Somatic hypermutation in autoimmune thyroid disease

Immunological Reviews

Volumn 162, Issue , 1998, Pages 219-231

  McIntosh, Richard ^a   Watson, Philip ^b   Weetman, Anthony ^b  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

THYROGLOBULIN; THYROID ANTIBODY; THYROID PEROXIDASE; THYROTROPIN RECEPTOR;

AUTOIMMUNE DISEASE; HUMAN; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION; THYROID DISEASE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY DIVERSITY; AUTOANTIBODIES; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IODIDE PEROXIDASE; MOLECULAR SEQUENCE DATA; MUTATION; RECEPTORS, THYROTROPIN; THYROGLOBULIN; THYROIDITIS, AUTOIMMUNE;

EID: 0031953639     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1998.tb01444.x     Document Type: Review

References (61)

1. Weetman AP, McGregor AM. Autoimmune thyroid disease: further developments in our understanding. Endocr Rev 1994;15:788-830.
2. Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature 1996;379:458-460.
3. Endo T, Kaneshige N, Nakazato M, Kogai T, Saito T, Onaya T. Autoantibody against thyroid iodide transporter in the sera from patients with Hashimoto's thyroiditis possesses iodide transport inhibitory activity. Biochem Biophys Res Commun 1996;228:199-202.
4. Rees Smith B, McLachlan SM, Furmaniak J. Autoantibodies to the thyrotropin receptor. Endocr Rev 1988;9:106-121.
5. Drexhage HA. Autoimmunity and thyroid growth. Where do we stand? Eur J Endocrinol 1996;135:39-45.
6. Giordano C, et al. Potential involvement of fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science 1997;275:960-963.
7. McIntosh RS, Asghar MS, Weetman AP. The antibody response in autoimmune thyroid disease. Clin Sci 1997;92:529-541.
8. Rapoport B, Portolano S, McLachlan SM. Combinatorial libraries: new insights into human organ-specific autoantibodies. Immunol Today 1995;16:43-49.
9. McLachlan SM, Rapoport B. Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: markers of the human thyroid autoimmune response. Clin Exp Immunol 1995;101:200-206.
10. McIntosh RS, Weetman AP. Molecular analysis of the antibody response to thyroid autoantigens. Thyroid 1997;7:471-487.
11. McLachlan SM, Rapoport B. The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimmune thyroid disease. Endocr Rev 1992;13:192-206.
12. Jaume JC, Kakinuma A, Chazenbalk GD, Rapoport B, McLachlan SM. Thyrotropin receptor autoantibodies in serum are present at much lower levels than thyroid peroxidase autoantibodies: analysis by flow cytometry, J Clin Endocrinol Metab 1997;82:500-507.
13. McLachlan SM, Rapoport B. Monoclonal, human autoantibodies to the TSH receptor: the holy grail and why are we looking for it? J Clin Endocrinol Metab 1996;81:3152-3154.
14. Petersen VB, et al. A human-mouse hybridoma which secretes monoclonal thyroglobulin autoantibody with properties similar to those of the donor patient's serum autoantibody. Autoimmunity 1989;4:89-102.
15. Fukuma N, Petersen VB, McLachlan SM, Pegg CAS, Rees Smith B. Human monoclonal thyroglobulin autoantibodies of high affinity. I. Production, characterisation and interaction with murine monoclonal thyroglobulin antibodies. Autoimmunity 1991;10:291-295.
16. Hexham JM, Furmaniak J, Pegg C, Burton DR, Rees Smith B. Cloning of a human autoimmune response: preparation and sequencing of a human anti-thyroglobulin autoantibody using a combinatorial approach. Autoimmunity 1992;12:135-141.
17. McIntosh RS, Tandon N, Metcalfe RA, Weetman AP. Cloning and analysis of IgM anti-thyroglobulin autoantibodies from patients with Hashimoto's thyroiditis. Biochim Biophys Acta 1994;1227:171-176.
18. Prentice L, et al. Monoclonal thyroglobulin autoantibodies: variable region analysis and epitope recognition. J Clin Endocrinol Metab 1995;80:977-986.
19. McIntosh RS, Asghar MS, Watson PF, Kemp EH, Weetman AP. Cloning and analysis of IgGκ and IgGλ anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: evidence for in vivo antigen-driven repertoire selection. J Immunol 1996;157:927-935.
20. Matsuda F, et al. Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat Genet 1993;3:88-94.
21. Matsuda F, Honjo T. Organization of the human immunoglobulin heavy-chain locus. Adv Immunol 1996;62:1-29.
22. Schäble KF, Zachau HG. The variable region genes of the human immunoglobulin kappa locus. Biol Chem Hoppe Seyler 1993;374:1001-1022.
23. λ repertoire. J Mol Biol 1996;264:220-232.
24. McIntosh RS, et al. Analysis of IgGκ anti-thyroid peroxidase antibodies from different tissues in Hashimoto's thyroiditis. J Clin Endocrinol Metab 1997;82:3818-3825.
25. Ozaki S, Abe M, Wolfenbarger D, Weiss DT, Solomon A. Preferential expression of human λ-light chain variable-region subgroups in multiple myeloma, AL amyloidosis and Waldenström's magroglobulinemia. Clin Immunol Immunopathol 1994;71:183-189.
26. Klein R, Zachau HG. Expression and hypermutation of human immunoglobulin κ genes. Ann N Y Acad Sci 1995;764:74-83.
27. Stollar BD. The expressed heavy chain V gene repertoire of circulating B cells in normal adults. Ann N Y Acad Sci 1995;764:265-274.
28. Avrameas S, Ternynck T. Natural autoantibodies: the other side of the immune system. Res Immunol 1995;146:235-248.
29. Bouanani M, Piechaczyk M, Pau B, Bastide M. Significance of the recognition of certain antigenic regions on the human thyroglobulin molecule by natural autoantibodies from healthy subjects. J Immunol 1989;143:1129-1132.
30. Portolano S, Seto P, Chazenbalk GD, Nagayama Y, McLachlan SM, Rapoport B. A human Fab fragment specific for thyroid peroxidase generated by cloning thyroid lymphocyte-derived immunoglobulin genes in a bacteriophage lambda library. Biochem Biophys Res Commun 1991;179:372-377.
31. Portolano S, Chazenbalk GD, Seto P, Hutchison JS, Rapoport B, McLachlan SM. Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase. J Clin Invest 1992;90:720-726.
32. Horimoto M, et al. Production and characterisation of a human monoclonal thyroid peroxidase autoantibody. Autoimmunity 1992;14:1-7.
33. Hexham JM, et al. Variable region sequence of a human monoclonal thyroid peroxidase autoantibody. Autoimmunity 1992;14:169-172.
34. Chazenbalk GD, Portolano S, Russo D, Hutchison JS, Rapoport B, McLachlan SM. Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ. J Clin Invest 1993;92:62-74.
35. Portolano S, Chazenbalk GD, Hutchison JS, McLachlan SM, Rapoport B. Lack of promiscuity in autoantigen-specific H and L chain combinations as revealed by human H and L chain "roulette". J Immunol 1993;150:880-887.
36. Portolano S, McLachlan SM, Rapoport B. High affinity, thyroid-specific human autoantibodies displayed on the surface of filamentous phage use V genes similar to other autoantibodies. J Immunol 1993;151:2839-2851.
37. Prummel MF. Portolano S, Costante G, Rapoport B, McLachlan SM. Isolation and characterization of a monoclonal human thyroid peroxidase autoantibody of lambda light chain type. Mol Cell Endocrinol 1994;102:161-166.
38. Hexham JM, et al. Cloning and characterisation of TPO autoantibodies using combinatorial phage display libraries. Autoimmunity 1994;17:167-179.
39. Portolano S, Prummel MF, Rapoport B, McLachlan SM. Molecular cloning and characterization of human thyroid peroxidase autoantibodies of lambda light chain type. Mol Immunol 1995;32:1157-1169.
40. Jaume JC, Portolano S, Rapoport B, McLachlan SM. Influence of the light chain repertoire on immunoglobulin genes encoding thyroid autoantibody Fab from combinatorial libraries. Autoimmunity 1996;24:11-23.
41. Jaume JC, Guo J, Rapoport B, McLachlan SM. The epitopic fingerprint of thyroid peroxidase-specific Fab isolated from a patient's thyroid gland by the combinatorial library approach resembles that of autoantibodies in the donors serum. Clin Immunol Immunopathol 1997;84:150-157.
