Covariance structure of neuroticism and agreeableness: A twin and molecular genetic analysis of the role of the serotonin transporter gene

Journal of Personality and Social Psychology

Volumn 81, Issue 2, 2001, Pages 295-304

  Jang, Kerry L ^a   Livesley, W John ^a   Riemann, Rainer ^d   Vernon, Philip A ^f   Hu, Stella ^b   Angleitner, Alois ^c   Ando, Juko ^e   Ono, Yutaka ^e   Hamer, Dean H ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NATIONAL CANCER INSTITUTE   (United States)

^c BIELEFELD UNIVERSITY   (Germany)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^e KEIO UNIVERSITY   (Japan)

^f UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; SEROTONIN; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BEHAVIOR GENETICS; CANADA; CLINICAL TRIAL; DIZYGOTIC TWINS; EMOTION; FEMALE; GENETICS; GERMANY; HUMAN; JAPAN; MALE; METHODOLOGY; MONOZYGOTIC TWINS; MULTICENTER STUDY; NUCLEAR FAMILY; PERSONALITY; PERSONALITY TEST; PHYSIOLOGY; PRINCIPAL COMPONENT ANALYSIS; PSYCHOLOGICAL ASPECT; STATISTICS; TWINS; UNITED STATES;

ADULT; ANALYSIS OF VARIANCE; CANADA; CARRIER PROTEINS; EMOTIONS; FEMALE; GENETICS, BEHAVIORAL; GERMANY; HUMANS; JAPAN; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NUCLEAR FAMILY; PERSONALITY; PERSONALITY INVENTORY; PRINCIPAL COMPONENT ANALYSIS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TWINS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; UNITED STATES;

EID: 85047681302     PISSN: 00223514     EISSN: None     Source Type: Journal    
DOI: 10.1037/0022-3514.81.2.295     Document Type: Article

References (54)

1. Benjamin, J., Osher, Y., Lichtenberg, P., Bachner-Melman, R., Gritsenko, I., Kotler, M., Belmaker, R. H., Valsky, V., Drendel, M., & Ebstein, R. P. (2000). An interaction between the catechol O-methyltransferase and serotonin transporter promoter region polymorphisms contributes to Tridimensional Personality Questionnaire persistence scores in normal subjects. Neuropsychobiology, 41, 48-53.
2. Bouchard, T. J., Jr. (1997). The genetics of personality. In K. Blum & E. P. Noble (Eds.), Handbook of psychiatric genetics (pp. 273-296). Boca Raton, FL: CRC Press.
3. Carey, G. (1988). Inferences about genetic correlations. Behavior Genetics, 18, 329-338.
4. Carey, G., & DiLalla, D. L. (1994). Personality and psychopathology: Genetic perspectives. Journal of Abnormal Psychology, 103, 32-43.
5. Cloninger, C. R., Adolfsson, R., & Svrakic, N. M. (1996). Mapping genes for human personality. Nature Genetics, 12, 3-4.
6. Cloninger, C. R., Svrakic, D. M., & Przybeck, T. R. (1993). A psychobiological model of temperament and character. Archives of General Psychiatry, 50, 975-990.
7. Costa, P. T., & McCrae, R. R. (1992). The Revised NEO Personality Inventory (NEO-PI-R) and the NEO Five-Factor Inventory (NEO-FFI) professional manual. Odessa, FL: Psychological Assessment Resources.
8. Costa, P. T., & McCrae, R. R. (1995). Domains and facets: Hierarchical personality assessment using the Revised NEO Personality Inventory. Journal of Personality Assessment, 64, 21-50.
9. Costa, P. T., & McCrae, R. R. (1998). Six approaches to the explication of facet-level traits: Examples from conscientiousness. European Journal of Personality, 12, 117-134.
10. DeFries, J. C., & Fulker, D. W. (1985) Multiple regression analysis of twin data. Behavior Genetics, 15, 467-473.
11. Depue, R. A., & Collins, P. F. (1999). Neurobiology of the structure of personality: Dopamine, facilitation of incentive motivation, and extra-version. Behavioral and Brain Sciences, 22, 491-569.
12. Eysenck, H. J. (1991). Dimensions of personality: 16, 5, or 3? Criteria for a taxonomic paradigm. Personality and Individual Differences, 12, 773-790.
13. Eysenck, H. J. (1992). Four ways five factors are not basic. Personality and Individual Differences, 13, 667-673.
14. Eysenck, H. J., & Eysenck, S. B. G. (1992). Manual for the Eysenck Personality Questionnaire - Revised. San Diego, CA: Educational and Industrial Testing Service.
15. Gayan, J., Smith, S. D., Cherny, S. S., Cardon, L. R., Fulker, D. W., Brower, M., Olson, R. K., Pennington, B. F., & DeFries, J. C. (1999). Quantitative trait locus for specific language and reading deficits on chromosome 6p. American Journal of Human Genetics, 64, 157-164.
16. Gelernter, J., Kranzler, H., Coccaro, E. F., Siever, L. J., & New, A. S. (1998). Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects. American Journal of Psychiatry, 155, 1332-1338.
17. Goldberg, L. R. (1993). The structure of phenotypic personality traits. American Psychologist, 48, 26-34.
18. Graeff, F. G., Guimaraes, F. S., De Andrade, T. G., & Deakin, J. F. (1996). Role of 5-HT in stress, anxiety, and depression. Pharmacological and Biochemical Behavior, 54, 129-141.
19. Greenberg, B. D., Li, Q., Lucas, F. R., Hu, S., Sirota, L. A., Benjamin, J., Lesch, K. P., Hamer, D., & Murphy, D. L. (2000). Association between the serotonin transporter polymorphism and personality traits in a primarily female population sample. American Journal of Medical Genetics, 96, 202-216.
20. Greenberg, B. D., Tolliver, T. J., Huang, S. J., Li, Q., Bengel, D., & Murphy, D. L. (1999). Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. American Journal of Medical Genetics, 88, 83-87.
21. Gustavsson, J. P., Nöthen, M. M., Jonsson, E. G., Neidt, H., Forslund, K., Rylander, G., Mattila-Evenden, M., Sedvall, G. C., Propping, P., & Åsberg, M. (1999). No association between serotonin transporter gene polymorphisms and personality traits. American Journal of Medical Genetics, 88, 430-436.
22. Hamer, D. H., Greenberg, B. D., Sabol, S. Z., & Murphy, D. L. (1999). Role of serotonin transporter gene in temperament and character. Journal of Personality Disorders, 13, 312-328.
23. Hansenne, M., & Ansseau, M. (1999). Harm avoidance and serotonin. Biological Psychology, 51, 77-81.
24. Heils, A., Teufel, A., Petri, S., Stober, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry, 66, 2621-2624.
25. Herbst, J. H., Zonderman, A. B., McCrae, R. R., & Costa, P. T. (2000). Do the dimensions of the Temperament and Character Inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis. American Journal of Psychiatry, 157, 1285-1290.
26. Jang, K. L., McCrae, R. R., Angleitner, A., Riemann, R., & Livesley, W. J. (1998). Heritability of facet-level traits in a cross-cultural twin sample: Support for a hierarchical model of personality. Journal of Personality and Social Psychology, 74, 1556-1565.
27. Jöreskog, K., & Sörbom, D. (1993). PRELIS 2: A preprocessor for LISREL. Chicago, IL: Scientific Software International.
28. Knopik, V. S., Alarcon, M., & DeFries, J. C. (1997). Comorbidity of mathematics and reading deficits: Evidence for a genetic etiology. Behavior Genetics, 27, 447-453.
