메뉴 건너뛰기




Volumn 29, Issue , 2016, Pages 12-20

Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury

Author keywords

Fatty liver; Palmitate; Saturated fat; Steatohepatitis; Sucrose; Sugar; Triglyceride

Indexed keywords

CARBOHYDRATE DIET; FAT INTAKE;

EID: 84958180587     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2015.10.020     Document Type: Article
Times cited : (17)

References (59)
  • 1
    • 84906279651 scopus 로고    scopus 로고
    • Metabolically healthy and unhealthy obese - the 2013 Stock Conference report
    • Samocha-Bonet D., Dixit V.D., Kahn C.R., Leibel R.L., Lin X., Nieuwdorp M., et al. Metabolically healthy and unhealthy obese - the 2013 Stock Conference report. Obes Rev 2014, 15:697-708.
    • (2014) Obes Rev , vol.15 , pp. 697-708
    • Samocha-Bonet, D.1    Dixit, V.D.2    Kahn, C.R.3    Leibel, R.L.4    Lin, X.5    Nieuwdorp, M.6
  • 2
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning J.D., Szczepaniak L.S., Dobbins R., Nuremberg P., Horton J.D., Cohen J.C., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004, 40:1387-1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3    Nuremberg, P.4    Horton, J.D.5    Cohen, J.C.6
  • 4
    • 77956634470 scopus 로고    scopus 로고
    • High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
    • Kohli R., Kirby M., Xanthakos S.A., Softic S., Feldstein A.E., Saxena V., et al. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology 2010, 52:934-944.
    • (2010) Hepatology , vol.52 , pp. 934-944
    • Kohli, R.1    Kirby, M.2    Xanthakos, S.A.3    Softic, S.4    Feldstein, A.E.5    Saxena, V.6
  • 5
    • 80055026523 scopus 로고    scopus 로고
    • Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition
    • Charlton M., Krishnan A., Viker K., Sanderson S., Cazanave S., McConico A., et al. Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am J Physiol Gastrointest Liver Physiol 2011, 301:G825-G834.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , pp. G825-G834
    • Charlton, M.1    Krishnan, A.2    Viker, K.3    Sanderson, S.4    Cazanave, S.5    McConico, A.6
  • 6
    • 84861975560 scopus 로고    scopus 로고
    • Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis
    • Savard C., Tartaglione E.V., Kuver R., Haigh W.G., Farrell G.C., Subramanian S., et al. Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis. Hepatology 2013, 57:81-92.
    • (2013) Hepatology , vol.57 , pp. 81-92
    • Savard, C.1    Tartaglione, E.V.2    Kuver, R.3    Haigh, W.G.4    Farrell, G.C.5    Subramanian, S.6
  • 7
    • 84927696639 scopus 로고    scopus 로고
    • Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis
    • Mells J.E., Fu P.P., Kumar P., Smith T., Karpen S.J., Anania F.A. Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis. J Nutr Biochem 2015, 26:285-292.
    • (2015) J Nutr Biochem , vol.26 , pp. 285-292
    • Mells, J.E.1    Fu, P.P.2    Kumar, P.3    Smith, T.4    Karpen, S.J.5    Anania, F.A.6
  • 8
    • 0023833533 scopus 로고
    • The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes
    • Yao Z.M., Vance D.E. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem 1988, 263:2998-3004.
    • (1988) J Biol Chem , vol.263 , pp. 2998-3004
    • Yao, Z.M.1    Vance, D.E.2
  • 9
    • 0022413049 scopus 로고
    • The role of phosphatidylcholine biosynthesis in the secretion of lipoproteins from hepatocytes
    • Vance J.E., Vance D.E. The role of phosphatidylcholine biosynthesis in the secretion of lipoproteins from hepatocytes. Can J Biochem Cell Biol 1985, 63:870-881.
