T cell selection and differential activation on structurally related HLA-DR4 ligands

Journal of Immunology

Volumn 167, Issue 6, 2001, Pages 3250-3256

  Gebe, J A ^a   Novak, E J ^a   Kwok, W W ^a   Farr, A G ^a   Nepom, G T ^a   Buckner, J H ^a  

^a BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; HEMAGGLUTININ; HLA ANTIGEN CLASS 2; HLA DR1 ANTIGEN; HLA DR4 ANTIGEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN; TETRAMER;

ALLELE; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL SELECTION; CONTROLLED STUDY; IMMUNE RESPONSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CLONE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; THYMUS;

EID: 0035884780     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.6.3250     Document Type: Article

References (38)

1. The crystal structure of a T cell receptor in complex with peptide and MHC class II
2. Structure of a covalently stabilized complex of a human αβ T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1
3. Structural basis of specificity and degeneracy of T cell recognition: Pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR
4. Modulation of naive CD4 T cell activation with altered peptide ligands: The nature of the peptide and presentation in the context of costimulation are critical for a sustained response
5. An altered peptide ligand specifically inhibits Th2 cytokine synthesis by abrogating TCR signaling
6. Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition
7. On the interaction of promiscuous antigenic peptides with different DR alleles: Identification of common structural motifs
8. Molecular basis for the recognition of two structurally different major histocompatibility complex/peptide complexes by a single T-cell receptor
9. The orientation of a T cell receptor to its MHC class II: Peptide ligands
10. Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance
11. + T cells by antigenic peptides altered for TCR binding
12. The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis
13. The association of HLA DR B alleles with self-limiting and persistent forms of early symmetrical polyarthritis
14. HLA heterozygosity contributes to susceptibility to rheumatoid arthritis
15. The shared epitope hypothesis: An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
16. Epitopes are the functional units of 1a molecules and form the molecular basis for disease susceptibility
17. Studies on T cell maturation in defined thymic stromal cell populations in vitro
18. MHC class II-positive epithelium and mesenchyme cells are both required for T cell development in the thymus
19. + T cells proliferating in response to influenza A antigen
20. Use of peptide libraries to map the substrate specificity of a peptide- modifying enzyme: A 13 residue consensus peptide specifies biotinylation in Escherichia coli
21. The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells
22. In vitro positive selection and anergy induction of class II-restricted TCR transgenic thymocytes by a cortical thymic epithelial cell line
23. Mapping T cell recognition: The identification of a T cell receptor residue critical to the specific interaction with an influenza hemagglutinin peptide
24. HLA-DR4Dw4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions
25. Peptide recognition by T-cell clones of an HLA-DRB1*1501/*0901 heterozygous donor is promiscuous only between parental alleles
26. Cross-restriction of a T cell clone to HLA-DR alleles associated with rheumatoid arthritis: Clues to arthritogenic peptide motifs
27. TCR-independent pathways mediate the effects of antigen dose and altered peptide ligands on Th cell polarization
28. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
29. Differential CD3ζ phosphorylation is not required for the induction of T cell antagonism by altered peptide ligands
30. Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands
31. Enhanced antigen-specific antitumor immunity with altered peptide ligands that stabilize the MHC-peptide-TCR complex
32. Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: Implications for TCR signaling
33. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo
34. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon γ by T cells
35. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers
36. X-ray crystal structure of HLA-DR4 (DRA1*0101, DRB1*0401) complexed with a peptide from human collagen II
37. Use of T cell receptor/HLA-DRB1*04 molecular modeling to predict site-specific interactions for the DR shared epitope associated with rheumatoid arthritis
38. Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis