Defects in cytokinesis, actin reorganization and the contractile vacuole in cells deficient in RhoGDI

EMBO Journal

Volumn 21, Issue 17, 2002, Pages 4539-4549

  Rivero, Francisco ^a   Illenberger, Daria ^b   Somesh, Baggavalli P ^a   Dislich, Heidrun ^a   Adam, Nicola ^b   Meyer, Ann Kathrin ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Actin; Contractile vacuole; Dictyostelium; Rac; RhoGDI

Indexed keywords

ACTIN; CHEMOATTRACTANT; CONTRACTILE PROTEIN; CYCLIC AMP; GUANOSINE TRIPHOSPHATASE; PROTEIN INHIBITOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ACTIN FILAMENT; AMINO TERMINAL SEQUENCE; ARTICLE; CELL MUTANT; CELL VACUOLE; CYTOKINESIS; DICTYOSTELIUM; DISSOCIATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOCYTOSIS; PINOCYTOSIS; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SPECIES DIVERSITY;

ACTINS; AMINO ACID SEQUENCE; ANIMALS; BIOPOLYMERS; CELL DIVISION; CHEMOTAXIS; CYTOCHALASINS; CYTOSKELETON; DICTYOSTELIUM; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; MOLECULAR SEQUENCE DATA; PROTOZOAN PROTEINS; RAC GTP-BINDING PROTEINS; RHO GTP-BINDING PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; TWO-HYBRID SYSTEM TECHNIQUES; VACUOLAR PROTON-TRANSLOCATING ATPASES; VACUOLES;

DICTYOSTELIUM;

EID: 0037009362     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf449     Document Type: Article

References (49)

1. rac1
2. Drainin required for membrane fusion of the contractile vacuole in Dictyostelium is the prototype of a protein family also represented in man
3. A role for a Rab4-like GTPase in endocytosis and in regulation of contractile vacuole structure and function in Dictyostelium discoideum
4. Membrane recruitment of Rac1 triggers phagocytosis
5. Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells
6. Water and ion transport
7. The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading
8. Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI
9. Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium
10. Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the RhoGTPase CDC42Hs
11. Rho1P and Cdc42p act after Ypt7p to regulate vacuole docking
12. Regulation of endocytic traffic by Rho family GTPases
13. Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins
14. Chemotactic reorientation of granulocytes stimulated with micropipettes containing fMet-Leu-Phe
15. Vav, a GDP/GTP nuclotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation
16. Rho GTPases and the actin cytoskeleton
17. Relationship of pseudopod extension to chemotactic hormone-induced actin polymerization in amoeboid cells
18. A Rab11-like GTPase associates with and regulates the structure and function of the contractile vacuole system in Dictyostelium
19. A GDP dissociation inhibitor that serves as a GTPase inhibitor of the Ras-like protein CDC42Hs
20. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI
21. Post translational modifications of the C-terminal region of the rho protein are important for its interaction with the membranes and inhibitory GDP/GTP exchange proteins
22. 2 by the Rho GTPases Cdc42Hs and Rac1
23. Targeted gene disruption reveals a role for vacuolin B in the late endocytic pathway and exocytosis
24. The Dictyostelium Bcr/Abr-related protein DRG regulates both Rac- and Rab-dependent pathways
25. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
26. Regulation of receptor-mediated endocytosis by Rho and Rac
27. Role of the Dictyostelium race in cytokinesis: Mutational analysis and localization studies by use of green fluorescent protein
28. Differential localization of Rho GTPases in live cells: Regulation by hypervariable regions and RhoGDI binding
29. The specific binding of small molecule isoprenoids to rhoGDP dissociation inhibitor (rhoGDI)
30. Dictyostelium discoideum protein disulfide isomerase, an endoplasmic reticulum resident enzyme lacking a KDEL-type retrieval signal
31. The actin cytoskeleton of Dictyostelium: A story told by mutants
32. Rho guanine dissociation inhibitors: Pivotal molecules in cellular signalling
33. Mutant Rac1b expression in Dictyostelium: Effects on morphology, growth, endocytosis, development and the actin cytoskeleton
34. A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors
35. Coronin and vacuolin identify consecutive stages of a late, actin-coated endocytic compartment in Dictyostelium
36. Rho GTPases and cell migration
37. RacF1, a novel member of the Rho protein family in Dictyostelium discoideum, associates transiently with cell contact areas, macropinosomes and phagosomes
38. The Dictyostelium family of Rho-related proteins
39. The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI
40. Overexpression of a novel Rho family GTPase, RacC, induces unusual actin-based structures and positively affects phagocytosis in Dictyostelium discoideum
41. Monoclonal antibodies prepared against Dictyostelium actin: Characterization and interaction with actin
42. Computer-assisted systems for the analysis of amoeboid cell motility
43. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
44. Progressive impairment of kidneys and reproductive organs in mice lacking RhoGDIα
45. Characterization of Rac1- and RhoGDI-associated lipid kinase signalling complex
46. Rho GTPases and signaling networks
47. Microfilament dynamics during cell movement and chemotaxis monitored using a GFP-actin fusion
48. Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases