Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the a-Ketoglutarate Signaling Pathway

Cancer Research

Volumn 78, Issue 11, 2018, Pages 2799-2812

  Tseng, Chien Wei ^a,b   Kuo, Wen Hung ^c   Chan, Shih Hsuan ^a,b,d   Chan, Hong Lin ^d   Chang, King Jen ^e   Wang, Lu Hai ^a,b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^e TAIWAN ADVENTIST HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; DOCETAXEL; DOXORUBICIN; FUMARATE HYDRATASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; OXYTHIAMINE; TRANSKETOLASE;

ALPHA KETOGLUTARATE SIGNALING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GROWTH; CANCER SURVIVAL; CELL CYCLE PROGRESSION; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; LYMPH NODE METASTASIS; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METASTASIS INHIBITION; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SURVIVAL RATE; TRIPLE NEGATIVE BREAST CANCER; TUMOR INVASION; TUMOR VOLUME; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; MCF-7 CELL LINE; METABOLISM; METASTASIS; PATHOLOGY; PHYSIOLOGY; SCID MOUSE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; FEMALE; FUMARATE HYDRATASE; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KETOGLUTARIC ACIDS; MCF-7 CELLS; MICE; MICE, INBRED BALB C; MICE, SCID; NEOPLASM METASTASIS; OXIDATIVE PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSKETOLASE; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 85048040586     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-17-2906     Document Type: Article

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