메뉴 건너뛰기




Volumn 6, Issue 1, 2018, Pages

Biomarkers of cytokine release syndrome and neurotoxicity related to CAR-T cell therapy

Author keywords

Biomarker; CAR T; Chimeric antigen receptor; CRS; Neurotoxicity

Indexed keywords

ALEMTUZUMAB; BIOLOGICAL MARKER; BLINATUMOMAB; CD19 ANTIGEN; CHIMERIC ANTIGEN RECEPTOR; CYCLOPHOSPHAMIDE; DEXAMETHASONE; FLUDARABINE; GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 6; NIVOLUMAB; OKT 3; RITUXIMAB; TOCILIZUMAB; TUMOR NECROSIS FACTOR;

EID: 85047660251     PISSN: None     EISSN: 20507771     Source Type: Journal    
DOI: 10.1186/s40364-018-0116-0     Document Type: Review
Times cited : (213)

References (97)
  • 1
    • 85076576389 scopus 로고    scopus 로고
    • T-cell therapy approved in U.S
    • First-Ever CAR. T-cell therapy approved in U.S. Cancer Discov; 2017. https://doi.org/10.1158/2159-8290.CD-NB2017-126.
    • (2017) Cancer Discov
  • 2
    • 85055123893 scopus 로고    scopus 로고
    • FDA Approves Second CAR T-cell Therapy
    • FDA Approves Second CAR T-cell Therapy. Cancer Discov; 2017. https://doi.org/10.1158/2159-8290.cd-nb2017-155.
    • (2017) Cancer Discov
  • 3
    • 85019166246 scopus 로고    scopus 로고
    • CAR-T's forge ahead, despite Juno deaths
    • DeFrancesco L. CAR-T's forge ahead, despite Juno deaths. Nat Biotechnol. 2017;35:6-7.
    • (2017) Nat Biotechnol , vol.35 , pp. 6-7
    • DeFrancesco, L.1
  • 4
    • 85011955241 scopus 로고    scopus 로고
    • Identification of predictive biomarkers for cytokine release syndrome after Chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia
    • Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, et al. Identification of predictive biomarkers for cytokine release syndrome after Chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Cancer Discov. 2016;6:664-79.
    • (2016) Cancer Discov , vol.6 , pp. 664-679
    • Teachey, D.T.1    Lacey, S.F.2    Shaw, P.A.3    Melenhorst, J.J.4    Maude, S.L.5    Frey, N.6
  • 5
    • 85018404714 scopus 로고    scopus 로고
    • Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment
    • Wang Z, Guo Y, Han W. Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment. Protein Cell; 2017. https://doi.org/10.1007/s13238-017-0400-z.
    • (2017) Protein Cell
    • Wang, Z.1    Guo, Y.2    Han, W.3
  • 6
    • 84979268324 scopus 로고    scopus 로고
    • Chimeric antigen receptors modified T-cells for cancer therapy
    • Dai H, Wang Y, Lu X, Han W. Chimeric antigen receptors modified T-cells for cancer therapy. J Natl Cancer Inst. 2016;108:djv439.
    • (2016) J Natl Cancer Inst , vol.108
    • Dai, H.1    Wang, Y.2    Lu, X.3    Han, W.4
  • 7
    • 85038250731 scopus 로고    scopus 로고
    • Chimeric antigen receptor T-cell therapies for lymphoma
    • Brudno JN, Kochenderfer JN. Chimeric antigen receptor T-cell therapies for lymphoma. Nat Rev Clin Oncol; 2017. https://doi.org/10.1038/nrclinonc.2017.128.
    • (2017) Nat Rev Clin Oncol
    • Brudno, J.N.1    Kochenderfer, J.N.2
  • 9
    • 85030464634 scopus 로고    scopus 로고
    • Global registration trial of efficacy and safety of CTL019 in pediatric and young adult patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL): update to the interim analysis
    • Buechner J, Grupp SA, Maude SL, Boyer M, Bittencourt H, Laetsch TW, et al. Global registration trial of efficacy and safety of CTL019 in pediatric and young adult patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL): update to the interim analysis. Clinical Lymphoma Myeloma Leuk. 2017;17:S263-4.
    • (2017) Clinical Lymphoma Myeloma Leuk , vol.17 , pp. S263-S264
    • Buechner, J.1    Grupp, S.A.2    Maude, S.L.3    Boyer, M.4    Bittencourt, H.5    Laetsch, T.W.6
  • 11
    • 84904097189 scopus 로고    scopus 로고
    • Current concepts in the diagnosis and management of cytokine release syndrome
    • Lee DW, Gardner R, Porter DL, Louis CU, Ahmed N, Jensen M, et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood. 2014;124:188-95.
    • (2014) Blood , vol.124 , pp. 188-195
    • Lee, D.W.1    Gardner, R.2    Porter, D.L.3    Louis, C.U.4    Ahmed, N.5    Jensen, M.6
  • 12
    • 84987881530 scopus 로고    scopus 로고
    • Cytokine release syndrome after Chimeric antigen receptor T cell therapy for acute lymphoblastic leukemia
    • Fitzgerald JC, Weiss SL, Maude SL, Barrett DM, Lacey SF, Melenhorst JJ, et al. Cytokine release syndrome after Chimeric antigen receptor T cell therapy for acute lymphoblastic leukemia. Crit Care Med. 2017;45:e124-31.
