Glutathione depletion upregulates P-glycoprotein expression at the blood-brain barrier in rats

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 6, 2009, Pages 819-824

  Wu, Jing ^a   Hong, Hao ^a   Ji, Hui ^a   Wang, Ying Yu ^a   Wang, Ying ^a   Li, Yong Qi ^a   Li, Wei Guang ^a   Long, Yan ^a   Xia, Yuan Zheng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Blood brain barrier; Glutathione; Oxidative stress; P glycoprotein

Indexed keywords

ACETYLCYSTEINE; EVANS BLUE; GLUTATHIONE; GLYCOPROTEIN P; MALEIC ACID DIETHYL ESTER; MESSENGER RNA; RHODAMINE 123; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; MALEIC ACID DERIVATIVE; SCAVENGER;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; EXTRAVASATION; IN VIVO STUDY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECT; GENETICS; METABOLISM; SPRAGUE DAWLEY RAT;

ACETYLCYSTEINE; ANIMALS; BLOOD-BRAIN BARRIER; DOSE-RESPONSE RELATIONSHIP, DRUG; EVANS BLUE; FREE RADICAL SCAVENGERS; GLUTATHIONE; INDICATORS AND REAGENTS; MALE; MALEATES; OXIDATIVE STRESS; P-GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHODAMINE 123; RNA, MESSENGER; UP-REGULATION;

EID: 85047685994     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.06.0016     Document Type: Article

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