CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response

Nature Medicine

Volumn 24, Issue 7, 2018, Pages 927-930

  Haapaniemi, Emma ^a,b   Botla, Sandeep ^a   Persson, Jenna ^a   Schmierer, Bernhard ^a   Taipale, Jussi ^a,b,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; RIBONUCLEOPROTEIN;

ARTICLE; CONTROLLED STUDY; CRISPR-CAS9 SYSTEM; DNA DAMAGE RESPONSE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EDITING; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IMMORTALIZED CELL LINE; PIGMENT CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; RETINAL PIGMENT EPITHELIUM; CELL CYCLE; CRISPR CAS SYSTEM; DNA DAMAGE; GENETICS; HEK293 CELL LINE; METABOLISM; TUMOR CELL LINE;

CELL CYCLE; CELL LINE, TUMOR; CRISPR-ASSOCIATED PROTEIN 9; CRISPR-CAS SYSTEMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; GENE EDITING; HEK293 CELLS; HUMANS; RIBONUCLEOPROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85048349385     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/s41591-018-0049-z     Document Type: Article

References (18)

1. Hustedt, N. &Durocher, D. Nat. Cell Biol. 19, 1-9 (2016).
2. Hohmann, S. &Gozalbo, D. Mol. Gen. Genet. 211, 446-454 (1988).
3. Richardson, C. D., Ray, G. J., DeWitt, M. A., Curie, G. L. &Corn, J. E. Nat. Biotechnol. 34, 339-344 (2016).
4. DeWitt, M. A. et al. Sci. Transl. Med. 8, 360ra134 (2016).
5. Yin, H. et al. Nat. Biotechnol. 32, 551-553 (2014).
6. Dever, D. P. et al. Nature 539, 384-389 (2016).
7. Lee, K. et al. eLife 6, e25312 (2017).
8. Maruyama, T. et al. Nat. Biotechnol. 33, 538-542 (2015).
9. Schmierer, B. et al. Mol. Syst. Biol. 13, 945 (2017).
10. Luo, M. &Chen, Y. Int. J. Ophthalmol. 11, 150-159 (2018).
11. Otto, T. &Sicinski, P. Nat. Rev. Cancer 17, 93-115 (2017).
12. Sokolova, M. et al. Cell Cycle 16, 189-199 (2017).
13. Doench, J. G. et al. Nat. Biotechnol. 34, 184-191 (2016).
14. Wang, J., Vasaikar, S., Shi, Z., Greer, M. &Zhang, B. Nucleic Acids Res. 45, W130-W137 (2017).
15. Canny, M. D. et al. Nat. Biotechnol. 36, 95-102 (2018).
16. Cuella-Martin, R. et al. Mol. Cell 64, 51-64 (2016).
17. Muerdter, F. et al. Nat. Methods 15, 141-149 (2018).
18. Li, W. et al. Genome Biol. 15, 554 (2014).