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Volumn 21, Issue 4, 2018, Pages 277-282

Dietary carbohydrates and fatty liver disease: De novo lipogenesis

Author keywords

carbohydrate; fructose; lipogenesis; nonalcoholic fatty liver disease; sugar

Indexed keywords

FRUCTOSE;

EID: 85048273375     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000469     Document Type: Review
Times cited : (60)

References (43)
  • 1
    • 85012874026 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic steatohepatitis-associated cirrhosis in the United States: An analysis of national health and nutrition examination survey data
    • Kabbany MN, Conjeevaram Selvakumar PK, Watt K, et al. Prevalence of nonalcoholic steatohepatitis-associated cirrhosis in the United States: an analysis of national health and nutrition examination survey data. Am J Gastroenterol 2017; 112:581-587.
    • (2017) Am J Gastroenterol , vol.112 , pp. 581-587
    • Kabbany, M.N.1    Conjeevaram Selvakumar, P.K.2    Watt, K.3
  • 2
    • 85038838106 scopus 로고    scopus 로고
    • Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention
    • Younossi Z, Anstee QM, Marietti M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat RevGastroenterol Hepatol 2018; 15:11-20.
    • (2018) Nat RevGastroenterol Hepatol , vol.15 , pp. 11-20
    • Younossi, Z.1    Anstee, Q.M.2    Marietti, M.3
  • 3
    • 84976479130 scopus 로고    scopus 로고
    • Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes
    • Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 2016; 64:73-84.
    • (2016) Hepatology , vol.64 , pp. 73-84
    • Younossi, Z.M.1    Koenig, A.B.2    Abdelatif, D.3
  • 4
    • 84994908443 scopus 로고    scopus 로고
    • Role of gut microbiota and short chain fatty acids in modulating energy harvest and fat partitioning in youth
    • Goffredo M, Mass K, Parks EJ, et al. Role of gut microbiota and short chain fatty acids in modulating energy harvest and fat partitioning in youth. J Clin Endocrinol Metab 2016; 101:4367-4376.
    • (2016) J Clin Endocrinol Metab , vol.101 , pp. 4367-4376
    • Goffredo, M.1    Mass, K.2    Parks, E.J.3
  • 5
    • 85034607986 scopus 로고    scopus 로고
    • The intestinal microbiome in nonalcoholic fatty liver disease
    • Puri P, Sanyal AJ. The intestinal microbiome in nonalcoholic fatty liver disease. Clin Liver Dis 2018; 22:121-132.
    • (2018) Clin Liver Dis , vol.22 , pp. 121-132
    • Puri, P.1    Sanyal, A.J.2
  • 6
    • 85048301096 scopus 로고    scopus 로고
    • Dietary carbohydrate restriction in the management of NAFLD and metabolic syndrome
    • In: Bergeron N, Siri-Tarino PW, Bray GA, Krauss RM, editors. Boca Raton, FL: CRC Press
    • Jones GM, Mulligan K, Schwarz JM. Dietary carbohydrate restriction in the management of NAFLD and metabolic syndrome. In: Bergeron N, Siri-Tarino PW, Bray GA, Krauss RM, editors. Nutrition and cardiometabolic health. Boca Raton, FL: CRC Press; 2017. pp. 275-296.
    • (2017) Nutrition and Cardiometabolic Health , pp. 275-296
    • Jones, G.M.1    Mulligan, K.2    Schwarz, J.M.3
  • 7
    • 85026655560 scopus 로고    scopus 로고
    • Conversion of sugar to fat: Is hepatic de novo lipogenesis leading to metabolic syndrome and associated chronic diseases?
    • Schwarz JM, Clearfield M, Mulligan K. Conversion of sugar to fat: is hepatic de novo lipogenesis leading to metabolic syndrome and associated chronic diseases? J Am Osteopath Assoc 2017; 117:520-527.
    • (2017) J Am Osteopath Assoc , vol.117 , pp. 520-527
    • Schwarz, J.M.1    Clearfield, M.2    Mulligan, K.3
  • 8
    • 84894327806 scopus 로고    scopus 로고
    • Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease
    • Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology 2014; 146:726-735.
    • (2014) Gastroenterology , vol.146 , pp. 726-735
    • Lambert, J.E.1    Ramos-Roman, M.A.2    Browning, J.D.3    Parks, E.J.4
  • 9
    • 85032440331 scopus 로고    scopus 로고
    • Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets
    • Umpleby AM, Shojaee-Moradie F, Fielding B, et al. Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets. Clin Sci 2017; 131:2561-2573.