    • (1985) Can J Biochem Cell Biol , vol.63 , pp. 870-881
    • Vance, J.E.1    Vance, D.E.2
  • 10
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    • Leclercq I.A., Farrell G.C., Field J., Bell D.R., Gonzalez F.J., Robertson G.R. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest 2000, 105:1067-1075.
    • (2000) J Clin Invest , vol.105 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4    Gonzalez, F.J.5    Robertson, G.R.6
  • 11
    • 33845574569 scopus 로고    scopus 로고
    • Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1
    • Rizki G., Arnaboldi L., Gabrielli B., Yan J., Lee G.S., Ng R.K., et al. Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1. J Lipid Res 2006, 47:2280-2290.
    • (2006) J Lipid Res , vol.47 , pp. 2280-2290
    • Rizki, G.1    Arnaboldi, L.2    Gabrielli, B.3    Yan, J.4    Lee, G.S.5    Ng, R.K.6
  • 12
    • 70350417312 scopus 로고    scopus 로고
    • Dietary sucrose is essential to the development of liver injury in the MCD model of steatohepatitis
    • Pickens M.K., Yan J.S., Ng R.K., Ogata H., Grenert J.P., Beyson C., et al. Dietary sucrose is essential to the development of liver injury in the MCD model of steatohepatitis. J Lipid Res 2009, 50:2072-2082.
    • (2009) J Lipid Res , vol.50 , pp. 2072-2082
    • Pickens, M.K.1    Yan, J.S.2    Ng, R.K.3    Ogata, H.4    Grenert, J.P.5    Beyson, C.6
  • 13
    • 79951638303 scopus 로고    scopus 로고
    • Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine-choline-deficient diet
    • Pickens M.K., Ogata H., Soon R.K., Grenert J.P., Maher J.J. Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine-choline-deficient diet. Liver Int 2010, 30:1229-1239.
    • (2010) Liver Int , vol.30 , pp. 1229-1239
    • Pickens, M.K.1    Ogata, H.2    Soon, R.K.3    Grenert, J.P.4    Maher, J.J.5
  • 14
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner D.E., Brunt E.M., Van Natta M., Behling C., Contos M.J., Cummings O.W., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 15
    • 40949123364 scopus 로고    scopus 로고
    • Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis
    • Lackner C., Gogg-Kamerer M., Zatloukal K., Stumptner C., Brunt E.M., Denk H. Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis. J Hepatol 2008, 48:821-828.
    • (2008) J Hepatol , vol.48 , pp. 821-828
    • Lackner, C.1    Gogg-Kamerer, M.2    Zatloukal, K.3    Stumptner, C.4    Brunt, E.M.5    Denk, H.6
  • 16
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957, 226:497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 17
    • 34548154602 scopus 로고    scopus 로고
    • Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury
    • Lee G.S., Yan J.S., Ng R.K., Kakar S., Maher J.J. Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury. J Lipid Res 2007, 48:1885-1896.
    • (2007) J Lipid Res , vol.48 , pp. 1885-1896
    • Lee, G.S.1    Yan, J.S.2    Ng, R.K.3    Kakar, S.4    Maher, J.J.5
  • 19
    • 0025988275 scopus 로고
    • Use of mass isotopomer distributions in secreted lipids to sample lipogenic acetyl-CoA pool in vivo in humans
    • Hellerstein M.K., Kletke C., Kaempfer S., Wu K., Shackleton C.H. Use of mass isotopomer distributions in secreted lipids to sample lipogenic acetyl-CoA pool in vivo in humans. Am J Physiol 1991, 261:E479-E486.
    • (1991) Am J Physiol , vol.261 , pp. E479-E486
    • Hellerstein, M.K.1    Kletke, C.2    Kaempfer, S.3    Wu, K.4    Shackleton, C.H.5
  • 20
    • 0033038503 scopus 로고    scopus 로고
    • Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations
    • Hellerstein M.K., Neese R.A. Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations. Am J Physiol 1999, 276:E1146-E1170.