    • (2017) Crit Care Med , vol.45 , pp. e124-e131
    • Fitzgerald, J.C.1    Weiss, S.L.2    Maude, S.L.3    Barrett, D.M.4    Lacey, S.F.5    Melenhorst, J.J.6
  • 13
    • 85034805472 scopus 로고    scopus 로고
    • Kinetics and biomarkers of severe cytokine release syndrome after CD19 Chimeric antigen receptor-modified T cell therapy
    • Hay KA, Hanafi LA, Li D, Gust J, Liles WC, Wurfel MM, et al. Kinetics and biomarkers of severe cytokine release syndrome after CD19 Chimeric antigen receptor-modified T cell therapy. Blood; 2017. https://doi.org/10.1182/blood-2017-06-793141.
    • (2017) Blood
    • Hay, K.A.1    Hanafi, L.A.2    Li, D.3    Gust, J.4    Liles, W.C.5    Wurfel, M.M.6
  • 14
    • 85037359093 scopus 로고    scopus 로고
    • Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells
    • Gust J, Hay KA, Hanafi LA, Li D, Myerson D, Gonzalez-Cuyar LF, et al. Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells. Cancer Discov. 2017;7:1404-19.
    • (2017) Cancer Discov , vol.7 , pp. 1404-1419
    • Gust, J.1    Hay, K.A.2    Hanafi, L.A.3    Li, D.4    Myerson, D.5    Gonzalez-Cuyar, L.F.6
  • 15
    • 85037656336 scopus 로고    scopus 로고
    • Cytokine release syndrome associated with chimeric-antigen receptor T-cell therapy; clinicopathological insights
    • Obstfeld AE, Frey NV, Mansfield K, Lacey SF, June CH, Porter DL, et al. Cytokine release syndrome associated with chimeric-antigen receptor T-cell therapy; clinicopathological insights. Blood. 2017; https://doi.org/10.1182/blood-2017-08-802413.
    • (2017) Blood.
    • Obstfeld, A.E.1    Frey, N.V.2    Mansfield, K.3    Lacey, S.F.4    June, C.H.5    Porter, D.L.6
  • 16
    • 85039759162 scopus 로고    scopus 로고
    • Baseline and early post-treatment clinical and laboratory factors associated with severe neurotoxicity following 19-28z CAR T cells in adult patients with relapsed B-ALL
    • Park JH, Santomasso B, Riviere I, Senechal B, Wang X, Purdon T, et al. Baseline and early post-treatment clinical and laboratory factors associated with severe neurotoxicity following 19-28z CAR T cells in adult patients with relapsed B-ALL. J Clin Oncol. 2017;35:7024.
    • (2017) J Clin Oncol , vol.35 , pp. 7024
    • Park, J.H.1    Santomasso, B.2    Riviere, I.3    Senechal, B.4    Wang, X.5    Purdon, T.6
  • 17
    • 85030169193 scopus 로고    scopus 로고
    • Cytokine release syndrome: who is at risk and how to treat
    • Frey N. Cytokine release syndrome: who is at risk and how to treat. Best Pract Res Clin Haematol. 2017;30:336-40.
    • (2017) Best Pract Res Clin Haematol , vol.30 , pp. 336-340
    • Frey, N.1
  • 18
    • 85032908096 scopus 로고    scopus 로고
    • Global pivotal phase 2 trial of the Cd19-targeted therapy Ctl019 in adult patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (Dlbcl)-an interim analysis
    • Schuster SJ, Bishop MR, Tam C, Waller EK, Borchmann P, McGuirk J, et al. Global pivotal phase 2 trial of the Cd19-targeted therapy Ctl019 in adult patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (Dlbcl)-an interim analysis. Hematol Oncol. 2017;35:27.
    • (2017) Hematol Oncol , vol.35 , pp. 27
    • Schuster, S.J.1    Bishop, M.R.2    Tam, C.3    Waller, E.K.4    Borchmann, P.5    McGuirk, J.6
  • 19
    • 85019806116 scopus 로고    scopus 로고
    • Intent-to-treat leukemia remission by CD19 CAR T cells of defined formulation and dose in children and young adults
    • Gardner RA, Finney O, Annesley C, Brakke H, Summers C, Leger K, et al. Intent-to-treat leukemia remission by CD19 CAR T cells of defined formulation and dose in children and young adults. Blood. 2017;129:3322-31.
    • (2017) Blood , vol.129 , pp. 3322-3331
    • Gardner, R.A.1    Finney, O.2    Annesley, C.3    Brakke, H.4    Summers, C.5    Leger, K.6
  • 21
    • 85062927260 scopus 로고    scopus 로고
    • 32nd Annual Meeting and Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2017): Part One National Harbor, MD, USA
    • 8-12 November 2017 Abstracts
    • DeAngelo DJ, Ghobadi A, Park JH, Dinner SN, Mannis GN, Lunning MA, et al. 32nd Annual Meeting and Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2017): Part One National Harbor, MD, USA. 8-12 November 2017 Abstracts. J Immunother Cancer. 2017;5(Suppl 2):P217.
    • (2017) J Immunother Cancer. , vol.5 , pp. P217
    • DeAngelo, D.J.1    Ghobadi, A.2    Park, J.H.3    Dinner, S.N.4    Mannis, G.N.5    Lunning, M.A.6
  • 22
    • 85044187133 scopus 로고    scopus 로고
    • High durable CR rates in relapsed/refractory (R/R) aggressive B-NHL treated with the CD19-directed CAR T cell product JCAR017 (TRANSCEND NHL 001): defined composition allows for dose-finding and definition of pivotal cohort
    • Abramson JS, Palomba ML, Gordon LI, Lunning MA, Arnason JE, Wang M, et al. High durable CR rates in relapsed/refractory (R/R) aggressive B-NHL treated with the CD19-directed CAR T cell product JCAR017 (TRANSCEND NHL 001): defined composition allows for dose-finding and definition of pivotal cohort. Blood. 2017;130:581.