    • (2017) Clin Sci , vol.131 , pp. 2561-2573
    • Umpleby, A.M.1    Shojaee-Moradie, F.2    Fielding, B.3
  • 10
    • 85037618929 scopus 로고    scopus 로고
    • The transcriptomic signature of disease development and progression of nonalcoholic fatty liver disease
    • Cazanave S, Podtelezhnikov A, Jensen K, et al. The transcriptomic signature of disease development and progression of nonalcoholic fatty liver disease. Sci Rep 2017; 7:17193.
    • (2017) Sci Rep , vol.7 , pp. 17193
    • Cazanave, S.1    Podtelezhnikov, A.2    Jensen, K.3
  • 11
    • 85021736691 scopus 로고    scopus 로고
    • Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity
    • Zhang D, Tong X, VanDommelen K, et al. Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity. J Clin Invest 2017; 127:2855-2867.
    • (2017) J Clin Invest , vol.127 , pp. 2855-2867
    • Zhang, D.1    Tong, X.2    VanDommelen, K.3
  • 12
    • 84939618773 scopus 로고    scopus 로고
    • RGC-32 deficiency protects against hepatic steatosis by reducing lipogenesis
    • Cui XB, Luan JN, Chen SY. RGC-32 deficiency protects against hepatic steatosis by reducing lipogenesis. J Biol Chem 2015; 290:20387-20395.
    • (2015) J Biol Chem , vol.290 , pp. 20387-20395
    • Cui, X.B.1    Luan, J.N.2    Chen, S.Y.3
  • 13
    • 85048279366 scopus 로고    scopus 로고
    • Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition
    • [Epub ahead of print]
    • Patankar JV, Wong CK, Morampudi V, et al. Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition. Am J Physiol Endocrinol Metab 2017. [Epub ahead of print]
    • (2017) Am J Physiol Endocrinol Metab
    • Patankar, J.V.1    Wong, C.K.2    Morampudi, V.3
  • 14
    • 85032896266 scopus 로고    scopus 로고
    • Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling
    • The mouse study parsed out the distinct mechanisms underlying fructose-induced vs. glucose-induced hepatic steatosis. Through a series of studies, authors demonstrated that although high intakes of both sugars increase liver fat content, fructose does so by increasing de novo lipogenesis (DNL), whereas glucose increases triglyceride synthesis. Furthermore, these differences were observed on the background of a high saturated fat, and not chow diet, indicating the importance of other dietary factors in determining the extent of sugar-induced metabolic effects
    • Softic S, Gupta MK, Wang GX, et al. Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. J Clin Invest 2017; 127:4059-4074. The mouse study parsed out the distinct mechanisms underlying fructose-induced vs. glucose-induced hepatic steatosis. Through a series of studies, authors demonstrated that although high intakes of both sugars increase liver fat content, fructose does so by increasing de novo lipogenesis (DNL), whereas glucose increases triglyceride synthesis. Furthermore, these differences were observed on the background of a high saturated fat, and not chow diet, indicating the importance of other dietary factors in determining the extent of sugar-induced metabolic effects.
    • (2017) J Clin Invest , vol.127 , pp. 4059-4074
    • Softic, S.1    Gupta, M.K.2    Wang, G.X.3
  • 15
    • 85016500191 scopus 로고    scopus 로고
    • Pharmacological interventions for nonalcohol related fatty liver disease (NAFLD): An attempted network metaanalysis
    • Lombardi R, Onali S, Thorburn D, et al. Pharmacological interventions for nonalcohol related fatty liver disease (NAFLD): an attempted network metaanalysis. Cochrane Database Syst Rev 2017; 3:CD011640.
    • (2017) Cochrane Database Syst Rev , vol.3 , pp. CD011640
    • Lombardi, R.1    Onali, S.2    Thorburn, D.3
  • 16
    • 85021827837 scopus 로고    scopus 로고
    • Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight Male subjects: A randomized, double-blind, crossover study
    • Stiede K, Miao W, Blanchette HS, et al. Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: a randomized, double-blind, crossover study. Hepatology 2017; 66:324-334.
    • (2017) Hepatology , vol.66 , pp. 324-334
    • Stiede, K.1    Miao, W.2    Blanchette, H.S.3
  • 17
    • 85025820702 scopus 로고    scopus 로고
    • Acetyl CoA carboxylase inhibition reduces hepatic steatosis but elevates plasma triglycerides in mice and humans: A bedside to bench investigation
    • e6
    • Kim CW, Addy C, Kusunoki J, et al. Acetyl CoA carboxylase inhibition reduces hepatic steatosis but elevates plasma triglycerides in mice and humans: a bedside to bench investigation. Cell Metab 2017; 26:394-406.e6.
