NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: The effects of isoflurane and dizocilpine

Journal of Neurosurgical Anesthesiology

Volumn 18, Issue 4, 2006, Pages 240-246

  Wise Faberowski, Lisa ^a   Pearlstein, Robert D ^a   Warner, David S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Caspase 3; Caspase 9; Dizocilpine; Excitotoxicity; Isoflurane; Necrosis; Oligonucleosomal DNA fragmentation; Tunel

Indexed keywords

AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; CASP3 PROTEIN, RAT; CASP9 PROTEIN, RAT; CASPASE; CASPASE 3; CASPASE 9; DIZOCILPINE MALEATE; INHALATION ANESTHETIC AGENT; ISOFLURANE; LACTATE DEHYDROGENASE; N METHYLASPARTIC ACID;

ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BRAIN CORTEX; CELL CULTURE; COCULTURE; CYTOLOGY; DNA FRAGMENTATION; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GLIA; METABOLISM; NERVE CELL; NICK END LABELING; RAT; SPRAGUE DAWLEY RAT;

ANESTHETICS, INHALATION; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CASPASES; CELLS, CULTURED; CEREBRAL CORTEX; COCULTURE TECHNIQUES; DIZOCILPINE MALEATE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; IN SITU NICK-END LABELING; ISOFLURANE; L-LACTATE DEHYDROGENASE; N-METHYLASPARTATE; NEUROGLIA; NEURONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 85047700286     PISSN: 08984921     EISSN: 15371921     Source Type: Journal    
DOI: 10.1097/00008506-200610000-00004     Document Type: Article

References (38)

1. Baughman VL, Hoffman WE, Thomas C, et al. The interaction of nitrous oxide and isoflurane with incomplete cerebral ischemia in the rat. Anesthesiology. 1989;70: 767-774.
2. Mackensen GB, Nellgard B, Miura Y, et al. Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat. Anesthesiology. 1999;90: 873-881.
3. Miura Y, Grocott HP, Bart RD, et al. Differential effects of anesthetic agents on outcome from near-complete but not incomplete global ischemia in the rat. Anesthesiology. 1998;89: 391-400.
4. Elsersy H, Sheng H, Lynch JR, et al. Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. Anesthesiology. 2004;100: 1160-1166.
5. Kawaguchi M, Kimbro JR, Drummond JC, et al. Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia. Anesthesiology. 2000;92: 1335-1342.
6. Wise-Faberowski L, Zhang H, Ing R, et al. Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures. Anesth Analg. 2005;101: 651-667; table of contents.
7. Ferrer I, Planas AM. Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra. J Neuropathol Exp Neurol. 2003;62: 329-339.
8. Ferrer I, Martin F, Serrano T, et al. Both apoptosis and necrosis occur following intrastriatal administration of excitotoxins. Acta Neuropathol (Berl). 1995;90: 504-510.
9. Du C, Hu R, Csernansky CA, et al. Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J Cereb Blood Flow Metab. 1996;16: 195-201.
10. Wise-Faberowski L, Raizada MK, Sumners C. Oxygen and glucose deprivation-induced neuronal apoptosis is attenuated by halothane and isoflurane. Anesth Analg. 2001;93: 1281-1287.
11. Huang Y, Zuo Z. Effects of isoflurane on oxygen-glucose deprivation-induced changes of gene expression profiling in glial-neuronal cocultures. Acta Anaesthesiol Scand. 2005;49: 1544-1551.
12. Engelhard K, Werner C, Eberspacher E, et al. Sevoflurane and propofol influence the expression of apoptosis-regulating proteins after cerebral ischaemia and reperfusion in rats. Eur J Anaesthesiol. 2004;21: 530-537.
13. Beirne JP, Pearlstein RD, Massey GW, et al. Effect of halothane in cortical cell cultures exposed to N-methyl-D-aspartate. Neurochem Res. 1998;23: 17-23.
14. Kudo M, Aono M, Lee Y, et al. Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures. Anesthesiology. 2001;95: 756-765.
15. Blanck TJ, Thompson M. Measurement of halothane by ultraviolet spectroscopy. Anesth Analg. 1980;59: 481-483.
16. Koh JY, Choi DW. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J Neurosci Methods. 1987;20: 83-90.
17. Ankarcrona M, Dypbukt JM, Bonfoco E, et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 1995;15: 961-973.
18. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119: 493-501.
19. Wyllie AH, Kerr JF, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol. 1980;68: 251-306.
20. Wyllie AH, Morris RG, Smith AL, et al. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol. 1984;142: 67-77.
21. Wise-Faberowski L, Aono M, Pearlstein RD, et al. Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity. Anesth Analg. 2004;99: 1708-1714; table of contents.
22. Tenneti L, D’Emilia DM, Troy CM, et al. Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons. J Neurochem. 1998;71: 946-959.
23. Tenneti L, Lipton SA. Involvement of activated caspase-3-like proteases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons. J Neurochem. 2000;74: 134-142.
24. Kawaguchi M, Drummond JC, Cole DJ, et al. Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia. Anesth Analg. 2004;98: 798-805; table of contents.
25. Cho S, Liu D, Gonzales C, et al. Temporal assessment of caspase activation in experimental models of focal and global ischemia. Brain Res. 2003;982: 146-155.
26. Hakem R, Hakem A, Duncan GS, et al. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 1998;94: 339-352.
27. Lorenzo HK, Susin SA, Penninger J, et al. Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ. 1999;6: 516-524.
28. Daugas E, Nochy D, Ravagnan L, et al. Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett. 2000;476: 118-123.
29. Velier JJ, Ellison JA, Kikly KK, et al. Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat. J Neurosci. 1999;19: 5932-5941.
30. Jin K, Graham SH, Mao X, et al. Fas (CD95) may mediate delayed cell death in hippocampal CA1 sector after global cerebral ischemia. J Cereb Blood Flow Metab. 2001;21: 1411-1421.
31. Susin SA, Daugas E, Ravagnan L, et al. Two distinct pathways leading to nuclear apoptosis. J Exp Med. 2000;192: 571-580.
32. Stroh C, Schulze-Osthoff K. Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ. 1998;5: 997-1000.
33. Strasser A, O’Connor L, Dixit VM. Apoptosis signaling. Annu Rev Biochem. 2000;69: 217-245.
34. Benchoua A, Guegan C, Couriaud C, et al. Specific caspase pathways are activated in the two stages of cerebral infarction. J Neurosci. 2001;21: 7127-7134.
35. Krupinski J, Lopez E, Marti E, et al. Expression of caspases and their substrates in the rat model of focal cerebral ischemia. Neurobiol Dis. 2000;7: 332-342.
36. Zhang C, Shen W, Zhang G. N-methyl-D-aspartate receptor and L-type voltage-gated Ca(2+) channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemia. Neurosci Lett. 2002;328: 265-268.
37. Schulz JB, Weller M, Matthews RT, et al. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Cell Death Differ. 1998;5: 847-857.
38. Fink K, Zhu J, Namura S, et al. Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation. J Cereb Blood Flow Metab. 1998;18: 1071-1076.