   Gandin, Ilaria ^bd   Harris, Sarah E ^av   Zemunik, Tatijana ^bu   Lu, Yingchang ^bf   Evangelou, Evangelos ^bp,bv   Shah, Nabi ^bw,bx   De Borst, Martin H ^c   Mangino, Massimo ^j,by   Prins, Bram P ^bz   Campbell, Archie ^aw,ax   Li Gao, Ruifang ^b   Chauhan, Ganesh ^ca,cb   Oldmeadow, Christopher ^cc   Abecasis, Gonçalo ^cd   Abedi, Maryam ^f   Barbieri, Caterina M ^ba   Barnes, Michael R ^k   Batini, Chiara ^a   Beilby, John ^ce,cf,cg   Blake, Tineka ^a   Boehnke, Michael ^bn   Bottinger, Erwin P ^bf   Braund, Peter S ^a,bo   Brown, Morris ^k   Brumat, Marco ^bd   Campbell, Harry ^au   Chambers, John C ^bp,bt,cj   Cocca, Massimiliano ^bd   Collins, Francis ^x   Connell, John ^bw   Cordell, Heather J ^ck   Damman, Jeffrey J ^cm   Davies, Gail ^b,av   De Geus, Eco J ^g   De Mutsert, Renée ^b   Deelen, Joris ^b   Demirkale, Yusuf ^y   Doney, Alex S F ^bw   Dörr, Marcus ^b,ag   Farrall, Martin ^ao,ap   Ferreira, Teresa ^ao   Frånberg, Mattias ^o,p,cn   Gao, He ^bp   Giedraitis, Vilmantas ^co   Gieger, Christian ^ah   Giulianini, Franco ^l   Gow, Alan J ^av,cp   Hamsten, Anders ^o,p   Harris, Tamara B ^cq   Hofman, Albert ^b,cr   Holliday, Elizabeth G ^cc   Hui, Jennie ^ce,cf,cg,ch   Jarvelin, Marjo Riitta ^bq,cs,ct,cu   Johansson, Åsa ^bm   Johnson, Andrew D ^i,v   Jousilahti, Pekka ^b   Jula, Antti ^b   Kähönen, Mika ^an,cv   Kathiresan, Sekar ^t,cw,cx   Khaw, Kay Tee ^cz   Kolcic, Ivana ^bu   Koskinen, Seppo ^b   Langenberg, Claudia ^aq   Larson, Marty ⁱ   Launer, Lenore J ^cq   Lehne, Benjamin ^bp   Liewald, David C M ^b,av   Lin, Li ^da   Lind, Lars ^db   Mach, François ^da   Mamasoula, Chrysovalanto ^cl   Menni, Cristina ^j   Mifsud, Borbala ^k   Milaneschi, Yuri ^g   Morgan, Anna ^bd   Morris, Andrew D ^dc   Morrison, Alanna C ^dd   Munson, Peter J ^y   Nandakumar, Priyanka ^u   Nguyen, Quang Tri ^y   Nutile, Teresa ^bi   Oldehinkel, Albertine J ^d   Oostra, Ben A ^m   Org, Elin ^q   Padmanabhan, Sandosh ^ax,de   Palotie, Aarno ^dg   Paré, Guillaume ^dh   Pattie, Alison ^b   Penninx, Brenda W J H ^g   Poulter, Neil ^bp   Pramstaller, Peter P ^be,di,dj   Raitakari, Olli T ^dk,dl   Ren, Meixia ^k,dm   Rice, Kenneth ^b   Ridker, Paul M ^h,l   Riese, Harriëtte ^d   Ripatti, Samuli ^dg   