    • (2017) Blood , vol.130 , pp. 581
    • Abramson, J.S.1    Palomba, M.L.2    Gordon, L.I.3    Lunning, M.A.4    Arnason, J.E.5    Wang, M.6
  • 23
    • 85038251149 scopus 로고    scopus 로고
    • Efficacy of CD19-targeted chimeric antigen receptor T cells in the treatment of relapsed extramedullary B-cell acute lymphoblastic leukemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL)
    • Hu Y, Wu Z, Yu J, Wang J, Wei G, Wu W, et al. Efficacy of CD19-targeted chimeric antigen receptor T cells in the treatment of relapsed extramedullary B-cell acute lymphoblastic leukemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL). J Clin Oncol. 2017;35:-e14549.
    • (2017) J Clin Oncol. , vol.35
    • Hu, Y.1    Wu, Z.2    Yu, J.3    Wang, J.4    Wei, G.5    Wu, W.6
  • 24
    • 85032027433 scopus 로고    scopus 로고
    • Efficacy of anti-CD19 chimeric antigen receptor modified T(CAR-T) cell therapy in Chinese patients with relapsed/refractory acute lymphocytic leukemia in a multicenter trial
    • Xiao L, Huang H, Huang X, Ke X, Hu Y, Li J, et al. Efficacy of anti-CD19 chimeric antigen receptor modified T(CAR-T) cell therapy in Chinese patients with relapsed/refractory acute lymphocytic leukemia in a multicenter trial. J Clin Oncol. 2017;35:7028.
    • (2017) J Clin Oncol , vol.35 , pp. 7028
    • Xiao, L.1    Huang, H.2    Huang, X.3    Ke, X.4    Hu, Y.5    Li, J.6
  • 25
    • 85032013859 scopus 로고    scopus 로고
    • CD133-redirected chimeric antigen receptor engineered autologous T-cell treatment in patients with advanced and metastatic malignancies
    • Wang Y, Chen M, Wu Z, Tong C, Huang J, Lv H, et al. CD133-redirected chimeric antigen receptor engineered autologous T-cell treatment in patients with advanced and metastatic malignancies. J Clin Oncol. 2017;35:3042.
    • (2017) J Clin Oncol , vol.35 , pp. 3042
    • Wang, Y.1    Chen, M.2    Wu, Z.3    Tong, C.4    Huang, J.5    Lv, H.6
  • 26
    • 85062924116 scopus 로고    scopus 로고
    • Yescarta (axicabtagene ciloleucel) suspension for intravenous infusion prescribing information, Kite Pharma, Inc, October 2017
    • Accessed 7 Nov
    • Yescarta (axicabtagene ciloleucel) suspension for intravenous infusion prescribing information, Kite Pharma, Inc, October 2017. Available at https://www.fda.gov/BiologicsBloodVaccines/CellularGeneTherapyProducts/ApprovedProducts/ucm581222.htm. Accessed 7 Nov 2017.
    • (2017)
  • 27
    • 85062925312 scopus 로고    scopus 로고
    • Kymriah (tisagenlecleucel) suspension for intravenous infusion prescribing information, Novartis Pharmaceuticals Corp
    • Accessed 6 Sept 2017.
    • Kymriah (tisagenlecleucel) suspension for intravenous infusion prescribing information, Novartis Pharmaceuticals Corp; 2017. Available at www.fda.gov/downloads/BiologicsBloodVaccines/CellularGeneTherapyProducts/ApprovedProducts/UCM573941.pdf. Accessed 6 Sept 2017.
    • (2017)
  • 29
    • 84896335556 scopus 로고    scopus 로고
    • Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
    • Davila ML, Riviere I, Wang X, Bartido S, Park J, Curran K, et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med. 2014;6:224ra225.
    • (2014) Sci Transl Med , vol.6 , pp. 224-225
    • Davila, M.L.1    Riviere, I.2    Wang, X.3    Bartido, S.4    Park, J.5    Curran, K.6
  • 30
    • 85017180898 scopus 로고    scopus 로고
    • Neurological toxicities and coagulation disorders in the cytokine release syndrome during CAR-T therapy
    • Mei H, Jiang H, Wu Y, Guo T, Xia L, Jin R, et al. Neurological toxicities and coagulation disorders in the cytokine release syndrome during CAR-T therapy. Br J Haematol; 2017. https://doi.org/10.1111/bjh.14680.
    • (2017) Br J Haematol
    • Mei, H.1    Jiang, H.2    Wu, Y.3    Guo, T.4    Xia, L.5    Jin, R.6
  • 31
    • 84941758827 scopus 로고    scopus 로고
    • Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia
    • Dai H, Zhang W, Li X, Han Q, Guo Y, Zhang Y, et al. Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia. Oncoimmunology. 2015;4:e1027469.
    • (2015) Oncoimmunology , vol.4
    • Dai, H.1    Zhang, W.2    Li, X.3    Han, Q.4    Guo, Y.5    Zhang, Y.6
  • 32
    • 84977477922 scopus 로고    scopus 로고
    • Toxicities of chimeric antigen receptor T cells: recognition and management
    • Brudno JN, Kochenderfer JN. Toxicities of chimeric antigen receptor T cells: recognition and management. Blood. 2016;127:3321-30.
