Zizimin and dock guanine nucleotide exchange factors in cell function and disease

Small GTPases

Volumn 4, Issue 1, 2013, Pages

  Pakes, Nicholl K ^a   Veltman, Douwe M ^b   Williams, Robin S B ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Dictyostelium; Dock proteins; RacGEFs; Rho Small GTPases; Zizimins

Indexed keywords

DOCK PROTEIN; DOCK1 PROTEIN; DOCK2 PROTEIN; DOCK3 PROTEIN; DOCK4 PROTEIN; DOCK5 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; TUBULIN; UNCLASSIFIED DRUG; ZIZIMIN PROTEIN; ZIZIMINA PROTEIN; ZIZIMINB PROTEIN; PROTOZOAL PROTEIN;

ACTIN FILAMENT; ADAMS OLIVER SYNDROME; ARTICLE; CELLULAR DISTRIBUTION; CHEMOTAXIS; DICTYOSTELIUM DISCOIDEUM; FILOPODIUM; HUMAN; HYPER IGE SYNDROME; IMMUNE DEFICIENCY; LUNG SQUAMOUS CELL CARCINOMA; MICROTUBULE ORGANIZING CENTER; NONHUMAN; PHYLOGENY; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; DICTYOSTELIUM; DOCK PROTEINS; EVOLUTION; GENETICS; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; RACGEFS; RHO SMALL GTPASES; ZIZIMINS;

DICTYOSTELIUM; DOCK PROTEINS; RACGEFS; RHO SMALL GTPASES; ZIZIMINS;

ANIMALS; BIOLOGICAL EVOLUTION; DICTYOSTELIUM; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MUTATION; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS;

EID: 85046983882     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.22087     Document Type: Article

References (45)

