X-ray crystal structure of a monoclonal antibody that binds to a major autoantigenic epitope on thyroid peroxidase

Thyroid

Volumn 11, Issue 12, 2001, Pages 1091-1099

  Hendry, E ^a   Grennan Jones, F ^b   Sullivan, A ^b   Taylor, G ^a   Liddy, N ^b   Godfrey, J ^b   Hayakawa, N ^b,c   Powell, M ^b   Sanders, J ^b   Furmaniak, J ^b   Rees Smith, B ^b,c  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b RSR LTD   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 4 F 5; THYROID PEROXIDASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANTIBODY AFFINITY; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ANALYSIS; FEMALE; MOLECULAR CLONING; MOUSE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; X RAY ANALYSIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; AUTOANTIGENS; BINDING SITES, ANTIBODY; CARRIER PROTEINS; CHEMISTRY, PHYSICAL; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; EPITOPES; FEMALE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA-CHAINS; IODIDE PEROXIDASE; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NEOPLASM PROTEINS;

EID: 85047699286     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/10507250152740920     Document Type: Article

References (54)

1. Autoantigens in the autoimmune endocrinopathies
2. Autoimmune endocrinopathies: Aspects of pathogenesis and the role of immune assays in investigation and management
3. The immunoendocrinopathies part 2: Autoimmune thyroid disease, autoimmune Addison disease, and related disorders
4. Human thyroid peroxidase-myeloperoxidase chimeric molecules: Tools for the study of antigen recognition by thyroid peroxidase autoantibodies
5. Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: Markers of the human thyroid autoimmune response
6. Majority of thyroid peroxidase autoantibodies in patients with autoimmune thyroid disease are directed to a single TPO domain
7. An analysis of the structure and antigenicity of different forms of human thyroid peroxidase
8. Mapping thyroid peroxidase epitopes using recombinant protein fragments
9. Unique autoantibody epitopes in an immunodominant region of thyroid peroxidase
10. Analysis of autoantibody epitopes on human thyroid peroxidase
11. The quest for autoantibody immunodominant region on thyroid peroxidase: Guided mutagenesis based on a hypothetical three-dimensional model
12. Identification of an immunodominant region recognized by human autoantibodies in a three-dimensional model of thyroid peroxidase
13. Relationship between autoantibody epitopic recognition and immunoglobulin gene usage
14. Production and characterisation of a human monoclonal thyroid peroxidase autoantibody
15. Structural studies of human autoantibodies. Crystal structure of a thyroid peroxidase autoantibody Fab
16. Recombinant human thyroid peroxidase produced in insect cells has similar properties to native human thyroid peroxidase
17. B-lymphocytes
18. Highly sensitive assays of autoantibodies to thyroglobulin and to thyroid peroxidase
19. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
20. The attraction of proteins for small molecules and ions
21. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction
22. Optimization of primers for cloning libraries of mouse immunoglobulin genes using the polymerase chain reaction
23. DNA sequencing with chain-terminating inhibitors
24. Accessing the Kabat antibody sequence database by computer
25. CINEMA - A novel colour interactive editor for multiple alignments
26. An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complemetarity
27. Processing of x-ray diffraction data collected in oscillation mode
28. The interpretation protein structures: Estimation of static accessibility
29. Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
30. Principles of protein-protein interactions derived from structural studies
31. Improved methods for binding protein models in electron density maps and the location of errors in these models
32. Molscript: A program to produce both detailed and schematic plots of protein structures
33. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
34. Analysis of immunoglobulin heavy chain V-region genes belonging to the V NP-gene family
35. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
36. The variable genes and gene families of the mouse immunoglobulin κ locus
37. The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes
38. Three-dimensional structure of an antibody-antigen complex
39. Crystallography and NMR system: A new software suite for macromolecular structure determination
40. Standard conformations for the canonical structures of immunoglobulins
41. Anatomy of the antibody molecule
42. Antibody-antigen interactions: Contact analysis and binding site topography
43. Identification of specificity-determining residues in antibodies
44. Length distribution of CDRH3 in antibodies
45. Somatic hypermutation in autoimmune thyroid disease
46. Evolutionary nucleotide replacements in DNA
47. On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands
48. Interactions of protein antigens with antibodies
49. Structural insights into the evolution of an antibody combining site
50. Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction
51. Recombinant thyroid peroxidase autoantibodies can be used for epitopic fingerprinting of thyroid peroxidase autoantibodies in the sera of individual patient