42. Sanz I. Multiple mechanisms participate in the generation of diversity of human H-chain CDR3 regions. J Immunol 1991;147:1720-1729.
43. Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, Rovera G. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J Exp Med 1991;173:395-407.
44. Ruf J, Toubert M-E, Czarnocka B, Durand-Gorde J-M, Ferrand M, Carayon P. Relationship between immunological structure and biochemical properties of human thyroid peroxidase. Endocrinology 1989;125:1211-1218.
45. Czarnocka B, et al. IgGκ anti-thyroid peroxidase antibodies in Hashimoto's thyroiditis: epitope mapping analysis. J Clin Endocrinol Metab 1997;82:2639-2644.
46. Guo J, McIntosh RS, Czarnocka B, Weetman AP, Rapoport B, McLachlan SM. Relationship between autoantibody epitope recognition and immunoglobulin gene usage. Clin Exp Immunol 1998;111:408-414.
47. Costante G, et al. Recombinant thyroid peroxidase-specific autoantibodies. II. Role of individual heavy and light chains in determining epitope recognition. Endocrinology 1994;135:25-30.
48. Ruf J, Feldt-Rasmussen U, Hegedues L, Ferrand M, Carayon P. Bispecific thyroglobulin and thyroperoxidase autoantibodies in patients with various thyroid and autoimmune diseases. J Clin Endocrinol Metab 1994;79:1404-1409.
49. Fan J-L, Desai RK, Dallas JS, Wagle NM, Seetharamaiah GS, Prabhakar BS. High frequency of B cells capable of producing anti-thyrotropin receptor antibodies in patients with Graves' disease. Clin Immunol Immunopathol 1994;71:69-74.
50. Akamizu T, Kohn LD, Mori T. Molecular studies on thyrotropin (TSH) receptor and anti-TSH receptor antibodies. Endocr J 1995;42:617-627.
51. Harfst E, Johnstone AP, Nussey SS. Characterisation of the extracellular region of the human thyrotropin receptor expressed as a recombinant protein. J Mol Endocrinol 1992;9:227-236.
52. Rapoport B, McLachlan SM, Kakinuma A, Chazenbalk GD. Critical relationship between autoantibody recognition and TSH receptor maturation as reflected in the acquisition of mature carbohydrate. J Clin Endocrinol Metab 1996;81:2523-2533.
53. Huang GC, Page MJ, Nicholson LB, Collison KS, McGregor AM, Banga JP. The thyrotropin hormone receptor of Graves' disease: overexpression of the extracellular domain in insect cells using recombinant baculovirus, immunoaffinity purification and analysis of autoantibody binding. J Mol Endocrinol 1993;10:127-142.
54. Okamoto Y, Hayashi Y, DeGroot LJ. Expression of human thyrotropin receptor by recombinant adenovirus. Thyroid 1995;5:51-53.
55. McLachlan SM, Rapoport B. Recombinant thyroid antigens: the keys to the pathogenesis of autoimmune thyroid disease. J Intern Med 1992;234:347-359.
56. Shin EK, et al. Variable regions of Ig heavy chain genes encoding antithyrotropin receptor antibodies of patients with Graves' disease. J Immunol 1994;152:1485-1492.
57. Akamizu T, et al. Molecular analysis of stimulatory anti-thyrotropin receptor antibodies (TSAbs) involved in Graves' disease. Isolation and reconstruction of antibody genes and production of monoclonal TSAbs. J Immunol 1996;157:3148-3152.
58. Li H, et al. Isolation of Epstein-Barr-virus-transformed lymphocytes producing IgG class monoclonal antibodies using a magnetic cell separator: preparation of thyroid-stimulating IgG antibodies from patients with Graves' disease. Biochem Biophys Res Commun 1995;207:985-993.
59. Morgenthaler NG, et al. Human-immunoglobulin G autoantibodies to the thyrotropin receptor from Epstein Barr virus-transformed B lymphocytes: characterisation by immunoprecipitation with recombinant antigen and biological activity. J Clin Endocrinol Metab 1996;81:3155-3161.
60. Asghar MS. Cloning and analysis of autoantibodies in autoimmune thyroid disease. University of Sheffield, UK; 1997 (PhD thesis).
61. Kakinuma A, Portolano S, Chazenbalk G, Rapoport B, McLachlan SM. Insight into screening immunoglobulin gene combinatorial libraries in a phage display vector: a tale of two antibodies. Autoimmunity 1997;25:73-84.