1. Hall A. Rho GTPases and the actin cytoskeleton. Science 1998; 279:509-14; PMID:9438836; http://dx.doi.org/10.1126/science.279.5350.509.
2. Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005; 21:247-69; PMID:16212495; http://dx.doi.org/10.1146/annurev.cellbio.21.020604.150721.
3. Vlahou G, Rivero F. Rho GTPase signaling in Dictyostelium discoideum: insights from the genome. Eur J Cell Biol 2006; 85:947-59; PMID:16762450; http://dx.doi.org/10.1016/j.ejcb.2006.04.011.
4. Pakes NK, Veltman DM, Rivero F, Nasir J, Insall R, Williams RS. The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium. J Cell Sci 2012; 125:2457-65; PMID:22366457; http://dx.doi.org/10.1242/jcs.100966.
5. Côté JF, Motoyama AB, Bush JA, Vuori K. A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nat Cell Biol 2005; 7:797-807; PMID:16025104; http://dx.doi.org/10.1038/ncb1280.
6. Côté JF, Vuori K. In vitro guanine nucleotide exchange activity of DHR-2/DOCKER/CZH2 domains. Methods Enzymol 2006; 406:41-57; PMID:16472648; http://dx.doi.org/10.1016/S0076-6879(06)06004-6.
7. Meller N, Merlot S, Guda C. CZH proteins: a new family of Rho-GEFs. J Cell Sci 2005; 118:4937-46; PMID:16254241; http://dx.doi.org/10.1242/jcs.02671.
8. Kobayashi S, Shirai T, Kiyokawa E, Mochizuki N, Matsuda M, Fukui Y. Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3. Biochem J 2001; 354:73-8; PMID:11171081; http://dx.doi.org/10.1042/0264-6021:3540073.
9. Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, et al. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol 2002; 4:574-82; PMID:12134158.
10. Meller N, Irani-Tehrani M, Kiosses WB, Del Pozo MA, Schwartz MA. Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. Nat Cell Biol 2002; 4:639-47; PMID:12172552; http://dx.doi.org/10.1038/ncb835.
11. Zheng Y, Zangrilli D, Cerione RA, Eva A. The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting. J Biol Chem 1996; 271:19017-20; PMID:8702569; http://dx.doi.org/10.1074/jbc.271.32.19017.
12. Cavalier-Smith T. Kingdoms Protozoa and Chromista and the eozoan root of the eukaryotic tree. Biol Lett 2010; 6:342-5; PMID:20031978; http://dx.doi.org/10.1098/rsbl.2009.0948.
13. Fauvarque MO, Williams MJ. Drosophila cellular immunity: a story of migration and adhesion. J Cell Sci 2011; 124:1373-82; PMID:21502134; http://dx.doi.org/10.1242/jcs.064592.
14. Sampson CJ, Valanne S, Fauvarque MO, Hultmark D, Rämet M, Williams MJ. The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42. Dev Comp Immunol 2012; 38:160-8; PMID:22634526; http://dx.doi.org/10.1016/j.dci.2012.05.004.
15. Kunisaki Y, Nishikimi A, Tanaka Y, Takii R, Noda M, Inayoshi A, et al. DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J Cell Biol 2006; 174:647-52; PMID:16943182; http://dx.doi.org/10.1083/jcb.200602142.
16. Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, et al. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol Cell Biol 1996; 16:1770-6; PMID:8657152.
17. Sanders MA, Ampasala D, Basson MD. DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. J Biol Chem 2009; 284:27-35; PMID:19004829; http://dx.doi.org/10.1074/jbc.M808010200.
18. Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, et al. Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science 2009; 324:384-7; PMID:19325080; http://dx.doi.org/10.1126/science.1170179.
19. Namekata K, Harada C, Taya C, Guo X, Kimura H, Parada LF, et al. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc Natl Acad Sci U S A 2010; 107:7586-91; PMID:20368433; http://dx.doi.org/10.1073/pnas.0914514107.
20. Para A, Krischke M, Merlot S, Shen Z, Oberholzer M, Lee S, et al. Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility. Mol Biol Cell 2009; 20:699-707; PMID:19037099; http://dx.doi.org/10.1091/mbc.E08-09-0899.
21. Gadea G, Sanz-Moreno V, Self A, Godi A, Marshall CJ. DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr Biol 2008; 18:1456-65; PMID:18835169; http://dx.doi.org/10.1016/j.cub.2008.08.053.
22. Nishikimi A, Meller N, Uekawa N, Isobe K, Schwartz MA, Maruyama M. Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. FEBS Lett 2005; 579:1039-46; PMID:15710388; http://dx.doi.org/10.1016/j.febslet.2005.01.006.
23. Sakabe I, Asai A, Iijima J, Maruyama M. Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells. Immun Ageing 2012; 9:2; PMID:22494997; http://dx.doi.org/10.1186/1742-4933-9-2.
24. Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, et al. DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood 2012; 119:4451-61; PMID:22461490; http://dx.doi.org/10.1182/blood-2012-01-407098.