    • (2016) Blood , vol.127 , pp. 3321-3330
    • Brudno, J.N.1    Kochenderfer, J.N.2
  • 33
    • 85038248162 scopus 로고    scopus 로고
    • Tocilizumab-refractory cytokine release syndrome (CRS) triggered by Chimeric antigen receptor (CAR)-Transduced T cells may have distinct cytokine profiles compared to typical CRS
    • Ishii K, Shalabi H, Yates B, Delbrook C, Mackall CL, Fry TJ, et al. Tocilizumab-refractory cytokine release syndrome (CRS) triggered by Chimeric antigen receptor (CAR)-Transduced T cells may have distinct cytokine profiles compared to typical CRS. Blood. 2016;128:3358.
    • (2016) Blood , vol.128 , pp. 3358
    • Ishii, K.1    Shalabi, H.2    Yates, B.3    Delbrook, C.4    Mackall, C.L.5    Fry, T.J.6
  • 34
    • 85034844703 scopus 로고    scopus 로고
    • Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia
    • Mueller KT, Maude SL, Porter DL, Frey N, Wood P, Han X, et al. Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia. Blood; 2017. https://doi.org/10.1182/blood-2017-06-786129.
    • (2017) Blood
    • Mueller, K.T.1    Maude, S.L.2    Porter, D.L.3    Frey, N.4    Wood, P.5    Han, X.6
  • 35
    • 84929915562 scopus 로고    scopus 로고
    • Refractory cytokine release syndrome in recipients of Chimeric antigen receptor (CAR) T cells
    • Frey NV, Levine BL, Lacey SF, Grupp SA, Maude SL, Schuster SJ, et al. Refractory cytokine release syndrome in recipients of Chimeric antigen receptor (CAR) T cells. Blood. 2014;124:2296.
    • (2014) Blood , vol.124 , pp. 2296
    • Frey, N.V.1    Levine, B.L.2    Lacey, S.F.3    Grupp, S.A.4    Maude, S.L.5    Schuster, S.J.6
  • 36
    • 84891832317 scopus 로고    scopus 로고
    • Cytokine release syndrome in cancer immunotherapy with chimeric antigen receptor engineered T cells
    • Xu XJ, Tang YM. Cytokine release syndrome in cancer immunotherapy with chimeric antigen receptor engineered T cells. Cancer Lett. 2014;343:172-8.
    • (2014) Cancer Lett , vol.343 , pp. 172-178
    • Xu, X.J.1    Tang, Y.M.2
  • 37
    • 84961848733 scopus 로고    scopus 로고
    • An analytical biomarker for treatment of patients with recurrent B-ALL after remission induced by infusion of anti-CD19 chimeric antigen receptor T (CAR-T) cells
    • Zhang Y, Zhang W, Dai H, Wang Y, Shi F, Wang C, et al. An analytical biomarker for treatment of patients with recurrent B-ALL after remission induced by infusion of anti-CD19 chimeric antigen receptor T (CAR-T) cells. Sci China Life Sci. 2016;59:379-85.
    • (2016) Sci China Life Sci , vol.59 , pp. 379-385
    • Zhang, Y.1    Zhang, W.2    Dai, H.3    Wang, Y.4    Shi, F.5    Wang, C.6
  • 38
    • 85014625466 scopus 로고    scopus 로고
    • Autologous T cells expressing CD30 Chimeric antigen receptors for relapsed or refractory Hodgkin lymphoma: an open-label phase I trial
    • Wang CM, Wu ZQ, Wang Y, Guo YL, Dai HR, Wang XH, et al. Autologous T cells expressing CD30 Chimeric antigen receptors for relapsed or refractory Hodgkin lymphoma: an open-label phase I trial. Clin Cancer Res. 2017;23:1156-66.
    • (2017) Clin Cancer Res , vol.23 , pp. 1156-1166
    • Wang, C.M.1    Wu, Z.Q.2    Wang, Y.3    Guo, Y.L.4    Dai, H.R.5    Wang, X.H.6
  • 39
    • 85028952993 scopus 로고    scopus 로고
    • Overcoming barriers of car T-cell therapy in patients with mesothelin-expressing cancers
    • O'Hara MH, Stashwick C, Plesa G, Tanyi JL. Overcoming barriers of car T-cell therapy in patients with mesothelin-expressing cancers. Immunotherapy. 2017;9:767-80.
    • (2017) Immunotherapy , vol.9 , pp. 767-780
    • O'Hara, M.H.1    Stashwick, C.2    Plesa, G.3    Tanyi, J.L.4
  • 40
    • 77950480974 scopus 로고    scopus 로고
    • Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial
    • Brentjens R, Yeh R, Bernal Y, Riviere I, Sadelain M. Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial. Mol Ther. 2010;18:666-8.
    • (2010) Mol Ther , vol.18 , pp. 666-668
    • Brentjens, R.1    Yeh, R.2    Bernal, Y.3    Riviere, I.4    Sadelain, M.5
  • 41
    • 84997241574 scopus 로고    scopus 로고
    • Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia
    • Cai B, Guo M, Wang Y, Zhang Y, Yang J, Guo Y, et al. Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia. J Hematol Oncol. 2016;9:131.
    • (2016) J Hematol Oncol , vol.9 , pp. 131
    • Cai, B.1    Guo, M.2    Wang, Y.3    Zhang, Y.4    Yang, J.5    Guo, Y.6
  • 42
    • 84923019006 scopus 로고    scopus 로고
    • T Cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
    • Lee DW, Kochenderfer JN, Stetler-Stevenson M, Cui YK, Delbrook C, Feldman SA et al. T Cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet (London Engl). 2015; 385:517-528.
    • (2015) Lancet (London Engl). , vol.385 , pp. 517-528
    • Lee, D.W.1    Kochenderfer, J.N.2    Stetler-Stevenson, M.3    Cui, Y.K.4    Delbrook, C.5    Feldman, S.A.6
  • 43
    • 84940881287 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
    • Porter DL, Hwang WT, Frey NV, Lacey SF, Shaw PA, Loren AW, et al. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Sci Transl Med. 2015;7:303ra139.