    • (1999) Am J Physiol , vol.276 , pp. E1146-E1170
    • Hellerstein, M.K.1    Neese, R.A.2
  • 21
    • 0029836892 scopus 로고    scopus 로고
    • Tracing lipogenesis in humans using deuterated water
    • Jones P.J. Tracing lipogenesis in humans using deuterated water. Can J Physiol Pharmacol 1996, 74:755-760.
    • (1996) Can J Physiol Pharmacol , vol.74 , pp. 755-760
    • Jones, P.J.1
  • 23
    • 33845587374 scopus 로고    scopus 로고
    • Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans
    • Vedala A., Wang W., Neese R.A., Christiansen M.P., Hellerstein M.K. Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans. J Lipid Res 2006, 47:2562-2574.
    • (2006) J Lipid Res , vol.47 , pp. 2562-2574
    • Vedala, A.1    Wang, W.2    Neese, R.A.3    Christiansen, M.P.4    Hellerstein, M.K.5
  • 24
    • 71749086155 scopus 로고    scopus 로고
    • Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios
    • Peter A., Cegan A., Wagner S., Lehmann R., Stefan N., Konigsrainer A., et al. Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios. Clin Chem 2009, 55:2113-2120.
    • (2009) Clin Chem , vol.55 , pp. 2113-2120
    • Peter, A.1    Cegan, A.2    Wagner, S.3    Lehmann, R.4    Stefan, N.5    Konigsrainer, A.6
  • 25
    • 71749102895 scopus 로고    scopus 로고
    • The delta9 fatty acid desaturation index as a predictor of metabolic disease
    • Flowers M.T. The delta9 fatty acid desaturation index as a predictor of metabolic disease. Clin Chem 2009, 55:2071-2073.
    • (2009) Clin Chem , vol.55 , pp. 2071-2073
    • Flowers, M.T.1
  • 26
    • 36348935003 scopus 로고    scopus 로고
    • Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet
    • Matsuzawa N., Takamura T., Kurita S., Misu H., Ota T., Ando H., et al. Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology 2007, 46:1392-1403.
    • (2007) Hepatology , vol.46 , pp. 1392-1403
    • Matsuzawa, N.1    Takamura, T.2    Kurita, S.3    Misu, H.4    Ota, T.5    Ando, H.6
  • 27
    • 34347235098 scopus 로고    scopus 로고
    • Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
    • Monetti M., Levin M.C., Watt M.J., Sajan M.P., Marmor S., Hubbard B.K., et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab 2007, 6:69-78.
    • (2007) Cell Metab , vol.6 , pp. 69-78
    • Monetti, M.1    Levin, M.C.2    Watt, M.J.3    Sajan, M.P.4    Marmor, S.5    Hubbard, B.K.6
  • 28
    • 84887023370 scopus 로고    scopus 로고
    • High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
    • Ishimoto T., Lanaspa M.A., Rivard C.J., Roncal-Jimenez C.A., Orlicky D.J., Cicerchi C., et al. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology 2013, 58:1632-1643.
    • (2013) Hepatology , vol.58 , pp. 1632-1643
    • Ishimoto, T.1    Lanaspa, M.A.2    Rivard, C.J.3    Roncal-Jimenez, C.A.4    Orlicky, D.J.5    Cicerchi, C.6
  • 29
    • 84884979408 scopus 로고    scopus 로고
    • Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF-alpha-converting enzyme activity in mice
    • Jiang J.X., Chen X., Fukada H., Serizawa N., Devaraj S., Torok N.J. Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF-alpha-converting enzyme activity in mice. Hepatology 2013, 58:1339-1348.
    • (2013) Hepatology , vol.58 , pp. 1339-1348
    • Jiang, J.X.1    Chen, X.2    Fukada, H.3    Serizawa, N.4    Devaraj, S.5    Torok, N.J.6
  • 30
    • 43049170503 scopus 로고    scopus 로고
    • Fructose consumption as a risk factor for non-alcoholic fatty liver disease
    • Ouyang X., Cirillo P., Sautin Y., McCall S., Bruchette J.L., Diehl A.M., et al. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol 2008, 48:993-999.