25. Miyamoto Y, Yamauchi J, Sanbe A, Tanoue A. Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth. Exp Cell Res 2007; 313:791-804; PMID:17196961; http://dx.doi.org/10.1016/j.yexcr.2006.11.017.
26. Kuramoto K, Negishi M, Katoh H. Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons. J Neurosci Res 2009; 87:1794-805; PMID:19156867; http://dx.doi.org/10.1002/jnr.21997.
27. Eichinger L, Pachebat JA, Glöckner G, Rajandream MA, Sucgang R, Berriman M, et al. The genome of the social amoeba Dictyostelium discoideum. Nature 2005; 435:43-57; PMID:15875012; http://dx.doi.org/10.1038/nature03481.
28. Boeckeler K, Williams RSB. Dictyostelium As a Biomedical Model. Encyclopedia of Life Sciences 2007; In Press; http://dx.doi.org/ 10.1002/9780470015902.a0006038.
29. Williams RS, Boeckeler K, Gräf R, Müller-Taubenberger A, Li Z, Isberg RR, et al. Towards a molecular understanding of human diseases using Dictyostelium discoideum. Trends Mol Med 2006; 12:415-24; PMID:16890490; http://dx.doi.org/10.1016/j.molmed.2006.07.003.
30. Ludtmann MH, Boeckeler K, Williams RS. Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder. Semin Cell Dev Biol 2011; 22:105-13; PMID:21093602; http://dx.doi.org/10.1016/j.semcdb.2010.11.002.
31. Rivero F, Köppel B, Peracino B, Bozzaro S, Siegert F, Weijer CJ, et al. The role of the cortical cytoskeleton: F-actin crosslinking proteins protect against osmotic stress, ensure cell size, cell shape and motility, and contribute to phagocytosis and development. J Cell Sci 1996; 109:2679-91; PMID:8937986.
32. Rivero F, Illenberger D, Somesh BP, Dislich H, Adam N, Meyer AK. Defects in cytokinesis, actin reorganization and the contractile vacuole in cells deficient in RhoGDI. EMBO J 2002; 21:4539-49; PMID:12198156; http://dx.doi.org/10.1093/emboj/cdf449.
33. Dumontier M, Höcht P, Mintert U, Faix J. Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium. J Cell Sci 2000; 113:2253-65; PMID:10825297.
34. Lambe T, Crawford G, Johnson AL, Crockford TL, Bouriez-Jones T, Smyth AM, et al. DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory. Eur J Immunol 2011; 41:3423-35; PMID:21969276; http://dx.doi.org/10.1002/eji.201141759.
35. Engelhardt KR, McGhee S, Winkler S, Sassi A, Woellner C, Lopez-Herrera G, et al. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol 2009; 124:1289-302, e4; PMID:20004785; http://dx.doi.org/10.1016/j.jaci.2009.10.038.
36. Zhang Q, Davis JC, Lamborn IT, Freeman AF, Jing H, Favreau AJ, et al. Combined immunodeficiency associated with DOCK8 mutations. N Engl J Med 2009; 361:2046-55; PMID:19776401; http://dx.doi.org/10.1056/NEJMoa0905506.
37. Takahashi K, Kohno T, Ajima R, Sasaki H, Minna JD, Fujiwara T, et al. Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. Int J Oncol 2006; 28:321-8; PMID:16391785.
38. Shaheen R, Faqeih E, Sunker A, Morsy H, Al-Sheddi T, Shamseldin HE, et al. Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome. Am J Hum Genet 2011; 89:328-33; PMID:21820096; http://dx.doi.org/10.1016/j.ajhg.2011.07.009.
39. Detera-Wadleigh SD, Liu CY, Maheshwari M, Cardona I, Corona W, Akula N, et al.; NIMH Genetics Initiative for Bipolar Disorder Consortium. Sequence variation in DOCK9 and heterogeneity in bipolar disorder. Psychiatr Genet 2007; 17:274-86; PMID:17728666; http://dx.doi.org/10.1097/YPG.0b013e328133f352.
40. Zhou L, Opalinska J, Sohal D, Yu Y, Mo Y, Bhagat T, et al. Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q. J Biol Chem 2011; 286:25211-23; PMID:21532034; http://dx.doi.org/10.1074/jbc.M111.235028.
41. Yajnik V, Paulding C, Sordella R, McClatchey AI, Saito M, Wahrer DC, et al. DOCK4, a GTPase activator, is disrupted during tumorigenesis. Cell 2003; 112:673-84; PMID:12628187; http://dx.doi.org/10.1016/S0092-8674(03)00155-7.
42. Pagnamenta AT, Bacchelli E, de Jonge MV, Mirza G, Scerri TS, Minopoli F, et al.; International Molecular Genetic Study Of Autism Consortium. Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biol Psychiatry 2010; 68:320-8; PMID:20346443; http://dx.doi.org/10.1016/j.biopsych.2010.02.002.
43. Tachi N, Hashimoto Y, Matsuoka M. MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins. Biochem J 2012; 442:413-22; PMID:22115042; http://dx.doi.org/10.1042/BJ20100993.
44. Gadea G, Sanz-Moreno V, Self A, Godi A, Marshall CJ. DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr Biol 2008; 18:1456-65; PMID:18835169; http://dx.doi.org/10.1016/j.cub.2008.08.053.
45. Watabe-Uchida M, John KA, Janas JA, Newey SE, Van Aelst L. The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron 2006; 51:727-39; PMID:16982419; http://dx.doi.org/10.1016/j.neuron.2006.07.020.