    • (2017) Cell Metab , vol.26 , pp. 394-406
    • Kim, C.W.1    Addy, C.2    Kusunoki, J.3
  • 18
    • 85016311226 scopus 로고    scopus 로고
    • Liver-specific activation of AMPK prevents steatosis on a high-fructose diet
    • The study in mice with chronic liver-specific activation of AMP activated protein kinase gene (AMPK) provides evidence for AMPK as an attractive pharmaceutical target for nonalcoholic fatty liver disease. Activation of AMPK in the liver dramatically reduced liver fat in mice consuming a high-fructose diet, with no other detectable metabolic effects
    • Woods A, Williams JR, Muckett PJ, et al. Liver-specific activation of AMPK prevents steatosis on a high-fructose diet. Cell Rep 2017; 18:3043-3051. The study in mice with chronic liver-specific activation of AMP activated protein kinase gene (AMPK) provides evidence for AMPK as an attractive pharmaceutical target for nonalcoholic fatty liver disease. Activation of AMPK in the liver dramatically reduced liver fat in mice consuming a high-fructose diet, with no other detectable metabolic effects.
    • (2017) Cell Rep , vol.18 , pp. 3043-3051
    • Woods, A.1    Williams, J.R.2    Muckett, P.J.3
  • 19
    • 85030242549 scopus 로고    scopus 로고
    • Discovery of fragment-derived small molecules for in vivo inhibition of ketohexokinase (KHK)
    • Huard K, Ahn K, Amor P, et al. Discovery of fragment-derived small molecules for in vivo inhibition of ketohexokinase (KHK). J Med Chem 2017; 60: 7835-7849.
    • (2017) J Med Chem , vol.60 , pp. 7835-7849
    • Huard, K.1    Ahn, K.2    Amor, P.3
  • 20
    • 85050579211 scopus 로고    scopus 로고
    • Genetic predisposition in nonalcoholic fatty liver disease
    • Sookoian S, Pirola CJ. Genetic predisposition in nonalcoholic fatty liver disease. Clin Mol Hepatol 2017; 23:1-12.
    • (2017) Clin Mol Hepatol , vol.23 , pp. 1-12
    • Sookoian, S.1    Pirola, C.J.2
  • 21
    • 85044116085 scopus 로고    scopus 로고
    • Liver fat content, nonalcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279,013 individuals
    • Lauridsen BK, Stender S, Kristensen TS, et al. Liver fat content, nonalcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279,013 individuals. Eur Heart J 2018; 39:385-393.
    • (2018) Eur Heart J , vol.39 , pp. 385-393
    • Lauridsen, B.K.1    Stender, S.2    Kristensen, T.S.3
  • 22
    • 84929347096 scopus 로고    scopus 로고
    • Paradoxical dissociation between hepatic fat content and de novo lipogenesis due to PNPLA3 sequence variant
    • Mancina RM, Matikainen N, Maglio C, et al. Paradoxical dissociation between hepatic fat content and de novo lipogenesis due to PNPLA3 sequence variant. J Clin Endocrinol Metab 2015; 100:E821-E825.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. E821-E825
    • Mancina, R.M.1    Matikainen, N.2    Maglio, C.3
  • 23
    • 84939168174 scopus 로고    scopus 로고
    • Hepatic de novo lipogenesis in obese youth is modulated by a common variant in the GCKR gene
    • Santoro N, Caprio S, Pierpont B, et al. Hepatic de novo lipogenesis in obese youth is modulated by a common variant in the GCKR gene. J Clin Endocrinol Metab 2015; 100:E1125-E1132.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. E1125-E1132
    • Santoro, N.1    Caprio, S.2    Pierpont, B.3
  • 24
    • 85030176004 scopus 로고    scopus 로고
    • The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
    • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology 2018; 67:328-357.
    • (2018) Hepatology , vol.67 , pp. 328-357
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 25
    • 84879090877 scopus 로고    scopus 로고
    • Dietary fructose in nonalcoholic fatty liver disease
    • Vos MB, Lavine JE. Dietary fructose in nonalcoholic fatty liver disease. Hepatology 2013; 57:2525-2531.
    • (2013) Hepatology , vol.57 , pp. 2525-2531
    • Vos, M.B.1    Lavine, J.E.2
  • 26
    • 85048264160 scopus 로고    scopus 로고
    • World Health Organization. Guidelines: Sugar Intake for Adults and Children. Geneva, Switzerland: World Health Organization; 2015
    • World Health Organization. Guidelines: Sugar Intake for Adults and Children. Geneva, Switzerland: World Health Organization; 2015.