    • (2008) J Hepatol , vol.48 , pp. 993-999
    • Ouyang, X.1    Cirillo, P.2    Sautin, Y.3    McCall, S.4    Bruchette, J.L.5    Diehl, A.M.6
  • 31
    • 34848830434 scopus 로고    scopus 로고
    • Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study
    • Zelber-Sagi S., Nitzan-Kaluski D., Goldsmith R., Webb M., Blendis L., Halpern Z., et al. Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study. J Hepatol 2007, 47:711-717.
    • (2007) J Hepatol , vol.47 , pp. 711-717
    • Zelber-Sagi, S.1    Nitzan-Kaluski, D.2    Goldsmith, R.3    Webb, M.4    Blendis, L.5    Halpern, Z.6
  • 32
    • 77952692915 scopus 로고    scopus 로고
    • Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    • Abdelmalek M.F., Suzuki A., Guy C., Unalp-Arida A., Colvin R., Johnson R.J., et al. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 2010, 51:1961-1971.
    • (2010) Hepatology , vol.51 , pp. 1961-1971
    • Abdelmalek, M.F.1    Suzuki, A.2    Guy, C.3    Unalp-Arida, A.4    Colvin, R.5    Johnson, R.J.6
  • 33
    • 84870389895 scopus 로고    scopus 로고
    • Does fructose consumption contribute to non-alcoholic fatty liver disease?
    • Tappy L., Le K.A. Does fructose consumption contribute to non-alcoholic fatty liver disease?. Clin Res Hepatol Gastroenterol 2012, 36:554-560.
    • (2012) Clin Res Hepatol Gastroenterol , vol.36 , pp. 554-560
    • Tappy, L.1    Le, K.A.2
  • 34
    • 84907334403 scopus 로고    scopus 로고
    • Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis
    • Chung M., Ma J., Patel K., Berger S., Lau J., Lichtenstein A.H. Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis. Am J Clin Nutr 2014, 100:833-849.
    • (2014) Am J Clin Nutr , vol.100 , pp. 833-849
    • Chung, M.1    Ma, J.2    Patel, K.3    Berger, S.4    Lau, J.5    Lichtenstein, A.H.6
  • 35
    • 84897993613 scopus 로고    scopus 로고
    • Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials
    • Chiu S., Sievenpiper J.L., de Souza R.J., Cozma A.I., Mirrahimi A., Carleton A.J., et al. Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials. Eur J Clin Nutr 2014, 68:416-423.
    • (2014) Eur J Clin Nutr , vol.68 , pp. 416-423
    • Chiu, S.1    Sievenpiper, J.L.2    de Souza, R.J.3    Cozma, A.I.4    Mirrahimi, A.5    Carleton, A.J.6
  • 36
    • 84908613508 scopus 로고    scopus 로고
    • Higher fructose intake is inversely associated with risk of nonalcoholic fatty liver disease in older Finnish adults
    • Kanerva N., Sandboge S., Kaartinen N.E., Mannisto S., Eriksson J.G. Higher fructose intake is inversely associated with risk of nonalcoholic fatty liver disease in older Finnish adults. Am J Clin Nutr 2014, 100:1133-1138.
    • (2014) Am J Clin Nutr , vol.100 , pp. 1133-1138
    • Kanerva, N.1    Sandboge, S.2    Kaartinen, N.E.3    Mannisto, S.4    Eriksson, J.G.5
  • 37
    • 84916940992 scopus 로고    scopus 로고
    • The role of dietary sugars and de novo lipogenesis in non-alcoholic fatty liver disease
    • Moore J.B., Gunn P.J., Fielding B.A. The role of dietary sugars and de novo lipogenesis in non-alcoholic fatty liver disease. Nutrients 2014, 6:5679-5703.
    • (2014) Nutrients , vol.6 , pp. 5679-5703
    • Moore, J.B.1    Gunn, P.J.2    Fielding, B.A.3
  • 38
    • 84903207987 scopus 로고    scopus 로고
    • Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans
    • Rosqvist F., Iggman D., Kullberg J., Cedernaes J., Johansson H.E., Larsson A., et al. Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans. Diabetes 2014, 63:2356-2368.
    • (2014) Diabetes , vol.63 , pp. 2356-2368
    • Rosqvist, F.1    Iggman, D.2    Kullberg, J.3    Cedernaes, J.4    Johansson, H.E.5    Larsson, A.6
  • 39
    • 0037382071 scopus 로고    scopus 로고
    • Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
    • Musso G., Gambino R., De Michieli F., Cassader M., Rizzetto M., Durazzo M., et al. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology 2003, 37:909-916.
    • (2003) Hepatology , vol.37 , pp. 909-916
    • Musso, G.1    Gambino, R.2    De Michieli, F.3    Cassader, M.4    Rizzetto, M.5    Durazzo, M.6
  • 40
    • 59649114145 scopus 로고    scopus 로고
    • Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver
    • Musso G., Gambino R., Pacini G., De Michieli F., Cassader M. Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver. Am J Clin Nutr 2009, 89:558-567.
    • (2009) Am J Clin Nutr , vol.89 , pp. 558-567
    • Musso, G.1    Gambino, R.2    Pacini, G.3    De Michieli, F.4    Cassader, M.5
  • 41
    • 84904760759 scopus 로고    scopus 로고
    • A cross-sectional study assessing dietary intake and physical activity in Canadian patients with nonalcoholic fatty liver disease vs healthy controls
    • Da Silva H.E., Arendt B.M., Noureldin S.A., Therapondos G., Guindi M., Allard J.P. A cross-sectional study assessing dietary intake and physical activity in Canadian patients with nonalcoholic fatty liver disease vs healthy controls. J Acad Nutr Diet 2014, 114:1181-1194.
    • (2014) J Acad Nutr Diet , vol.114 , pp. 1181-1194
    • Da Silva, H.E.1    Arendt, B.M.2    Noureldin, S.A.3    Therapondos, G.4    Guindi, M.5    Allard, J.P.6
  • 42
    • 84929486073 scopus 로고    scopus 로고
    • Childhood energy intake is associated with nonalcoholic fatty liver disease in adolescents
    • Anderson E.L., Howe L.D., Fraser A., Macdonald-Wallis C., Callaway M.P., Sattar N., et al. Childhood energy intake is associated with nonalcoholic fatty liver disease in adolescents. J Nutr 2015, 145:983-989.
    • (2015) J Nutr , vol.145 , pp. 983-989
    • Anderson, E.L.1    Howe, L.D.2    Fraser, A.3    Macdonald-Wallis, C.4    Callaway, M.P.5    Sattar, N.6
  • 43
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly K.L., Smith C.I., Schwarzenberg S.J., Jessurun J., Boldt M.D., Parks E.J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005, 115:1343-1351.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 44
    • 84894327806 scopus 로고    scopus 로고
    • Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease
    • Lambert J.E., Ramos-Roman M.A., Browning J.D., Parks E.J. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology 2014, 146:726-735.
    • (2014) Gastroenterology , vol.146 , pp. 726-735
    • Lambert, J.E.1    Ramos-Roman, M.A.2    Browning, J.D.3    Parks, E.J.4
  • 45
    • 84932623164 scopus 로고    scopus 로고
    • Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis
    • Pierce A.A., Pickens M.K., Siao K., Grenert J.P., Maher J.J. Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis. BMC Gastroenterol 2015, 15:72.
    • (2015) BMC Gastroenterol , vol.15 , pp. 72
    • Pierce, A.A.1    Pickens, M.K.2    Siao, K.3    Grenert, J.P.4    Maher, J.J.5
  • 46
    • 34547193134 scopus 로고    scopus 로고
    • Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity
    • Malhi H., Barreyro F.J., Isomoto H., Bronk S.F., Gores G.J. Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut 2007, 56:1124-1131.
    • (2007) Gut , vol.56 , pp. 1124-1131
    • Malhi, H.1    Barreyro, F.J.2    Isomoto, H.3    Bronk, S.F.4    Gores, G.J.5
  • 47
    • 80053554640 scopus 로고    scopus 로고
    • Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation
    • Holzer R.G., Park E.J., Li N., Tran H., Chen M., Choi C., et al. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 2011, 147:173-184.
    • (2011) Cell , vol.147 , pp. 173-184
    • Holzer, R.G.1    Park, E.J.2    Li, N.3    Tran, H.4    Chen, M.5    Choi, C.6
  • 48
    • 83555162619 scopus 로고    scopus 로고
    • Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes
    • Sharma M., Urano F., Jaeschke A. Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. J Hepatol 2012, 56:192-198.
    • (2012) J Hepatol , vol.56 , pp. 192-198
    • Sharma, M.1    Urano, F.2    Jaeschke, A.3
  • 49
    • 0017738601 scopus 로고
    • A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis
    • McGarry J.D., Mannaerts G.P., Foster D.W. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J Clin Invest 1977, 60:265-270.
    • (1977) J Clin Invest , vol.60 , pp. 265-270
    • McGarry, J.D.1    Mannaerts, G.P.2    Foster, D.W.3
  • 50
    • 0031043030 scopus 로고    scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
    • McGarry J.D., Brown N.F. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem 1997, 244:1-14.
    • (1997) Eur J Biochem , vol.244 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 51
    • 34047269605 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-mediates the pro-lipogenic effects of dietary saturated fat
    • Sampath H., Miyazaki M., Dobrzyn A., Ntambi J.M. Stearoyl-CoA desaturase-mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem 2007, 282:2483-2493.
    • (2007) J Biol Chem , vol.282 , pp. 2483-2493
    • Sampath, H.1    Miyazaki, M.2    Dobrzyn, A.3    Ntambi, J.M.4
  • 52
    • 19944430411 scopus 로고    scopus 로고
    • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
    • Lin J., Yang R., Tarr P.T., Wu P.H., Handschin C., Li S., et al. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell 2005, 120:261-273.
    • (2005) Cell , vol.120 , pp. 261-273
    • Lin, J.1    Yang, R.2    Tarr, P.T.3    Wu, P.H.4    Handschin, C.5    Li, S.6
  • 53
    • 0026745069 scopus 로고
    • Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver
    • Ntambi J.M. Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver. J Biol Chem 1992, 267:10925-10930.
    • (1992) J Biol Chem , vol.267 , pp. 10925-10930
    • Ntambi, J.M.1
  • 55
    • 0036081544 scopus 로고    scopus 로고
    • Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis
    • Bassilian S., Ahmed S., Lim S.K., Boros L.G., Mao C.S., Lee W.N. Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis. Am J Physiol Endocrinol Metab 2002, 282:E507-E513.
    • (2002) Am J Physiol Endocrinol Metab , vol.282 , pp. E507-E513
    • Bassilian, S.1    Ahmed, S.2    Lim, S.K.3    Boros, L.G.4    Mao, C.S.5    Lee, W.N.6
  • 56
    • 84918577122 scopus 로고    scopus 로고
    • A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice
    • Duarte J.A., Carvalho F., Pearson M., Horton J.D., Browning J.D., Jones J.G., et al. A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice. J Lipid Res 2014, 55:2541-2553.
    • (2014) J Lipid Res , vol.55 , pp. 2541-2553
    • Duarte, J.A.1    Carvalho, F.2    Pearson, M.3    Horton, J.D.4    Browning, J.D.5    Jones, J.G.6
  • 59
    • 38349125024 scopus 로고    scopus 로고
    • A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet
    • Baumgardner J.N., Shankar K., Hennings L., Badger T.M., Ronis M.J. A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet. Am J Physiol Gastrointest Liver Physiol 2008, 294:G27-G38.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , pp. G27-G38
    • Baumgardner, J.N.1    Shankar, K.2    Hennings, L.3    Badger, T.M.4    Ronis, M.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.