    • (2015) Sci Transl Med , vol.7 , pp. 139-303
    • Porter, D.L.1    Hwang, W.T.2    Frey, N.V.3    Lacey, S.F.4    Shaw, P.A.5    Loren, A.W.6
  • 44
    • 85014362982 scopus 로고    scopus 로고
    • Cytokine release syndrome with novel therapeutics for acute lymphoblastic leukemia
    • Frey NV, Porter DL. Cytokine release syndrome with novel therapeutics for acute lymphoblastic leukemia. Hematol Am Soc Hematol Educ Program. 2016;2016:567-72.
    • (2016) Hematol Am Soc Hematol Educ Program , vol.2016 , pp. 567-572
    • Frey, N.V.1    Porter, D.L.2
  • 45
    • 0027462585 scopus 로고
    • Consensus statement regarding OKT3-induced cytokine-release syndrome and human antimouse antibodies
    • Norman DJ, Chatenoud L, Cohen D, Goldman M. Consensus statement regarding OKT3-induced cytokine-release syndrome and human antimouse antibodies. Transplant Proc. 1993;25:89-92.
    • (1993) Transplant Proc , vol.25 , pp. 89-92
    • Norman, D.J.1    Chatenoud, L.2    Cohen, D.3    Goldman, M.4
  • 46
    • 0033214207 scopus 로고    scopus 로고
    • Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8)
    • Winkler U, Jensen M, Manzke O, Schulz H, Diehl V, Engert A. Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8). Blood. 1999;94:2217-24.
    • (1999) Blood , vol.94 , pp. 2217-2224
    • Winkler, U.1    Jensen, M.2    Manzke, O.3    Schulz, H.4    Diehl, V.5    Engert, A.6
  • 48
    • 0030453977 scopus 로고    scopus 로고
    • Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells
    • Wing MG, Moreau T, Greenwood J, Smith RM, Hale G, Isaacs J, et al. Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells. J Clin Invest. 1996;98:2819-26.
    • (1996) J Clin Invest , vol.98 , pp. 2819-2826
    • Wing, M.G.1    Moreau, T.2    Greenwood, J.3    Smith, R.M.4    Hale, G.5    Isaacs, J.6
  • 49
    • 84882782587 scopus 로고    scopus 로고
    • Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy
    • Teachey DT, Rheingold SR, Maude SL, Zugmaier G, Barrett DM, Seif AE, et al. Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy. Blood. 2013;121:5154-7.
    • (2013) Blood , vol.121 , pp. 5154-5157
    • Teachey, D.T.1    Rheingold, S.R.2    Maude, S.L.3    Zugmaier, G.4    Barrett, D.M.5    Seif, A.E.6
  • 53
    • 73849137192 scopus 로고    scopus 로고
    • Recent advances in the understanding of drug-mediated infusion reactions and cytokine release syndrome
    • Walker M, Makropoulos D, Achuthanandam R, Bugelski PJ. Recent advances in the understanding of drug-mediated infusion reactions and cytokine release syndrome. Curr Opin Drug Discov Devel. 2010;13:124-35.
    • (2010) Curr Opin Drug Discov Devel , vol.13 , pp. 124-135
    • Walker, M.1    Makropoulos, D.2    Achuthanandam, R.3    Bugelski, P.J.4
  • 54
    • 0034090602 scopus 로고    scopus 로고
    • Anti-inflammatory cytokines
    • Opal SM, DePalo VA. Anti-inflammatory cytokines. Chest. 2000;117:1162-72.
    • (2000) Chest , vol.117 , pp. 1162-1172
    • Opal, S.M.1    DePalo, V.A.2
  • 57
    • 84958744448 scopus 로고    scopus 로고
    • Adoptive T cell therapies: a comparison of T cell receptors and Chimeric antigen receptors
    • Harris DT, Kranz DM. Adoptive T cell therapies: a comparison of T cell receptors and Chimeric antigen receptors. Trends Pharmacol Sci. 2016;37:220-30.
    • (2016) Trends Pharmacol Sci , vol.37 , pp. 220-230
    • Harris, D.T.1    Kranz, D.M.2
  • 58
    • 85035020295 scopus 로고    scopus 로고
    • TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance
    • Yang Y, Kohler ME, Chien CD, Sauter CT, Jacoby E, Yan C, et al. TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance. Sci Transl Med; 2017. https://doi.org/10.1126/scitranslmed.aag1209.
    • (2017) Sci Transl Med
    • Yang, Y.1    Kohler, M.E.2    Chien, C.D.3    Sauter, C.T.4    Jacoby, E.5    Yan, C.6
  • 59
    • 84908891854 scopus 로고    scopus 로고
    • Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
    • Adusumilli PS, Cherkassky L, Villena-Vargas J, Colovos C, Servais E, Plotkin J, et al. Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity. Sci Transl Med. 2014;6:261ra151.
    • (2014) Sci Transl Med , vol.6 , pp. 151-261
    • Adusumilli, P.S.1    Cherkassky, L.2    Villena-Vargas, J.3    Colovos, C.4    Servais, E.5    Plotkin, J.6
  • 60
    • 84921651728 scopus 로고    scopus 로고
    • IFN-γ primes macrophage activation by increasing Phosphatase and Tensin homolog via Downregulation of miR-3473b
    • Wu C, Xue Y, Wang P, Lin L, Liu Q, Li N, et al. IFN-γ primes macrophage activation by increasing Phosphatase and Tensin homolog via Downregulation of miR-3473b. J Immunol. 2014;193:3036-44.