29. Knutson, B., Wolkowitz, O. M., Cole, S. W., Chan, T., Moore, E. A., Johnson, R. C., Terpstra, J., Turner, R. A., & Reus, V. I. (1998). Selective alteration of personality and social behavior by serotonergic intervention. American Journal of Psychiatry, 155, 373-379.
30. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., & Murphy, D. L. (1996). Selective alteration of personality and social behavior by serotonergic intervention. Science, 274, 1527-1531.
31. Little, K. Y., McLaughlin, D. P., Zhang, L., Livermore, C. S., Dalack, G. W., McFinton, P. R., DelProposto, Z. S., Hill, E., Cassin, B. J., Watson, S. J., & Cook, E. H. (1998). Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. American Journal of Psychiatry, 155, 207-213.
32. Livesley, W. J., Jang, K. L., & Vernon, P. A. (1998). Phenotypic and genetic structure of traits delineating personality disorder. Archives of General Psychiatry, 55, 941-948.
33. Martin, N. G., Boomsma, D., & Machin, G. (1997). A twin pronged attack on complex traits. Nature Genetics, 17, 387-392.
34. Mazzanti, C. M., Lappalainen, J., Long, J. C., Bengel, D., Naukkarinen, H., Eggert, M., Virkkunen, M., Linnoila, M., & Goldman, D. (1998). Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Archives of General Psychiatry, 55, 936-940.
35. McCrae, R. R., Jang, K. L., Livesley, W. J., Riemann, R., & Angleitner, A. (2001). Sources of structure: Genetic, environmental, and artifactual influences on the covariance of personality traits. Journal of Personality, 69, 511-535.
36. McGue, M., & Bouchard, T. J. (1984). Adjustment of twin data for the effects of age and sex. Behavior Genetics, 14, 325-343.
37. Murphy, D. L., Andrews, A. M., Wichems, C. H., Li, Q., Tohda, M., & Greenberg, B. (1998). Brain serotonin neurotransmission: An overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs. Journal of Clinical Psychiatry, 59, 4-12.
38. Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (1999). Mx: Statistical modeling (5th ed.). Richmond: Virginia Commonwealth University, Department of Psychiatry.
39. Neale, M. C., & Cardon, L. R. (1992). Methodology for genetic studies of twins and families. Dordrecht, The Netherlands: Kluwer.
40. Nichols, R. C., & Bilbro, W. C., Jr. (1966). The diagnosis of twin zygosity. Acta Geneteticae Medicae et Gemellollogiae, 16, 265-275.
41. Oniszczenko, W., Angleitner, A., Strelau, J., & Angert, T. (1993). The Questionnaire of Twins' Physical Resemblance. Unpublished manuscript, University of Warsaw and University of Bielefeld.
42. Ono, Y., Ando, J., Onoda, N., Yoshimura, K., & Asai, M. (2000). Genetic structure of the five factor model among Japanese population. Keio Journal of Medicine, 49, 152-158.
43. Ooki, S., Yamada, K., & Asaka, A. (1991). Zygosity diagnosis of twins by questionnaire for twin's mothers. Shoni Hoken Keikyu, 50, 71-76.
44. Ostendorf, F., & Angleitner, A. (1994, July). Psychometric properties of the German translation of the Revised NEO Personality Inventory (NEO-PI-R). Paper presented at the 7th European Conference on Personality, Madrid, Spain.
45. Paunonen, S. V., & Jackson, D. N. (1996). The Jackson Personality Inventory and the five-factor model of personality. Journal of Research in Personality, 30 42-59.
46. Peirson, A. R., Heuchert, J. W., Thomala, L., Berk, M., Plein, H., & Cloninger, C. R. (2000). Relationship between serotonin and the Temperament and Character Inventory. Psychiatry Research, 89, 29-37.
47. Plomin, R., DeFries, J. C., McClearn, G. E., & Rutter, M. (1997). Behavioral genetics. New York: Freeman.
48. Riemann, R., Angleitner, A., & Strelau, J. (1997). Genetic and environmental influences on personality: A study of twins reared together using the self- and peer-report NEO-FFI scales. Journal of Personality, 65, 449-475.
49. Rinne, T., Westenberg, H. G. M., den Boer, J. A., & Van den Brink, W. (2000). Serotonergic blunting to meta-chlorophenylpiperazine (m-CPP) highly correlates with sustained childhood abuse in impulsive and autoaggressive female borderline patients. Biological Psychiatry, 47, 548-556.
50. Sham, P. C., Sterne, A., Purcell, S., Cherny, S., Webster, M., Rijsdijk, F., Asherson, P., Ball, D., Craig, I., Eley, T., Goldberg, D., Gray, J., Mann, A., Owen, M., & Plomin, R. (2000). GENESiS: Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings. Twin Research, 3, 316-322.
51. Tellegen, A. (1982). Brief manual for the Differential Personality Questionnaire. Unpublished manuscript, University of Minnesota, Minneapolis.
52. Thomis, M. A., Vlietnick, R. F., Maes, H. H., Limkie, C. J., van Leemputte, M., Claessens, A. L., Marchal, G., & Beunen, G. P. (2000). Predictive power of individual genetic and environmental factor scores. Twin Research, 3, 99-108.
53. Turkheimer, E. (1998). Heritability and biological explanation. Psychological Review, 105, 782-791.
54. Yoshimura, K., Nakamura, K., Ono, Y., Sakurai, A., Saito, N., Mitani, M., Yamauchi, K., Onoda, N., & Asai, M. (1998). Reliability and validity of the Japanese version of the NEO Five-Factor Inventory (NEO-FFI): A population-based survey in Aomori prefecture. The Japanese Journal of Stress Sciences, 13, 45-53.