  • 27
    • 85048255245 scopus 로고    scopus 로고
    • U.S. Department of Health and Human Services and U.S. Department of Agriculture. 2015-2020 Dietary Guidelines for Americans. 8th Edition. December
    • U.S. Department of Health and Human Services and U.S. Department of Agriculture. 2015-2020 Dietary Guidelines for Americans. 8th Edition. December 2015. Available at https://health.gov/dietaryguidelines/2015/ guidelines/.
    • (2015)
  • 28
    • 85006894230 scopus 로고    scopus 로고
    • Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: A randomized crossover study
    • Bawden S, Stephenson M, Falcone Y, et al. Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: a randomized crossover study. Diabetes Obes Metab 2017; 19:70-77.
    • (2017) Diabetes Obes Metab , vol.19 , pp. 70-77
    • Bawden, S.1    Stephenson, M.2    Falcone, Y.3
  • 29
    • 84989205082 scopus 로고    scopus 로고
    • Effect of a low glycemic index Mediterranean diet on non-alcoholic fatty liver disease A randomized controlled clinici trial
    • Misciagna G, Del Pilar Diaz M, Caramia DV, et al. Effect of a low glycemic index Mediterranean diet on non-alcoholic fatty liver disease. A randomized controlled clinici trial. J Nutr Health Aging 2017; 21:404-412.
    • (2017) J Nutr Health Aging , vol.21 , pp. 404-412
    • Misciagna, G.1    Del Pilar Diaz, M.2    Caramia, D.V.3
  • 30
    • 84996553162 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease (NAFLD) in obese children-effect of refined carbohydrates in diet
    • Felix DR, Costenaro F, Gottschall CB, Coral GP. Nonalcoholic fatty liver disease (NAFLD) in obese children-effect of refined carbohydrates in diet. BMC Pediatr 2016; 16:187.
    • (2016) BMC Pediatr , vol.16 , pp. 187
    • Felix, D.R.1    Costenaro, F.2    Gottschall, C.B.3    Coral, G.P.4
  • 31
    • 85019065892 scopus 로고    scopus 로고
    • Randomized controlled trial of a MUFA or fiber-rich diet on hepatic fat in prediabetes
    • Errazuriz I, Dube S, Slama M, et al. Randomized controlled trial of a MUFA or fiber-rich diet on hepatic fat in prediabetes. J Clin Endocrinol Metab 2017; 102:1765-1774.
    • (2017) J Clin Endocrinol Metab , vol.102 , pp. 1765-1774
    • Errazuriz, I.1    Dube, S.2    Slama, M.3
  • 32
    • 85012897319 scopus 로고    scopus 로고
    • Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents
    • Mosca A, Nobili V, De Vito R, et al. Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents. J Hepatol 2017; 66:1031-1036.
    • (2017) J Hepatol , vol.66 , pp. 1031-1036
    • Mosca, A.1    Nobili, V.2    De Vito, R.3
  • 33
    • 84907334403 scopus 로고    scopus 로고
    • Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: A systematic review and meta-analysis
    • Chung M, Ma J, Patel K, et al. Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis. Am J Clin Nutr 2014; 100:833-849.
    • (2014) Am J Clin Nutr , vol.100 , pp. 833-849
    • Chung, M.1    Ma, J.2    Patel, K.3
  • 34
    • 84930809200 scopus 로고    scopus 로고
    • Effect of a high-fructose weightmaintaining diet on lipogenesis and liver fat
    • Schwarz JM, Noworolski SM, Wen MJ, et al. Effect of a high-fructose weightmaintaining diet on lipogenesis and liver fat. J Clin Endocrinol Metab 2015; 100:2434-2442.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 2434-2442
    • Schwarz, J.M.1    Noworolski, S.M.2    Wen, M.J.3
  • 35
    • 85021364651 scopus 로고    scopus 로고
    • Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity
    • The longer term 12-week study on the metabolic effects of increased fructose intake was conducted with more moderate fructose supplementation (75 g/day) in a relatively large sample size (n71). The study used an oral fat tolerance test to demonstrate that dietary fructose can elicit more chronic effects on DNL
    • Taskinen MR, Soderlund S, Bogl LH, et al. Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity. J Intern Med 2017; 282:187-201. The longer term 12-week study on the metabolic effects of increased fructose intake was conducted with more moderate fructose supplementation (75 g/day) in a relatively large sample size (n71). The study used an oral fat tolerance test to demonstrate that dietary fructose can elicit more chronic effects on DNL.
