The importance of brain PGE2 inhibition versus paw PGE 2 inhibition as a mechanism for the separation of analgesic and antipyretic effects of lornoxicam in rats with paw inflammation

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 5, 2009, Pages 607-614

  Futaki, Nobuko ^a   Harada, Masahiro ^a   Sugimoto, Masanori ^a   Hashimoto, Yuki ^a   Honma, Yusuke ^a   Arai, Iwao ^a   Nakaike, Shiro ^a   Hoshi, Keiko ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Analgesic activity; Antipyretic activity; Lornoxicam; Rat paw oedema

Indexed keywords

CELECOX; CELECOXIB; LORCAM; LORNOXICAM; LOXOPROFEN; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; DRUG DERIVATIVE; FREUND ADJUVANT; NONSTEROID ANTIINFLAMMATORY AGENT; PHENYLPROPIONIC ACID DERIVATIVE; PIROXICAM; PROSTAGLANDIN SYNTHASE INHIBITOR; PYRAZOLE DERIVATIVE; SULFONAMIDE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPYRETIC ACTIVITY; ARTICLE; CEREBROSPINAL FLUID; CHRONIC ARTHRITIS; CHRONIC INFLAMMATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENZYME IMMUNOASSAY; EXUDATE; HYPERALGESIA; HYPOTHALAMUS; INFLAMMATION; MALE; NONHUMAN; PAW EDEMA; PROSTAGLANDIN SYNTHESIS; RAT; ANIMAL; ARTHRITIS; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG EFFECT; EDEMA; FEVER; LEWIS RAT; LIMB; METABOLISM; ORAL DRUG ADMINISTRATION; PAIN ASSESSMENT; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; EDEMA; EXTREMITIES; FEVER; FREUND'S ADJUVANT; HYPERALGESIA; HYPOTHALAMUS; INFLAMMATION; MALE; PAIN MEASUREMENT; PHENYLPROPIONATES; PIROXICAM; PYRAZOLES; RATS; RATS, INBRED LEW; RATS, WISTAR; SULFONAMIDES;

EID: 85047684334     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.05.0009     Document Type: Article

References (30)

1. Vane JR, Botting RM. A better understanding of antiinflammatory drugs based on isoforms of cyclooxygenase (COX-1 and COX-2). Adv Prostaglandin Thromboxane Leukot Res 1995; 23: 41-48.
2. Smith WL, Dewitt DL. Prostaglandin endoperoxide H synthases-1 and -2. Adv Immunol 1996; 62: 167-215.
3. O'Banion MK. Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology. Crit Rev Neurobiol 1999; 13: 45-82.
4. Meade EA et al. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1993; 268: 6610-6614.
5. Brideau C et al. A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors. Inflamm Res 1996; 45: 68-74.
6. Warner TD et al. Nonsteroid drug selectivities for cyclooxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 1999; 96: 7563-7568.
7. Vane JR et al. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 1998; 38: 97-120.
8. Hay CH et al. The potential role of spinal cord cyclooxygenase-2 in the development of Freund's complete adjuvant-induced changes in hyperalgesia and allodynia. Neuroscience 1997; 78: 843-850.
9. Smith CJ et al. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci USA 1998; 95: 13313-13318.
10. Dirig DM et al. Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. J Pharmacol Exp Ther 1998; 285: 1031-1038.
11. Samad TA et al. Interleukin-1β-mediated induction of COX-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 2001; 410: 471-475.
12. 2 synthase-1. J Biol Chem 2004; 279: 24866-24872.
13. Kluger MJ. Fever: role of pyrogens and cryogens. Physiol Rev 1991; 71: 93-127.
14. Elmquist JK et al. Mechanisms of CNS response to systemic immune challenge: the febrile response. Trends Neurosci 1997; 20: 565-570.
15. Dinarello CA. Cytokines as endogenous pyrogens. J Infect Dis 1999; 179(Suppl 2): S294-S304.
16. Yamagata K et al. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci 2001; 21: 2669-2677.
17. Taniguchi Y et al. Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulide. Eur J Pharmacol 1997; 330: 221-229.
18. Okumura T et al. Pharmacological separation between peripheral and central function of cyclooxygenase-2 with CIAA, a novel cyclooxygenase-2 inhibitor. Eur J Pharmacol 2006; 539: 125-130.
19. Futaki N et al. Anti-inflammatory, analgesic, antipyretic and cyclooxygenase inhibitory effects of a non-steroidal antiinflammatory agent. lornoxicam. Jpn Pharmacol Ther 1997; 25: 925-941.
20. Amanuma F et al. The analgesic and antipyretic effects of a non-steroidal anti-inflammatory drug, oxaprozin, in experimental animals. Folia Pharmacol Japon 1984; 83: 345-354.
21. Yoshino T et al. Pharmacological profile of celecoxib, a specific cyclooxygenase-2 inhibitor. Arzneimittelforschung 2005; 55: 394-402.
22. Misaka E et al. Anti-inflammatory, analgesic and antipyretic activities of sodium 2-[4-(2-oxocyclopentan-1-ylmethyl) phenyl] propionate dihydrate (CS-600). Pharmacometrics 1981; 21: 753-771.
23. Noguchi M et al. Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites. Biol Pharm Bull 2005; 28(11): 2075-2079.
24. Mukherjee A et al. Predictability of the clinical potency of NSAIDs from the preclinical pharmacodynamics in rats. Inflamm Res 1996; 45: 531-540.
25. Philippe L et al. Relations between functional, inflammatory, and degenerative parameters during adjuvant arthritis in rats. Am J Physiol 1997; 273(4 Pt 2): R1550-R1556.
26. Berg J et al. The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. Inflamm Res 1999; 48(7): 369-379.
27. Urano H et al. Disposition of lornoxicam (2) - tissue distribution, foeto-placental transfer and transfer into milk after single administration to rats. Kiso to Rinsho 1997; 31: 1401-1413.
28. Vanegas H, Georg H. Prostaglandins and cyclooxygenases in the spinal cord. Prog Neurobiol 2001; 64: 327-363.
29. Vaughn LK et al. Antipyresis: its effect on mortality rate of bacterially infected rabbits. Brain Res Bull 1980; 5: 69-73.
30. Vaughn LK et al. Effects of antipyresis on bacterial numbers in infected rabbits. Brain Res Bull 1981; 7: 175-180.