Effects of Isoflurane Versus Fentanyl-Nitrous Oxide Anesthesia on Long-term Outcome from Severe Forebrain Ischemia in the Rat

Anesthesiology

Volumn 100, Issue 5, 2004, Pages 1160-1166

  Elsersy, Hazem ^a   Sheng, Huaxin ^a   Lynch, John R ^a   Moldovan, Maria ^b   Pearlstein, Robert D ^a   Warner, David S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FENTANYL DERIVATIVE; ISOFLURANE; NITROUS OXIDE;

ANESTHESIOLOGICAL TECHNIQUES; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE SEVERITY; DRUG EFFECT; FOREBRAIN; HIPPOCAMPUS; MALE; MAZE TEST; MOTOR PERFORMANCE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; TASK PERFORMANCE;

ANESTHESIA; ANIMALS; BRAIN ISCHEMIA; CELL DEATH; FENTANYL; ISOFLURANE; MALE; NITROUS OXIDE; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; TIME;

EID: 2142750926     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200405000-00018     Document Type: Article

References (39)

1. Wells BA, Keats AS, Cooley DA: Increased tolerance to cerebral ischemia produced by general anesthesia during temporary carotid occlusion. Surgery 1963; 54:216-23
2. 2O. ANESTHESIOLOGY 1988; 69:192-8
3. Werner C, Mollenberg O, Kochs E, Schulte am Esch J: Sevoflurane improves neurological outcome after incomplete cerebral ischaemia in rats. Br J Anaesth 1995; 75:756-60
4. Soonthon-Brant V, Patel P, Drummond JC, Cole DJ, Kelly PJ, Watson M: Fentanyl does not increase brain injury after focal cerebral ischemia in rats. Anesth Analg 1999; 88:49-55
5. 2+/calmodulin-dependent protein kinase in a canine cardiac arrest model. ANESTHESIOLOGY 2000; 93:1285-93
6. Miura Y, Grocott H, Bart RD, Pearlstein RD, Warner DS: Differential effects of anesthetic agents on outcome from near-complete but not incomplete global ischemia in the rat. ANESTHESIOLOGY 1998; 89:391-400
7. Verhaegen M, Todd MM, Warner DS: Ischemic depolarization during halothane-nitrous oxide and isoflurane-nitrous oxide anesthesia: An examination of cerebral blood flow thresholds and times to depolarization. ANESTHESIOLOGY 1994; 81:965-73
8. Warner DS, Hansen TD, Vust LH, Todd MM: Distribution of cerebral blood flow during deep isoflurane vs. pentobarbital anesthesia in rats with middle cerebral artery occlusion. J Neurosurg Anesth 1989; 1:219-26
9. Yang J, Zorumski CF: Effects of isoflurane on N-methyl-D-aspartate gated ion channels in cultured rat hippocampal neurons. Ann N Y Acad Sci 1991; 625:287-9
10. Kimbro JR, Kelly PJ, Drummond JC, Cole DJ, Patel PM: Isoflurane and pentobarbital reduce AMPA toxicity in vivo in the rat cerebral cortex. ANESTHESIOLOGY 2000; 92:806-12
11. Harada H, Kelly PJ, Cole DJ, Drummond JC, Patel PM: Isoflurane reduces N-methyl-D-aspartate toxicity in vivo in the rat cerebral cortex. Anesth Analg 1999; 89:1442-7
12. Patel P, Drummond JC, Cole DJ, Kelly PJ, Watson M: Isoflurane and pentobarbital reduce the frequency of transient ischemic depolarizations during focal ischemia in rats. Anesth Analg 1998; 86:773-80
13. Moody EJ, Suzdak PD, Paul SM, Skolnick P: Modulation of the benzodiazepine/γ-aminobutyric acid receptor chloride channel complex by inhalation anesthetics. J Neurochem 1988; 51:1386-93
14. Bickler PE, Warner DS, Strattman G, Schuyler J: GABA receptors contribute to isoflurane neuroprotection in organotypic hippocampal cultures. Anesth Analg 2003; 97:564-71
15. Homi HM, Mixco JM, Sheng H, Pearlstein RD, Warner DS: Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice. ANESTHESIOLOGY 2003; 99:1145-51
16. Kawaguchl M, Kimbro JR, Drummond JC, Cole DJ, Kelly PJ, Patel PM: Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia. ANESTHESIOLOGY 2000; 92:1335-42
17. The Hypothermia After Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346:549-56
18. Dietrich WD, Busto R, Alonso O, Globus MYT, Ginsberg MD: Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metab 1993; 13:541-9
19. Block F, Bozdag I, Nolden-Koch M: Inflammation contributes to postponed neuronal damage following treatment with a glummate antagonist in rats. Neurosci Lett 2001; 298:103-6
20. Valtysson J, Hillered L, Andine P, Hagberg H, Persson L: Neuropathologic endpoints in experimental pharmacotherapy: The importance of both early and late evaluation. Acta Neurochir (Wien) 1994; 129:58-63
21. Colbourne F, Li H, Buchan AM: Continuing postischemic neuronal death in CA1: Influence of ischemia duration and cytoprotective doses of NBQX and SNX-111 in rats. Stroke 1999; 30:662-7
22. Mackensen GB, Nellgård B, Miura Y, Dexter F, Pearlstein RD, Warner DS: Sympathetic blockade masks positive effect of isoflurane on histologic outcome from near-complete ischemia in the rat. ANESTHESIOLOGY 1999; 90:873-81
23. Smith M-L, Bendek G, Dahlgren N, Rosen I, Wieloch T, Siesjö BK: Models for studying long-term recovery following forebrain ischemia in the rat: II. A 2-vessel occlusion model. Acta Neurol Scand 1984; 69:385-401
24. Gionet TX, Warner DS, Verhaegen M, Thomas JD, Todd MM: Effects of intra-ischemic blood pressure on outcome from 2-vessel occlusion forebrain ischemia in the rat. Brain Res 1992; 586:188-94
25. Combs DJ, D'Alecy LG: Motor performance in rats exposed to severe forebrain ischemia: Effect of fasting and 1,3-butanediol. Stroke 1987; 18:503-11
26. Gionet TX, Thomas JD, Warner DS, Goodlett CR, Wasserman EA, West JR: Forebrain ischemia induces selective behavioral impairments associated with hippocampal injury in rats. Stroke 1991; 22:1040-7
27. Morris RGM: Developments of a water maze procedure for studying spatial learning in the rat. J Neurosci Meth 1984; 11:47-60
28. Smith M-L, Kalimo H, Warner DS, Siesjö BK: Morphologic lesions in the brain preceding the development of post-ischemic seizures. Acta Neuropathol 1988; 76:253-64
29. Auer RN, Kalimo H, Olsson Y, Siesjö BK: The temporal evolution of hypoglycemic brain damage: II. Light- and electron-microscopic findings in the hippocampal gyrus and subiculum of the rat Acta Neuropathol 1985; 67:25-36
30. Wolf HK, Buslei R, Schmidt-Kastner R, Schmidt-Kastner PK, Piestsch T, Wiesler OD, Bluhmke I: NeuN: A useful marker for diagnostic histopathology. J Histochem Cytochem 1996; 44:1167-71
31. Mackensen GB, Nellgård B, Kudo M, Sheng H, Pearlstein RD, Warner DS: Periischemic cerebral blood flow does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. ANESTHESIOLOGY 2000; 93:1101-06
32. Sullivan BL, Leu D, Taylor DM, Fahlman CS, Bickler PE: Isoflurane prevents delayed cell death in an organotypic slice culture model of cerebral ischemia. ANESTHESIOLOGY 2002; 96:189-95
33. Schmidt W, Reymann KG: Proliferating cells differentiate into neurons in the hippocampal CA1 region of gerbils after global cerebral ischemia. Neurosci Lett 2002; 334:153-6
34. Kokaia Z, Lindvall O: Neurogenesis after ischaemic brain insults. Curr Opin Neurobiol 2003; 13:127-32
35. Felling RJ, Levison SW: Enhanced neurogenesis following stroke. J Neurosci Res 2003; 73:277-83
36. Inoue S, Drummond JC, Davis DP, Cole DJ, Patel PM: Isoflurane and caspase 8 inhibition reduce cerebral injury in rats subjected to focal cerebral ischemia (abstract). ANESTHESIOLOGY 2003; 99:A-886
37. Cummings JL, Tomiyasu S, Read SJ, Benson DF: Amnesia with hippocampal lesions after cardiopulmonary arrest. Neurology 1984; 34:679-81
38. Zola-Morgan S, Squire L, Amaral DG: Human amnesia and medial temporal region: Enduring memory deficit following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci 1986; 6:2950-67
39. Grubb NR, Fox KA, Smith K, Best J, Blane A, Ebmeier KP, Glabus MF, O'Carroll RE: Memory impairment in out-of-hospital cardiac arrest survivors is associated with global reduction in brain volume, not focal hippocampal injury. Stroke 2000; 31:1509-14