    • (2017) J Intern Med , vol.282 , pp. 187-201
    • Taskinen, M.R.1    Soderlund, S.2    Bogl, L.H.3
  • 36
    • 84956578034 scopus 로고    scopus 로고
    • Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome
    • Lustig RH, Mulligan K, Noworolski SM, et al. Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome. Obesity 2016; 24:453-460.
    • (2016) Obesity , vol.24 , pp. 453-460
    • Lustig, R.H.1    Mulligan, K.2    Noworolski, S.M.3
  • 37
    • 85027050511 scopus 로고    scopus 로고
    • Effects of dietary fructose restriction on liver fat, de novo lipogenesis, and insulin kinetics in children with obesity
    • In this detailed and carefully conducted study in 41 obese children, fructose restriction within an energy balanced diet was shown to reduce DNL and liver fat as well as improve insulin kinetics in as little as 9 days, providing strong evidence for the benefit of reducing fructose intake
    • Schwarz JM, Noworolski SM, Erkin-Cakmak A, et al. Effects of dietary fructose restriction on liver fat, de novo lipogenesis, and insulin kinetics in children with obesity. Gastroenterology 2017; 153:743-752. In this detailed and carefully conducted study in 41 obese children, fructose restriction within an energy balanced diet was shown to reduce DNL and liver fat as well as improve insulin kinetics in as little as 9 days, providing strong evidence for the benefit of reducing fructose intake.
    • (2017) Gastroenterology , vol.153 , pp. 743-752
    • Schwarz, J.M.1    Noworolski, S.M.2    Erkin-Cakmak, A.3
  • 38
    • 85027162279 scopus 로고    scopus 로고
    • Effect of restriction of foods with high fructose corn syrup content on metabolic indices and fatty liver in obese children
    • Ibarra-Reynoso LDR, Lopez-Lemus HL,Garay-Sevilla ME, Malacara JM. Effect of restriction of foods with high fructose corn syrup content on metabolic indices and fatty liver in obese children. Obes Facts 2017; 10:332-340.
    • (2017) Obes Facts , vol.10 , pp. 332-340
    • Ibarra-Reynoso, L.D.R.1    Lopez-Lemus, H.L.2    Garay-Sevilla, M.E.3    Malacara, J.M.4
  • 39
    • 84954468744 scopus 로고    scopus 로고
    • Sugar-and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial
    • Campos V, Despland C, Brandejsky V, et al. Sugar-and artificially sweetened beverages and intrahepatic fat: a randomized controlled trial. Obesity 2015; 23:2335-2339.
    • (2015) Obesity , vol.23 , pp. 2335-2339
    • Campos, V.1    Despland, C.2    Brandejsky, V.3
  • 40
    • 0041659263 scopus 로고    scopus 로고
    • Fate of fatty acids at rest and during exercise: Regulatory mechanisms
    • Jensen MD. Fate of fatty acids at rest and during exercise: regulatory mechanisms. Acta Physiol Scand 2003; 178:385-390.
    • (2003) Acta Physiol Scand , vol.178 , pp. 385-390
    • Jensen, M.D.1
  • 41
    • 14844331384 scopus 로고    scopus 로고
    • Measuring very low density lipoprotein-triglyceride kinetics in man in vivo: How different the various methods really are
    • Magkos F, Sidossis LS. Measuring very low density lipoprotein-triglyceride kinetics in man in vivo: how different the various methods really are. Curr Opin Clin Nutr Metab Care 2004; 7:547-555.
    • (2004) Curr Opin Clin Nutr Metab Care , vol.7 , pp. 547-555
    • Magkos, F.1    Sidossis, L.S.2
  • 42
    • 85042698561 scopus 로고    scopus 로고
    • Energy metabolism: From the organ to the cell
    • In: Ichai C, Quintard H, Orban JC, editors. Cham: Springer
    • Quintard H, Fontaine E, Ichai C. Energy metabolism: from the organ to the cell. In: Ichai C, Quintard H, Orban JC, editors. Metabolic disorders and critically ill patients. Cham: Springer; 2018. pp. 441-451.
    • (2018) Metabolic Disorders and Critically Ill Patients , pp. 441-451
    • Quintard, H.1    Fontaine, E.2    Ichai, C.3
  • 43
    • 84958180587 scopus 로고    scopus 로고
    • Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury
    • Pierce AA, Duwaerts CC, Soon RK, et al. Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury. J Nutr Biochem 2016; 29:12-20.
    • (2016) J Nutr Biochem , vol.29 , pp. 12-20
    • Pierce, A.A.1    Duwaerts, C.C.2    Soon, R.K.3


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