    • (2014) J Immunol , vol.193 , pp. 3036-3044
    • Wu, C.1    Xue, Y.2    Wang, P.3    Lin, L.4    Liu, Q.5    Li, N.6
  • 61
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: an immunologic functional perspective
    • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol. 2009;27:451-83.
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 62
    • 85008331152 scopus 로고    scopus 로고
    • Chimeric antigen receptor T-cell neuropsychiatric toxicity in acute lymphoblastic leukemia
    • Prudent V, Breitbart WS. Chimeric antigen receptor T-cell neuropsychiatric toxicity in acute lymphoblastic leukemia. Palliat Support Care. 2017;15:499-503.
    • (2017) Palliat Support Care , vol.15 , pp. 499-503
    • Prudent, V.1    Breitbart, W.S.2
  • 63
    • 85040337972 scopus 로고    scopus 로고
    • CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy
    • Fry TJ, Shah NN, Orentas RJ, Stetler-Stevenson M, Yuan CM, Ramakrishna S, et al. CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy. Nat Med; 2017. https://doi.org/10.1038/nm.4441.
    • (2017) Nat Med
    • Fry, T.J.1    Shah, N.N.2    Orentas, R.J.3    Stetler-Stevenson, M.4    Yuan, C.M.5    Ramakrishna, S.6
  • 64
    • 85017489934 scopus 로고    scopus 로고
    • Trial of novel leukaemia drug is stopped for second time after two more deaths
    • Hawkes N. Trial of novel leukaemia drug is stopped for second time after two more deaths. BMJ. 2016;355:i6376.
    • (2016) BMJ , vol.355
    • Hawkes, N.1
  • 65
    • 85021859705 scopus 로고    scopus 로고
    • Approval filings, another CAR-T therapy patient death
    • Abbasi J, Amid FDA. Approval filings, another CAR-T therapy patient death. JAMA. 2017;317:2271.
    • (2017) JAMA , vol.317 , pp. 2271
    • Abbasi, J.1    Amid, F.D.A.2
  • 66
    • 84926099033 scopus 로고    scopus 로고
    • Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study
    • Topp MS, Gökbuget N, Stein AS, Zugmaier G, O'Brien S, Bargou RC, et al. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study. Lancet Oncol. 2015;16:57.
    • (2015) Lancet Oncol , vol.16 , pp. 57
    • Topp, M.S.1    Gökbuget, N.2    Stein, A.S.3    Zugmaier, G.4    O'Brien, S.5    Bargou, R.C.6
  • 67
    • 84938628792 scopus 로고    scopus 로고
    • Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia
    • Wu J, Fu J, Zhang M, Liu D. Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia. J Hematol Oncol. 2015;8:104.
    • (2015) J Hematol Oncol , vol.8 , pp. 104
    • Wu, J.1    Fu, J.2    Zhang, M.3    Liu, D.4
  • 68
    • 84950989868 scopus 로고    scopus 로고
    • Bispecific antibodies and their applications
    • Fan G, Wang Z, Hao M, Li J. Bispecific antibodies and their applications. J Hematol Oncol. 2015;8:130.
    • (2015) J Hematol Oncol , vol.8 , pp. 130
    • Fan, G.1    Wang, Z.2    Hao, M.3    Li, J.4
  • 69
    • 85025480254 scopus 로고    scopus 로고
    • A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
    • O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, et al. A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci Transl Med; 2017. https://doi.org/10.1126/scitranslmed.aaa0984.
    • (2017) Sci Transl Med
    • O'Rourke, D.M.1    Nasrallah, M.P.2    Desai, A.3    Melenhorst, J.J.4    Mansfield, K.5    Morrissette, J.J.D.6
  • 71
    • 84982181799 scopus 로고    scopus 로고
    • Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy
    • Hu Y, Sun J, Wu Z, Yu J, Cui Q, Pu C, et al. Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy. J Hematol Oncol. 2016;9:70.
    • (2016) J Hematol Oncol , vol.9 , pp. 70
    • Hu, Y.1    Sun, J.2    Wu, Z.3    Yu, J.4    Cui, Q.5    Pu, C.6
  • 72
    • 85037357141 scopus 로고    scopus 로고
    • CNS endothelial cell activation emerges as a driver of CAR T cell-associated neurotoxicity
    • Mackall CL, Miklos DB. CNS endothelial cell activation emerges as a driver of CAR T cell-associated neurotoxicity. Cancer Discov. 2017;7:1371-3.
    • (2017) Cancer Discov , vol.7 , pp. 1371-1373
    • Mackall, C.L.1    Miklos, D.B.2
  • 73
    • 84901623100 scopus 로고    scopus 로고
    • Marked elevation of interleukin-6 in mild encephalopathy with a reversible splenial lesion (MERS) associated with acute focal bacterial nephritis caused by Enterococcus faecalis
    • Kometani H, Kawatani M, Ohta G, Okazaki S, Ogura K, Yasutomi M, et al. Marked elevation of interleukin-6 in mild encephalopathy with a reversible splenial lesion (MERS) associated with acute focal bacterial nephritis caused by Enterococcus faecalis. Brain and Development. 2014;36:551-3.
    • (2014) Brain and Development , vol.36 , pp. 551-553
    • Kometani, H.1    Kawatani, M.2    Ohta, G.3    Okazaki, S.4    Ogura, K.5    Yasutomi, M.6
  • 74
    • 85062926620 scopus 로고    scopus 로고
    • JCAR015 Experience Informs Future CAR-T Studies
    • Accessed 10 Nov 2017.
    • Inman S. JCAR015 Experience Informs Future CAR-T Studies. OncLive; 2017. http://www.onclive.com/web-exclusives/jcar015-experience-informs-future-cart-studies. Accessed 10 Nov 2017.
