HNF1α and SREBP2 are important regulators of NPC1L1 in human liver

Journal of Lipid Research

Volumn 51, Issue 6, 2010, Pages 1354-1362

  Pramfalk, Camilla ^a   Jiang, Zhao Yan ^a,b   Cai, Qu ^b   Hu, Hai ^c   Zhang, Sheng Dao ^b   Han, Tian Quan ^b   Eriksson, Mats ^a   Parini, Paolo ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Tongji University   (China)

Author keywords

Chromatin immunoprecipitation; Correlation analysis; Cotransfection; Hepatic nuclear factor; Niemann Pick C1 like 1; Sterol regulatory element binding protein 2

Indexed keywords

CARRIER PROTEIN; CHOLESTEROL; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; MESSENGER RNA; NIEMANN PICK C1 LIKE 1 PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG; HEPATOCYTE NUCLEAR FACTOR 4; HNF4A PROTEIN, HUMAN; MEMBRANE PROTEIN; NPC1L1 PROTEIN, HUMAN;

ADULT; ARTICLE; BINDING SITE; CHINESE; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; GALLSTONE; GENETIC REGULATION; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; INTESTINE ABSORPTION; LIVER PARENCHYMA; MALE; NIEMANN PICK DISEASE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; CELL LINE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; LIVER; METABOLISM; NUCLEOTIDE SEQUENCE;

BASE SEQUENCE; CELL LINE; FEMALE; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; LIVER; MALE; MEMBRANE PROTEINS; PROMOTER REGIONS, GENETIC; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION, GENETIC;

EID: 85047683727     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M900274-JLR200     Document Type: Article

References (32)

1. Altmann, S. W., H. R. Davis, Jr., L. J. Zhu, X. Yao, L. M. Hoos, G. Tetzloff, S. P. Iyer, M. Maguire, A. Golovko, M. Zeng, et al. 2004. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science. 303: 1201-1204.
2. Garcia-Calvo, M., J. Lisnock, H. G. Bull, B. E. Hawes, D. A. Burnett, M. P. Braun, J. H. Crona, H. R. Davis, Jr., D. C. Dean, P. A. Detmers, et al. 2005. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proc. Natl. Acad. Sci. USA. 102: 8132-8137. (Pubitemid 40800055)
3. Davies, J. P., C. Scott, K. Oishi, A. Liapis, and Y. A. Ioannou. 2005. Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia. J. Biol. Chem. 280: 12710-12720. (Pubitemid 40491091)
4. Sané, A. T., D. Sinnett, E. Delvin, M. Bendayan, V. Marcil, D. Menard, J. F. Beaulieu, and E. Levy. 2006. Localization and role of NPC1L1 in cholesterol absorption in human intestine. J. Lipid Res. 47: 2112-2120.
5. van Heek, M., C. Farley, D. S. Compton, L. Hoos, K. B. Alton, E. J. Sybertz, and H. R. Davis, Jr. 2000. Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663. Br. J. Pharmacol. 129: 1748-1754.
6. Yu, L., S. Bharadwaj, J. M. Brown, Y. Ma, W. Du, M. A. Davis, P. Michaely, P. Liu, M. C. Willingham, and L. L. Rudel. 2006. Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake. J. Biol. Chem. 281: 6616-6624. (Pubitemid 43847596)
7. Brown, J. M., L. L. Rudel, and L. Yu. 2007. NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells. Biochem. J. 406: 273-283.
8. Temel, R. E., W. Tang, Y. Ma, L. L. Rudel, M. C. Willingham, Y. A. Ioannou, J. P. Davies, L. M. Nilsson, and L. Yu. 2007. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J. Clin. Invest. 117: 1968-1978.
9. Brown, M. S., and J. L. Goldstein. 1997. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 89: 331-340. (Pubitemid 27220877)
10. Wong, J., C. M. Quinn, and A. J. Brown. 2006. SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR. Biochem. J. 400: 485-491. (Pubitemid 44974460)
11. Schrem, H., J. Klempnauer, and J. Borlak. 2002. Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression. Pharmacol. Rev. 54: 129-158. (Pubitemid 34208830)
12. Shih, D. Q., M. Bussen, E. Sehayek, M. Ananthanarayanan, B. L. Shneider, F. J. Suchy, S. Shefer, J. S. Bollileni, F. J. Gonzalez, J. L. Breslow, et al. 2001. Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat. Genet. 27: 375-382.
13. Chen, W. S., K. Manova, D. C. Weinstein, S. A. Duncan, A. S. Plump, V. R. Prezioso, R. F. Bachvarova, and J. E. Darnell, Jr. 1994. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 8: 2466-2477.
14. Hayhurst, G. P., Y. H. Lee, G. Lambert, J. M. Ward, and F. J. Gonzalez. 2001. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21: 1393-1403.
15. Divine, J. K., S. P. McCaul, and T. C. Simon. 2003. HNF-1alpha and endodermal transcription factors cooperatively activate Fabpl: MODY3 mutations abrogate cooperativity. Am. J. Physiol. Gastrointest. Liver Physiol. 285: G62-G72.
16. Bjorkhaug, L., J. V. Sagen, P. Thorsby, O. Sovik, A. Molven, and P. R. Njolstad. 2003. Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in Norway. J. Clin. Endocrinol. Metab. 88: 920-931. (Pubitemid 36207843)
17. Chung, B. H., T. Wilkinson, J. C. Geer, and J. P. Segrest. 1980. Preparative and quantitative isolation of plasma lipoproteins: rapid, single discontinuous density gradient ultracentrifugation in a vertical rotor. J. Lipid Res. 21: 284-291.
18. Jiang, Z. Y., P. Parini, G. Eggertsen, M. A. Davis, H. Hu, G. J. Suo, S. D. Zhang, L. L. Rudel, T. Q. Han, and C. Einarsson. 2008. Increased expression of LXRalpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients. J. Lipid Res. 49: 464-472.
19. Pramfalk, C., M. A. Davis, M. Eriksson, L. L. Rudel, and P. Parini. 2005. Control of ACAT2 liver expression by HNF1. J. Lipid Res. 46: 1868-1876. (Pubitemid 41248483)
20. Azzout-Marniche, D., D. Becard, C. Guichard, M. Foretz, P. Ferre, and F. Foufelle. 2000. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes. Biochem. J. 350: 389-393.
21. Nilsson, L. M., A. Abrahamsson, S. Sahlin, U. Gustafsson, B. Angelin, P. Parini, and C. Einarsson. 2007. Bile acids and lipoprotein metabolism: effects of cholestyramine and chenodeoxycholic acid on human hepatic mRNA expression. Biochem. Biophys. Res. Commun. 357: 707-711.
22. Jeong, H. J., H. S. Lee, K. S. Kim, Y. K. Kim, D. Yoon, and S. W. Park. 2008. Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2. J. Lipid Res. 49: 399-409.
23. Alrefai, W. A., F. Annaba, Z. Sarwar, A. Dwivedi, S. Saksena, A. Singla, P. K. Dudeja, and R. K. Gill. 2007. Modulation of human Niemann-Pick C1-like 1 gene expression by sterol: role of sterol regulatory element binding protein 2. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G369-G376.
24. Iwayanagi, Y., T. Takada, and H. Suzuki. 2008. HNF4alpha is a crucial modulator of the cholesterol-dependent regulation of NPC1L1. Pharm. Res. 25: 1134-1141.
25. Kuo, C. J., P. B. Conley, L. Chen, F. M. Sladek, J. E. Darnell, Jr., and G. R. Crabtree. 1992. A transcriptional hierarchy involved in mammalian cell-type specification. Nature. 355: 457-461.
26. Rowley, C. W., L. J. Staloch, J. K. Divine, S. P. McCaul, and T. C. Simon. 2006. Mechanisms of mutual functional interactions between HNF-4alpha and HNF-1alpha revealed by mutations that cause maturity onset diabetes of the young. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G466-G475.
27. Telford, D. E., B. G. Sutherland, J. Y. Edwards, J. D. Andrews, P. H. Barrett, and M. W. Huff. 2007. The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin. J. Lipid Res. 48: 699-708.
28. Misawa, K., T. Horiba, N. Arimura, Y. Hirano, J. Inoue, N. Emoto, H. Shimano, M. Shimizu, and R. Sato. 2003. Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes. J. Biol. Chem. 278: 36176-36182. (Pubitemid 37139940)
29. Odom, D. T., N. Zizlsperger, D. B. Gordon, G. W. Bell, N. J. Rinaldi, H. L. Murray, T. L. Volkert, J. Schreiber, P. A. Rolfe, D. K. Gifford, et al. 2004. Control of pancreas and liver gene expression by HNF transcription factors. Science. 303: 1378-1381. (Pubitemid 38269432)
30. Pramfalk, C., E. Karlsson, L. Groop, L. L. Rudel, B. Angelin, M. Eriksson, and P. Parini. 2009. Control of ACAT2 liver expression by HNF4{alpha}: lesson From MODY1 patients. Arterioscler. Thromb. Vasc. Biol. 29: 1235-1241.
31. Davies, J. P., B. Levy, and Y. A. Ioannou. 2000. Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1. Genomics. 65: 137-145.
32. Dixit, S. S., D. E. Sleat, A. M. Stock, and P. Lobel. 2007. Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption? Biochem. J. 408: 1-5.