Robino, Antonietta ^bc   Rotter, Jerome I ^aa   Rudan, Igor ^au   Saba, Yasaman ^at   Saint Pierre, Aude ^be,dn   Sala, Cinzia F ^ba   Sarin, Antti Pekka ^dg   Schmidt, Reinhold ^ar,at   Scott, Rodney ^cc,do,dp   Seelen, Marc A ^c   Shields, Denis C ^bl   Siscovick, David ^dq   Sorice, Rossella ^bi,dr   Stanton, Alice ^ds   Stott, David J ^df   Sundström, Johan ^db   Swertz, Morris ^b   Taylor, Kent D ^aa   Thom, Simon ^br   Tzoulaki, Ioanna ^bp   Tzourio, Christophe ^ca,cb,dt   Uitterlinden, André G ^b,n   Völker, Uwe ^af,ag   Vollenweider, Peter ^dv   Wild, Sarah ^au   Willemsen, Gonneke ^g   Wright, Alan F ^ay   Yao, Jie ^z   Thériault, Sébastien ^dh   Conen, David ^dw   Attia, John ^cc,do,dp   Sever, Peter ^bs   Debette, Stéphanie ^ca,cb,du   Mook Kanamori, Dennis O ^b,ad   Zeggini, Eleftheria ^bz   Spector, Tim D ^j   Van Der Harst, Pim ^e   Palmer, Colin N A ^bw   Vergnaud, Anne Claire ^bp   Loos, Ruth J F ^aq,bf,bg   Polasek, Ozren ^bu   Starr, John M ^av   Girotto, Giorgia ^bc,bd   Hayward, Caroline ^ax,ay   Kooner, Jaspal S ^bt,cj,dx   Lindgren, Cecila M ^t,ao   Vitart, Veronique ^ay   Samani, Nilesh J ^a,bo   Tuomilehto, Jaakko ^az,dy,dz,ea   Gyllensten, Ulf ^bm   Knekt, Paul ^b   Deary, Ian J ^b,av   Ciullo, Marina ^bi,dr   Elosua, Roberto ^bh   Keavney, Bernard D ^eb   Hicks, Andrew A ^be   Scott, Robert A ^aq   Gasparini, Paolo ^bc,bd   Laan, Maris ^r   Liu, Yongmei ^ec   Watkins, Hugh ^ao,ap   Hartman, Catharina A ^d   Salomaa, Veikko ^b   Toniolo, Daniela ^ba   Perola, Markus ^b,q,dg   Wilson, James F ^au,ay   Schmidt, Helena ^b   Zhao, Jing Hua ^aq   Lehtimäki, Terho ^am,an   Van Duijn, Cornelia M ^m   Gudnason, Vilmundur ^ak,al   Psaty, Bruce M ^b,ai,aj,ed   Peters, Annette ^ah   Rettig, Rainer ^af   James, Alan ^ci,ee   Jukema, J Wouter ^b   Strachan, David P ^ef   Palmas, Walter ^eg   Metspalu, Andres ^q   Ingelsson, Erik ^bm,eh   Boomsma, Dorret I ^g   Franco, Oscar H ^b   Bochud, Murielle ^ab   Newton Cheh, Christopher ^t,cw,cy   Munroe, Patricia B ^k   Elliott, Paul ^bq   Chasman, Daniel I ^h,l   Chakravarti, Aravinda ^u   Knight, Joanne ^ei   Morris, Andrew P ^ao,ej   Levy, Daniel ^i,v   Tobin, Martin D ^a   Snieder, Harold ^b   Caulfield, Mark J ^k   Ehret, Georg B ^u,da   more..