    • (2017) OncLive
    • Inman, S.1
  • 75
    • 85029155281 scopus 로고    scopus 로고
    • Durable molecular remissions in chronic lymphocytic leukemia treated with CD19-specific Chimeric antigen receptor-modified T cells after failure of Ibrutinib
    • Turtle CJ, Hay KA, Hanafi LA, Li D, Cherian S, Chen X, et al. Durable molecular remissions in chronic lymphocytic leukemia treated with CD19-specific Chimeric antigen receptor-modified T cells after failure of Ibrutinib. J Clin Oncol. 2017;35:3010-20.
    • (2017) J Clin Oncol , vol.35 , pp. 3010-3020
    • Turtle, C.J.1    Hay, K.A.2    Hanafi, L.A.3    Li, D.4    Cherian, S.5    Chen, X.6
  • 77
    • 84908299844 scopus 로고    scopus 로고
    • Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T cells
    • Wang Y, Zhang WY, Han QW, Liu Y, Dai HR, Guo YL, et al. Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T cells. Clin Immunol. 2014;155:160-75.
    • (2014) Clin Immunol , vol.155 , pp. 160-175
    • Wang, Y.1    Zhang, W.Y.2    Han, Q.W.3    Liu, Y.4    Dai, H.R.5    Guo, Y.L.6
  • 78
    • 85011961068 scopus 로고    scopus 로고
    • Forecasting cytokine storms with new predictive biomarkers
    • Rouce RH, Heslop HE. Forecasting cytokine storms with new predictive biomarkers. Cancer Discov. 2016;6:579-80.
    • (2016) Cancer Discov , vol.6 , pp. 579-580
    • Rouce, R.H.1    Heslop, H.E.2
  • 79
    • 85007206434 scopus 로고    scopus 로고
    • Treatment of CD20-directed Chimeric antigen receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an early phase IIa trial report
    • Zhang W-y, Wang Y, Guo Y-l, Dai H-r, Yang Q-m, Zhang Y-j, et al. Treatment of CD20-directed Chimeric antigen receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an early phase IIa trial report. Signal Transduct Target Ther. 2016;1:16002.
    • (2016) Signal Transduct Target Ther , vol.1 , pp. 16002
    • Zhang, W.-Y.1    Wang, Y.2    Guo, Y.-L.3    Dai, H.-R.4    Yang, Q.-M.5    Zhang, Y.-J.6
  • 80
    • 85038218073 scopus 로고    scopus 로고
    • Cytokine release syndrome (CRS) and neurotoxicity (NT) after CD19-specific chimeric antigen receptor- (CAR-) modified T cells
    • Turtle CJ, Hay KA, Gust J, Hanafi L-A, Li D, Liles WC, et al. Cytokine release syndrome (CRS) and neurotoxicity (NT) after CD19-specific chimeric antigen receptor- (CAR-) modified T cells. J Clin Oncol. 2017;35:3020.
    • (2017) J Clin Oncol , vol.35 , pp. 3020
    • Turtle, C.J.1    Hay, K.A.2    Gust, J.3    Hanafi, L.-A.4    Li, D.5    Liles, W.C.6
  • 81
    • 84992635083 scopus 로고    scopus 로고
    • Impact of disease burden on long-term outcome of 19-28z CAR modified T cells in adult patients with relapsed B-ALL
    • Park JH, Riviere I, Wang XY, Purdon T, Sadelain M, Brentjens RJ. Impact of disease burden on long-term outcome of 19-28z CAR modified T cells in adult patients with relapsed B-ALL. J Clin Oncol. 2016;34:7003.
    • (2016) J Clin Oncol , vol.34 , pp. 7003
    • Park, J.H.1    Riviere, I.2    Wang, X.Y.3    Purdon, T.4    Sadelain, M.5    Brentjens, R.J.6
  • 82
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med. 2011;365:725-33.
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 83
    • 85023763854 scopus 로고    scopus 로고
    • Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers
    • Feng K, Liu Y, Guo Y, Qiu J, Wu Z, Dai H, et al. Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers. Protein Cell; 2017. https://doi.org/10.1007/s13238-017-0440-4.
    • (2017) Protein Cell
    • Feng, K.1    Liu, Y.2    Guo, Y.3    Qiu, J.4    Wu, Z.5    Dai, H.6
  • 84
    • 84988805188 scopus 로고    scopus 로고
    • Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cells
    • Turtle CJ, Hanafi LA, Berger C, Hudecek M, Pender B, Robinson E, et al. Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cells. Sci Transl Med. 2016;8:355ra116.
    • (2016) Sci Transl Med , vol.8 , pp. 116-355
    • Turtle, C.J.1    Hanafi, L.A.2    Berger, C.3    Hudecek, M.4    Pender, B.5    Robinson, E.6
  • 85
    • 84902590274 scopus 로고    scopus 로고
    • Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15
    • Xu Y, Zhang M, Ramos CA, Durett A, Liu E, Dakhova O, et al. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15. Blood. 2014;123:3750-9.
    • (2014) Blood , vol.123 , pp. 3750-3759
    • Xu, Y.1    Zhang, M.2    Ramos, C.A.3    Durett, A.4    Liu, E.5    Dakhova, O.6
  • 86
    • 77954590000 scopus 로고    scopus 로고
    • Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma|[sol]|leukemia effects and safety
    • Hoyos V, Savoldo B, Quintarelli C, Mahendravada A, Zhang M, Vera J, et al. Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma|[sol]|leukemia effects and safety. Leukemia. 2010;24:1160.