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b Department of Epidemiology ^*

^c Division of Nephrology   (United Kingdom)

^d Interdisciplinary Center Psychopathology and Emotion Regulation (IPCE)   (United Kingdom)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^g VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^h HARVARD MEDICAL SCHOOL   (United States)

ⁱ FRAMINGHAM HEART STUDY   (United States)

^j KING'S COLLEGE LONDON   (United Kingdom)

^k QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^l BRIGHAM AND WOMEN S HOSPITAL   (United States)

^m Genetic Epidemiology Unit   (United States)

ⁿ ERASMUS MEDICAL CENTER   (Netherlands)

^o KAROLINSKA INSTITUTE   (Sweden)

^p KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^q UNIVERSITY OF TARTU   (Estonia)

^r Department of Biomedicine Institute of Biomedicine and Translational Medicine   (Estonia)

^s BOSTON CHILDREN S HOSPITAL   (United States)

^t BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^u JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^v NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^w NATIONAL INSTITUTE ON AGING   (United States)

^x NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^y NATIONAL INSTITUTES OF HEALTH   (United States)

^z Division of Genomic Outcomes Department of Pediatrics Institute for Translational Genomics and Population Sciences   (United States)

^aa HARBOR UCLA MEDICAL CENTER   (United States)

^ab UNIVERSITY OF LAUSANNE   (Switzerland)

^ac SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^ad LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^ae Institute for Community Medicine   (United States)

^af UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^ag DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^ah INSTITUTE OF EPIDEMIOLOGY   (Germany)

^ai Cardiovascular Health Research Unit   (United States)

^aj UNIVERSITY OF WASHINGTON   (United States)

^ak ICELANDIC HEART ASSOCIATION   (Iceland)

^al UNIVERSITY OF ICELAND   (Iceland)

^am FIMLAB LABORATORIES   (Finland)

^an TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^ao UNIVERSITY OF OXFORD   (United Kingdom)

^ap UNIVERSITY OF OXFORD   (United Kingdom)

^aq UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^ar Department of Neurology   (United States)

^as Institute of Medical Informatics   (United States)

^at MEDICAL UNIVERSITY OF GRAZ   (Austria)

^au Usher Institute of Population Health Sciences and Informatics   (United States)

^av UNIVERSITY OF EDINBURGH   (United Kingdom)

^aw Medical Genetics Section   (United States)

^ax Centre for Genomic and Experimental Medicine   (United States)

^ay UNIVERSITY OF EDINBURGH   (United Kingdom)

^az NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^ba SAN RAFFAELE HOSPITAL   (Italy)

^bb Data Tecnica International LLC   (United States)

^bc INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^bd UNIVERSITY OF TRIESTE   (Italy)

^be University of Lubeck   (Italy)

^bf Charles Bronfman Institute for Personalized Medicine   (United States)

^bg MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^bh INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^bi INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^bj BEAUMONT HOSPITAL   (Ireland)

^bk UNIVERSITY COLLEGE DUBLIN   (Ireland)

^bl UNIVERSITY COLLEGE DUBLIN   (Ireland)

^bm UPPSALA UNIVERSITY   (Sweden)

^bn UNIVERSITY OF MICHIGAN   (United States)

^bo GLENFIELD HOSPITAL   (United Kingdom)

^bp California State College   (United States)

^bq Faculty of Medicine and MRC Health Protection Agency   (United States)

^br International Centre for Circulatory Health   (United States)

^bs NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^bt EALING HOSPITAL   (United Kingdom)

^bu UNIVERSITY OF SPLIT   (Croatia)

^bv UNIVERSITY OF IOANNINA   (Greece)

^bw UNIVERSITY OF DUNDEE   (United Kingdom)

^bx Charles Bronfman Institute for Personalized Medicine ^*  (Pakistan)

^by and University of Bristol   (United Kingdom)

^bz WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^ca INSERM U657   (France)

^cb UNIVERSITÉ DE BORDEAUX   (France)

^cc HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^cd Center for Statistical Genetics   (United States)

^ce Busselton Pop Med Res Foundation   (Australia)

^cf PATHWEST LABORATORY MEDICINE   (Australia)

^cg Ear Science Institute Australia   (Australia)

^ch Sir Peter MacCallum Dept of Oncology   (Australia)

^ci UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^cj IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^ck Institute of Genetic Medicine   (United Kingdom)

^cl NEWCASTLE UNIVERSITY   (United Kingdom)

^cm ACADEMIC MEDICAL CENTER   (Netherlands)

^cn STOCKHOLM UNIVERSITY   (Sweden)

^co UPPSALA UNIVERSITY   (Sweden)

^cp HERIOT WATT UNIVERSITY   (United Kingdom)

^cq National Institute on Aging   (United Kingdom)

^cr HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^cs Center for Life Course Health Research   (United States)

^ct UNIVERSITY OF OULU   (Finland)

^cu OULU UNIVERSITY HOSPITAL   (Finland)

^cv TAMPERE UNIVERSITY HOSPITAL   (Finland)

^cw Cardiovascular Research Center   (United States)

^cx Flemish Institute for Biotechnology   (United States)

^cy MASSACHUSETTS GENERAL HOSPITAL   (United States)

^cz UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^da GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^db Department of Medical Sciences   (Switzerland)

^dc UNIVERSITY OF EDINBURGH   (United Kingdom)

^dd UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^de UNIVERSITY OF GLASGOW   (United Kingdom)

^df UNIVERSITY OF GLASGOW   (United Kingdom)

^dg UNIVERSITY OF HELSINKI   (Finland)

^dh MCMASTER UNIVERSITY   (Canada)

^di General Central Hospital   (Italy)

^dj UNIVERSITY OF LÜBECK   (Germany)

^dk TURKU UNIVERSITY HOSPITAL   (Finland)

^dl UNIVERSITY OF TURKU   (Finland)

^dm FUJIAN MEDICAL UNIVERSITY   (China)

^dn ETABLISSEMENT FRANÇAIS DU SANG   (France)

^do UNIVERSITY OF NEWCASTLE   (Australia)

^dp JOHN HUNTER HOSPITAL   (Australia)

^dq NEW YORK ACADEMY OF MEDICINE   (United States)

^dr IRCCS NEUROMED   (Italy)

^ds ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^dt MASSACHUSETTS DEPARTMENT OF PUBLIC HEALTH   (United States)

^du BORDEAUX UNIVERSITY HOSPITAL   (France)

^dv LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^dw MCMASTER UNIVERSITY   (Canada)

^dx HAMMERSMITH HOSPITAL   (United Kingdom)

^dy DASMAN DIABETES INSTITUTE   (Kuwait)

^dz KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^ea DANUBE UNIVERSITY KREMS   (Austria)

^eb UNIVERSITY OF MANCHESTER   (United Kingdom)

^ec WAKE FOREST SCHOOL OF MEDICINE   (United States)

^ed Kaiser Washington Health Research Institute   (United States)

^ee SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^ef ST GEORGE S HOSPITAL   (United Kingdom)

^eg Department of Medicine   (United States)

^eh STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ei LANCASTER UNIVERSITY   (United Kingdom)

^ej UNIVERSITY OF LIVERPOOL   (United Kingdom)

more..

Author keywords

blood pressure; cardiovascular risk; complex traits; eSNP; GWAS; hypertension

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL SUBUNIT 1; ACTIVATING TRANSCRIPTION FACTOR 1; AUTOPHAGY RELATED PROTEIN 7; BLK PROTEIN; CARNITINE TRANSPORTER 1; CARNITINE TRANSPORTER 2; CDK2AP1 PROTEIN; CHMP1A PROTEIN; CLCN6 PROTEIN; CRIP3 PROTEIN; DCAKD PROTEIN; DNA METHYLTRANSFERASE 1; EPITHELIAL SODIUM CHANNEL; FANCONI ANEMIA GROUP A PROTEIN; FHL3 PROTEIN; INITIATION FACTOR 4B; INTERFERON REGULATORY FACTOR 5; MTHFR PROTEIN; MYOSIN BINDING PROTEIN C; PABPC4 PROTEIN; PROTEIN; PROTEIN KINASE B BETA; PROTEIN MDMX; SCAMP2 PROTEIN; SF3A3 PROTEIN; STK39 PROTEIN; TNPO3 PROTEIN; TRANSCRIPTION FACTOR ARNTL; UNCLASSIFIED DRUG; ZNF589 PROTEIN;

ANCESTRY GROUP; ARTICLE; BLOOD PRESSURE REGULATION; COMPARATIVE STUDY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ELEVATED BLOOD PRESSURE; EUROPEAN; FOLLOW UP; GENE EXPRESSION; GENE FREQUENCY; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE REPLICATION; GENETIC DATABASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; HUMAN TISSUE; KIDNEY TISSUE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PULSE PRESSURE; QUANTITATIVE TRAIT LOCUS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

EID: 85027077950     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.117.09438     Document Type: Article

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