    • (2010) Leukemia , vol.24 , pp. 1160
    • Hoyos, V.1    Savoldo, B.2    Quintarelli, C.3    Mahendravada, A.4    Zhang, M.5    Vera, J.6
  • 87
    • 84911021644 scopus 로고    scopus 로고
    • Interleukin-15 in the treatment of cancer
    • Waldmann TA. Interleukin-15 in the treatment of cancer. Expert Rev Clin Immunol. 2014;10:1689.
    • (2014) Expert Rev Clin Immunol , vol.10 , pp. 1689
    • Waldmann, T.A.1
  • 88
    • 85017643829 scopus 로고    scopus 로고
    • Lymphoma remissions caused by anti-CD19 Chimeric antigen receptor T cells are associated with high serum Interleukin-15 levels
    • Kochenderfer JN, Somerville RPT, Lu T, Shi V, Bot A, Rossi J, et al. Lymphoma remissions caused by anti-CD19 Chimeric antigen receptor T cells are associated with high serum Interleukin-15 levels. J Clin Oncol. 2017;35:1803-13.
    • (2017) J Clin Oncol , vol.35 , pp. 1803-1813
    • Kochenderfer, J.N.1    Somerville, R.P.T.2    Lu, T.3    Shi, V.4    Bot, A.5    Rossi, J.6
  • 89
    • 85021089637 scopus 로고    scopus 로고
    • Biomarkers of cytokine release syndrome and neurotoxicity after CD19 CAR-T cells and mitigation of toxicity by cell dose
    • Turtle CJ, Hay KA, Juliane G, Hanafi LA, Li D, Chaney C, et al. Biomarkers of cytokine release syndrome and neurotoxicity after CD19 CAR-T cells and mitigation of toxicity by cell dose. Blood. 2016;128:1852.
    • (2016) Blood , vol.128 , pp. 1852
    • Turtle, C.J.1    Hay, K.A.2    Juliane, G.3    Hanafi, L.A.4    Li, D.5    Chaney, C.6
  • 90
    • 85020612225 scopus 로고    scopus 로고
    • Decreased rates of severe CRS seen with early intervention strategies for CD19 CAR-T cell toxicity management
    • Gardner R, Leger KJ, Annesley CE, Summers C, Rivers J, Gust J, et al. Decreased rates of severe CRS seen with early intervention strategies for CD19 CAR-T cell toxicity management. Blood. 2016;128:586.
    • (2016) Blood , vol.128 , pp. 586
    • Gardner, R.1    Leger, K.J.2    Annesley, C.E.3    Summers, C.4    Rivers, J.5    Gust, J.6
  • 91
    • 85053004799 scopus 로고    scopus 로고
    • Preliminary results of prophylactic Tocilizumab after Axicabtageneciloleucel (axi-cel; KTE-C19) treatment for patients with Refractory,Aggressive non-Hodgkin lymphoma (NHL)
    • Locke FL, Neelapu SS, Bartlett NL, Lekakis LJ, Jacobson CA, Braunschweig I, et al. Preliminary results of prophylactic Tocilizumab after Axicabtageneciloleucel (axi-cel; KTE-C19) treatment for patients with Refractory,Aggressive non-Hodgkin lymphoma (NHL). Blood. 2017;130:-1547.
    • (2017) Blood. , vol.130 , pp. 1547
    • Locke, F.L.1    Neelapu, S.S.2    Bartlett, N.L.3    Lekakis, L.J.4    Jacobson, C.A.5    Braunschweig, I.6
  • 92
    • 85014216230 scopus 로고    scopus 로고
    • New development in CAR-T cell therapy
    • Wang Z, Wu Z, Liu Y, Han W. New development in CAR-T cell therapy. J Hematol Oncol. 2017;10:53.
    • (2017) J Hematol Oncol , vol.10 , pp. 53
    • Wang, Z.1    Wu, Z.2    Liu, Y.3    Han, W.4
  • 93
    • 85026297318 scopus 로고    scopus 로고
    • Chimeric antigen receptor T-cells for B-cell malignancies
    • Lichtman EI, Dotti G. Chimeric antigen receptor T-cells for B-cell malignancies. Transl Res; 2017. https://doi.org/10.1016/j.trsl.2017.06.011.
    • (2017) Transl Res
    • Lichtman, E.I.1    Dotti, G.2
  • 95
    • 80051589534 scopus 로고    scopus 로고
    • A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells
    • Wang X, Chang WC, Wong CW, Colcher D, Sherman M, Ostberg JR, et al. A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells. Blood. 2011;118:1255-63.
    • (2011) Blood , vol.118 , pp. 1255-1263
    • Wang, X.1    Chang, W.C.2    Wong, C.W.3    Colcher, D.4    Sherman, M.5    Ostberg, J.R.6
  • 96
    • 84907373133 scopus 로고    scopus 로고
    • A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy
    • Philip B, Kokalaki E, Mekkaoui L, Thomas S, Straathof K, Flutter B, et al. A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy. Blood. 2014;124:1277-87.
    • (2014) Blood , vol.124 , pp. 1277-1287
    • Philip, B.1    Kokalaki, E.2    Mekkaoui, L.3    Thomas, S.4    Straathof, K.5    Flutter, B.6
  • 97
    • 85011392403 scopus 로고    scopus 로고
    • Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells
    • Qasim W, Zhan H, Samarasinghe S, Adams S, Amrolia P, Stafford S, et al. Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells. Sci Transl Med; 2017. https://doi.org/10.1126/scitranslmed.aaj2013.
    • (2017) Sci Transl Med
    • Qasim, W.1    Zhan, H.2    Samarasinghe, S.3    Adams, S.4    Amrolia, P.5    Stafford, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.